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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Mortality 16% Improvement Relative Risk ICU time 9% Time to improvement 33% Recovery time 7% Hospitalization time 17% Time to viral- 13% c19early.org/fm Chowdhury et al. NCT04504240 Famotidine RCT ICU Favors famotidine Favors control
Role of H2 receptor blocker famotidine over the clinical recovery of COVID-19 patients: A randomized controlled trial
Chowdhury et al., World Journal of Clinical Cases, doi:10.12998/wjcc.v10.i23.8170, NCT04504240 (history)
16 Aug 2022    Source   PDF   Share   Tweet
RCT 208 ICU patients in Bangladesh, showing improved recovery with famotidine. Famotidine 40mg (<60kg) or 60mg every 8 hours.
risk of death, 16.1% lower, RR 0.84, p = 0.53, treatment 26 of 104 (25.0%), control 31 of 104 (29.8%), NNT 21.
ICU time, 9.3% lower, relative time 0.91, p = 0.33, treatment 78, control 73.
time to improvement, 32.9% lower, relative time 0.67, p < 0.001, treatment mean 9.53 (±5.0) n=78, control mean 14.21 (±5.6) n=73, time to clinical improvement.
recovery time, 7.3% lower, relative time 0.93, p = 0.14, treatment mean 17.9 (±5.4) n=78, control mean 19.3 (±6.3) n=73, time to symptomatic recovery.
hospitalization time, 17.0% lower, relative time 0.83, p = 0.01, treatment 78, control 73.
time to viral-, 13.0% lower, relative time 0.87, p = 0.002, treatment 78, control 73.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chowdhury et al., 16 Aug 2022, Randomized Controlled Trial, Bangladesh, peer-reviewed, mean age 57.1, 11 authors, trial NCT04504240 (history).
Contact: 39485572@qq.com, bpgoffice@wjgnet.com, dyyyjxk@mail.xjtu.edu.cn.
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Late treatment
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