Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly Subjects to COVID-19 Vaccination: A Randomized Controlled Trial

{ 'indexed': {'date-parts': [[2024, 8, 5]], 'date-time': '2024-08-05T18:42:19Z', 'timestamp': 1722883339092}, 'reference-count': 51, 'publisher': 'MDPI AG', 'issue': '1', 'license': [ { 'start': { 'date-parts': [[2022, 1, 5]], 'date-time': '2022-01-05T00:00:00Z', 'timestamp': 1641340800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100004587', 'name': 'Instituto de Salud Carlos III', 'doi-asserted-by': 'publisher', 'award': ['JR18/00014'], 'id': [{'id': '10.13039/501100004587', 'id-type': 'DOI', 'asserted-by': 'publisher'}]}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Elderly people are particularly vulnerable to COVID-19, with a high risk of ' 'developing severe disease and a reduced immune response to the COVID-19 vaccine. A ' 'randomized, placebo-controlled, double-blind trial to assess the effect of the consumption of ' 'the probiotic Loigolactobacillus coryniformis K8 CECT 5711 on the immune response generated ' 'by the COVID-19 vaccine in an elderly population was performed. Two hundred nursing home ' 'residents &gt;60 yrs that had not COVID-19 were randomized to receive L. coryniformis K8 or a ' 'placebo daily for 3 months. All volunteers received a complete vaccination schedule of a mRNA ' 'vaccine, starting the intervention ten days after the first dose. Specific IgG and IgA ' 'antibody levels were analyzed 56 days after the end of the immunization process. No ' 'differences between the groups were observed in the antibody levels. During the intervention, ' '19 subjects had COVID-19 (11 receiving K8 vs. 8 receiving placebo, p = 0.457). Subgroup ' 'analysis in these patients showed that levels of IgG were significantly higher in those ' 'receiving K8 compared to placebo (p = 0.038). Among subjects &gt;85 yrs that did not get ' 'COVID-19, administration of K8 tended to increase the IgA levels (p = 0.082). The ' 'administration of K8 may enhance the specific immune response against COVID-19 and may ' 'improve the COVID-19 vaccine-specific responses in elderly populations.</jats:p>', 'DOI': '10.3390/nu14010228', 'type': 'journal-article', 'created': {'date-parts': [[2022, 1, 10]], 'date-time': '2022-01-10T01:21:56Z', 'timestamp': 1641777716000}, 'page': '228', 'source': 'Crossref', 'is-referenced-by-count': 20, 'title': 'Effects of Loigolactobacillus coryniformis K8 CECT 5711 on the Immune Response of Elderly ' 'Subjects to COVID-19 Vaccination: A Randomized Controlled Trial', 'prefix': '10.3390', 'volume': '14', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-7348-7337', 'authenticated-orcid': False, 'given': 'Anxo', 'family': 'Fernández-Ferreiro', 'sequence': 'first', 'affiliation': [ { 'name': 'Pharmacy Department, University Clinical Hospital of Santiago de ' 'Compostela (SERGAS), 15706 Santiago de Compostela, Spain'}, { 'name': 'Pharmacology Group, Health Research Institute Santiago ' 'Compostela (IDIS), 15706 Santiago de Compostela, Spain'}]}, { 'given': 'Francisco J.', 'family': 'Formigo-Couceiro', 'sequence': 'additional', 'affiliation': [ { 'name': 'Medicina Familiar y Comunitaria, 15706 Santiago de Compostela, ' 'Spain'}]}, { 'given': 'Roi', 'family': 'Veiga-Gutierrez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Pharmacy Department, University Clinical Hospital of Santiago de ' 'Compostela (SERGAS), 15706 Santiago de Compostela, Spain'}, { 'name': 'Pharmacology Group, Health Research Institute Santiago ' 'Compostela (IDIS), 15706 Santiago de Compostela, Spain'}]}, { 'given': 'Jose A.', 'family': 'Maldonado-Lobón', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research and Development Department, Biosearch Life, a Kerry ' 'Company, 18004 Granada, Spain'}]}, { 'given': 'Ana M.', 'family': 'Hermida-Cao', 'sequence': 'additional', 'affiliation': [ { 'name': 'Pharmacy Department, University Clinical Hospital of Santiago de ' 'Compostela (SERGAS), 15706 Santiago de Compostela, Spain'}, { 'name': 'Pharmacology Group, Health Research Institute Santiago ' 'Compostela (IDIS), 15706 Santiago de Compostela, Spain'}]}, { 'given': 'Carlos', 'family': 'Rodriguez', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research and Development Department, Biosearch Life, a Kerry ' 'Company, 18004 Granada, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-7418-5955', 'authenticated-orcid': False, 'given': 'Oscar', 'family': 'Bañuelos', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research and Development Department, Biosearch Life, a Kerry ' 'Company, 18004 Granada, Spain'}]}, { 'given': 'Mónica', 'family': 'Olivares', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research and Development Department, Biosearch Life, a Kerry ' 'Company, 18004 Granada, Spain'}]}, { 'ORCID': 'http://orcid.org/0000-0002-6159-3597', 'authenticated-orcid': False, 'given': 'Ruth', 'family': 'Blanco-Rojo', 'sequence': 'additional', 'affiliation': [ { 'name': 'Research and Development Department, Biosearch Life, a Kerry ' 'Company, 18004 Granada, Spain'}]}], 'member': '1968', 'published-online': {'date-parts': [[2022, 1, 5]]}, 'reference': [ { 'key': 'ref_1', 'unstructured': '(2021, October 15). 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