Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and Meta-analysis

{ 'indexed': {'date-parts': [[2022, 9, 8]], 'date-time': '2022-09-08T23:42:23Z', 'timestamp': 1662680543617}, 'reference-count': 47, 'publisher': 'Georg Thieme Verlag KG', 'license': [ { 'start': { 'date-parts': [[2022, 9, 8]], 'date-time': '2022-09-08T00:00:00Z', 'timestamp': 1662595200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:title>Abstract</jats:title><jats:p>The efficacy of mouthwash for reducing the viral ' 'load in patients with the novel coronavirus disease 2019 (COVID-19) remains unclear. This ' 'systematic review and meta-analysis comprehensively examined the effects of chlorhexidine ' '(CHX) and povidone-iodine (PVP-I) on the viral load in patients with COVID-19. We performed ' 'methodological analysis, systematic review, and meta-analysis of included studies using the ' 'Comprehensive Meta-analysis Software. PubMed, EMBASE, Cochrane Library, and ProQuest were ' 'searched from December 1, 2019, to December 2, 2021. In total, we included 10 studies of ' '1,339 patients with COVID-19. Compared with the control group, both CHX and PVP-I ' 'significantly reduced the number of negative reverse-transcription polymerase chain reaction ' '(RT-PCR) results (p&lt;0.001) among COVID-19 patients. The CHX and PVP-I were effective on ' 'reducing the number of negative RT-PCR results in COVID-19 patients. Additional studies using ' 'adequate randomization methods and larger samples are warned.</jats:p>', 'DOI': '10.1055/s-0042-1753470', 'type': 'journal-article', 'created': {'date-parts': [[2022, 9, 8]], 'date-time': '2022-09-08T23:05:51Z', 'timestamp': 1662678351000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Effects of Chlorhexidine and Povidone-Iodine on the SARS-CoV-2 Load: A Systematic Review and ' 'Meta-analysis', 'prefix': '10.1055', 'author': [ { 'given': 'Faizul', 'family': 'Hasan', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Nursing, College of Nursing, Taipei Medical ' 'University, Taipei, Taiwan'}]}, { 'given': 'Hsiao-Yean', 'family': 'Chiu', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Nursing, College of Nursing, Taipei Medical ' 'University, Taipei, Taiwan'}]}, { 'given': 'Eisner', 'family': 'Salamanca', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Dentistry, College of Dentistry, Taipei Medical ' 'University, Taipei, Taiwan'}]}, { 'ORCID': 'http://orcid.org/0000-0003-3711-0601', 'authenticated-orcid': False, 'given': 'Edi S.', 'family': 'Ridwan', 'sequence': 'additional', 'affiliation': [ { 'name': 'School of Nursing, Faculty of Health Sciences, Alma Ata ' 'University, Yogyakarta, Indonesia'}]}, { 'given': 'Bayu S.', 'family': 'Wiratama', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Epidemiology, Biostatistics and Population Health, ' 'Faculty of Medicine, Public Health and Nursing, Universitas ' 'Gadjah Mada, Yogyakarta City, Indonesia'}]}, { 'ORCID': 'http://orcid.org/0000-0002-5518-3372', 'authenticated-orcid': False, 'given': 'Hendrik S.', 'family': 'Budi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Oral Biology, Dental Pharmacology, Faculty of ' 'Dental Medicine, Universitas Airlangga, Surabaya, Indonesia'}]}], 'member': '194', 'published-online': {'date-parts': [[2022, 9, 8]]}, 'reference': [ { 'issue': '08', 'key': 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