Patterns of Dietary Supplement Use during the COVID-19 Pandemic in Poland: Focus on Vitamin D and Magnesium
Patrycja Grosman-Dziewiszek, Izabela Jęśkowiak-Kossakowska, Adam Szeląg, Benita Wiatrak
Nutrients, doi:10.3390/nu16193225
Background: The COVID-19 pandemic has brought significant attention to the role of dietary supplements, particularly Vitamin D, in enhancing immunity and possibly mitigating the severity of the disease. The pandemic has highlighted the importance of nutritional health in preventing severe outcomes from infections. Objective: This study aimed to assess consumption patterns of dietary supplements, with a focus on Vitamin D, among the Polish population during the COVID-19 pandemic and to identify the demographic factors influencing these patterns. Methods: An anonymous survey was conducted in March 2021 among 926 pharmacy patients in Poland. The study analyzed the use of dietary supplements such as vitamin D, magnesium, and others in relation to variables like age, gender, and education level. Statistical analyses were performed using the Pearson chi-square test. Results: The study revealed that 77.1% of the respondents reported using dietary supplements, with Vitamin D being the most frequently mentioned, used by 64.6% of participants. Magnesium was also widely used, with a higher overall prevalence of 67.3%, making it the most commonly consumed supplement. The use of supplements was significantly higher among women and individuals with higher education. Younger age groups, particularly those aged 18-30, were more likely to use supplements. Conclusions: The use of supplements was significantly higher among women, individuals with higher education, and those aged 18-30. However, the findings also indicate a growing awareness and increased use across the general population. This trend reflects increased public awareness of the potential health benefits of these supplements in boosting immunity. However, the study also highlights the need for public education on the risks of over-supplementation and the importance of appropriate dosages.
Conflicts of Interest: The authors declare no conflicts of interest.
References
Ashraf, Ashraf, Ashraf, Imran, Kalsoom et al., A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial, Trials, 
doi:10.1186/s13063-021-05081-3Benskin, A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency, Front. Public Health, 
doi:10.3389/fpubh.2020.00513Bistrian, Parenteral Fish-Oil Emulsions in Critically Ill COVID-19 Emulsions, J. Parenter. Enter. Nutr, 
doi:10.1002/jpen.1871Bochenek, Godman, Lipowska, Mikrut, Zuziak et al., Over-the-counter medicine and dietary supplement consumption among academic youth in Poland, Expert Rev. Pharmacoeconomics Outcomes Res, 
doi:10.1586/14737167.2016.1154790Bouillon, Manousaki, Rosen, Trajanoska, Rivadeneira et al., The health effects of vitamin D supplementation: Evidence from human studies, Nature reviews, 
doi:10.1038/s41574-021-00593-zBrunvoll, Nygaard, Ellingjord-Dale, Holland, Istre et al., Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: Quadruple blinded, randomised placebo controlled trial, BMJ, 
doi:10.1136/bmj-2022-071245Chinni, El-Khoury, Perera, Bellomo, Jones et al., Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities, Br. J. Clin. Pharmacol, 
doi:10.1111/bcp.14826Crowe, Steur, Allen, Appleby, Travis et al., Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: Results from the EPIC-Oxford study, Public Health Nutr, 
doi:10.1017/S1368980010002454Dai, Zhu, Manson, Song, Li et al., Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial, Am. J. Clin. Nutr, 
doi:10.1093/ajcn/nqy274Delange, Bürgi, Iodine deficiency disorders in Europe, Bull. World Health Organ
Djuricic, Calder, Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021, Nutrients, 
doi:10.3390/nu13072421Durden, Ezaldin, Amos, Kemper, Campbell, Rise in Serum 25-Hydroxyvitamin D Levels during the COVID-19 Pandemic, Nutrients, 
doi:10.3390/nu16152449Eyles, Burne, Mcgrath, Vitamin, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease, Front. Neuroendocrinol, 
