Analgesics
Antiandrogens
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All selenium studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchSeleniumSelenium (more..)
Melatonin Meta
Metformin Meta
Azvudine Meta
Bromhexine Meta Molnupiravir Meta
Budesonide Meta
Colchicine Meta
Conv. Plasma Meta Nigella Sativa Meta
Curcumin Meta Nitazoxanide Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis    Recent:   

COVID-19 and Selenium Deficiency: a Systematic Review

Fakhrolmobasheri et al., Biological Trace Element Research, doi:10.1007/s12011-021-02997-4
Nov 2021  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Review of 11 studies, 9 showing lower serum selenium levels associated with worse COVID-19 outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Authors conclude that cautious selenium supplementation may be helpful to prevent disease progression.
Currently there are 4 selenium treatment studies and meta analysis shows:
OutcomeImprovement
Mortality35% lower [-273‑89%]
Hospitalization22% lower [-106‑70%]
Cases41% fewer [-98‑82%]
Fakhrolmobasheri et al., 5 Nov 2021, peer-reviewed, 7 authors. Contact: marek_kieliszek@sggw.edu.pl, zeinalianmehrdad@gmail.com.
This PaperSeleniumAll
COVID-19 and Selenium Deficiency: a Systematic Review
Mohammad Fakhrolmobasheri, Sadegh Mazaheri-Tehrani, Marek Kieliszek, Mehrdad Zeinalian, Mehdi Abbasi, Fateme Karimi, Amir Mohamad Mozafari
Biological Trace Element Research, doi:10.1007/s12011-021-02997-4
Several studies have indicated that selenium deficiency may be detrimental in the context of various viral disorders, and in the case of COVID-19, several studies have reported heterogeneous results concerning the association of selenium deficiency with the severity of disease. To summarize the available data surrounding the association of body selenium levels with the outcomes of COVID-19, a systematic search was performed in the Medline database (PubMed), Scopus, Cochrane Library, Embase, and Web of Science using keywords including "SARS-CoV-2," "COVID-19," and "selenium," Studies evaluating the association of COVID-19 with body selenium levels were included. Among 1,862 articles viewed in the database search, 10 articles were included after title, abstract, and full-text review. One study was further included after searching the literature again for any newly published articles. Out of 11 included studies, 10 studies measured serum selenium level, and one study investigated urinary selenium level. Three of 10 studies measured serum SELENOP level as well as selenium level. Glutathione peroxidase-3 level in serum was also assessed in one study. The reported outcomes were severity, mortality, and risk of COVID-19. Nine studies indicated that a lower serum selenium level is associated with worse outcomes. Two studies reported no significant association between serum selenium level and COVID-19. In one study, urinary selenium level was reported to be higher in severe and fatal cases compared to non-severe and recovered patients, respectively. In most cases, selenium deficiency was associated with worse outcomes, and selenium levels in COVID-19 patients were lower than in healthy individuals. Thus, it could be concluded that cautious selenium supplementation in COVID-19 patients may be helpful to prevent disease progression. However, randomized clinical trials are needed to confirm this.
Author Contribution M. F. contributed to the main idea development, designing the article review and data extraction process, and writing of the article. S. M.-T., M. K., and M. Z. had contributed in the article review and data extraction process and article writing. M. K., F. K., and M. A. contributed in the database screening and article review process. A. M. as the medical librarian had developed the search strategy of the study. All authors have read and approved the manuscript. Declarations Ethics Approval and Consent to Participate Not applicable. Conflict of Interest The authors declare no competing interests. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.
