Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
 
next
study
previous
study
c19early.org COVID-19 treatment researchVitamin DVitamin D (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients

Bucurica et al., Diagnostics, doi:10.3390/diagnostics13050998
Mar 2023  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Case, 20ng/mL 28% Improvement Relative Risk Case, 30ng/mL -7% Vitamin D for COVID-19  Bucurica et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 11,182 patients in Romania (June 2020 - May 2022) Fewer cases with higher vitamin D levels (p<0.000001) c19early.org Bucurica et al., Diagnostics, March 2023 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 111 treatments. c19early.org
Retrospective 11,182 hospitalized patients in Romania, showing vitamin D deficiency associated with COVID-19 cases.
This is the 163rd of 209 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 293,154,636 vigintillion).
risk of case, 27.6% lower, OR 0.72, p < 0.001, high D levels (≥20ng/mL) 7,958, low D levels (<20ng/mL) 3,224, inverted to make OR<1 favor high D levels (≥20ng/mL), RR approximated with OR.
risk of case, 7.4% higher, OR 1.07, p = 0.19, high D levels (≥30ng/mL) 4,367, low D levels (<30ng/mL) 6,815, inverted to make OR<1 favor high D levels (≥30ng/mL), RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bucurica et al., 6 Mar 2023, retrospective, Romania, peer-reviewed, mean age 55.2, 9 authors, study period 1 June, 2020 - 31 May, 2022. Contact: fionita04@yahoo.com (corresponding author).
This PaperVitamin DAll
Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Sandica Bucurica, Ioana Prodan, Mihaela Pavalean, Corina Taubner, Ana Bucurica, Calin Socol, Roxana Calin, Florentina Ionita-Radu, Mariana Jinga
Diagnostics, doi:10.3390/diagnostics13050998
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20-30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories.
References
Adenote, Dumic, Madrid, Barusya, Nordstrom et al., Infection, a Nuanced Relationship, Can. J. Gastroenterol. Hepatol, doi:10.1155/2021/5556354
Aggarwal, Akhthar, Jain, Coronary artery disease and its association with Vitamin D deficiency, J. Midlife Health, doi:10.4103/0976-7800.185334
Agrawal, Yin, Vitamin D and inflammatory diseases, J. Inflamm. Res, doi:10.2147/jir.s63898
Alkhatatbeh, Abdul-Razzak, Khasawneh, Saadeh, High Prevalence of Vitamin D Deficiency and Correlation of Serum Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome, Metab. Syndr. Relat. Disord
Alkundi, Momoh, Musa, Nwafor, Vitamin D intoxication and severe hypercalcaemia complicating nutritional supplements misuse, BMJ Case Rep, doi:10.1136/bcr-2022-250553
Alsafar, Grant, Hijazi, Uddin, Alkaabi et al., COVID-19 Disease Severity and Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE Residents, Nutrients, doi:10.3390/nu13051714
Amrein, Scherkl, Hoffmann, Neuwersch-Sommeregger, Köstenberger et al., deficiency 2.0: An update on the current status worldwide, Eur. J. Clin. Nutr, doi:10.1038/s41430-020-0558-y
Bikle, Vitamin, Metabolism, Mechanism of Action, and Clinical Applications, Chem. Biol, doi:10.1016/j.chembiol.2013.12.016
Botros, Besibes, Bahaaeldin, Elyazed, Vitamin D Status in Hospitalized Chronically Ill Patients, J. Am. Coll. Nutr, doi:10.1080/07315724.2018.1446194
Caprio, Infante, Calanchini, Mammi, Fabbri et al., Not just the bone. Evidence for beneficial pleiotropic extraskeletal effects, Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes, doi:10.1007/s40519-016-0312-6
Cashman, Dowling, Škrabáková, Gonzalez-Gross, Valtueña et al., Vitamin D deficiency in Europe: Pandemic?, Am. J. Clin. Nutr
Cashman, Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of Addressing, Calcif. Tissue Int, doi:10.1007/s00223-019-00559-4
Chirita-Emandi, Socolov, Haivas, Calapis, Gheorghiu et al., Vitamin D Status: A Different Story in the Very Young versus the Very Old Romanian Patients, PLoS ONE, doi:10.1371/journal.pone.0128010
Christakos, Dhawan, Verstuyf, Verlinden, Carmeliet et al., Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects, Physiol. Rev, doi:10.1152/physrev.00014.2015
Cosentino, Campodonico, Milazzo, De Metrio, Brambilla et al., Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives, Nutrients, doi:10.3390/nu13103603