doi:10.1016/j.yfrne.2012.07.001Fitero, Bungau, Tit, Endres, Khan et al., Comorbidities, Associated Diseases, and Risk Assessment in COVID-19-A Systematic Review, Int. J. Clin. Pract, 
doi:10.1155/2022/1571826Galior, Grebe, Singh, Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports, Nutrients, 
doi:10.3390/nu10080953Galmés, Serra, Palou, Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework, Nutrients, 
doi:10.3390/nu12092738Griffin, Hewison, Hopkin, Kenny, Quinton et al., Vitamin D and COVID-19: Evidence and recommendations for supplementation, R. Soc. Open Sci, 
doi:10.1098/rsos.201912Grosman-Dziewiszek, Wiatrak, Jęśkowiak, Szel Ąg, Patients' Habits and the Role of Pharmacists and Telemedicine as Elements of a Modern Health Care System during the COVID-19 Pandemic, J. Clin. Med, 
doi:10.3390/jcm10184211Habib, Ibrahim, Zaim, Ibrahim, The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators, Biomed. Pharmacother. Biomed. Pharmacother, 
doi:10.1016/j.biopha.2021.111228Ikonen, Lumme, Seppälä, Pesonen, Piltonen et al., The determinants and longitudinal changes in vitamin D status in middle-age: A Northern Finland Birth Cohort 1966 study, Eur. J. Nutr, 
doi:10.1007/s00394-021-02606-zJames, Ali, Armitage, Bonell, Cerami et al., The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review, J. Nutr, 
doi:10.1093/jn/nxab059Jęśkowiak, Wiatrak, Grosman-Dziewiszek, Szel Ąg, The Incidence and Severity of Post-Vaccination Reactions after Vaccination against COVID-19, Vaccines, 
doi:10.3390/vaccines9050502Khalesi, Vandelanotte, Thwaite, Russell, Dawson et al., Awareness and Attitudes of Gut Health, Probiotics and Prebiotics in Australian Adults, J. Diet. Suppl, 
doi:10.1080/19390211.2020.1783420Kilis-Pstrusinska, Akutko, Braksator, Dancewicz, Grosman-Dziewiszek et al., Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes, J. Clin. Med, 
doi:10.3390/jcm10235522Kočovská, Gaughran, Krivoy, Meier, Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism, Front. Psychiatry, 
doi:10.3389/fpsyt.2017.00047Kumar, Kubota, Chernov, Kasuya, Potential role of zinc supplementation in prophylaxis and treatment of COVID-19, Med. Hypotheses, 
doi:10.1016/j.mehy.2020.109848Manoy, Yuktanandana, Tanavalee, Anomasiri, Ngarmukos et al., Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients, Nutrients, 
doi:10.3390/nu9080799Martineau, Jolliffe, Greenberg, Aloia, Bergman et al., Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis, Health Technol. Assess, 
doi:10.3310/hta23020Mercola, Grant, Wagner, Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity, Nutrients, 
doi:10.3390/nu12113361Muñoz, Grant, Vitamin, Cancer: An Historical Overview of the Epidemiology and Mechanisms, Nutrients, 
doi:10.3390/nu14071448Nasser, Naffaa, Mashiach, Azzam, Braun, The association between serum magnesium levels and communityacquired pneumonia 30-day mortality, BMC Infect. Dis, 
doi:10.1186/s12879-018-3627-2Nawaz, Ashraf, Ali, Shabbir, Shabbir et al., Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque, Life, 
doi:10.3390/life12091424Nekoukar, Manouchehri, Zakariaei, Accidental vitamin D3 overdose in a young man. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin-und Ernahrungsforschung, J. Int. Vitaminol. Nutr, 
doi:10.1024/0300-9831/a000798Pludowski, Holick, Grant, Konstantynowicz, Mascarenhas et al., Vitamin D supplementation guidelines, J. Steroid Biochem. Mol. Biol, 
doi:10.1016/j.jsbmb.2017.01.021Poluektova, Sankova, Volchkova, Larina, Maloletneva et al., The possibility of predicting the COVID-19 severity by clinical-laboratory criteria taking into account the SARS-CoV-2 strain: An analytical review, Epidemiol. Infect. Dis, 
doi:10.17816/EID629244Pozo De La Calle, Alonso Ledesma, Nuñez, Castelló Pastor, Lope Carvajal et al., Composition and Nutritional Quality of the Diet in Spanish Households during the First Wave of the COVID-19 Pandemic, Nutrients, 
doi:10.3390/nu13051443Sailike, Onzhanova, Akbay, Tokay, Molnár, Vitamin D in Central Nervous System: Implications for Neurological Disorders, Int. J. Mol. Sci, 