References
Adeniyi, Agoreyo, Nigeria and the selenium micronutrient: a review, Ann Med Health Sci Res
Akhtar, Das, Ismail, Nutritional perspectives for the prevention and mitigation of COVID-19, Nutr Rev, doi:10.1093/nutrit/nuaa063
Alkattan, Alabdulkareem, Kamel, Correlation between micronutrient plasma concentration and disease severity in COVID-19 patients, Alex J Med, doi:10.1080/20905068.2020.1870788
Bermano, Méplan, Mercer, Hesketh, Selenium and viral infection: are there lessons for COVID-19?, Br J Nutr, doi:10.1017/S0007114520003128
Bodnar, Szczyglowska, Konieczka, Namiesnik, Methods of selenium supplementation: bioavailability and determination of selenium compounds, Crit Rev Food Sci Nutr, doi:10.1080/10408398.2012.709550
Combs, Biomarkers of selenium status, Nutrients, doi:10.3390/nu7042209
Cong, Bai, Li, Selenium nanoparticles as an efficient nanomedicine for the therapy of Huntington's disease, ACS Appl Mater Interfaces, doi:10.1021/acsami.9b12319
Cuschieri, The STROBE guidelines, Saudi J Anaesth, doi:10.4103/sja.SJA_543_18
Damayanthi, Prabani, Nutritional determinants and COVID-19 outcomes of older patients with COVID-19: a systematic review, Arch Gerontol Geriatr, doi:10.1016/j.archger.2021.104411
Domingo, Marquès, The effects of some essential and toxic metals/metalloids in COVID-19: a review, Food Chem Toxicol, doi:10.1016/j.fct.2021.112161
Erol, Polat, Akdas, Maternal selenium status plays a crucial role on clinical outcomes of pregnant women with COVID-19 infection, J Med Virol, doi:10.1002/jmv.27064
Fakhrolmobasheri, Nasr-Esfahany, Khanahmad, Zeinalian, Selenium supplementation can relieve the clinical complications of COVID-19 and other similar viral infections, Int J Vitam Nutr Res, doi:10.1024/0300-9831/a000663
Gabarre, Dumas, Dupont, Acute kidney injury in critically ill patients with COVID-19, Intensive Care Med, doi:10.1007/s00134-020-06153-9
Gasmi, Tippairote, Mujawdiya, Micronutrients as immunomodulatory tools for COVID-19 management, Clin Immunol, doi:10.1016/j.clim.2020.108545
Gladyshev, Arnér, Berry, Selenoprotein gene nomenclature, J Biol Chem, doi:10.1074/jbc.M116.756155
Gröber, Holick, The coronavirus disease (COVID-19) -a supportive approach with selected micronutrients, Int J Vitam Nutr Res Int Z Vitam-Ernahrungsforschung J Int Vitaminol Nutr, doi:10.1024/0300-9831/a000693
Guillin, Vindry, Ohlmann, Chavatte, Selenium, selenoproteins and viral infection, Nutrients, doi:10.3390/nu11092101
Guillin, Vindry, Ohlmann, Chavatte, Selenium, selenoproteins and viral infection, Nutrients, doi:10.3390/nu11092101
Hackler, Heller, Sun, Updating the diagnostic criteria of COVID-19 "suspected case" and "confirmed case" is necessary, Mil Med Res, doi:10.1186/s40779-020-00245-9
Harvey, Carabelli, Jackson, SARS-CoV-2 variants, spike mutations and immune escape, Nat Rev Microbiol, doi:10.1038/s41579-021-00573-0
He, Zhao, Wang, Using nano-selenium to combat coronavirus disease 2019 (COVID-19), Nano Today, doi:10.1016/j.nantod.2020.101037
Heller, Sun, Hackler, Prediction of survival odds in COVID-19 by zinc, age and selenoprotein P as composite biomarker, Redox Biol, doi:10.1016/j.redox.2020.101764
Hiffler, Rakotoambinina, Selenium and RNA virus interactions: potential implications for SARS-CoV-2 infection (COVID-19), Front Nutr, doi:10.3389/fnut.2020.00164
Hu, Zhao, Hu, Yin, Food sources of selenium and its relationship with chronic diseases, Nutrients, doi:10.3390/nu13051739
Im, Je, Baek, Nutritional status of patients with COVID-19, Int J Infect Dis, doi:10.1016/j.ijid.2020.08.018
Jayawardena, Sooriyaarachchi, Chourdakis, Enhancing immunity in viral infections, with special emphasis on COVID-19: a review, Diabetes Metab Syndr Clin Res Rev, doi:10.1016/j.dsx.2020.04.015
Johnson, Fordyce, Rayman, Symposium on "geographical and geological influences on nutrition": factors controlling the distribution of selenium in the environment and their impact on health and nutrition, Proc Nutr Soc, doi:10.1017/S0029665109991807
Khatiwada, Subedi, A mechanistic link between selenium and coronavirus disease 2019 (COVID-19), Curr Nutr Rep, doi:10.1007/s13668-021-00354-4
Kieliszek, Bano, Zare, A comprehensive review on selenium and its effects on human health and distribution in Middle Eastern countries, Biol Trace Elem Res, doi:10.1007/s12011-021-02716-z