Cuomo, Maina, Bolognesi, Rosso, Crescenzi et al., Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness, Front. Psychiatry, doi:10.3389/fpsyt.2019.00167
Da Silveira, Moura, Castro, Kac, Hadler et al., Prevalence of Vitamin D and Calcium Deficiency and Insufficiency in Women of Childbearing Age and Associated Risk Factors: A Systematic Review and Meta-Analysis, Nutrients, doi:10.3390/nu14204351
Dudenkov, Yawn, Oberhelman, Fischer, Singh et al., Changing Incidence of Serum 25-Hydroxyvitamin D Values above 50 ng/mL: A 10-Year Population-Based Study, Mayo Clin. Proc, doi:10.1016/j.mayocp.2015.02.012
Elizondo-Montemayor, Castillo, Rodríguez-López, Villarreal-Calderón, Gómez-Carmona et al., Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults, Mediat. Inflamm, doi:10.1155/2017/5719461
Ene, Terþiu, Vrâncianu, Chifiriuc, Vitamin D Status in Adult and Pediatric Romanian Population
Feldman, Krishnan, Swami, Giovannucci, Feldman, The role of vitamin D in reducing cancer risk and progression, Nat. Rev. Cancer, doi:10.1038/nrc3691
Finstad, Murphy, Markey, Connor, Murphy, Prevalence of vitamin D3 deficiency among women with early breast cancer receiving chemotherapy in an oncology dayward, Ann. Oncol, doi:10.1093/annonc/mdz240.106
Fontanive, Dick, Valente, Laranjeira, Antunes et al., Seasonal variation of vitamin D among healthy adult men in a subtropical region, Rev. Assoc. Med. Bras, doi:10.1590/1806-9282.66.10.1431
Gaksch, Jorde, Grimnes, Joakimsen, Schirmer et al., Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium, PLoS ONE, doi:10.1371/journal.pone.0170791
Giustina, Bouillon, Binkley, Sempos, Adler et al., Controversies in Vitamin D: A Statement From the Third International Conference, JBMR Plus
Gois, Ferreira, Olenski, Seguro, Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?, Nutrients, doi:10.3390/nu9070651
Graedel, Merker, Felder, Kutz, Haubitz et al., Deficiency Strongly Predicts Adverse Medical Outcome Across Different Medical Inpatient Populations: Results from a Prospective Study, Medicine, doi:10.1097/MD.0000000000003533
Griffin, Wall, Blake, Griffin, Robinson et al., Vitamin D Status of Adults in the Community, in Outpatient Clinics, in Hospital, and in Nursing Homes in the West of Ireland, J. Gerontol. Ser. A, doi:10.1093/gerona/glaa010
Gupta, Vashi, Trukova, Lis, Lammersfeld, Prevalence of serum vitamin D deficiency and insufficiency in cancer: Review of the epidemiological literature, Exp. Ther. Med, doi:10.3892/etm.2011.205
Hays, Flores, Kothari, Bilek, Geske et al., Vitamin D Status and Seasonal Variation: A Retrospective Single Institution Database Study of Patients Pursuing Metabolic/Bariatric Surgery, Clin. Nutr. Open Sci, doi:10.1016/j.nutos.2021.11.002
Holick, Binkley, Bischoff-Ferrari, Gordon, Hanley et al., Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline, Med. J. Clin. Endocrinol. Metab, doi:10.1210/jc.2011-0385
Holick, High Prevalence of Vitamin D Inadequacy and Implications for Health, Mayo Clin. Proc, doi:10.4065/81.3.353
Holick, Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an Up-to-Date Perspective, Mayo Clin. Proc, doi:10.1016/j.mayocp.2015.03.015
Hopkins, Owen, Ahearn, Fedirko, Flanders et al., Effects of Supplemental Vitamin D and Calcium on Biomarkers of Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled Clinical Trial, Cancer Prev. Res, doi:10.1158/1940-6207.CAPR-11-0105
Huang, Lu, Chen, Zeng, Xu, The efficacy of vitamin D supplementation for irritable bowel syndrome: A systematic review with meta-analysis, Nutr. J, doi:10.1186/s12937-022-00777-x
Janoušek, Pilařová, Macáková, Nomura, Veiga-Matos et al., Sources, physiological role, biokinetics, deficiency, therapeutic use, toxicity, and overview of analytical methods for detection of vitamin D and its metabolites, Crit. Rev. Clin. Lab. Sci, doi:10.1080/10408363.2022.2070595
Kantas, Capriles, Babor, Tamdin, Al-Rihani et al., Relationship between Chronic Kidney Disease Staging and Vitamin D Deficiency: A Retrospective Study, Cureus, doi:10.7759/cureus.r55
Khadilkar, Kajale, Oza, Oke, Gondhalekar et al., Vitamin D status and determinants in Indian children and adolescents: A multicentre study, Sci. Rep, doi:10.1038/s41598-022-21279-0