doi:10.3390/ijms25147809Soininen, Eloranta, Schwab, Lakka, Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents, Eur. J. Nutr, 
doi:10.1007/s00394-022-03039-yStaszuk, Wiatrak, Tadeusiewicz, Karuga-Kuźniewska, Rybak, Telerehabilitation approach for patients with hand impairment, Acta Bioeng. Biomech
Szkudlarek, Gębarowski, Hauzer, Wiatrak, The Concept of Health Debt Incurred during the COVID-19 Pandemic on the Example of Basal Cell Skin Cancer Diagnosis in Lower Silesia, J. Clin. Med, 
doi:10.3390/jcm13164923Taneri, Gómez-Ochoa, Llanaj, Raguindin, Rojas et al., Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis, Eur. J. Epidemiol, 
doi:10.1007/s10654-020-00678-5Tekin, Kılıç, Impact of COVID-19 pandemic on health-promoting lifestyle behaviors: A cross-sectional study, J. Acute Dis, 
doi:10.4103/2221-6189.369073Thomas, Patel, Bittel, Wolski, Wang et al., Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs. Usual Care on Symptom Length and Reduction among Ambulatory Patients with SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial, JAMA Netw. Open, 
doi:10.1001/jamanetworkopen.2021.0369Trapani, Rosanoff, Baniasadi, Barbagallo, Castiglioni et al., The relevance of magnesium homeostasis in COVID-19, Eur. J. Nutr, 
doi:10.1007/s00394-021-02704-yTsang, Chan, Cho, Yu, Yim et al., An update on COVID-19 pandemic: The epidemiology, pathogenesis, prevention and treatment strategies, Expert Rev. Anti-Infect. Ther, 
doi:10.1080/14787210.2021.1863146Vyas, Kurian, Bagchi, Manu, Saravu et al., Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects, J. Am. Coll. Nutr, 
doi:10.1080/07315724.2020.1806758Wassif, Alrehely, Alharbi, Aljohani, The Impact of Vitamin D on Neuropsychiatric Disorders, Cureus, 
doi:10.7759/cureus.47716Winder, Kosztyła, Boral, Kocełak, Chudek, The Impact of Iodine Concentration Disorders on Health and Cancer, Nutrients, 
doi:10.3390/nu14112209Wróbel, Zastawna, Milewska, Marczak, Kozłowski, Comparison between the American and the European Systems of Monitoring Adverse Effects of Dietary Supplements and Their Usefulness on the Polish Market, Int. J. Environ. Res. Public Health, 
doi:10.3390/ijerph20020902Xiang, Xu, Zhan, Lu, Li et al., Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus, Nutrients, 
doi:10.3390/nu15030639Žmitek, Hribar, Lavriša, Hristov, Kušar et al., Socio-Demographic and Knowledge-Related Determinants of Vitamin D Supplementation in the Context of the COVID-19 Pandemic: Assessment of an Educational Intervention, Front. Nutr, 
doi:10.3389/fnut.2021.648450DOI record:
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    {
      "DOI": "10.1080/14787210.2021.1863146",
      "article-title": "An update on COVID-19 pandemic: The epidemiology, pathogenesis, prevention and treatment strategies",
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    },
    {
      "DOI": "10.3390/jcm10235522",
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      "unstructured": "Kilis-Pstrusinska, K., Akutko, K., Braksator, J., Dancewicz, A., Grosman-Dziewiszek, P., Jamer, T., Juszczyńska, K., Konikowska, K., Koruba, M., and Pupek, M. (2021). Kidney Dysfunction and Its Progression in Patients Hospitalized Duo to COVID-19: Contribution to the Clinical Course and Outcomes. J. Clin. Med., 10."
    },
    {
      "DOI": "10.1155/2022/1571826",
      "article-title": "Comorbidities, Associated Diseases, and Risk Assessment in COVID-19-A Systematic Review",
      "author": "Fitero",
      "doi-asserted-by": "crossref",
      "first-page": "1571826",
      "journal-title": "Int. J. Clin. Pract.",
      "key": "ref_5",
      "volume": "2022",
      "year": "2022"
    },
    {
      "DOI": "10.3390/jcm13164923",
      "doi-asserted-by": "crossref",
      "key": "ref_6",
      "unstructured": "Szkudlarek, D., Gębarowski, T., Hauzer, N., and Wiatrak, B. (2024). The Concept of Health Debt Incurred during the COVID-19 Pandemic on the Example of Basal Cell Skin Cancer Diagnosis in Lower Silesia. J. Clin. Med., 13."
