Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Sandica Bucurica, Ioana Prodan, Mihaela Pavalean, Corina Taubner, Ana Bucurica, Calin Socol, Roxana Calin, Florentina Ionita-Radu, Mariana Jinga
Diagnostics, doi:10.3390/diagnostics13050998
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20-30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories.
References
Adenote, Dumic, Madrid, Barusya, Nordstrom et al., Infection, a Nuanced Relationship, Can. J. Gastroenterol. Hepatol,
doi:10.1155/2021/5556354Aggarwal, Akhthar, Jain, Coronary artery disease and its association with Vitamin D deficiency, J. Midlife Health,
doi:10.4103/0976-7800.185334Alkhatatbeh, Abdul-Razzak, Khasawneh, Saadeh, High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome, Metab. Syndr. Relat. Disord
Alkundi, Momoh, Musa, Nwafor, Vitamin D intoxication and severe hypercalcaemia complicating nutritional supplements misuse, BMJ Case Rep,
doi:10.1136/bcr-2022-250553Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents, Nutrients,
doi:10.3390/nu13051714Amrein, Scherkl, Hoffmann, Neuwersch-Sommeregger, Köstenberger et al., deficiency 2.0: An update on the current status worldwide, Eur. J. Clin. Nutr,
doi:10.1038/s41430-020-0558-yCaprio, Infante, Calanchini, Mammi, Fabbri et al., Not just the bone. Evidence for beneficial pleiotropic extraskeletal effects, Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes,
doi:10.1007/s40519-016-0312-6Cashman, Dowling, Škrabáková, Gonzalez-Gross, Valtueña et al., Vitamin D deficiency in Europe: Pandemic?, Am. J. Clin. Nutr
Chirita-Emandi, Socolov, Haivas, Calapis, Gheorghiu et al., Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients, PLoS ONE,
doi:10.1371/journal.pone.0128010Christakos, Dhawan, Verstuyf, Verlinden, Carmeliet et al., Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects, Physiol. Rev,
doi:10.1152/physrev.00014.2015Cosentino, Campodonico, Milazzo, De Metrio, Brambilla et al., Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives, Nutrients,
doi:10.3390/nu13103603Cuomo, Maina, Bolognesi, Rosso, Crescenzi et al., Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness, Front. Psychiatry,
doi:10.3389/fpsyt.2019.00167Da Silveira, Moura, Castro, Kac, Hadler et al., Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis, Nutrients,
doi:10.3390/nu14204351Dudenkov, Yawn, Oberhelman, Fischer, Singh et al., Changing Incidence of Serum 25-Hydroxyvitamin D Values above 50 ng/mL: A 10-Year Population-Based Study, Mayo Clin. Proc,
doi:10.1016/j.mayocp.2015.02.012Elizondo-Montemayor, Castillo, Rodríguez-López, Villarreal-Calderón, Gómez-Carmona et al., Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults, Mediat. Inflamm,
doi:10.1155/2017/5719461Ene, Terþiu, Vrâncianu, Chifiriuc, Vitamin D Status in Adult and Pediatric Romanian Population
Feldman, Krishnan, Swami, Giovannucci, Feldman, The role of vitamin D in reducing cancer risk and progression, Nat. Rev. Cancer,
doi:10.1038/nrc3691Finstad, Murphy, Markey, Connor, Murphy, Prevalence of vitamin D3 deficiency among women with early breast cancer receiving chemotherapy in an oncology dayward, Ann. Oncol,
doi:10.1093/annonc/mdz240.106Fontanive, Dick, Valente, Laranjeira, Antunes et al., Seasonal variation of vitamin D among healthy adult men in a subtropical region, Rev. Assoc. Med. Bras,
doi:10.1590/1806-9282.66.10.1431Gaksch, Jorde, Grimnes, Joakimsen, Schirmer et al., Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium, PLoS ONE,
doi:10.1371/journal.pone.0170791Giustina, Bouillon, Binkley, Sempos, Adler et al., Controversies in Vitamin D: A Statement From the Third International Conference, JBMR Plus
Gois, Ferreira, Olenski, Seguro, Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?, Nutrients,
doi:10.3390/nu9070651Graedel, Merker, Felder, Kutz, Haubitz et al., Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results from a Prospective Study, Medicine,
doi:10.1097/MD.0000000000003533Griffin, Wall, Blake, Griffin, Robinson et al., Vitamin D Status of Adults in the Community, in Outpatient Clinics, in Hospital, and in Nursing Homes in the West of Ireland, J. Gerontol. Ser. A,
doi:10.1093/gerona/glaa010Gupta, Vashi, Trukova, Lis, Lammersfeld, Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature, Exp. Ther. Med,
doi:10.3892/etm.2011.205Hays, Flores, Kothari, Bilek, Geske et al., Vitamin D Status and Seasonal Variation: A Retrospective Single Institution Database Study of Patients Pursuing Metabolic/Bariatric Surgery, Clin. Nutr. Open Sci,