Kovalenko, Zhang, Cui, Clinton, Fleet, 1,25 dihydroxyvitamin D-mediated orchestration of anticancer, transcript-level effects in the immortalized, non-transformed prostate epithelial cell line, RWPE1. BMC Genom, doi:10.1186/1471-2164-11-26
Kweder, Eidi, Vitamin D deficiency in elderly: Risk factors and drugs impact on vitamin D status, Avicenna J. Med, doi:10.4103/ajm.AJM_20_18
Lahoz, Sánchez, Górriz, Calmarza, Comparative study of two immunoassays used for the determination of serum vitamin D, Pract. Lab. Med, doi:10.1016/j.plabm.2021.e00242
Li, Liu, Luo, Huang, Zhang et al., Vitamin D deficiency associated with Crohn's disease and ulcerative colitis: A meta-analysis of 55 observational studies, J. Transl. Med, doi:10.1186/s12967-019-2070-5
Lips, Cashman, Lamberg-Allardt, Bischoff-Ferrari, Obermayer-Pietsch et al., Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: A position statement of the European Calcified Tissue Society, Eur. J. Endocrinol, doi:10.1530/EJE-18-0736
Lips, Eekhoff, Van Schoor, Oosterwerff, De Jongh et al., Vitamin D and type 2 diabetes, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2016.11.021
Lips, Vitamin, physiology, Prog. Biophys. Mol. Biol, doi:10.1016/j.pbiomolbio.2006.02.016
Mahdavi, A brief review of interplay between vitamin D and angiotensin-converting enzyme 2: Implications for a potential treatment for COVID-19, Rev. Med. Virol, doi:10.1002/rmv.2119
Malinovschi, Masoero, Bellocchia, Ciuffreda, Solidoro et al., Severe vitamin D deficiency is associated with frequent exacerbations and hospitalization in COPD patients, Respir. Res, doi:10.1186/s12931-014-0131-0
Manson, Bassuk, Buring, Vital Research, Group, Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and updated meta-analyses of relevant vitamin D trials, J. Steroid Biochem. Mol. Biol, doi:10.1016/j.jsbmb.2019.105522
Manson, Cook, Lee, Christen, Bassuk et al., Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease, N. Engl. J. Med, doi:10.1056/NEJMoa1809944
Mc Williams, Golestany, Sharma, Nejati, Cyrus-Murden et al., Correlation of admitted nursing home residents' hospital length of stay and vitamin D levels, J. Community Hosp. Intern. Med. Perspect, doi:10.3402/jchimp.v1i3.6313
Melamed, Thadhani, Vitamin D Therapy in Chronic Kidney Disease and End Stage Renal Disease, Clin. J. Am. Soc. Nephrol, doi:10.2215/CJN.04040411
Mensah, Wei, Sorlie, Fine, Rosenberg et al., Decline in Cardiovascular Mortality: Possible Causes and Implications, Circ. Res
Merker, Amsler, Pereira, Bolliger, Tribolet et al., Vitamin D deficiency is highly prevalent in malnourished inpatients and associated with higher mortality, Medicine
Miragliotta, Miragliotta, Vitamin, and Infectious Diseases, Endocr. Metab. Immune Disord.-Drug Targets, doi:10.2174/1871530314666141027102627
Moore, Kiebzak, Suboptimal vitamin D status is a highly prevalent but treatable condition in both hospitalized patients and the general population, J. Am. Acad. Nurse Pract, doi:10.1111/j.1745-7599.2007.00277.x
Niculescu, Capatina, Dusceac, Caragheorgheopol, Ghemigian et al., Seasonal variation of serum vitamin D levels in Romania, Arch. Osteoporos, doi:10.1007/s11657-017-0407-3
Nimavat, Singh, Singh, Singh, Sinha, Vitamin D deficiency and COVID-19: A case-control study at a tertiary care hospital in India, Ann. Med. Surg, doi:10.1016/j.amsu.2021.102661
Obi, Hamano, Isaka, Prevalence and Prognostic Implications of Vitamin D Deficiency in Chronic Kidney Disease, Dis. Markers, doi:10.1155/2015/868961
Okan, Okan, Demir, Relation of Vitamin D Status with Season, Living Place, Age Gender and Chronic Disease, Erciyes Med. J, doi:10.14744/etd.2019.45577
Petrelli, Oldani, Borgonovo, Cabiddu, Dognini et al., Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of Systematic Reviews and Meta-Analyses, Antioxidants, doi:10.3390/antiox12020247
Pinzariu, Sova, Maranduca, Filip, Drochioi et al., Vitamin D Deficiency in Both Oral and Systemic Manifestations in SARS-CoV-2 Infection: Updated Review, Medicina, doi:10.3390/medicina59010068
Pludowski, Takacs, Boyanov, Belaya, Diaconu et al., Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin D Deficiency: A Central and Eastern European Expert Consensus Statement, Nutrients, doi:10.3390/nu14071483