    },
    {
      "article-title": "Telerehabilitation approach for patients with hand impairment",
      "author": "Staszuk",
      "first-page": "55",
      "journal-title": "Acta Bioeng. Biomech.",
      "key": "ref_7",
      "volume": "18",
      "year": "2016"
    },
    {
      "DOI": "10.1098/rsos.201912",
      "article-title": "Vitamin D and COVID-19: Evidence and recommendations for supplementation",
      "author": "Griffin",
      "doi-asserted-by": "crossref",
      "first-page": "201912",
      "journal-title": "R. Soc. Open Sci.",
      "key": "ref_8",
      "volume": "7",
      "year": "2020"
    },
    {
      "DOI": "10.1017/S1368980010002454",
      "article-title": "Plasma concentrations of 25-hydroxyvitamin D in meat eaters, fish eaters, vegetarians and vegans: Results from the EPIC-Oxford study",
      "author": "Crowe",
      "doi-asserted-by": "crossref",
      "first-page": "340",
      "journal-title": "Public Health Nutr.",
      "key": "ref_9",
      "volume": "14",
      "year": "2011"
    },
    {
      "article-title": "Sources of vitamin D and determinants of serum 25-hydroxyvitamin D in Finnish adolescents",
      "author": "Soininen",
      "first-page": "1011",
      "journal-title": "Eur. J. Nutr.",
      "key": "ref_10",
      "volume": "62",
      "year": "2023"
    },
    {
      "DOI": "10.1007/s00394-021-02606-z",
      "article-title": "The determinants and longitudinal changes in vitamin D status in middle-age: A Northern Finland Birth Cohort 1966 study",
      "author": "Ikonen",
      "doi-asserted-by": "crossref",
      "first-page": "4541",
      "journal-title": "Eur. J. Nutr.",
      "key": "ref_11",
      "volume": "60",
      "year": "2021"
    },
    {
      "DOI": "10.3390/nu9080799",
      "doi-asserted-by": "crossref",
      "key": "ref_12",
      "unstructured": "Manoy, P., Yuktanandana, P., Tanavalee, A., Anomasiri, W., Ngarmukos, S., Tanpowpong, T., and Honsawek, S. (2017). Vitamin D Supplementation Improves Quality of Life and Physical Performance in Osteoarthritis Patients. Nutrients, 9."
    },
    {
      "DOI": "10.1136/practneurol-2017-001720",
      "article-title": "Vitamin D supplementation",
      "author": "Dobson",
      "doi-asserted-by": "crossref",
      "first-page": "35",
      "journal-title": "Pract. Neurol.",
      "key": "ref_13",
      "volume": "18",
      "year": "2018"
    },
    {
      "DOI": "10.3390/nu14071448",
      "doi-asserted-by": "crossref",
      "key": "ref_14",
      "unstructured": "Muñoz, A., and Grant, W.B. (2022). Vitamin D and Cancer: An Historical Overview of the Epidemiology and Mechanisms. Nutrients, 14."
    },
    {
      "DOI": "10.3310/hta23020",
      "article-title": "Vitamin D supplementation to prevent acute respiratory infections: Individual participant data meta-analysis",
      "author": "Martineau",
      "doi-asserted-by": "crossref",
      "first-page": "1",
      "journal-title": "Health Technol. Assess.",
      "key": "ref_15",
      "volume": "23",
      "year": "2019"
    },
    {
      "DOI": "10.3390/children1020208",
      "article-title": "Vitamin D in Children’s Health",
      "author": "Weydert",
      "doi-asserted-by": "crossref",
      "first-page": "208",
      "journal-title": "Children",
      "key": "ref_16",
      "volume": "1",
      "year": "2014"
    },
    {
      "DOI": "10.1016/j.pedneo.2019.04.007",
      "article-title": "Vitamin D and health—The missing vitamin in humans",
      "author": "Chang",
      "doi-asserted-by": "crossref",
      "first-page": "237",
      "journal-title": "Pediatr. Neonatol.",
      "key": "ref_17",
      "volume": "60",
      "year": "2019"
    },
    {
      "DOI": "10.1016/j.yfrne.2012.07.001",
      "article-title": "Vitamin D, effects on brain development, adult brain function and the links between low levels of vitamin D and neuropsychiatric disease",
      "author": "Eyles",
      "doi-asserted-by": "crossref",
      "first-page": "47",
      "journal-title": "Front. Neuroendocrinol.",
      "key": "ref_18",
      "volume": "34",
      "year": "2013"
    },
    {
      "DOI": "10.3390/nu13051443",
      "doi-asserted-by": "crossref",
      "key": "ref_19",
      "unstructured": "Del Pozo de la Calle, S., Alonso Ledesma, I., Nuñez, O., Castelló Pastor, A., Lope Carvajal, V., Fernández de Larrea Baz, N., Pérez-Gómez, B., Pollán, M., and Ruiz Moreno, E. (2021). Composition and Nutritional Quality of the Diet in Spanish Households during the First Wave of the COVID-19 Pandemic. Nutrients, 13."
