Antiseptics as effective virucidal agents against SARS-CoV-2: Systematic review and Bayesian network meta-analysis

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Timeline: WHO`s COVID-19 response [Internet]. [Accesed 2025 Jan 31]. Available at: 〈https://www.who.int/emergencies/diseases/novel-coronavirus-2019/interactive-timeline/〉." }, { "key": "10.1016/j.jdsr.2025.05.001_bib2", "unstructured": "World Health Organization. WHO director-general’s remarks at the media briefing on 2019-nCoV on 11 February 2020. 2020; [Accesed 2025 Jan 31]. Available at: 〈https://www.who.int/director-general/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020〉." }, { "article-title": "Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19 disease", "author": "Struyf", "first-page": "CD013665", "issue": "7", "journal-title": "Cochrane Database Syst Rev", "key": "10.1016/j.jdsr.2025.05.001_bib3", "volume": "7", "year": "2020" }, { "DOI": "10.1111/all.14657", "article-title": "Risk factors for severe and critically ill COVID-19 patients: a review", "author": "Gao", "doi-asserted-by": "crossref", "first-page": "428", "issue": "2", "journal-title": "Allergy", "key": "10.1016/j.jdsr.2025.05.001_bib4", "volume": "76", "year": "2021" }, { "DOI": "10.1007/s12016-022-08921-5", "article-title": "Risk and protective factors for COVID-19 morbidity, severity, and mortality", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "90", "issue": "1", "journal-title": "Clin Rev Allergy Immunol", "key": "10.1016/j.jdsr.2025.05.001_bib5", "volume": "64", "year": "2023" }, { "key": "10.1016/j.jdsr.2025.05.001_bib6", "unstructured": "World Health Organization. WHO COVID-19 dashboard. 2024;[Last update 2025 Jan 12]. Available at: 〈https://data.who.int/dashboards/covid19/〉." }, { "key": "10.1016/j.jdsr.2025.05.001_bib7", "unstructured": "World Health Organization. Statement on the fifteenth meeting of the IHR (2005) Emergency Commitee on the COVID-19 pandemic. 2023. Available at: https://www.who.int/news/item/05-05-2023-statement-on-the-fifteenth-meeting-of-the-international-health-regulations-(2005)-emergency-committee-regarding-the-coronavirus-disease-(covid-19)-pandemic." }, { "DOI": "10.1002/jmv.27487", "article-title": "COVID-19 vaccinations: The unknowns, challenges, and hopes", "author": "Mohamed", "doi-asserted-by": "crossref", "first-page": "1336", "issue": "4", "journal-title": "J Med Virol", "key": "10.1016/j.jdsr.2025.05.001_bib8", "volume": "94", "year": "2022" }, { "DOI": "10.1002/rmv.2507", "article-title": "Safety and efficacy of COVID-19 vaccines: a systematic review and meta-analysis of controlled and randomized clinical trials", "author": "Beladiya", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Rev Med Virol", "key": "10.1016/j.jdsr.2025.05.001_bib9", "volume": "34", "year": "2024" }, { "key": "10.1016/j.jdsr.2025.05.001_bib10", "unstructured": "Mathieu E., Ritchie H., Rodés-Guirao L., Appel C., Gavrilov D., Giattino C., et al. Coronavirus (COVID-19) vaccinations. Our World in Data [Internet]. 2024 [Last update: 2024 Aug 12]. Available at: 〈https://ourworldindata.org/covid-vaccinations〉." }, { "DOI": "10.1186/s12879-023-08553-w", "article-title": "SARS-CoV-2 vaccine breakthrough infection in the older adults: a meta-analysis and systematic review", "author": "Jing", "doi-asserted-by": "crossref", "first-page": "577", "issue": "1", "journal-title": "BMC Infect Dis", "key": "10.1016/j.jdsr.2025.05.001_bib11", "volume": "23", "year": "2023" }, { "DOI": "10.1097/MD.0000000000035201", "article-title": "Efficacy of adjuvant-associated COVID-19 vaccines against SARS-CoV-2 variants of concern in randomized controlled trials: a systematic review and