doi:10.1016/j.nutos.2021.11.002Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline, Med. J. Clin. Endocrinol. Metab,
doi:10.1210/jc.2011-0385Holick, High Prevalence of Vitamin D Inadequacy and Implications for Health, Mayo Clin. Proc,
doi:10.4065/81.3.353Hopkins, Owen, Ahearn, Fedirko, Flanders et al., Effects of Supplemental Vitamin D and Calcium on Biomarkers of Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled Clinical Trial, Cancer Prev. Res,
doi:10.1158/1940-6207.CAPR-11-0105Huang, Lu, Chen, Zeng, Xu, The efficacy of vitamin D supplementation for irritable bowel syndrome: A systematic review with meta-analysis, Nutr. J,
doi:10.1186/s12937-022-00777-xJanoušek, Pilařová, Macáková, Nomura, Veiga-Matos et al., Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites, Crit. Rev. Clin. Lab. Sci,
doi:10.1080/10408363.2022.2070595Kantas, Capriles, Babor, Tamdin, Al-Rihani et al., Relationship between Chronic Kidney Disease Staging and Vitamin D Deficiency: A Retrospective Study, Cureus,
doi:10.7759/cureus.r55Khadilkar, Kajale, Oza, Oke, Gondhalekar et al., Vitamin D status and determinants in Indian children and adolescents: A multicentre study, Sci. Rep,
doi:10.1038/s41598-022-21279-0Kovalenko, Zhang, Cui, Clinton, Fleet, 1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genom,
doi:10.1186/1471-2164-11-26Kweder, Eidi, Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status, Avicenna J. Med,
doi:10.4103/ajm.AJM_20_18Lahoz, Sánchez, Górriz, Calmarza, Comparative study of two immunoassays used for the determination of serum vitamin D, Pract. Lab. Med,
doi:10.1016/j.plabm.2021.e00242Li, Liu, Luo, Huang, Zhang et al., Vitamin D deficiency associated with Crohn's disease and ulcerative colitis: A meta-analysis of 55 observational studies, J. Transl. Med,
doi:10.1186/s12967-019-2070-5Lips, Cashman, Lamberg-Allardt, Bischoff-Ferrari, Obermayer-Pietsch et al., Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society, Eur. J. Endocrinol,
doi:10.1530/EJE-18-0736Mahdavi, A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19, Rev. Med. Virol,
doi:10.1002/rmv.2119Malinovschi, Masoero, Bellocchia, Ciuffreda, Solidoro et al., Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients, Respir. Res,
doi:10.1186/s12931-014-0131-0Manson, Bassuk, Buring, Vital Research, Group, Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials, J. Steroid Biochem. Mol. Biol,
doi:10.1016/j.jsbmb.2019.105522Manson, Cook, Lee, Christen, Bassuk et al., Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease, N. Engl. J. Med,
doi:10.1056/NEJMoa1809944Mc Williams, Golestany, Sharma, Nejati, Cyrus-Murden et al., Correlation of admitted nursing home residents' hospital length of stay and vitamin D levels, J. Community Hosp. Intern. Med. Perspect,
doi:10.3402/jchimp.v1i3.6313Melamed, Thadhani, Vitamin D Therapy in Chronic Kidney Disease and End Stage Renal Disease, Clin. J. Am. Soc. Nephrol,
doi:10.2215/CJN.04040411Mensah, Wei, Sorlie, Fine, Rosenberg et al., Decline in Cardiovascular Mortality: Possible Causes and Implications, Circ. Res
Merker, Amsler, Pereira, Bolliger, Tribolet et al., Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality, Medicine
Moore, Kiebzak, Suboptimal vitamin D status is a highly prevalent but treatable condition in both hospitalized patients and the general population, J. Am. Acad. Nurse Pract,
doi:10.1111/j.1745-7599.2007.00277.xNiculescu, Capatina, Dusceac, Caragheorgheopol, Ghemigian et al., Seasonal variation of serum vitamin D levels in Romania, Arch. Osteoporos,
doi:10.1007/s11657-017-0407-3Nimavat, Singh, Singh, Singh, Sinha, Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India, Ann. Med. Surg,
doi:10.1016/j.amsu.2021.102661Obi, Hamano, Isaka, Prevalence and Prognostic Implications of Vitamin D Deficiency in Chronic Kidney Disease, Dis. Markers,
doi:10.1155/2015/868961Okan, Okan, Demir, Relation of Vitamin D Status with Season, Living Place, Age Gender and Chronic Disease, Erciyes Med. J,
doi:10.14744/etd.2019.45577Petrelli, Oldani, Borgonovo, Cabiddu, Dognini et al., Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses, Antioxidants,
doi:10.3390/antiox12020247Pinzariu, Sova, Maranduca, Filip, Drochioi et al., Vitamin D Deficiency in Both Oral and Systemic Manifestations in SARS-CoV-2 Infection: Updated Review, Medicina,
doi:10.3390/medicina59010068Pludowski, Takacs, Boyanov, Belaya, Diaconu et al., Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement, Nutrients,