    },
    {
      "DOI": "10.3389/fpsyt.2017.00047",
      "doi-asserted-by": "crossref",
      "key": "ref_20",
      "unstructured": "Kočovská, E., Gaughran, F., Krivoy, A., and Meier, U.C. (2017). Vitamin-D Deficiency As a Potential Environmental Risk Factor in Multiple Sclerosis, Schizophrenia, and Autism. Front. Psychiatry, 8."
    },
    {
      "DOI": "10.3390/ijms25147809",
      "doi-asserted-by": "crossref",
      "key": "ref_21",
      "unstructured": "Sailike, B., Onzhanova, Z., Akbay, B., Tokay, T., and Molnár, F. (2024). Vitamin D in Central Nervous System: Implications for Neurological Disorders. Int. J. Mol. Sci., 25."
    },
    {
      "article-title": "The Impact of Vitamin D on Neuropsychiatric Disorders",
      "author": "Wassif",
      "first-page": "e47716",
      "journal-title": "Cureus",
      "key": "ref_22",
      "volume": "15",
      "year": "2023"
    },
    {
      "DOI": "10.1097/MJT.0000000000001222",
      "article-title": "Vitamin D Supplementation in COVID-19 Patients: A Clinical Case Series",
      "author": "Ohaegbulam",
      "doi-asserted-by": "crossref",
      "first-page": "e485",
      "journal-title": "Am. J. Ther.",
      "key": "ref_23",
      "volume": "27",
      "year": "2020"
    },
    {
      "article-title": "The health effects of vitamin D supplementation: Evidence from human studies. Nature reviews",
      "author": "Bouillon",
      "first-page": "96",
      "journal-title": "Endocrinology",
      "key": "ref_24",
      "volume": "18",
      "year": "2022"
    },
    {
      "DOI": "10.3389/fpubh.2020.00513",
      "doi-asserted-by": "crossref",
      "key": "ref_25",
      "unstructured": "Benskin, L.L. (2020). A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency. Front. Public Health, 8."
    },
    {
      "DOI": "10.1080/07315724.2020.1806758",
      "article-title": "Vitamin D in Prevention and Treatment of COVID-19: Current Perspective and Future Prospects",
      "author": "Vyas",
      "doi-asserted-by": "crossref",
      "first-page": "632",
      "journal-title": "J. Am. Coll. Nutr.",
      "key": "ref_26",
      "volume": "40",
      "year": "2021"
    },
    {
      "DOI": "10.3389/fnut.2021.648450",
      "doi-asserted-by": "crossref",
      "key": "ref_27",
      "unstructured": "Žmitek, K., Hribar, M., Lavriša, Ž., Hristov, H., Kušar, A., and Pravst, I. (2021). Socio-Demographic and Knowledge-Related Determinants of Vitamin D Supplementation in the Context of the COVID-19 Pandemic: Assessment of an Educational Intervention. Front. Nutr., 8."