Schleicher, Sternberg, Looker, Yetley, Lacher et al., National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite Concentrations Measured by Liquid Chromatography-Tandem Mass Spectrometry in the US Population during 2007-2010, J. Nutr, doi:10.3945/jn.115.227728
Schöttker, Hagen, Zhang, Gào, Holleczek et al., Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong Associations With Age and All-Cause Mortality Independent From Telomere Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels, J. Gerontol. Ser. A, doi:10.1093/gerona/gly253
Souberbielle, Massart, Brailly-Tabard, Cavalier, Chanson, Prevalence and determinants of vitamin D deficiency in healthy French adults: The VARIETE study, Endocrine, doi:10.1007/s12020-016-0960-3
Tazzyman, Richards, Trueman, Evans, Grant et al., Vitamin D associates with improved quality of life in participants with irritable bowel syndrome: Outcomes from a pilot trial, BMJ Open Gastroenterol, doi:10.1136/bmjgast-2015-000052
Tebben, Singh, Kumar, Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment, Endocr. Rev, doi:10.1210/er.2016-1070
Tomaschitz, Pilz, Ritz, Grammer, Drechsler et al., Independent association between 1,25-dihydroxyvitamin D, 25-hydroxyvitamin D and the renin-angiotensin system: The Ludwigshafen Risk and Cardiovascular Health (LURIC) study, Clin. Chim. Acta, doi:10.1016/j.cca.2010.05.037
Udomsinprasert, Jittikoon, Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies, Biomed. Pharmacother, doi:10.1016/j.biopha.2018.10.140
Varikasuvu, Thangappazham, Vykunta, Duggina, Manne et al., COVID-19 and vitamin D (Co-VIVID study): A systematic review and meta-analysis of randomized controlled trials, Expert Rev. Anti Infect. Ther, doi:10.1080/14787210.2022.2035217
Venkatram, Chilimuri, Adrish, Salako, Patel et al., Vitamin D deficiency is associated with mortality in the medical intensive care unit, Crit. Care, doi:10.1186/cc10585
Vranić, Mikolašević, Milić, Vitamin, Deficiency: Consequence or Cause of Obesity?, Medicina, doi:10.3390/medicina55090541
Wang, Chen, Li, Yin, Zhang et al., Vitamin D and Chronic Diseases, Aging Dis
Wang, Yang, Zhou, Zhang, Yi, Effects of Vitamin D Supplementation on Renal Function, Inflammation and Glycemic Control in Patients with Diabetic Nephropathy: A Systematic Review and Meta-Analysis, Kidney Blood Press. Res, doi:10.1159/000498838
Wei, Zhu, Ji, A Comparison Study of Vitamin D Deficiency among Older Adults in China and the United States, Sci. Rep, doi:10.1038/s41598-019-56297-y
Wintermeyer, Ihle, Ehnert, Stöckle, Ochs et al., Crucial Role of Vitamin D in the Musculoskeletal System, Nutrients, doi:10.3390/nu8060319
Wu, Liu, Deng, The Role of Vitamin D in Immune System and Inflammatory Bowel Disease, J. Inflamm. Res, doi:10.2147/JIR.S363840
Zierold, Nehring, Deluca, Nuclear receptor 4A2 and C/EBPβ regulate the parathyroid hormone-mediated transcriptional regulation of the 25-hydroxyvitamin D3-1α-hydroxylase, Arch. Biochem. Biophys, doi:10.1016/j.abb.2006.11.028
Zittermann, Trummer, Theiler-Schwetz, Lerchbaum, März et al., Vitamin D and Cardiovascular Disease: An Updated Narrative Review, Int. J. Mol. Sci, doi:10.3390/ijms22062896
Zittermann, Vitamin D Status, Supplementation and Cardiovascular Disease, Anticancer Res, doi:10.21873/anticanres.12338
{ 'indexed': {'date-parts': [[2023, 3, 7]], 'date-time': '2023-03-07T05:42:58Z', 'timestamp': 1678167778938}, 'reference-count': 82, 'publisher': 'MDPI AG', 'issue': '5', 'license': [ { 'start': { 'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T00:00:00Z', 'timestamp': 1678060800000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [{'name': 'Ministry of Research and Innovation', 'award': ['33PFE/30.12.2021']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Vitamin D deficiency is one of the most common medical conditions, with approximately ' 'one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic ' 'effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a ' 'better immune response. The aim of this research was to evaluate the prevalence of vitamin D ' 'deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well ' 'as assessing the possibility of its associations with different comorbidities. Of 11,182 ' 'Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, ' '32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was ' 'associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 ' 'infection, older age and the male sex. Vitamin D deficiency was prevalent and showed ' 'pathology association, while insufficiency of vitamin D (20–30 ng/mL) had lower statistical ' 'relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are ' 'necessary for homogeneity of the monitoring and management of inadequately vitamin D status ' 'in the risk categories.