meta-analysis", "author": "Cheng", "doi-asserted-by": "crossref", "issue": "7", "journal-title": "Medicine", "key": "10.1016/j.jdsr.2025.05.001_bib12", "volume": "103", "year": "2024" }, { "DOI": "10.3390/ijms23031431", "article-title": "Oral pathology in COVID-19 and SARS-CoV-2 infection—molecular aspects", "author": "Drozdzik", "doi-asserted-by": "crossref", "first-page": "1431", "issue": "3", "journal-title": "Int J Mol Sci", "key": "10.1016/j.jdsr.2025.05.001_bib13", "volume": "23", "year": "2022" }, { "key": "10.1016/j.jdsr.2025.05.001_bib14", "unstructured": "World Health Organization. Considerations for the provision of essential oral health services in the context of COVID-19: interim guidance, 3 Agust 2020. 2020. Available at: 〈https://iris.who.int/handle/10665/333625〉." }, { "DOI": "10.1093/function/zqaa002", "article-title": "Potential role of oral rinses targeting the viral lipid envelope in SARS-CoV-2 infection", "author": "O’Donnell", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Function", "key": "10.1016/j.jdsr.2025.05.001_bib15", "volume": "1", "year": "2020" }, { "DOI": "10.1111/jcpe.13746", "article-title": "Randomized clinical trial to assess the impact of oral intervention with cetylpyridinium chloride to reduce salivary SARS-CoV-2 viral load", "author": "Tarragó-Gil", "doi-asserted-by": "crossref", "first-page": "288", "issue": "3", "journal-title": "J Clin Periodontol", "key": "10.1016/j.jdsr.2025.05.001_bib16", "volume": "50", "year": "2023" }, { "article-title": "Effect of phthalocyanine oral and nasal antiseptic solutions on the infectivity of SARS-CoV-2 in patients with COVID-19: a randomized controlled trial", "author": "Colado-Simão", "first-page": "Doc07", "journal-title": "Ger Med Sci", "key": "10.1016/j.jdsr.2025.05.001_bib17", "volume": "21", "year": "2023" }, { "article-title": "In vivo evaluation of the virucidal efficacy of chlorhexidine and povidone-iodine mouthwashes against salivary SARS-CoV-2. A randomized-controlled clinical trial", "author": "Elzein", "issue": "3", "journal-title": "J Evid Based Dent Pr", "key": "10.1016/j.jdsr.2025.05.001_bib18", "volume": "21", "year": "2021" }, { "DOI": "10.1016/j.jdsr.2021.03.001", "article-title": "Can povidone iodine gargle/mouthrinse inactivate SARS-CoV-2 and decrease the risk of nosocomial and community transmission during the COVID-19 pandemic? an evidence-based update", "author": "Chopra", "doi-asserted-by": "crossref", "first-page": "39", "journal-title": "Jpn Dent Sci Rev", "key": "10.1016/j.jdsr.2025.05.001_bib19", "volume": "57", "year": "2021" }, { "DOI": "10.1590/1807-3107bor-2023.vol37.0038", "article-title": "Efficacy of mouthrinses in reducing oral SARS-COV-2 load: a review", "author": "Pannuti", "doi-asserted-by": "crossref", "journal-title": "Braz Oral Res", "key": "10.1016/j.jdsr.2025.05.001_bib20", "volume": "37", "year": "2023" }, { "DOI": "10.1016/j.jhin.2023.06.022", "article-title": "Effectiveness of mouth rinses against COVID-19: a systematic review and network meta-analysis", "author": "Lin", "doi-asserted-by": "crossref", "first-page": "175", "journal-title": "J Hosp Infect", "key": "10.1016/j.jdsr.2025.05.001_bib21", "volume": "139", "year": "2023" }, { "DOI": "10.1016/j.jdsr.2023.09.003", "article-title": "Efficacy of different mouthwashes against COVID-19: a systematic review and network meta-analysis", "author": "Sbricoli", "doi-asserted-by": "crossref", "first-page": "334", "journal-title": "Jpn Dent Sci Rev", "key": "10.1016/j.jdsr.2025.05.001_bib22", "volume": "59", "year": "2023" }, { "DOI": "10.1002/bimj.202200316", "article-title": "Sharing information across patient subgroups to draw conclusions from sparse treatment networks", "author": "Evrenoglou", "doi-asserted-by": "crossref", "issue": "3", "journal-title": "Biom J", "key": "10.1016/j.jdsr.2025.05.001_bib23", "volume": "66", "year": "2024" }, { "DOI": "10.7326/M14-2385", "article-title": "The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations", "author": "Hutton", "doi-asserted-by": "crossref", "first-page": "777", "issue": "11", "journal-title": "Ann Intern Med", "key": "10.1016/j.jdsr.2025.05.001_bib24", "volume": "162", "year": "2015" }, { "key": "10.1016/j.jdsr.2025.05.001_bib25", "unstructured": "R Core Team. R: A language and environment for statistical computing. R Foundation for Statistical Computing. 