    },
    {
      "DOI": "10.4103/2221-6189.369073",
      "article-title": "Impact of COVID-19 pandemic on health-promoting lifestyle behaviors: A cross-sectional study",
      "author": "Tekin",
      "doi-asserted-by": "crossref",
      "first-page": "10",
      "journal-title": "J. Acute Dis.",
      "key": "ref_28",
      "volume": "12",
      "year": "2023"
    },
    {
      "DOI": "10.1080/19390211.2020.1783420",
      "article-title": "Awareness and Attitudes of Gut Health, Probiotics and Prebiotics in Australian Adults",
      "author": "Khalesi",
      "doi-asserted-by": "crossref",
      "first-page": "418",
      "journal-title": "J. Diet. Suppl.",
      "key": "ref_29",
      "volume": "18",
      "year": "2021"
    },
    {
      "article-title": "The possibility of predicting the COVID-19 severity by clinical-laboratory criteria taking into account the SARS-CoV-2 strain: An analytical review",
      "author": "Poluektova",
      "first-page": "192",
      "journal-title": "Epidemiol. Infect. Dis.",
      "key": "ref_30",
      "volume": "29",
      "year": "2024"
    },
    {
      "DOI": "10.3390/nu16152449",
      "doi-asserted-by": "crossref",
      "key": "ref_31",
      "unstructured": "Durden, W., Ezaldin, S., Amos, J., Kemper, S., and Campbell, J. (2024). Rise in Serum 25-Hydroxyvitamin D Levels during the COVID-19 Pandemic. Nutrients, 16."
    },
    {
      "DOI": "10.1024/0300-9831/a000798",
      "article-title": "Accidental vitamin D3 overdose in a young man. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung",
      "author": "Nekoukar",
      "doi-asserted-by": "crossref",
      "first-page": "82",
      "journal-title": "J. Int. Vitaminol. Nutr.",
      "key": "ref_32",
      "volume": "94",
      "year": "2024"
    },
    {
      "DOI": "10.3390/nu5093605",
      "article-title": "Vitamin D: Deficiency, sufficiency and toxicity",
      "author": "Alshahrani",
      "doi-asserted-by": "crossref",
      "first-page": "3605",
      "journal-title": "Nutrients",
      "key": "ref_33",
      "volume": "5",
      "year": "2013"
    },
    {
      "DOI": "10.3390/nu10080953",
      "doi-asserted-by": "crossref",
      "key": "ref_34",
      "unstructured": "Galior, K., Grebe, S., and Singh, R. (2018). Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports. Nutrients, 10."
    },
    {
      "DOI": "10.1016/j.jsbmb.2017.01.021",
      "article-title": "Vitamin D supplementation guidelines",
      "author": "Pludowski",
      "doi-asserted-by": "crossref",
      "first-page": "125",
      "journal-title": "J. Steroid Biochem. Mol. Biol.",
      "key": "ref_35",
      "volume": "175",
      "year": "2018"
    },
    {
      "DOI": "10.3390/nu12113361",
      "doi-asserted-by": "crossref",
      "key": "ref_36",
      "unstructured": "Mercola, J., Grant, W.B., and Wagner, C.L. (2020). Evidence Regarding Vitamin D and Risk of COVID-19 and Its Severity. Nutrients, 12."
    },
    {
      "DOI": "10.1016/j.pcd.2021.04.004",
      "article-title": "Insulin resistance in COVID-19 and diabetes",
      "author": "Govender",
      "doi-asserted-by": "crossref",
      "first-page": "629",
      "journal-title": "Prim. Care Diabetes",
      "key": "ref_37",
      "volume": "15",
      "year": "2021"
    },
    {
      "DOI": "10.1038/s41591-023-02235-5",
      "article-title": "Optimal dietary patterns for prevention of chronic disease",
      "author": "Wang",
      "doi-asserted-by": "crossref",
      "first-page": "719",
      "journal-title": "Nat. Med.",
      "key": "ref_38",
      "volume": "29",
      "year": "2023"
    },
    {
      "DOI": "10.3390/nu15030639",
      "doi-asserted-by": "crossref",
      "key": "ref_39",
      "unstructured": "Xiang, Q., Xu, H., Zhan, J., Lu, S., Li, S., Wang, Y., Wang, Y., He, J., Ni, Y., and Li, L. (2023). Association between the Triglyceride-Glucose Index and Vitamin D Status in Type 2 Diabetes Mellitus. Nutrients, 15."