doi:10.3390/nu14071483Schleicher, Sternberg, Looker, Yetley, Lacher et al., National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry in the US Population during 2007-2010, J. Nutr,
doi:10.3945/jn.115.227728Schöttker, Hagen, Zhang, Gào, Holleczek et al., Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels, J. Gerontol. Ser. A,
doi:10.1093/gerona/gly253Souberbielle, Massart, Brailly-Tabard, Cavalier, Chanson, Prevalence and determinants of vitamin D deficiency in healthy French adults: The VARIETE study, Endocrine,
doi:10.1007/s12020-016-0960-3Tazzyman, Richards, Trueman, Evans, Grant et al., Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: Outcomes from a pilot trial, BMJ Open Gastroenterol,
doi:10.1136/bmjgast-2015-000052Tebben, Singh, Kumar, Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment, Endocr. Rev,
doi:10.1210/er.2016-1070Tomaschitz, Pilz, Ritz, Grammer, Drechsler et al., Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study, Clin. Chim. Acta,
doi:10.1016/j.cca.2010.05.037Varikasuvu, Thangappazham, Vykunta, Duggina, Manne et al., COVID-19 and vitamin D (Co-VIVID study): A systematic review and meta-analysis of randomized controlled trials, Expert Rev. Anti Infect. Ther,
doi:10.1080/14787210.2022.2035217Venkatram, Chilimuri, Adrish, Salako, Patel et al., Vitamin D deficiency is associated with mortality in the medical intensive care unit, Crit. Care,
doi:10.1186/cc10585Wang, Chen, Li, Yin, Zhang et al., Vitamin D and Chronic Diseases, Aging Dis
Wang, Yang, Zhou, Zhang, Yi, Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis, Kidney Blood Press. Res,
doi:10.1159/000498838Wintermeyer, Ihle, Ehnert, Stöckle, Ochs et al., Crucial Role of Vitamin D in the Musculoskeletal System, Nutrients,
doi:10.3390/nu8060319Wu, Liu, Deng, The Role of Vitamin D in Immune System and Inflammatory Bowel Disease, J. Inflamm. Res,
doi:10.2147/JIR.S363840Zierold, Nehring, Deluca, Nuclear receptor 4A2 and C/EBPβ regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1α-hydroxylase, Arch. Biochem. Biophys,
doi:10.1016/j.abb.2006.11.028Zittermann, Trummer, Theiler-Schwetz, Lerchbaum, März et al., Vitamin D and Cardiovascular Disease: An Updated Narrative Review, Int. J. Mol. Sci,
doi:10.3390/ijms22062896DOI record:
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"article-title": "Vitamin D Metabolism, Mechanism of Action, and Clinical Applications",
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"article-title": "Comparative study of two immunoassays used for the determination of serum vitamin D",
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"article-title": "Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India",
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"year": "2007"
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"DOI": "10.1016/j.cca.2010.05.037",
"article-title": "Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin–angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study",
"author": "Tomaschitz",
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"journal-title": "Clin. Chim. Acta",
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"volume": "411",
"year": "2010"
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"DOI": "10.1371/journal.pone.0170791",
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},
{
"article-title": "Coronary artery disease and its association with Vitamin D deficiency",
"author": "Aggarwal",
"first-page": "56",
"journal-title": "J. Midlife Health",
"key": "ref_11",
"volume": "7",
"year": "2016"
},
{
"DOI": "10.1016/j.jsbmb.2016.11.021",
"article-title": "Vitamin D and type 2 diabetes",
"author": "Lips",
"doi-asserted-by": "crossref",
"first-page": "280",
"journal-title": "J. Steroid Biochem. Mol. Biol.",
"key": "ref_12",
"volume": "173",
"year": "2017"
},
{
"DOI": "10.1016/j.biopha.2018.10.140",
"article-title": "Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies",
"author": "Udomsinprasert",
"doi-asserted-by": "crossref",
"first-page": "1351",
"journal-title": "Biomed. Pharmacother.",
"key": "ref_13",
"volume": "109",
"year": "2019"
},
{
"DOI": "10.3390/nu14071483",
"doi-asserted-by": "crossref",
"key": "ref_14",
"unstructured": "Pludowski, P., Takacs, I., Boyanov, M., Belaya, Z., Diaconu, C.C., Mokhort, T., Zherdova, N., Rasa, I., Payer, J., and Pilz, S. (2022). Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement. Nutrients, 14."