2022. Available at: 〈https://www.R-project.org/〉." }, { "article-title": "Data extraction and synthesis in systematic reviews of diagnostic test accuracy: a corpus for automating and evaluating the process", "author": "Norman", "first-page": "826", "journal-title": "AMIA Annu Symp Proc", "key": "10.1016/j.jdsr.2025.05.001_bib26", "volume": "817", "year": "2018" }, { "article-title": "Text Mining Package", "author": "Feinerer", "journal-title": "R Package Version 0.7-10.", "key": "10.1016/j.jdsr.2025.05.001_bib27", "year": "2022" }, { "DOI": "10.18637/jss.v025.i05", "article-title": "Text mining infrastructure in R", "author": "Feinerer", "doi-asserted-by": "crossref", "first-page": "1", "issue": "5", "journal-title": "J Stat Softw", "key": "10.1016/j.jdsr.2025.05.001_bib28", "volume": "25", "year": "2008" }, { "key": "10.1016/j.jdsr.2025.05.001_bib29", "unstructured": "Hornik K. NLP: natural language processing infrastructure. R Package Version 0.2-1.2020. Available at: https://CRAN.R-project.org/package=NLP." }, { "DOI": "10.1111/jcpe.13188", "article-title": "Accuracy of single molecular biomarkers in gingival crevicular fluid for the diagnosis of periodontitis: a systematic review and meta-analysis", "author": "Arias-Bujanda", "doi-asserted-by": "crossref", "first-page": "1166", "issue": "12", "journal-title": "J Clin Periodontol", "key": "10.1016/j.jdsr.2025.05.001_bib30", "volume": "46", "year": "2019" }, { "DOI": "10.1111/jcpe.13202", "article-title": "Accuracy of single molecular biomarkers in saliva for the diagnosis of periodontitis: a systematic review and meta-analysis", "author": "Arias-Bujanda", "doi-asserted-by": "crossref", "first-page": "2", "issue": "1", "journal-title": "J Clin Periodontol", "key": "10.1016/j.jdsr.2025.05.001_bib31", "volume": "47", "year": "2020" }, { "author": "Higgins", "key": "10.1016/j.jdsr.2025.05.001_bib32", "series-title": "Chapter 8: Assessing risk of bias in a randomized trial [last updated October 2019]", "year": "2024" }, { "DOI": "10.1201/9781003107347", "doi-asserted-by": "crossref", "key": "10.1016/j.jdsr.2025.05.001_bib33", "unstructured": "M. Harrer P. Cuijpers T. Furukawa D. Ebert Doing meta-analysis with R: a hands-on guide 1st ed. 2021 Chapman Hall/CRC." }, { "author": "Higgins", "key": "10.1016/j.jdsr.2025.05.001_bib34", "series-title": "Chapter 23: Including variants on randomized trials [last updated October 2019]", "year": "2024" }, { "DOI": "10.18637/jss.v106.i02", "article-title": "netmeta: An R package for network meta-analysis using frequentist methods", "author": "Balduzzi", "doi-asserted-by": "crossref", "first-page": "1", "issue": "2", "journal-title": "J Stat Soft", "key": "10.1016/j.jdsr.2025.05.001_bib35", "volume": "106", "year": "2023" }, { "key": "10.1016/j.jdsr.2025.05.001_bib36", "unstructured": "van-Valkenhoef G., Kuiper J. Network meta-analysis using bayesian methods. R Package Version 1.0-2.2023. Available at: 〈https://CRAN.R-project.org/package=gemtc〉." }, { "author": "Gelman", "key": "10.1016/j.jdsr.2025.05.001_bib37", "series-title": "Bayesian data analysis", "year": "2013" }, { "author": "Lunn", "key": "10.1016/j.jdsr.2025.05.001_bib38", "series-title": "The BUGS Book: a practical introduction to Bayesian analysis", "year": "2012" }, { "article-title": "CODA: convergence diagnosis and output