DOI record: { "DOI": "10.1055/s-0042-1753470", "ISSN": [ "1305-7456", "1305-7464" ], "URL": "http://dx.doi.org/10.1055/s-0042-1753470", "abstract": "<jats:title>Abstract</jats:title><jats:p>The efficacy of mouthwash for reducing the viral load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This systematic review and meta-analysis comprehensively examined the effects of chlorhexidine (CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed methodological analysis, systematic review, and meta-analysis of included studies using the Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of 1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I significantly reduced the number of negative reverse-transcription polymerase chain reaction (RT-PCR) results (p&lt;0.001) among COVID-19 patients. The CHX and PVP-I were effective on reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using adequate randomization methods and larger samples are warned.</jats:p>", "author": [ { "affiliation": [ { "name": "School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan" } ], "family": "Hasan", "given": "Faizul", "sequence": "additional" }, { "affiliation": [ { "name": "School of Nursing, College of Nursing, Taipei Medical University, Taipei, Taiwan" } ], "family": "Chiu", "given": "Hsiao-Yean", "sequence": "additional" }, { "affiliation": [ { "name": "School of Dentistry, College of Dentistry, Taipei Medical University, Taipei, Taiwan" } ], "family": "Salamanca", "given": "Eisner", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0003-3711-0601", "affiliation": [ { "name": "School of Nursing, Faculty of Health Sciences, Alma Ata University, Yogyakarta, Indonesia" } ], "authenticated-orcid": false, "family": "Ridwan", "given": "Edi S.", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Epidemiology, Biostatistics and Population Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta City, Indonesia" } ], "family": "Wiratama", "given": "Bayu S.", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-5518-3372", "affiliation": [ { "name": "Department of Oral Biology, Dental Pharmacology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia" } ], "authenticated-orcid": false, "family": "Budi", "given": "Hendrik S.", "sequence": "additional" } ], "container-title": "European Journal of Dentistry", "container-title-short": "Eur J Dent", "content-domain": { "crossmark-restriction": false, "domain": [] }, "created": { "date-parts": [ [ 2022, 9, 8 ] ], "date-time": "2022-09-08T23:05:51Z", "timestamp": 1662678351000 }, "deposited": { "date-parts": [ [ 2022, 9, 8 ] ], "date-time": "2022-09-08T23:12:49Z", "timestamp": 1662678769000 }, "indexed": { "date-parts": [ [ 2022, 9, 8 ] ], "date-time": "2022-09-08T23:42:23Z", "timestamp": 1662680543617 }, "is-referenced-by-count": 0, "issued": { "date-parts": [ [ 2022, 9, 8 ] ] }, "language": "en", "license": [ { "URL": "https://creativecommons.org/licenses/by/4.0/", "content-version": "vor", "delay-in-days": 0, "start": { "date-parts": [ [ 2022, 9, 8 ] ], "date-time": "2022-09-08T00:00:00Z", "timestamp": 1662595200000 } } ], "link": [ { "URL": "http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0042-1753470.pdf", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "194", "original-title": [], "prefix": "10.1055", "published": { "date-parts": [ [ 2022, 9, 8 ] ] }, "published-online": { "date-parts": [ [ 2022, 9, 8 ] ] }, "publisher": "Georg Thieme Verlag KG", "reference": [ { "DOI": "10.1056/NEJMoa2001017", "article-title": "A novel coronavirus from patients with pneumonia in China, 2019", "author": "N Zhu", "doi-asserted-by": "crossref", "first-page": "727", "issue": "08", 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"references-count": 47, "relation": {}, "resource": { "primary": { "URL": "http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1753470" } }, "score": 1, "short-title": [], "source": "Crossref", "subject": [ "General Dentistry" ], "subtitle": [], "title": "Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis", "type": "journal-article" }