},
{
"DOI": "10.1530/EJE-18-0736",
"article-title": "Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society",
"author": "Lips",
"doi-asserted-by": "crossref",
"first-page": "P23",
"journal-title": "Eur. J. Endocrinol.",
"key": "ref_15",
"volume": "180",
"year": "2019"
},
{
"DOI": "10.1002/jbm4.10417",
"article-title": "Controversies in Vitamin D: A Statement From the Third International Conference",
"author": "Giustina",
"doi-asserted-by": "crossref",
"first-page": "e10417",
"journal-title": "JBMR Plus",
"key": "ref_16",
"volume": "4",
"year": "2020"
},
{
"key": "ref_17",
"unstructured": "(2023, February 19). Anexa2-Ghid-Pentru-Evaluarea-Statusului-Vitaminei-D-La-Adulti-1-1.pdf. Available online: https://www.ms.ro/wp-content/uploads/2019/07/Anexa2-Ghid-pentru-evaluarea-statusului-vitaminei-D-la-adulti-1-1.pdf."
},
{
"key": "ref_18",
"unstructured": "(2023, February 19). ANEXA1vit-D-La-Nou-Nascut-Copil-Gravida.pdf. Available online: https://www.ms.ro/wp-content/uploads/2019/07/ANEXA1vit-D-la-nou-nascut-copil-gravida.pdf."
},
{
"DOI": "10.1186/s12931-014-0131-0",
"article-title": "Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients",
"author": "Malinovschi",
"doi-asserted-by": "crossref",
"first-page": "131",
"journal-title": "Respir. Res.",
"key": "ref_19",
"volume": "15",
"year": "2014"
},
{
"DOI": "10.3402/jchimp.v1i3.6313",
"article-title": "Correlation of admitted nursing home residents’ hospital length of stay and vitamin D levels",
"author": "Golestany",
"doi-asserted-by": "crossref",
"first-page": "6313",
"journal-title": "J. Community Hosp. Intern. Med. Perspect.",
"key": "ref_20",
"volume": "1",
"year": "2011"
},
{
"DOI": "10.1080/07315724.2018.1446194",
"article-title": "Vitamin D Status in Hospitalized Chronically Ill Patients",
"author": "Botros",
"doi-asserted-by": "crossref",
"first-page": "578",
"journal-title": "J. Am. Coll. Nutr.",
"key": "ref_21",
"volume": "37",
"year": "2018"
},
{
"DOI": "10.1186/cc10585",
"article-title": "Vitamin D deficiency is associated with mortality in the medical intensive care unit",
"author": "Venkatram",
"doi-asserted-by": "crossref",
"first-page": "R292",
"journal-title": "Crit. Care",
"key": "ref_22",
"volume": "15",
"year": "2011"
},
{
"DOI": "10.1093/gerona/glaa010",
"article-title": "Vitamin D Status of Adults in the Community, in Outpatient Clinics, in Hospital, and in Nursing Homes in the West of Ireland",
"author": "Griffin",
"doi-asserted-by": "crossref",
"first-page": "2418",
"journal-title": "J. Gerontol. Ser. A",
"key": "ref_23",
"volume": "75",
"year": "2020"
},
{
"DOI": "10.1111/j.1745-7599.2007.00277.x",
"article-title": "Suboptimal vitamin D status is a highly prevalent but treatable condition in both hospitalized patients and the general population",
"author": "Moore",
"doi-asserted-by": "crossref",
"first-page": "642",
"journal-title": "J. Am. Acad. Nurse Pract.",
"key": "ref_24",
"volume": "19",
"year": "2007"
},
{
"DOI": "10.3390/antiox12020247",
"doi-asserted-by": "crossref",
"key": "ref_25",
"unstructured": "Petrelli, F., Oldani, S., Borgonovo, K., Cabiddu, M., Dognini, G., Ghilardi, M., Parati, M.C., Petro’, D., Dottorini, L., and Rea, C. (2023). Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses. Antioxidants, 12."