analysis for MCMC", "author": "Plummer", "first-page": "7", "issue": "1", "journal-title": "R News", "key": "10.1016/j.jdsr.2025.05.001_bib39", "volume": "6", "year": "2006" }, { "DOI": "10.35566/jbds/v2n2/p3", "article-title": "The performances of Gelman-Rubin and Geweke’s convergence diagnostics of Monte Carlo Markov chains in Bayesian analysis", "author": "Du", "doi-asserted-by": "crossref", "first-page": "47", "issue": "2", "journal-title": "J Behav Data Sci", "key": "10.1016/j.jdsr.2025.05.001_bib40", "volume": "2", "year": "2022" }, { "DOI": "10.1002/sim.3767", "article-title": "Checking consistency in mixed treatment comparison meta-analysis", "author": "Dias", "doi-asserted-by": "crossref", "first-page": "932", "issue": "7-8", "journal-title": "Stat Med", "key": "10.1016/j.jdsr.2025.05.001_bib41", "volume": "29", "year": "2010" }, { "DOI": "10.1016/j.jclinepi.2010.03.016", "article-title": "Graphical methods and numerical summaries for presenting results from multiple-treatment meta-analysis: an overview and tutorial", "author": "Salanti", "doi-asserted-by": "crossref", "first-page": "163", "issue": "2", "journal-title": "J Clin Epidemiol", "key": "10.1016/j.jdsr.2025.05.001_bib42", "volume": "64", "year": "2011" }, { "DOI": "10.1371/journal.pone.0076654", "article-title": "Graphical tools for network meta-analysis in STATA", "author": "Chaimani", "doi-asserted-by": "crossref", "issue": "10", "journal-title": "PLoS One", "key": "10.1016/j.jdsr.2025.05.001_bib43", "volume": "8", "year": "2013" }, { "DOI": "10.4103/njcp.njcp_320_22", "article-title": "Evaluating the effect of gargling with hydrogen peroxide and povidone-iodine on salivary viral load of SARS-CoV-2: a pilot randomized clinical trial", "author": "Adl", "doi-asserted-by": "crossref", "first-page": "391", "issue": "4", "journal-title": "Niger J Clin Pr", "key": "10.1016/j.jdsr.2025.05.001_bib44", "volume": "26", "year": "2023" }, { "DOI": "10.1177/00220345221102310", "article-title": "Cetylpyridinium chloride mouthwash to reduce shedding of infectious SARS-CoV-2: a double-blind randomized clinical trial", "author": "Alemany", "doi-asserted-by": "crossref", "first-page": "1450", "issue": "12", "journal-title": "J Dent Res", "key": "10.1016/j.jdsr.2025.05.001_bib45", "volume": "101", "year": "2022" }, { "DOI": "10.1186/s12879-024-09137-y", "article-title": "Efficacy of povidone-iodine nasal rinse and mouth wash in COVID-19 management: a prospective, randomized pilot clinical trial (povidone-iodine in COVID-19 management)", "author": "Alsaleh", "doi-asserted-by": "crossref", "first-page": "271", "issue": "1", "journal-title": "BMC Infect Dis", "key": "10.1016/j.jdsr.2025.05.001_bib46", "volume": "24", "year": "2024" }, { "DOI": "10.1002/jmv.28412", "article-title": "Mouth rinses efficacy on salivary SARS-CoV-2 viral load: a randomized clinical trial", "author": "Alzahrani", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "J Med Virol", "key": "10.1016/j.jdsr.2025.05.001_bib47", "volume": "95", "year": "2023" }, { "DOI": "10.3390/antibiotics12121724", "article-title": "Application of octenidine into nasal vestibules does not influence SARS-CoV-2 detection via PCR or antigen test methods", "author": "Assadian", "doi-asserted-by": "crossref", "first-page": "1724", "issue": "12", "journal-title": "Antibiotics", "key": "10.1016/j.jdsr.2025.05.001_bib48", "volume": "12", "year": "2023" }, { "DOI": "10.1080/20002297.2022.2152179", "article-title": "Antimicrobial oral lavage reduces the SARS-CoV-2 load in intubated patients: randomized clinical trial", "author": "Bezinelli", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "J Oral Microbiol", "key": "10.1016/j.jdsr.2025.05.001_bib49", "volume": "15", "year": "2022" }, { "DOI": "10.1177/00220345231156415", "article-title": "Efficacy of a mouthwash containing CHX and CPC in SARS-CoV-2–positive patients: a randomized controlled clinical trial", "author": "Bonn", "doi-asserted-by": "crossref", "first-page": "608", "issue": "6", "journal-title": "J Dent Res", "key": "10.1016/j.jdsr.2025.05.001_bib50", "volume": "102", "year": "2023" }, { "DOI": "10.1111/jcpe.13905", "article-title": "Eligibility and efficacy of a CPC- and CHX-based antiviral mouthwash for the elimination of SARS-CoV-2 from the saliva: a randomized, double-blind, controlled clinical trial", "author": "Brunello", "doi-asserted-by": "crossref", "first-page": "158", "issue": "2", "journal-title": "J Clin Periodontol", "key": "10.1016/j.jdsr.2025.05.001_bib51", "volume": "51", "year": "2024" }, { "DOI": "10.1016/j.cmi.2021.05.028", "article-title": "Use of an antiviral mouthwash as a barrier measure in the SARS-CoV-2 transmission in adults with asymptomatic to mild COVID-19: a multicentre, randomized, double-blind controlled trial", "author": "Carrouel", "doi-asserted-by": "crossref", "first-page": "1494", "issue": "10", "journal-title": "Clin Microbiol Infect", "key": "10.1016/j.jdsr.2025.05.001_bib52", "volume": "27", "year": "2021" }, { "DOI": "10.1111/odi.14086", "article-title": "Chlorhexidine mouthwash reduces the salivary viral load of SARS-CoV-2: a randomized clinical trial", "author": "Costa", "doi-asserted-by": "crossref", "first-page": "2500", "issue": "S2", "journal-title": "Oral Dis", "key": "10.1016/j.jdsr.2025.05.001_bib53", "volume": "28", "year": "2022" }, { "DOI": "10.1016/j.amjoto.2022.103549", "article-title": "Efficacy of antiseptic mouthrinses against SARS-CoV-2: a prospective randomized placebo-controlled pilot study", "author": "Fantozzi", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "Am J Otolaryngol", "key": "10.1016/j.jdsr.2025.05.001_bib54", "volume": "43", "year": "2022" }, { "DOI": "10.1038/s41598-021-03461-y", "article-title": "Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2", "author": "Ferrer", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Sci Rep", "key": "10.1016/j.jdsr.2025.05.001_bib55", "volume": "11", "year": "2021" }, { "DOI": "10.1007/s00784-020-03549-1", "article-title": "A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2", "author": "Gottsauner", "doi-asserted-by": "crossref", "first-page": "3707", "issue": "10", "journal-title": "Clin Oral Invest", "key": "10.1016/j.jdsr.2025.05.001_bib56", "volume": "24", "year": "2020" }, { "DOI": "10.1111/odi.14118", "article-title": "Reducing the viral load of SARS-CoV-2 in the saliva of patients with COVID-19", "author": "Guimarães", "doi-asserted-by": "crossref", "first-page": "2474", "issue": "S2", "journal-title": "Oral Dis", "key": "10.1016/j.jdsr.2025.05.001_bib57", "volume": "28", "year": "2022" }, { "DOI": "10.1097/MD.0000000000028925", "article-title": "The short-term effect of different chlorhexidine forms versus povidone iodine mouth rinse in minimizing the oral SARS-CoV-2 viral load: an open label randomized controlled clinical trial study", "author": "Natto", "doi-asserted-by": "crossref", "issue": "30", "journal-title": "Medicine", "key": "10.1016/j.jdsr.2025.05.001_bib58", "volume": "101", "year": "2024" }, { "DOI": "10.4103/jisp.jisp_469_22", "article-title": "In vivo efficacy of 2% povidone iodine, chlorhexidine gluconate, and herbal extract mouthwash on SARS-CoV-2 viral load in saliva: a randomized clinical trial", "author": "Nazrine", "doi-asserted-by": "crossref", "first-page": "607", "issue": "6", "journal-title": "J Indian Soc Periodontol", "key": "10.1016/j.jdsr.2025.05.001_bib59", "volume": "27", "year": "2023" }, { "DOI": "10.1016/j.eimc.2021.10.005", "article-title": "Utility of mouth rinses with povidone-iodine and hydrogen peroxide in patients with