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Major dietary patterns in relation to disease severity, symptoms, and inflammatory markers in patients recovered from COVID-19

Ebrahimzadeh et al., Frontiers in Nutrition, doi:10.3389/fnut.2022.929384
Aug 2022  
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Severe case 69% Improvement Relative Risk Hospitalization 56% Recovery 68% Diet for COVID-19  Ebrahimzadeh et al.  Prophylaxis Is a healthy diet beneficial for COVID-19? Retrospective study in Iran (June - September 2021) Lower severe cases (p=0.0037) and improved recovery (p=0.0032) c19early.org Ebrahimzadeh et al., Frontiers in Nutr.., Aug 2022 Favorshealthy diet Favorscontrol 0 0.5 1 1.5 2+
Diet for COVID-19
22nd treatment shown to reduce risk in June 2021
 
*, now with p < 0.00000000001 from 28 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 250 recovered COVID-19 patients, showing lower risk of severe cases and shorter recovery and hospitalization times with a healthy diet.
Notably, all individual symptoms show lower incidence with a healthy diet with the exception of fever and chills. Fever and chills help the immune system fight infections (shivering helps to raise the body temperature).
risk of severe case, 69.0% lower, OR 0.31, p = 0.004, healthy diet, T3 vs. T1, model 3, RR approximated with OR.
risk of hospitalization, 56.0% lower, OR 0.44, p = 0.07, hospitalization time, healthy diet, T3 vs. T1, model 3, RR approximated with OR.
risk of no recovery, 68.0% lower, OR 0.32, p = 0.003, recovery duration, healthy diet, T3 vs. T1, model 3, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Ebrahimzadeh et al., 19 Aug 2022, retrospective, Iran, peer-reviewed, survey, 3 authors, study period June 2021 - September 2021. Contact: mohsenta44@yahoo.com, amkhv@yahoo.com.
This PaperDietAll
Major dietary patterns in relation to disease severity, symptoms, and inflammatory markers in patients recovered from COVID
Takashi Shigematsu, Timotius Ivan Hariyanto, Omid Sadeghi, Mohsen Taghizadeh, Armin Ebrahimzadeh, Alireza Milajerdi
CITATION Ebrahimzadeh A, Taghizadeh M and Milajerdi A ( ) Major dietary patterns in relation to disease severity, symptoms, and inflammatory markers in patients recovered from COVID-.
Ethics statement The studies involving human participants were reviewed and approved by Ethics Committee of Kashan University of Medical Sciences. The patients/participants provided their written informed consent to participate in this study. Author contributions AE: conceptualization, formal analysis, writing-original draft, writing-review and editing, and data collection. AM: supervision, conceptualization, methodology, investigation, funding acquisition, formal analysis, writing-original draft, and writing-review and editing. MT: supervision, conceptualization, formal analysis, writing-original draft, and writing-review and editing. All authors contributed to the article and approved the submitted version. Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher. Supplementary material The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/ fnut.2022.929384/full#supplementary-material
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{ 'indexed': {'date-parts': [[2022, 8, 20]], 'date-time': '2022-08-20T04:12:21Z', 'timestamp': 1660968741333}, 'reference-count': 40, 'publisher': 'Frontiers Media SA', 'license': [ { 'start': { 'date-parts': [[2022, 8, 19]], 'date-time': '2022-08-19T00:00:00Z', 'timestamp': 1660867200000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/501100004048', 'name': 'Kashan University of Medical Sciences', 'doi-asserted-by': 'publisher'}], 'content-domain': {'domain': ['frontiersin.org'], 'crossmark-restriction': True}, 'abstract': '<jats:sec><jats:title>Background</jats:title><jats:p>COVID-19 is a highly transmissible viral ' 'infection with high morbidity. Few studies have been done about dietary intakes in patients ' 'with COVID-19. This study aimed to evaluate the association between major dietary patterns ' 'before COVID-19 diagnosis in recovered patients and the risk of disease severity and symptoms ' 'after the disease ' 'begins.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Overall, 250 ' 'recovered cases with both genders completed study questionnaires providing data on ' 'demographic characteristics, self-reported web-based 168-item food frequency questionnaire ' '(FFQ), and COVID-19 outcomes in Shahid Beheshti Hospital, Kashan. PCR was used to determine a ' 'positive diagnosis of COVID-19. We used multivariable logistic regression models to assess ' 'the association between major dietary patterns and study outcomes. All statistical analyses ' 'were done by SPSS version ' '16.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>We identified three ' 'major dietary patterns—unhealthy, traditional, and healthy dietary patterns. Serum levels of ' 'C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were significantly higher ' 'in patients with unhealthy and traditional dietary patterns and lower in those with healthy ' 'dietary patterns. There was a significant direct relationship between unhealthy and ' 'traditional patterns with risk of severe COVID-19 and hospitalization duration and a ' 'significant direct association between an unhealthy pattern and the odds ratio (OR) of ' 'convalescence duration. A significant inverse relationship was found between healthy pattern ' 'and risk of severe COVID-19 and OR of convalescence duration. We found a significant direct ' 'association between unhealthy pattern and OR of cough, fever, chilling, weakness, myalgia, ' 'nausea and vomiting, and sore throat and between traditional pattern and OR of cough, fever, ' 'and chilling. In contrast, a significant inverse association was seen between healthy pattern ' 'and OR of dyspnea, weakness, and sore ' 'throat.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>This study ' 'showed that high adherence to an healthy pattern was associated with lower CRP and ESR levels ' 'and lower risk of severe COVID-19, hospitalization, and convalescence duration in patients ' 'who recovered from COVID-19. More adherence to unhealthy or traditional dietary patterns was ' 'associated with higher CRP and ESR levels and a higher risk of severe COVID-19 and ' 'hospitalization duration. A direct association was found between unhealthy and traditional ' 'patterns and the risk of some COVID-19 symptoms, while an inverse association was found for a ' 'healthy dietary pattern.</jats:p></jats:sec>', 'DOI': '10.3389/fnut.2022.929384', 'type': 'journal-article', 'created': {'date-parts': [[2022, 8, 19]], 'date-time': '2022-08-19T17:24:42Z', 'timestamp': 1660929882000}, 'update-policy': 'http://dx.doi.org/10.3389/crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Major dietary patterns in relation to disease severity, symptoms, and inflammatory markers in ' 'patients recovered from COVID-19', 'prefix': '10.3389', 'volume': '9', 'author': [ {'given': 'Armin', 'family': 'Ebrahimzadeh', 'sequence': 'first', 'affiliation': []}, {'given': 'Mohsen', 'family': 'Taghizadeh', 'sequence': 'additional', 'affiliation': []}, {'given': 'Alireza', 'family': 'Milajerdi', 'sequence': 'additional', 'affiliation': []}], 'member': '1965', 'published-online': 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'http://dx.doi.org/10.3389/fnut.2022.929384', 'relation': {}, 'ISSN': ['2296-861X'], 'subject': ['Nutrition and Dietetics', 'Endocrinology, Diabetes and Metabolism', 'Food Science'], 'container-title-short': 'Front. Nutr.', 'published': {'date-parts': [[2022, 8, 19]]}}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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