},
{
"article-title": "Relation of Vitamin D Status with Season, Living Place, Age Gender and Chronic Disease",
"author": "Okan",
"first-page": "78",
"journal-title": "Erciyes Med. J.",
"key": "ref_26",
"volume": "42",
"year": "2020"
},
{
"DOI": "10.3945/jn.115.227728",
"article-title": "National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography–Tandem Mass Spectrometry in the US Population during 2007–2010",
"author": "Schleicher",
"doi-asserted-by": "crossref",
"first-page": "1051",
"journal-title": "J. Nutr.",
"key": "ref_27",
"volume": "146",
"year": "2016"
},
{
"DOI": "10.3945/ajcn.115.120873",
"article-title": "Vitamin D deficiency in Europe: Pandemic?",
"author": "Cashman",
"doi-asserted-by": "crossref",
"first-page": "1033",
"journal-title": "Am. J. Clin. Nutr.",
"key": "ref_28",
"volume": "103",
"year": "2016"
},
{
"DOI": "10.1007/s00223-019-00559-4",
"article-title": "Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing",
"author": "Cashman",
"doi-asserted-by": "crossref",
"first-page": "14",
"journal-title": "Calcif. Tissue Int.",
"key": "ref_29",
"volume": "106",
"year": "2020"
},
{
"DOI": "10.1038/s41430-020-0558-y",
"article-title": "Vitamin D deficiency 2.0: An update on the current status worldwide",
"author": "Amrein",
"doi-asserted-by": "crossref",
"first-page": "1498",
"journal-title": "Eur. J. Clin. Nutr.",
"key": "ref_30",
"volume": "74",
"year": "2020"
},
{
"DOI": "10.1371/journal.pone.0128010",
"doi-asserted-by": "crossref",
"key": "ref_31",
"unstructured": "Chirita-Emandi, A., Socolov, D., Haivas, C., Calapiș, A., Gheorghiu, C., and Puiu, M. (2015). Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients. PLoS ONE, 10."
},
{
"DOI": "10.1007/s11657-017-0407-3",
"article-title": "Seasonal variation of serum vitamin D levels in Romania",
"author": "Niculescu",
"doi-asserted-by": "crossref",
"first-page": "113",
"journal-title": "Arch. Osteoporos.",
"key": "ref_32",
"volume": "12",
"year": "2017"
},
{
"key": "ref_33",
"unstructured": "Ene, M.C., Terþiu, O., Vrâncianu, O., and Chifiriuc, M.C. (2023, February 19). Vitamin D Status in Adult and Pediatric Romanian Population. Available online: https://roami.ro/wp-content/uploads/2019/08/198-212-Art-Marin-Cristian-Ene-Archives-32018-1.pdf."
},
{
"DOI": "10.1097/MD.0000000000018113",
"article-title": "Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality",
"author": "Merker",
"doi-asserted-by": "crossref",
"first-page": "e18113",
"journal-title": "Medicine",
"key": "ref_34",
"volume": "98",
"year": "2019"
},
{
"DOI": "10.1007/s12020-016-0960-3",
"article-title": "Prevalence and determinants of vitamin D deficiency in healthy French adults: The VARIETE study",
"author": "Souberbielle",
"doi-asserted-by": "crossref",
"first-page": "543",
"journal-title": "Endocrine",
"key": "ref_35",
"volume": "53",
"year": "2016"
},
{
"DOI": "10.1038/s41598-022-21279-0",
"article-title": "Vitamin D status and determinants in Indian children and adolescents: A multicentre study",
"author": "Khadilkar",
"doi-asserted-by": "crossref",
"first-page": "16790",
"journal-title": "Sci. Rep.",
"key": "ref_36",
"volume": "12",
"year": "2022"
},
{
"DOI": "10.3390/nu14204351",
"doi-asserted-by": "crossref",
"key": "ref_37",
"unstructured": "da Silveira, E.A., Moura, L.d.A.N.e., Castro, M.C.R., Kac, G., Hadler, M.C.C.M., Noll, P.R.E.S., Noll, M., Rezende, A.T.d.O., Delpino, F.M., and de Oliveira, C. (2022). Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis. Nutrients, 14."