</jats:p>', 'DOI': '10.3390/diagnostics13050998', 'type': 'journal-article', 'created': {'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T11:29:06Z', 'timestamp': 1678102146000}, 'page': '998', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients', 'prefix': '10.3390', 'volume': '13', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-8787-3829', 'authenticated-orcid': False, 'given': 'Sandica', 'family': 'Bucurica', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, ' 'Romania'}]}, { 'given': 'Ioana', 'family': 'Prodan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}]}, { 'given': 'Mihaela', 'family': 'Pavalean', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}]}, { 'given': 'Corina', 'family': 'Taubner', 'sequence': 'additional', 'affiliation': [ { 'name': 'Medical Analysis Laboratory, “Carol Davila” University Central ' 'Emergency Military Hospital, 010825 Bucharest, Romania'}]}, { 'given': 'Ana', 'family': 'Bucurica', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}]}, { 'given': 'Calin', 'family': 'Socol', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}]}, { 'given': 'Roxana', 'family': 'Calin', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, Pucioasa City Hospital, 135400 ' 'Pucioasa, Romania'}]}, { 'given': 'Florentina', 'family': 'Ionita-Radu', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, ' 'Romania'}]}, { 'given': 'Mariana', 'family': 'Jinga', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Gastroenterology, “Carol Davila” University of ' 'Medicine and Pharmacy Bucharest, 020021 Bucharest, Romania'}, { 'name': 'Department of Gastroenterology, “Carol Davila” University ' 'Central Emergency Military Hospital, 010825 Bucharest, ' 'Romania'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 3, 6]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'first-page': '1911', 'DOI': '10.1210/jc.2011-0385', 'article-title': 'Evaluation, Treatment, and Prevention of Vitamin D Deficiency: An ' 'Endocrine Society Clinical Practice Guideline', 'volume': '96', 'author': 'Holick', 'year': '2011', 'journal-title': 'Med. J. Clin. Endocrinol. Metab.'}, { 'key': 'ref_2', 'doi-asserted-by': 'crossref', 'first-page': '365', 'DOI': '10.1152/physrev.00014.2015', 'article-title': 'Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic ' 'Effects', 'volume': '96', 'author': 'Christakos', 'year': '2016', 'journal-title': 'Physiol. Rev.'}, { 'key': 'ref_3', 'doi-asserted-by': 'crossref', 'first-page': '319', 'DOI': '10.1016/j.chembiol.2013.12.016', 'article-title': 'Vitamin D Metabolism, Mechanism of Action, and Clinical Applications', 'volume': '21', 'author': 'Bikle', 'year': '2014', 'journal-title': 'Chem. Biol.'}, { 'key': 'ref_4', 'doi-asserted-by': 'crossref', 'first-page': 'e00242', 'DOI': '10.1016/j.plabm.2021.e00242', 'article-title': 'Comparative study of two immunoassays used for the determination of ' 'serum vitamin D', 'volume': '26', 'author': 'Lahoz', 'year': '2021', 'journal-title': 'Pract. Lab. Med.'}, { 'key': 'ref_5', 'doi-asserted-by': 'crossref', 'first-page': '517', 'DOI': '10.1080/10408363.2022.2070595', 'article-title': 'Vitamin D: Sources, physiological role, biokinetics, deficiency, ' 'therapeutic use, toxicity, and overview of analytical methods for ' 'detection of vitamin D and its metabolites', 'volume': '59', 'author': 'Nomura', 'year': '2022', 'journal-title': 'Crit. Rev. Clin. Lab. Sci.'}, { 'key': 'ref_6', 'doi-asserted-by': 'crossref', 'first-page': '102661', 'DOI': '10.1016/j.amsu.2021.102661', 'article-title': 'Vitamin D deficiency and COVID-19: A case-control study at a tertiary ' 'care hospital in India', 'volume': '68', 'author': 'Nimavat', 'year': '2021', 'journal-title': 'Ann. Med. Surg.'