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Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit

Chiscano-Camón et al., Frontiers in Medicine, doi:10.3389/fmed.2023.1301001
Dec 2023  
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Vitamin C for COVID-19
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Observational study of 43 critically ill COVID-19 patients requiring respiratory support showing vitamin C deficiency present at ICU admission and persisting throughout ICU stay. 86% of patients had undetectable vitamin C levels (<1.5mg/L) on ICU admission, 83% on day 5, and 88% on day 10.
Chiscano-Camón et al., 20 Dec 2023, prospective, Spain, peer-reviewed, survey, mean age 62.0, 14 authors, study period 12 November, 2020 - 24 February, 2021. Contact:
This PaperVitamin CAll
Vitamin C deficiency in critically ill COVID-19 patients admitted to intensive care unit
Luis Chiscano-Camón, Juan Carlos Ruiz-Rodriguez, Erika P Plata-Menchaca, Laura Martin, Ivan Bajaña, Cristina Martin-Rodríguez, Clara Palmada, Roser Ferrer-Costa, Silvia Camos, Yolanda Villena-Ortiz, Vicent Ribas, Adolf Ruiz-Sanmartin, Marcos Pérez-Carrasco, Ricard Ferrer
Frontiers in Medicine, doi:10.3389/fmed.2023.1301001
Objectives: To determine vitamin C plasma kinetics, through the measurement of vitamin C plasma concentrations, in critically ill Coronavirus infectious disease 2019 (COVID-19) patients, identifying eventually the onset of vitamin C deficiency.
Ethics statement The studies involving humans were approved by Clinical Research Ethics Committee (CEIm) of Vall d'Hebron University Hospital [PR(AG)687/2020]. The studies were conducted in accordance with the local legislation and institutional requirements. The ethics committee/ institutional review board waived the requirement of written informed consent for participation from the participants or the participants' legal guardians/next of kin because the informed consent was waived due to epimediological situation, in between COVID-19 outbreak. Author contributions Conflict of interest The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Publisher's note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
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