COVID-19", "author": "Pablo-Marcos", "doi-asserted-by": "crossref", "first-page": "173", "issue": "3", "journal-title": "Enferm Infecc Microbiol Clin", "key": "10.1016/j.jdsr.2025.05.001_bib60", "volume": "41", "year": "2023" }, { "DOI": "10.1080/22221751.2022.2098059", "article-title": "Effect of oral antiseptics in reducing SARS-CoV-2 infectivity: evidence from a randomized double-blind clinical trial", "author": "Sánchez-Barrueco", "doi-asserted-by": "crossref", "first-page": "1833", "issue": "1", "journal-title": "Emerg Microbes Infect", "key": "10.1016/j.jdsr.2025.05.001_bib61", "volume": "11", "year": "2022" }, { "DOI": "10.1080/20002297.2023.2198432", "article-title": "In vivo effect of mouthwashes on viable viral load of SARS-CoV-2 in saliva: a pilot study", "author": "Sánchez-Barrueco", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "J Oral Microbiol", "key": "10.1016/j.jdsr.2025.05.001_bib62", "volume": "15", "year": "2023" }, { "DOI": "10.1007/s00405-021-06873-8", "article-title": "Mouthrinses against SARS-CoV-2: anti-inflammatory effectivity and a clinical pilot study", "author": "Schürmann", "doi-asserted-by": "crossref", "first-page": "5059", "issue": "12", "journal-title": "Eur Arch Otorhinolaryngol", "key": "10.1016/j.jdsr.2025.05.001_bib63", "volume": "278", "year": "2021" }, { "DOI": "10.17219/dmp/150831", "article-title": "Effect of oral antiseptics on the viral load of SARS-CoV-2: a randomized controlled trial", "author": "Sevinç-Gül", "doi-asserted-by": "crossref", "first-page": "357", "issue": "3", "journal-title": "Dent Med Probl", "key": "10.1016/j.jdsr.2025.05.001_bib64", "volume": "59", "year": "2022" }, { "DOI": "10.1099/acmi.0.000722.v3", "article-title": "Investigating the effectiveness of commercially available mouthwash on SARS-CoV-2 in vivo using viable virus titre as the primary outcome. A randomised controlled trial", "author": "Seymour", "doi-asserted-by": "crossref", "first-page": "000722.v3", "issue": "7", "journal-title": "Access Microbiol", "key": "10.1016/j.jdsr.2025.05.001_bib65", "volume": "6", "year": "2024" }, { "DOI": "10.12688/f1000research.110843.2", "author": "Sulistyani", "doi-asserted-by": "crossref", "first-page": "1238", "journal-title": "F1000Res", "key": "10.1016/j.jdsr.2025.05.001_bib66", "volume": "11", "year": "2024" }, { "author": "Chaimani", "key": "10.1016/j.jdsr.2025.05.001_bib67", "series-title": "Chapter 11: Undertaking network meta-analyses", "year": "2024" }, { "DOI": "10.1136/bmjebm-2022-111928", "article-title": "Theory and practice of bayesian and frequentist frameworks for network meta-analysis", "author": "Sadeghirad", "doi-asserted-by": "crossref", "first-page": "204", "issue": "3", "journal-title": "BMJ Evid Based Med", "key": "10.1016/j.jdsr.2025.05.001_bib68", "volume": "28", "year": "2023" }, { "DOI": "10.1007/s40121-019-00260-x", "article-title": "Infectious disease management and control with povidone iodine", "author": "Eggers", "doi-asserted-by": "crossref", "first-page": "581", "issue": "4", "journal-title": "Infect Dis Ther", "key": "10.1016/j.jdsr.2025.05.001_bib69", "volume": "8", "year": "2019" }, { "DOI": "10.1186/s12903-023-03126-4", "article-title": "Effectiveness of mouthwashes on reducing SARS-CoV-2 viral load in oral cavity: a systematic review and meta-analysis", "author": "Ebrahimi", "doi-asserted-by": "crossref", "first-page": "443", "issue": "1", "journal-title": "BMC Oral Health", "key": "10.1016/j.jdsr.2025.05.001_bib70", "volume": "23", "year": "2023" }, { "DOI": "10.1055/s-0042-1753470", "article-title": "Effects of chlorhexidine and povidone-iodine on the SARS-CoV-2 load: a systematic review and meta-analysis", "author": "Hasan", "doi-asserted-by": "crossref", "first-page": "587", "issue": "03", "journal-title": "Eur J Dent", "key": "10.1016/j.jdsr.2025.05.001_bib71", "volume": "17", "year": "2023" }, { "DOI": "10.1186/s12879-023-08669-z", "article-title": "Efficacy of mouthwash on reducing salivary SARS-CoV-2 viral load and clinical symptoms: a systematic review and meta-analysis", "author": "Zhang", "doi-asserted-by": "crossref", "first-page": "678", "issue": "1", "journal-title": "BMC Infect Dis", "key": "10.1016/j.jdsr.2025.05.001_bib72", "volume": "23", "year": "2023" }, { "article-title": "In: Auer J.A., Stick J.A, editors. Chapter 9 - Instrument preparation, sterilization, and antiseptics", "author": "Freeman", "first-page": "98", "key": "10.1016/j.jdsr.2025.05.001_bib73", "series-title": "Equine Surgery (Fourth Edition)", "year": "2012" }, { "DOI": "10.1177/0022034520943574", "article-title": "Interventions to reduce aerosolized microbes in dental practice: a systematic review with network meta-analysis of randomized controlled trials", "author": "Koletsi", "doi-asserted-by": "crossref", "first-page": "1228", "issue": "11", "journal-title": "J Dent Res", "key": "10.1016/j.jdsr.2025.05.001_bib74", "volume": "99", "year": "2020" }, { "DOI": "10.1016/j.identj.2022.01.005", "article-title": "Chlorhexidine in dentistry: pharmacology, uses, and adverse effects", "author": "Poppolo-Deus", "doi-asserted-by": "crossref", "first-page": "269", "issue": "3", "journal-title": "Int Dent J", "key": "10.1016/j.jdsr.2025.05.001_bib75", "volume": "72", "year": "2022" }, { "DOI": "10.1128/AEM.02633-14", "article-title": "Quaternary ammonium biocides: efficacy in application", "author": "Gerba", "doi-asserted-by": "crossref", "first-page": "464", "issue": "2", "journal-title": "Appl Environ Microbiol", "key": "10.1016/j.jdsr.2025.05.001_bib76", "volume": "81", "year": "2015" }, { "DOI": "10.46658/JBIMES-24-01", "doi-asserted-by": "crossref", "key": "10.1016/j.jdsr.2025.05.001_bib77", "unstructured": "Aromataris E., Lockwood C., Porritt K., Pilla B., Jordan Z. JBI Manual for Evidence Synthesis. JBI; 2024. Available at: 〈https://synthesismanual.jbi.global〉." }, { "DOI": "10.3390/ijerph19148768", "article-title": "Oral antiseptics against SARS-CoV-2: A literature review", "author": "Guerrero Bernal", "doi-asserted-by": "crossref", "first-page": "8768", "issue": "14", "journal-title": "Int J Environ Res Public Health", "key": "10.1016/j.jdsr.2025.05.001_bib78", "volume": "19", "year": "2022" }, { "DOI": "10.1016/j.micpath.2020.104620", "article-title": "An updated and comprehensive review of the antiviral potential of essential oils and their chemical constituents with special focus on their mechanism of action against various influenza and coronaviruses", "author": "Wani", "doi-asserted-by": "crossref", "journal-title": "Micro Pathog", "key": "10.1016/j.jdsr.2025.05.001_bib79", "volume": "152", "year": "2021" }, { "DOI": "10.1002/lary.31430", "article-title": "Phase II trial of the impact 0.5% povidone-iodine nasal spray (Nasodine®) on shedding of SARS-CoV-2", "author": "Friedland", "doi-asserted-by": "crossref", "first-page": "3947", "issue": "9", "journal-title": "Laryngoscope", "key": "10.1016/j.jdsr.2025.05.001_bib80", "volume": "134", "year": "2024" }, { "DOI": "10.1038/s41598-023-39308-x", "article-title": "Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study", "author": "Perussolo", "doi-asserted-by": "crossref", "issue": "1", "journal-title": "Sci Rep", "key": "10.1016/j.jdsr.2025.05.001_bib81", "volume": "13", "year": "2023" }, { "article-title": "Elimination of SARS-CoV-2 in nasopharynx and oropharynx after use of an adjuvant gargling and rinsing protocol with an antiseptic mouthwash", "author": "Vilhena", "journal-title": "Einst (São Paulo)", "key": "10.1016/j.jdsr.2025.05.001_bib82", "volume": "19", "year": "2021" }, { "DOI": "10.3346/jkms.2020.35.e195", "article-title": "Clinical