    },
    {
      "DOI": "10.1007/s00394-021-02704-y",
      "article-title": "The relevance of magnesium homeostasis in COVID-19",
      "author": "Trapani",
      "doi-asserted-by": "crossref",
      "first-page": "625",
      "journal-title": "Eur. J. Nutr.",
      "key": "ref_40",
      "volume": "61",
      "year": "2022"
    },
    {
      "DOI": "10.1093/ajcn/nqy274",
      "article-title": "Magnesium status and supplementation influence vitamin D status and metabolism: Results from a randomized trial",
      "author": "Dai",
      "doi-asserted-by": "crossref",
      "first-page": "1249",
      "journal-title": "Am. J. Clin. Nutr.",
      "key": "ref_41",
      "volume": "108",
      "year": "2018"
    },
    {
      "DOI": "10.1186/s12879-018-3627-2",
      "doi-asserted-by": "crossref",
      "key": "ref_42",
      "unstructured": "Nasser, R., Naffaa, M.E., Mashiach, T., Azzam, Z.S., and Braun, E. (2018). The association between serum magnesium levels and community-acquired pneumonia 30-day mortality. BMC Infect. Dis., 18."
    },
    {
      "DOI": "10.1111/bcp.14826",
      "article-title": "Zinc supplementation as an adjunct therapy for COVID-19: Challenges and opportunities",
      "author": "Chinni",
      "doi-asserted-by": "crossref",
      "first-page": "3737",
      "journal-title": "Br. J. Clin. Pharmacol.",
      "key": "ref_43",
      "volume": "87",
      "year": "2021"
    },
    {
      "DOI": "10.1001/jamanetworkopen.2021.0369",
      "article-title": "Effect of High-Dose Zinc and Ascorbic Acid Supplementation vs. Usual Care on Symptom Length and Reduction among Ambulatory Patients with SARS-CoV-2 Infection: The COVID A to Z Randomized Clinical Trial",
      "author": "Thomas",
      "doi-asserted-by": "crossref",
      "first-page": "e210369",
      "journal-title": "JAMA Netw. Open",
      "key": "ref_44",
      "volume": "4",
      "year": "2021"
    },
    {
      "DOI": "10.1093/advances/nmz013",
      "article-title": "The Role of Zinc in Antiviral Immunity",
      "author": "Read",
      "doi-asserted-by": "crossref",
      "first-page": "696",
      "journal-title": "Adv. Nutr.",
      "key": "ref_45",
      "volume": "10",
      "year": "2019"
    },
    {
      "DOI": "10.1016/j.mehy.2020.109848",
      "article-title": "Potential role of zinc supplementation in prophylaxis and treatment of COVID-19",
      "author": "Kumar",
      "doi-asserted-by": "crossref",
      "first-page": "109848",
      "journal-title": "Med. Hypotheses",
      "key": "ref_46",
      "volume": "144",
      "year": "2020"
    },
    {
      "DOI": "10.1093/jn/nxab059",
      "article-title": "The Role of Nutrition in COVID-19 Susceptibility and Severity of Disease: A Systematic Review",
      "author": "James",
      "doi-asserted-by": "crossref",
      "first-page": "1854",
      "journal-title": "J. Nutr.",
      "key": "ref_47",
      "volume": "151",
      "year": "2021"
    },
    {
      "DOI": "10.3390/nu12092738",
      "doi-asserted-by": "crossref",
      "key": "ref_48",
      "unstructured": "Galmés, S., Serra, F., and Palou, A. (2020). Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework. Nutrients, 12."
    },
    {
      "DOI": "10.1016/j.biopha.2021.111228",
      "doi-asserted-by": "crossref",
      "key": "ref_49",
      "unstructured": "Habib, H.M., Ibrahim, S., Zaim, A., and Ibrahim, W.H. (2021). The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators. Biomed. Pharmacother. Biomed. Pharmacother., 136."
    },
    {
      "DOI": "10.1007/s10654-020-00678-5",
      "article-title": "Anemia and iron metabolism in COVID-19: A systematic review and meta-analysis",
      "author": "Taneri",
      "doi-asserted-by": "crossref",
      "first-page": "763",
      "journal-title": "Eur. J. Epidemiol.",
      "key": "ref_50",
      "volume": "35",
      "year": "2020"
    },
    {
      "DOI": "10.1177/026010600902000204",
      "article-title": "Iodine in evolution of salivary glands and in oral health",
      "author": "Venturi",
      "doi-asserted-by": "crossref",
      "first-page": "119",
      "journal-title": "Nutr. Health",
      "key": "ref_51",
      "volume": "20",
      "year": "2009"
    },
    {
      "article-title": "Iodine deficiency disorders in Europe",
      "author": "Delange",
      "first-page": "317",
      "journal-title": "Bull. World Health Organ.",
      "key": "ref_52",
      "volume": "67",
      "year": "1989"
    },
    {
      "DOI": "10.3390/nu14112209",
      "doi-asserted-by": "crossref",
      "key": "ref_53",
      "unstructured": "Winder, M., Kosztyła, Z., Boral, A., Kocełak, P., and Chudek, J. (2022). The Impact of Iodine Concentration Disorders on Health and Cancer. Nutrients, 14."
    },
    {
      "DOI": "10.3390/life12091424",
      "doi-asserted-by": "crossref",
      "key": "ref_54",
      "unstructured": "Nawaz, M., Ashraf, M.A., Ali, M.A., Shabbir, M.Z., Shabbir, M.A.B., Altaf, I., Raza, S., Rafique, S., Hassan, S., and Sardar, N. (2022). Renessans Helps in Early Clearance of SARS-CoV-2: In-Vivo Activity of the Iodine Complex in Rhesus macaque. Life, 12."
    },
    {
      "DOI": "10.1186/s13063-021-05081-3",
      "article-title": "A quadruple blinded placebo controlled randomised trial to evaluate the effectiveness of an Iodine complex for patients with mild to moderate COVID-19 in Pakistan (I-COVID-PK): A structured summary of a study protocol for a randomised controlled trial",
      "author": "Ashraf",
      "doi-asserted-by": "crossref",
      "first-page": "127",
      "journal-title": "Trials",
      "key": "ref_55",
      "volume": "22",
      "year": "2021"
    },
    {
      "DOI": "10.3390/nu13072421",
      "doi-asserted-by": "crossref",
      "key": "ref_56",
      "unstructured": "Djuricic, I., and Calder, P.C. (2021). Beneficial Outcomes of Omega-6 and Omega-3 Polyunsaturated Fatty Acids on Human Health: An Update for 2021. Nutrients, 13."
    },
    {
      "DOI": "10.1136/bmj-2022-071245",
      "article-title": "Prevention of covid-19 and other acute respiratory infections with cod liver oil supplementation, a low dose vitamin D supplement: Quadruple blinded, randomised placebo controlled trial",
      "author": "Brunvoll",
      "doi-asserted-by": "crossref",
      "first-page": "e071245",
      "journal-title": "BMJ",
      "key": "ref_57",
      "volume": "378",
      "year": "2022"
    },
    {
      "DOI": "10.1038/s41579-020-0433-9",
      "article-title": "Gut microbiota in human metabolic health and disease",
      "author": "Fan",
      "doi-asserted-by": "crossref",
      "first-page": "55",
      "journal-title": "Nat. Rev. Microbiol.",
      "key": "ref_58",
      "volume": "19",
      "year": "2021"
    },
    {
      "DOI": "10.1002/jpen.1871",
      "article-title": "Parenteral Fish-Oil Emulsions in Critically Ill COVID-19 Emulsions",
      "author": "Bistrian",
      "doi-asserted-by": "crossref",
      "first-page": "1168",
      "journal-title": "J. Parenter. Enter. Nutr.",
      "key": "ref_59",
      "volume": "44",
      "year": "2020"
    },
    {
      "DOI": "10.1586/14737167.2016.1154790",
      "article-title": "Over-the-counter medicine and dietary supplement consumption among academic youth in Poland",
      "author": "Bochenek",
      "doi-asserted-by": "crossref",
      "first-page": "199",
      "journal-title": "Expert Rev. Pharmacoeconomics Outcomes Res.",
      "key": "ref_60",
      "volume": "16",
      "year": "2016"
    },
    {
      "DOI": "10.3390/ijerph20020902",
      "doi-asserted-by": "crossref",
      "key": "ref_61",
      "unstructured": "Wróbel, K., Zastawna, B., Milewska, A.J., Marczak, M., and Kozłowski, R. (2023). Comparison between the American and the European Systems of Monitoring Adverse Effects of Dietary Supplements and Their Usefulness on the Polish Market. Int. J. Environ. Res. Public Health, 20."
    }
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