},
{
"DOI": "10.4103/ajm.AJM_20_18",
"article-title": "Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status",
"author": "Kweder",
"doi-asserted-by": "crossref",
"first-page": "139",
"journal-title": "Avicenna J. Med.",
"key": "ref_38",
"volume": "8",
"year": "2018"
},
{
"DOI": "10.1038/s41598-019-56297-y",
"article-title": "A Comparison Study of Vitamin D Deficiency among Older Adults in China and the United States",
"author": "Wei",
"doi-asserted-by": "crossref",
"first-page": "19713",
"journal-title": "Sci. Rep.",
"key": "ref_39",
"volume": "9",
"year": "2019"
},
{
"DOI": "10.4065/81.3.353",
"article-title": "High Prevalence of Vitamin D Inadequacy and Implications for Health",
"author": "Holick",
"doi-asserted-by": "crossref",
"first-page": "353",
"journal-title": "Mayo Clin. Proc.",
"key": "ref_40",
"volume": "81",
"year": "2006"
},
{
"article-title": "Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels",
"author": "Hagen",
"first-page": "121",
"journal-title": "J. Gerontol. Ser. A",
"key": "ref_41",
"volume": "74",
"year": "2018"
},
{
"DOI": "10.1016/j.nutos.2021.11.002",
"article-title": "Vitamin D Status and Seasonal Variation: A Retrospective Single Institution Database Study of Patients Pursuing Metabolic/Bariatric Surgery",
"author": "Hays",
"doi-asserted-by": "crossref",
"first-page": "1",
"journal-title": "Clin. Nutr. Open Sci.",
"key": "ref_42",
"volume": "41",
"year": "2021"
},
{
"DOI": "10.1590/1806-9282.66.10.1431",
"article-title": "Seasonal variation of vitamin D among healthy adult men in a subtropical region",
"author": "Fontanive",
"doi-asserted-by": "crossref",
"first-page": "1431",
"journal-title": "Rev. Assoc. Med. Bras.",
"key": "ref_43",
"volume": "66",
"year": "2020"
},
{
"article-title": "Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults",
"author": "Castillo",
"first-page": "1",
"journal-title": "Mediat. Inflamm.",
"key": "ref_44",
"volume": "2017",
"year": "2017"
},
{
"DOI": "10.2174/1871530314666141027102627",
"article-title": "Vitamin D and Infectious Diseases",
"author": "Miragliotta",
"doi-asserted-by": "crossref",
"first-page": "267",
"journal-title": "Endocr. Metab. Immune Disord.—Drug Targets",
"key": "ref_45",
"volume": "14",
"year": "2014"
},
{
"DOI": "10.1080/14787210.2022.2035217",
"article-title": "COVID-19 and vitamin D (Co-VIVID study): A systematic review and meta-analysis of randomized controlled trials",
"author": "Varikasuvu",
"doi-asserted-by": "crossref",
"first-page": "907",
"journal-title": "Expert Rev. Anti Infect. Ther.",
"key": "ref_46",
"volume": "20",
"year": "2022"
},
{
"DOI": "10.3390/medicina59010068",
"doi-asserted-by": "crossref",
"key": "ref_47",
"unstructured": "Pinzariu, A.C., Sova, I.A., Maranduca, M.A., Filip, N., Drochioi, I.C., Vamesu, C.G., Clim, A., Hurjui, L.L., Moscalu, M., and Soroceanu, R.P. (2022). Vitamin D Deficiency in Both Oral and Systemic Manifestations in SARS-CoV-2 Infection: Updated Review. Medicina, 59."
},
{
"DOI": "10.3390/nu9070651",
"doi-asserted-by": "crossref",
"key": "ref_48",
"unstructured": "Gois, P.H.F., Ferreira, D., Olenski, S., and Seguro, A.C. (2017). Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?. Nutrients, 9."
},
{
"DOI": "10.3390/nu13051714",
"doi-asserted-by": "crossref",
"key": "ref_49",
"unstructured": "AlSafar, H., Grant, W.B., Hijazi, R., Uddin, M., Alkaabi, N., Tay, G., Mahboub, B., and Al Anouti, F. (2021). COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents. Nutrients, 13."
},
{
"article-title": "A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19",
"author": "Mahdavi",
"first-page": "e2119",
"journal-title": "Rev. Med. Virol.",
"key": "ref_50",
"volume": "30",
"year": "2020"
},
{
"DOI": "10.1016/j.jsbmb.2019.105522",
"article-title": "Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials",
"author": "Manson",
"doi-asserted-by": "crossref",
"first-page": "105522",
"journal-title": "J. Steroid Biochem. Mol. Biol.",
"key": "ref_51",
"volume": "198",
"year": "2019"
},
{
"DOI": "10.3390/ijms22062896",
"doi-asserted-by": "crossref",
"key": "ref_52",
"unstructured": "Zittermann, A., Trummer, C., Theiler-Schwetz, V., Lerchbaum, E., März, W., and Pilz, S. (2021). Vitamin D and Cardiovascular Disease: An Updated Narrative Review. Int. J. Mol. Sci., 22."