}, { 'key': 'ref_7', 'doi-asserted-by': 'crossref', 'first-page': '233', 'DOI': '10.1016/j.abb.2006.11.028', 'article-title': 'Nuclear receptor 4A2 and C/EBPβ regulate the parathyroid ' 'hormone-mediated transcriptional regulation of the 25-hydroxyvitamin ' 'D3-1α-hydroxylase', 'volume': '460', 'author': 'Zierold', 'year': '2007', 'journal-title': 'Arch. Biochem. Biophys.'}, { 'key': 'ref_8', 'doi-asserted-by': 'crossref', 'first-page': '1354', 'DOI': '10.1016/j.cca.2010.05.037', 'article-title': 'Independent association between 1,25-dihydroxyvitamin D, ' '25-hydroxyvitamin D and the renin–angiotensin system: The Ludwigshafen ' 'Risk and Cardiovascular Health (LURIC) study', 'volume': '411', 'author': 'Tomaschitz', 'year': '2010', 'journal-title': 'Clin. Chim. Acta'}, { 'key': 'ref_9', 'doi-asserted-by': 'crossref', 'unstructured': 'Kovalenko, P.L., Zhang, Z., Cui, M., Clinton, S.K., and Fleet, J.C. ' '(2010). 1,25 dihydroxyvitamin D-mediated orchestration of anticancer, ' 'transcript-level effects in the immortalized, non-transformed prostate ' 'epithelial cell line, RWPE1. BMC Genom., 11.', 'DOI': '10.1186/1471-2164-11-26'}, { 'key': 'ref_10', 'doi-asserted-by': 'crossref', 'unstructured': 'Gaksch, M., Jorde, R., Grimnes, G., Joakimsen, R., Schirmer, H., ' 'Wilsgaard, T., Mathiesen, E.B., Njølstad, I., Løchen, M.-L., and März, ' 'W. (2017). Vitamin D and mortality: Individual participant data ' 'meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals ' 'from a European consortium. PLoS ONE, 12.', 'DOI': '10.1371/journal.pone.0170791'}, { 'key': 'ref_11', 'first-page': '56', 'article-title': 'Coronary artery disease and its association with Vitamin D deficiency', 'volume': '7', 'author': 'Aggarwal', 'year': '2016', 'journal-title': 'J. Midlife Health'}, { 'key': 'ref_12', 'doi-asserted-by': 'crossref', 'first-page': '280', 'DOI': '10.1016/j.jsbmb.2016.11.021', 'article-title': 'Vitamin D and type 2 diabetes', 'volume': '173', 'author': 'Lips', 'year': '2017', 'journal-title': 'J. Steroid Biochem. Mol. Biol.'}, { 'key': 'ref_13', 'doi-asserted-by': 'crossref', 'first-page': '1351', 'DOI': '10.1016/j.biopha.2018.10.140', 'article-title': 'Vitamin D and liver fibrosis: Molecular mechanisms and clinical studies', 'volume': '109', 'author': 'Udomsinprasert', 'year': '2019', 'journal-title': 'Biomed. Pharmacother.'}, { 'key': 'ref_14', 'doi-asserted-by': 'crossref', 'unstructured': 'Pludowski, P., Takacs, I., Boyanov, M., Belaya, Z., Diaconu, C.C., ' 'Mokhort, T., Zherdova, N., Rasa, I., Payer, J., and Pilz, S. (2022). ' 'Clinical Practice in the Prevention, Diagnosis and Treatment of Vitamin ' 'D Deficiency: A Central and Eastern European Expert Consensus Statement. ' 'Nutrients, 14.', 'DOI': '10.3390/nu14071483'}, { 'key': 'ref_15', 'doi-asserted-by': 'crossref', 'first-page': 'P23', 'DOI': '10.1530/EJE-18-0736', 'article-title': 'Current vitamin D status in European and Middle East countries and ' 'strategies to prevent vitamin D deficiency: A position statement of the ' 'European Calcified Tissue Society', 'volume': '180', 'author': 'Lips', 'year': '2019', 'journal-title': 'Eur. J. Endocrinol.'}, { 'key': 'ref_16', 'doi-asserted-by': 'crossref', 'first-page': 'e10417', 'DOI': '10.1002/jbm4.10417', 'article-title': 'Controversies in Vitamin D: A Statement From the Third International ' 'Conference', 'volume': '4', 'author': 'Giustina', 'year': '2020', 'journal-title': 'JBMR Plus'}, { 'key': 'ref_17', 'unstructured': '(2023, February 19). ' 'Anexa2-Ghid-Pentru-Evaluarea-Statusului-Vitaminei-D-La-Adulti-1-1.pdf. ' 'Available online: ' 'https://www.ms.ro/wp-content/uploads/2019/07/Anexa2-Ghid-pentru-evaluarea-statusului-vitaminei-D-la-adulti-1-1.pdf.'}, { 'key': 'ref_18', 'unstructured': '(2023, February 19). ANEXA1vit-D-La-Nou-Nascut-Copil-Gravida.pdf. ' 'Available online: ' 'https://www.ms.ro/wp-content/uploads/2019/07/ANEXA1vit-D-la-nou-nascut-copil-gravida.pdf.'}, { 'key': 'ref_19', 'doi-asserted-by': 'crossref', 'first-page': '131', 'DOI': '10.1186/s12931-014-0131-0', 'article-title': 'Severe vitamin D deficiency is associated with frequent exacerbations ' 'and hospitalization in COPD patients', 'volume': '15', 'author': 'Malinovschi', 'year': '2014', 'journal-title': 'Respir. Res.'}, { 'key': 'ref_20', 'doi-asserted-by': 'crossref', 'first-page': '6313', 'DOI': '10.3402/jchimp.v1i3.6313', 'article-title': 'Correlation of admitted nursing home residents’ hospital length of stay ' 'and vitamin D levels', 'volume': '1', 'author': 'Golestany', 'year': '2011', 'journal-title': 'J. Community Hosp. Intern. Med. Perspect.'}, { 'key': 'ref_21', 'doi-asserted-by': 'crossref', 'first-page': '578', 'DOI': '10.1080/07315724.2018.1446194', 'article-title': 'Vitamin D Status in Hospitalized Chronically Ill Patients', 'volume': '37', 'author': 'Botros', 'year': '2018', 'journal-title': 'J. Am. Coll. Nutr.'}, { 'key': 'ref_22', 'doi-asserted-by': 'crossref', 'first-page': 'R292', 'DOI': '10.1186/cc10585', 'article-title': 'Vitamin D deficiency is associated with mortality in the medical ' 'intensive care unit', 'volume': '15', 'author': 'Venkatram', 'year': '2011', 'journal-title': 'Crit. Care'}, { 'key': 'ref_23', 'doi-asserted-by': 'crossref', 'first-page': '2418', 'DOI': '10.1093/gerona/glaa010', 'article-title': 'Vitamin D Status of Adults in the Community, in Outpatient Clinics, in ' 'Hospital, and in Nursing Homes in the West of Ireland', 'volume': '75', 'author': 'Griffin', 'year': '2020', 'journal-title': 'J. Gerontol. Ser. A'}, { 'key': 'ref_24', 'doi-asserted-by': 'crossref', 'first-page': '642', 'DOI': '10.1111/j.1745-7599.2007.00277.x', 'article-title': 'Suboptimal vitamin D status is a highly prevalent but treatable ' 'condition in both hospitalized patients and the general population', 'volume': '19', 'author': 'Moore', 'year': '2007', 'journal-title': 'J. Am. Acad. Nurse Pract.'}, { 'key': 'ref_25', 'doi-asserted-by': 'crossref', 'unstructured': 'Petrelli, F., Oldani, S., Borgonovo, K., Cabiddu, M., Dognini, G., ' 'Ghilardi, M., Parati, M.C., Petro’, D., Dottorini, L., and Rea, C. ' '(2023). Vitamin D3 and COVID-19 Outcomes: An Umbrella Review of ' 'Systematic Reviews and Meta-Analyses. Antioxidants, 12.', 'DOI': '10.3390/antiox12020247'}, { 'key': 'ref_26', 'first-page': '78', 'article-title': 'Relation of Vitamin D Status with Season, Living Place, Age Gender and ' 'Chronic Disease', 'volume': '42', 'author': 'Okan', 'year': '2020', 'journal-title': 'Erciyes Med. J.'}, { 'key': 'ref_27', 'doi-asserted-by': 'crossref', 'first-page': '1051', 'DOI': '10.3945/jn.115.227728', 'article-title': 'National Estimates of Serum Total 25-Hydroxyvitamin D and Metabolite ' 'Concentrations Measured by Liquid Chromatography–Tandem Mass ' 'Spectrometry in the US Population during 2007–2010', 'volume': '146', 'author': 'Schleicher', 'year': '2016', 'journal-title': 'J. Nutr.'}, { 'key': 'ref_28', 'doi-asserted-by': 'crossref', 'first-page': '1033', 'DOI': '10.3945/ajcn.115.120873', 'article-title': 'Vitamin D deficiency in Europe: Pandemic?', 'volume': '103', 'author': 'Cashman', 'year': '2016', 'journal-title': 'Am. J. Clin. Nutr.'}, { 'key': 'ref_29', 'doi-asserted-by': 'crossref', 'first-page': '14', 'DOI': '10.1007/s00223-019-00559-4', 'article-title': 'Vitamin D Deficiency: Defining, Prevalence, Causes, and Strategies of ' 'Addressing', 'volume': '106', 'author': 'Cashman', 'year': '2020', 'journal-title': 'Calcif. Tissue Int.'}, { 'key': 'ref_30', 'doi-asserted-by': 'crossref', 'first-page': '1498', 'DOI': '10.1038/s41430-020-0558-y', 'article-title': 'Vitamin D deficiency 2.0: An update on the current status worldwide', 'volume': '74', 'author': 'Amrein', 'year': '2020', 'journal-title': 'Eur. J. Clin. Nutr.'}, { 'key': 'ref_31', 'doi-asserted-by': 'crossref', 'unstructured': 'Chirita-Emandi, A., Socolov, D., Haivas, C., Calapiș, A., Gheorghiu, C., ' 'and Puiu, M. (2015). Vitamin D Status: A Different Story in the Very ' 'Young versus the Very Old Romanian Patients. PLoS ONE, 10.', 'DOI': '10.1371/journal.pone.0128010'}, { 'key': 'ref_32', 'doi-asserted-by': 'crossref', 'first-page': '113', 'DOI': '10.1007/s11657-017-0407-3', 'article-title': 'Seasonal variation of serum vitamin D levels in Romania', 'volume': '12', 'author': 'Niculescu', 'year': '2017', 'journal-title': 'Arch. Osteoporos.'}, { 'key': 'ref_33', 'unstructured': 'Ene, M.C., Terþiu, O., Vrâncianu, O., and Chifiriuc, M.C. (2023, ' 'February 19). Vitamin D Status in Adult and Pediatric Romanian ' 'Population. Available online: ' 'https://roami.ro/wp-content/uploads/2019/08/198-212-Art-Marin-Cristian-Ene-Archives-32018-1.pdf.'