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0 0.5 1 1.5 2+ Case, 20ng/mL 28% Improvement Relative Risk Case, 30ng/mL -7% Vitamin D for COVID-19  Bucurica et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 11,182 patients in Romania (June 2020 - May 2022) Fewer cases with higher vitamin D levels (p<0.000001) c19early.org Bucurica et al., Diagnostics, March 2023 Favors vitamin D Favors control

Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients

Bucurica et al., Diagnostics, doi:10.3390/diagnostics13050998
Mar 2023  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 11,182 hospitalized patients in Romania, showing vitamin D deficiency associated with COVID-19 cases.
This is the 162nd of 196 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 11,637 vigintillion).
risk of case, 27.6% lower, OR 0.72, p < 0.001, high D levels (≥20ng/mL) 7,958, low D levels (<20ng/mL) 3,224, inverted to make OR<1 favor high D levels (≥20ng/mL), RR approximated with OR.
risk of case, 7.4% higher, OR 1.07, p = 0.19, high D levels (≥30ng/mL) 4,367, low D levels (<30ng/mL) 6,815, inverted to make OR<1 favor high D levels (≥30ng/mL), RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bucurica et al., 6 Mar 2023, retrospective, Romania, peer-reviewed, mean age 55.2, 9 authors, study period 1 June, 2020 - 31 May, 2022. Contact: fionita04@yahoo.com (corresponding author).
This PaperVitamin DAll
Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Sandica Bucurica, Ioana Prodan, Mihaela Pavalean, Corina Taubner, Ana Bucurica, Calin Socol, Roxana Calin, Florentina Ionita-Radu, Mariana Jinga
Diagnostics, doi:10.3390/diagnostics13050998
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20-30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories.
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The vitamin D deficiency was ' 'associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 ' 'infection, older age and the male sex. Vitamin D deficiency was prevalent and showed ' 'pathology association, while insufficiency of vitamin D (20–30 ng/mL) had lower statistical ' 'relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are ' 'necessary for homogeneity of the monitoring and management of inadequately vitamin D status ' 'in the risk categories.</jats:p>', 'alternative-id': ['diagnostics13050998'], 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-8787-3829', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, Romania'}], 'authenticated-orcid': False, 'family': 'Bucurica', 'given': 'Sandica', 'sequence': 'first'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}], 'family': 'Prodan', 'given': 'Ioana', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}], 'family': 'Pavalean', 'given': 'Mihaela', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Medical Analysis Laboratory, “Carol Davila” University Central ' 'Emergency Military Hospital, 010825 Bucharest, Romania'}], 'family': 'Taubner', 'given': 'Corina', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}], 'family': 'Bucurica', 'given': 'Ana', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}], 'family': 'Socol', 'given': 'Calin', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, Pucioasa City Hospital, 135400 ' 'Pucioasa, Romania'}], 'family': 'Calin', 'given': 'Roxana', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, Romania'}], 'family': 'Ionita-Radu', 'given': 'Florentina', 'sequence': 'additional'}, { 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, Romania'}], 'family': 'Jinga', 'given': 'Mariana', 'sequence': 'additional'}], 'container-title': 'Diagnostics', 'container-title-short': 'Diagnostics', 'content-domain': {'crossmark-restriction': False, 'domain': []}, 'created': {'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T11:29:06Z', 'timestamp': 1678102146000}, 'deposited': { 'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T13:01:42Z', 'timestamp': 1678107702000}, 'funder': [{'award': ['33PFE/30.12.2021'], 'name': 'Ministry of Research and Innovation'}], 'indexed': {'date-parts': [[2023, 3, 7]], 'date-time': '2023-03-07T05:42:58Z', 'timestamp': 1678167778938}, 'is-referenced-by-count': 0, 'issue': '5', 'issued': {'date-parts': [[2023, 3, 6]]}, 'journal-issue': {'issue': '5', 'published-online': {'date-parts': [[2023, 3]]}}, 'language': 'en', 'license': [ { 'URL': 'https://creativecommons.org/licenses/by/4.0/', 'content-version': 'vor', 'delay-in-days': 0, 'start': { 'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T00:00:00Z', 'timestamp': 1678060800000}}], 'link': [ { 'URL': 'https://www.mdpi.com/2075-4418/13/5/998/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'member': '1968', 'original-title': [], 'page': '998', 'prefix': '10.3390', 'published': {'date-parts': [[2023, 3, 6]]}, 'published-online': {'date-parts': [[2023, 3, 6]]}, 'publisher': 'MDPI AG', 'reference': [ { 'DOI': '10.1210/jc.2011-0385', 'article-title': 'Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An ' 'Endocrine Society Clinical Practice Guideline', 'author': 'Holick', 'doi-asserted-by': 'crossref', 'first-page': '1911', 'journal-title': 'Med. 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