},
{
"DOI": "10.1161/CIRCRESAHA.116.309115",
"article-title": "Decline in Cardiovascular Mortality: Possible Causes and Implications",
"author": "Mensah",
"doi-asserted-by": "crossref",
"first-page": "366",
"journal-title": "Circ. Res.",
"key": "ref_53",
"volume": "120",
"year": "2017"
},
{
"article-title": "Vitamin D Status, Supplementation and Cardiovascular Disease",
"author": "Zittermann",
"first-page": "1179",
"journal-title": "Anticancer Res.",
"key": "ref_54",
"volume": "38",
"year": "2018"
},
{
"DOI": "10.3390/nu13103603",
"doi-asserted-by": "crossref",
"key": "ref_55",
"unstructured": "Cosentino, N., Campodonico, J., Milazzo, V., De Metrio, M., Brambilla, M., Camera, M., and Marenzi, G. (2021). Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives. Nutrients, 13."
},
{
"DOI": "10.14336/AD.2016.1021",
"article-title": "Vitamin D and Chronic Diseases",
"author": "Wang",
"doi-asserted-by": "crossref",
"first-page": "346",
"journal-title": "Aging Dis.",
"key": "ref_56",
"volume": "8",
"year": "2017"
},
{
"DOI": "10.1016/j.pbiomolbio.2006.02.016",
"article-title": "Vitamin D physiology",
"author": "Lips",
"doi-asserted-by": "crossref",
"first-page": "4",
"journal-title": "Prog. Biophys. Mol. Biol.",
"key": "ref_57",
"volume": "92",
"year": "2006"
},
{
"DOI": "10.3390/medicina55090541",
"doi-asserted-by": "crossref",
"key": "ref_58",
"unstructured": "Vranić, L., Mikolašević, I., and Milić, S. (2019). Vitamin D Deficiency: Consequence or Cause of Obesity?. Medicina, 55."
},
{
"DOI": "10.1089/met.2017.0003",
"article-title": "High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome",
"author": "Alkhatatbeh",
"doi-asserted-by": "crossref",
"first-page": "213",
"journal-title": "Metab. Syndr. Relat. Disord.",
"key": "ref_59",
"volume": "15",
"year": "2017"
},
{
"DOI": "10.3892/etm.2011.205",
"article-title": "Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature",
"author": "Gupta",
"doi-asserted-by": "crossref",
"first-page": "181",
"journal-title": "Exp. Ther. Med.",
"key": "ref_60",
"volume": "2",
"year": "2011"
},
{
"DOI": "10.1038/nrc3691",
"article-title": "The role of vitamin D in reducing cancer risk and progression",
"author": "Feldman",
"doi-asserted-by": "crossref",
"first-page": "342",
"journal-title": "Nat. Rev. Cancer",
"key": "ref_61",
"volume": "14",
"year": "2014"
},
{
"DOI": "10.1056/NEJMoa1809944",
"article-title": "Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease",
"author": "Manson",
"doi-asserted-by": "crossref",
"first-page": "33",
"journal-title": "N. Engl. J. Med.",
"key": "ref_62",
"volume": "380",
"year": "2019"
},
{
"DOI": "10.1007/s40519-016-0312-6",
"article-title": "Vitamin D: Not just the bone. Evidence for beneficial pleiotropic extraskeletal effects",
"author": "Caprio",
"doi-asserted-by": "crossref",
"first-page": "27",
"journal-title": "Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes.",
"key": "ref_63",
"volume": "22",
"year": "2017"
},
{
"DOI": "10.1093/annonc/mdz240.106",
"article-title": "Prevalence of vitamin D3 deficiency among women with early breast cancer receiving chemotherapy in an oncology dayward",
"author": "Finstad",
"doi-asserted-by": "crossref",
"first-page": "v95",
"journal-title": "Ann. Oncol.",
"key": "ref_64",
"volume": "30",
"year": "2019"
},
{
"DOI": "10.2147/JIR.S363840",
"article-title": "The Role of Vitamin D in Immune System and Inflammatory Bowel Disease",
"author": "Wu",
"doi-asserted-by": "crossref",
"first-page": "3167",
"journal-title": "J. Inflamm. Res.",
"key": "ref_65",
"volume": "15",
"year": "2022"
},
{
"DOI": "10.1186/s12967-019-2070-5",
"article-title": "Vitamin D deficiency associated with Crohn’s disease and ulcerative colitis: A meta-analysis of 55 observational studies",
"author": "Li",
"doi-asserted-by": "crossref",
"first-page": "323",
"journal-title": "J. Transl. Med.",
"key": "ref_66",
"volume": "17",
"year": "2019"
},
{
"DOI": "10.1155/2021/5556354",
"article-title": "NAFLD and Infection, a Nuanced Relationship",
"author": "Adenote",
"doi-asserted-by": "crossref",