Kieliszek, Lipinski, Selenium supplementation in the prevention of coronavirus infections (COVID-19), Med Hypotheses, doi:10.1016/j.mehy.2020.109878
Kieliszek, Selenium-fascinating microelement, properties and sources in food, Molecules, doi:10.3390/molecules24071298
Kipp, Strohm, Brigelius-Flohé, Revised reference values for selenium intake, J Trace Elem Med Biol, doi:10.1016/j.jtemb.2015.07.005
Kiss, Importance of selenium homeostasis in chronic and end-stage kidney diseases, Orv Hetil, doi:10.1556/OH.2013.29733
Kuria, Tian, Li, Selenium status in the body and cardiovascular disease: a systematic review and meta-analysis, Crit Rev Food Sci Nutr, doi:10.1080/10408398.2020.1803200
Li, Bañuelos, Wu, Shi, The changing selenium nutritional status of Chinese residents, Nutrients, doi:10.3390/nu6031103
Liu, Zhao, Ma, Selenium (Se) plays a key role in the biological effects of some viruses: implications for COVID-19, Environ Res, doi:10.1016/j.envres.2021.110984
Majeed, Nagabhushanam, Gowda, Mundkur, An exploratory study of selenium status in healthy individuals and in patients with COVID-19 in a south Indian population: the case for adequate selenium status, Nutrition, doi:10.1016/j.nut.2020.111053
Mehdi, Hornick, Istasse, Dufrasne, Selenium in the environment, metabolism and involvement in body functions, Mol Basel Switz, doi:10.3390/molecules18033292
Moghaddam, Heller, Sun, Selenium deficiency is associated with mortality risk from COVID-19, Nutrients, doi:10.3390/nu12072098
Muhammad, Kani, Iliya, Deficiency of antioxidants and increased oxidative stress in COVID-19 patients: a cross-sectional comparative study in Jigawa, Northwestern Nigeria, SAGE Open Med, doi:10.1177/2050312121991246
Nedjimi, Can trace element supplementations (Cu, Se, and Zn) enhance human immunity against COVID-19 and its new variants? Beni-Suef, Univ J Basic Appl Sci, doi:10.1186/s43088-021-00123-w
Okunade, Olowoselu, Osanyin, Selenium deficiency and pregnancy outcome in pregnant women with HIV in Lagos, Nigeria, Int J Gynaecol Obstet Off Organ Int Fed Gynaecol Obstet, doi:10.1002/ijgo.12508
Page, Mckenzie, Bossuyt, The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ, doi:10.1136/bmj.n71
Pi, Jiang, Cai, GE11 peptide conjugated selenium nanoparticles for EGFR targeted oridonin delivery to achieve enhanced anticancer efficacy by inhibiting EGFR-mediated PI3K/ AKT and Ras/Raf/MEK/ERK pathways, Drug Deliv, doi:10.1080/10717544.2017.1386729
Pieczyńska, Płaczkowska, Sozański, Is maternal dietary selenium intake related to antioxidant status and the occurrence of pregnancy complications?, J Trace Elem Med Biol Organ Soc Miner Trace Elem GMS, doi:10.1016/j.jtemb.2019.04.010
Pincemail, Cavalier, Charlier, Oxidative stress status in COVID-19 patients hospitalized in intensive care unit for severe pneumonia. A Pilot Study, Antioxidants, doi:10.3390/antiox10020257
Rayman, Selenium and human health, Lancet Lond Engl, doi:10.1016/S0140-6736(11)61452-9
Sener, Dogan, Selenium deficiency and Keshan disease mechanism and management, J Clin Nutr Food Sci
Shakoor, Feehan, Dhaheri, Immune-boosting role of vitamins D, C, E, zinc, selenium and omega-3 fatty acids: could they help against COVID-19?, Maturitas, doi:10.1016/j.maturitas.2020.08.003
Skalny, Timashev, Aschner, Serum zinc, copper, and other biometals are associated with COVID-19 severity markers, Metabolites, doi:10.3390/metabo11040244
Tomo, Saikiran, Banerjee, Paul, Selenium to selenoproteins -role in COVID-19, EXCLI J, doi:10.17179/excli2021-3530
Ulfberg, Stehlik, Finland's handling of selenium is a model in these times of coronavirus infections, Br J Nutr, doi:10.1017/S0007114520003827
Zeng, Zhang, Wang, Urinary trace elements in association with disease severity and outcome in patients with COVID-19, Environ Res, doi:10.1016/j.envres.2020.110670
Zhang, Taylor, Bennett, Association between regional selenium status and reported outcome of COVID-19 cases in China, Am J Clin Nutr, doi:10.1093/ajcn/nqaa095
Zhang, Zhang, Lu, Association between fatality rate of COVID-19 and selenium deficiency in China, BMC Infect Dis, doi:10.1186/s12879-021-06167-8
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Vaccines and treatments are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit