Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional centre in the UK
Goodwin et al.
, Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional..
, PLOS ONE, doi:10.1371/journal.pone.0281915
Retrospective 604 outpatients in the UK, showing lower risk of hospitalization with sotrovimab treatment, without statistical significance due to the small number of hospitalizations.Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.1 [Liu, Sheward, VanBlargan] and a lack of efficacy for BA.2 [Zhou]. US EUA has been revoked.
risk of death, 75.0% lower, RR 0.25, p = 0.55, treatment 0 of 169 (0.0%), control 2 of 336 (0.6%), NNT 168, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
risk of hospitalization, 60.2% lower, RR 0.40, p = 0.35, treatment 2 of 169 (1.2%), control 10 of 336 (3.0%), NNT 56, COVID-19 related.
risk of hospitalization, 21.5% higher, RR 1.21, p = 0.69, treatment 11 of 169 (6.5%), control 18 of 336 (5.4%), all cause.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Goodwin et al., 15 Mar 2023, retrospective, United Kingdom, peer-reviewed, 3 authors, study period 22 December, 2021 - 20 February, 2022.
Abstract: PLOS ONE
Evaluation of outpatient treatment for nonhospitalised patients with COVID-19: The
experience of a regional centre in the UK
Amanda T. Goodwin ID1*, Jonathan S. Thompson2, Ian P. Hall1
1 NIHR Nottingham Biomedical Research Centre & University of Nottingham, Nottingham, United Kingdom,
2 Department of Infectious Diseases, Nottingham University Hospitals, Nottingham, United Kingdom
Citation: Goodwin AT, Thompson JS, Hall IP
(2023) Evaluation of outpatient treatment for nonhospitalised patients with COVID-19: The
experience of a regional centre in the UK. PLoS
ONE 18(3): e0281915. https://doi.org/10.1371/
Editor: Seung-Hwa Lee, Samsung Medical Center,
REPUBLIC OF KOREA
Received: July 18, 2022
Accepted: February 5, 2023
Published: March 15, 2023
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Copyright: © 2023 Goodwin et al. This is an open
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Data Availability Statement: All relevant data are
within the paper and its Supporting Information
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