"first-page": "1",
"journal-title": "Can. J. Gastroenterol. Hepatol.",
"key": "ref_67",
"volume": "2021",
"year": "2021"
},
{
"DOI": "10.1136/bmjgast-2015-000052",
"article-title": "Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: Outcomes from a pilot trial",
"author": "Tazzyman",
"doi-asserted-by": "crossref",
"first-page": "e000052",
"journal-title": "BMJ Open Gastroenterol.",
"key": "ref_68",
"volume": "2",
"year": "2015"
},
{
"DOI": "10.1186/s12937-022-00777-x",
"article-title": "The efficacy of vitamin D supplementation for irritable bowel syndrome: A systematic review with meta-analysis",
"author": "Huang",
"doi-asserted-by": "crossref",
"first-page": "24",
"journal-title": "Nutr. J.",
"key": "ref_69",
"volume": "21",
"year": "2022"
},
{
"DOI": "10.1158/1940-6207.CAPR-11-0105",
"article-title": "Effects of Supplemental Vitamin D and Calcium on Biomarkers of Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled Clinical Trial",
"author": "Hopkins",
"doi-asserted-by": "crossref",
"first-page": "1645",
"journal-title": "Cancer Prev. Res.",
"key": "ref_70",
"volume": "4",
"year": "2011"
},
{
"DOI": "10.2147/JIR.S63898",
"article-title": "Vitamin D and inflammatory diseases",
"author": "Agrawal",
"doi-asserted-by": "crossref",
"first-page": "69",
"journal-title": "J. Inflamm. Res.",
"key": "ref_71",
"volume": "7",
"year": "2014"
},
{
"DOI": "10.3389/fpsyt.2019.00167",
"article-title": "Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness",
"author": "Cuomo",
"doi-asserted-by": "crossref",
"first-page": "167",
"journal-title": "Front. Psychiatry",
"key": "ref_72",
"volume": "10",
"year": "2019"
},
{
"DOI": "10.3390/nu8060319",
"doi-asserted-by": "crossref",
"key": "ref_73",
"unstructured": "Wintermeyer, E., Ihle, C., Ehnert, S., Stöckle, U., Ochs, G., de Zwart, P., Flesch, I., Bahrs, C., and Nussler, A.K. (2016). Crucial Role of Vitamin D in the Musculoskeletal System. Nutrients, 8."
},
{
"DOI": "10.2215/CJN.04040411",
"article-title": "Vitamin D Therapy in Chronic Kidney Disease and End Stage Renal Disease",
"author": "Melamed",
"doi-asserted-by": "crossref",
"first-page": "358",
"journal-title": "Clin. J. Am. Soc. Nephrol.",
"key": "ref_74",
"volume": "7",
"year": "2012"
},
{
"DOI": "10.1159/000498838",
"article-title": "Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis",
"author": "Wang",
"doi-asserted-by": "crossref",
"first-page": "72",
"journal-title": "Kidney Blood Press. Res.",
"key": "ref_75",
"volume": "44",
"year": "2019"
},
{
"DOI": "10.1155/2015/868961",
"article-title": "Prevalence and Prognostic Implications of Vitamin D Deficiency in Chronic Kidney Disease",
"author": "Obi",
"doi-asserted-by": "crossref",
"first-page": "868961",
"journal-title": "Dis. Markers",
"key": "ref_76",
"volume": "2015",
"year": "2015"
},
{
"DOI": "10.7759/cureus.r55",
"doi-asserted-by": "crossref",
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},
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"DOI": "10.1097/MD.0000000000003533",
"article-title": "Vitamin D Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results from a Prospective Study",
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"DOI": "10.1136/bcr-2022-250553",
"article-title": "Vitamin D intoxication and severe hypercalcaemia complicating nutritional supplements misuse",
"author": "Alkundi",
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"journal-title": "BMJ Case Rep.",
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"author": "Dudenkov",
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"journal-title": "Mayo Clin. Proc.",
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"DOI": "10.1016/j.mayocp.2015.03.015",
"article-title": "Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective",
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"article-title": "Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment",
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"first-page": "521",
"journal-title": "Endocr. Rev.",
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