significance of a high SARS-CoV-2 viral load in the saliva", "author": "Yoon", "doi-asserted-by": "crossref", "issue": "20", "journal-title": "J Korean Med Sci", "key": "10.1016/j.jdsr.2025.05.001_bib83", "volume": "35", "year": "2020" }, { "DOI": "10.1186/s12903-024-04246-1", "article-title": "Oral mouthwashes for asymptomatic to mildly symptomatic adults with COVID-19 and salivary viral load: a randomized, placebo-controlled, open-label clinical trial", "author": "Onozuka", "doi-asserted-by": "crossref", "first-page": "491", "issue": "1", "journal-title": "BMC Oral Health", "key": "10.1016/j.jdsr.2025.05.001_bib84", "volume": "24", "year": "2024" }, { "DOI": "10.1016/j.jlr.2022.100208", "article-title": "The SARS-CoV2 envelope differs from host cells, exposes procoagulant lipids, and is disrupted in vivo by oral rinses", "author": "Saud", "doi-asserted-by": "crossref", "issue": "6", "journal-title": "J Lipid Res", "key": "10.1016/j.jdsr.2025.05.001_bib85", "volume": "63", "year": "2022" }, { "DOI": "10.1177/00220345221110444", "article-title": "Preprocedural mouthwashes for reduction of SARS-CoV-2 viral load and infectivity", "author": "Cieplik", "doi-asserted-by": "crossref", "first-page": "1421", "issue": "12", "journal-title": "J Dent Res", "key": "10.1016/j.jdsr.2025.05.001_bib86", "volume": "101", "year": "2022" }, { "DOI": "10.1016/j.trac.2022.116750", "article-title": "Current trends in COVID-19 diagnosis and its new variants in physiological fluids: surface antigens, antibodies, nucleic acids, and RNA sequencing", "author": "Mostafa", "doi-asserted-by": "crossref", "journal-title": "Trends Anal Chem", "key": "10.1016/j.jdsr.2025.05.001_bib87", "volume": "157", "year": "2022" }, { "DOI": "10.1046/j.1469-0691.2000.00149.x", "article-title": "Committee for Antimicrobial Susceptibility Testing (EUCAST) of the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). Terminology relating to methods for the determination of susceptibility of bacteria to antimicrobial agents", "author": "European", "doi-asserted-by": "crossref", "first-page": "503", "issue": "9", "journal-title": "Clin Microbiol Infect", "key": "10.1016/j.jdsr.2025.05.001_bib88", "volume": "6", "year": "2000" }, { "DOI": "10.1371/journal.pone.0297291", "article-title": "Cetylpyridinium chloride and chlorhexidine show antiviral activity against influenza A virus and respiratory syncytial virus in vitro", "author": "Rius-Salvador", "doi-asserted-by": "crossref", "issue": "2", "journal-title": "PLoS ONE", "key": "10.1016/j.jdsr.2025.05.001_bib89", "volume": "19", "year": "2024" }, { "DOI": "10.1007/s40121-018-0200-7", "article-title": "In vitro bactericidal and virucidal efficacy of povidone-iodine gargle/mouthwash against respiratory and oral tract pathogens", "author": "Eggers", "doi-asserted-by": "crossref", "first-page": "249", "issue": "2", "journal-title": "Infect Dis Ther", "key": "10.1016/j.jdsr.2025.05.001_bib90", "volume": "7", "year": "2018" }, { "DOI": "10.1016/j.jhin.2023.08.009", "article-title": "Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus", "author": "Meister", "doi-asserted-by": "crossref", "first-page": "25", "journal-title": "J Hosp Infect", "key": "10.1016/j.jdsr.2025.05.001_bib91", "volume": "141", "year": "2023" } ], "reference-count": 91, "references-count": 91, "relation": {}, "resource": { "primary": { "URL": "https://linkinghub.elsevier.com/retrieve/pii/S1882761625000092" } }, "score": 1, "short-title": [], "source": "Crossref", "special_numbering": "C", "subject": [], "subtitle": [], "title": "Antiseptics as effective virucidal agents against SARS-CoV-2: Systematic review and Bayesian network meta-analysis", "type": "journal-article", "update-policy": "https://doi.org/10.1016/elsevier_cm_policy", "volume": "61" }