}, { 'key': 'ref_34', 'doi-asserted-by': 'crossref', 'first-page': 'e18113', 'DOI': '10.1097/MD.0000000000018113', 'article-title': 'Vitamin D deficiency is highly prevalent in malnourished inpatients and ' 'associated with higher mortality', 'volume': '98', 'author': 'Merker', 'year': '2019', 'journal-title': 'Medicine'}, { 'key': 'ref_35', 'doi-asserted-by': 'crossref', 'first-page': '543', 'DOI': '10.1007/s12020-016-0960-3', 'article-title': 'Prevalence and determinants of vitamin D deficiency in healthy French ' 'adults: The VARIETE study', 'volume': '53', 'author': 'Souberbielle', 'year': '2016', 'journal-title': 'Endocrine'}, { 'key': 'ref_36', 'doi-asserted-by': 'crossref', 'first-page': '16790', 'DOI': '10.1038/s41598-022-21279-0', 'article-title': 'Vitamin D status and determinants in Indian children and adolescents: A ' 'multicentre study', 'volume': '12', 'author': 'Khadilkar', 'year': '2022', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_37', 'doi-asserted-by': 'crossref', 'unstructured': 'da Silveira, E.A., Moura, L.d.A.N.e., Castro, M.C.R., Kac, G., Hadler, ' 'M.C.C.M., Noll, P.R.E.S., Noll, M., Rezende, A.T.d.O., Delpino, F.M., ' 'and de Oliveira, C. (2022). Prevalence of Vitamin D and Calcium ' 'Deficiency and Insufficiency in Women of Childbearing Age and Associated ' 'Risk Factors: A Systematic Review and Meta-Analysis. Nutrients, 14.', 'DOI': '10.3390/nu14204351'}, { 'key': 'ref_38', 'doi-asserted-by': 'crossref', 'first-page': '139', 'DOI': '10.4103/ajm.AJM_20_18', 'article-title': 'Vitamin D deficiency in elderly: Risk factors and drugs impact on ' 'vitamin D status', 'volume': '8', 'author': 'Kweder', 'year': '2018', 'journal-title': 'Avicenna J. Med.'}, { 'key': 'ref_39', 'doi-asserted-by': 'crossref', 'first-page': '19713', 'DOI': '10.1038/s41598-019-56297-y', 'article-title': 'A Comparison Study of Vitamin D Deficiency among Older Adults in China ' 'and the United States', 'volume': '9', 'author': 'Wei', 'year': '2019', 'journal-title': 'Sci. Rep.'}, { 'key': 'ref_40', 'doi-asserted-by': 'crossref', 'first-page': '353', 'DOI': '10.4065/81.3.353', 'article-title': 'High Prevalence of Vitamin D Inadequacy and Implications for Health', 'volume': '81', 'author': 'Holick', 'year': '2006', 'journal-title': 'Mayo Clin. Proc.'}, { 'key': 'ref_41', 'first-page': '121', 'article-title': 'Serum 25-Hydroxyvitamin D Levels as an Aging Marker: Strong ' 'Associations With Age and All-Cause Mortality Independent From Telomere ' 'Length, Epigenetic Age Acceleration, and 8-Isoprostane Levels', 'volume': '74', 'author': 'Hagen', 'year': '2018', 'journal-title': 'J. Gerontol. Ser. A'}, { 'key': 'ref_42', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1016/j.nutos.2021.11.002', 'article-title': 'Vitamin D Status and Seasonal Variation: A Retrospective Single ' 'Institution Database Study of Patients Pursuing Metabolic/Bariatric ' 'Surgery', 'volume': '41', 'author': 'Hays', 'year': '2021', 'journal-title': 'Clin. Nutr. Open Sci.'}, { 'key': 'ref_43', 'doi-asserted-by': 'crossref', 'first-page': '1431', 'DOI': '10.1590/1806-9282.66.10.1431', 'article-title': 'Seasonal variation of vitamin D among healthy adult men in a ' 'subtropical region', 'volume': '66', 'author': 'Fontanive', 'year': '2020', 'journal-title': 'Rev. Assoc. Med. Bras.'}, { 'key': 'ref_44', 'first-page': '1', 'article-title': 'Seasonal Variation in Vitamin D in Association with Age, Inflammatory ' 'Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older ' 'Adults', 'volume': '2017', 'author': 'Castillo', 'year': '2017', 'journal-title': 'Mediat. Inflamm.'}, { 'key': 'ref_45', 'doi-asserted-by': 'crossref', 'first-page': '267', 'DOI': '10.2174/1871530314666141027102627', 'article-title': 'Vitamin D and Infectious Diseases', 'volume': '14', 'author': 'Miragliotta', 'year': '2014', 'journal-title': 'Endocr. Metab. Immune Disord.—Drug Targets'}, { 'key': 'ref_46', 'doi-asserted-by': 'crossref', 'first-page': '907', 'DOI': '10.1080/14787210.2022.2035217', 'article-title': 'COVID-19 and vitamin D (Co-VIVID study): A systematic review and ' 'meta-analysis of randomized controlled trials', 'volume': '20', 'author': 'Varikasuvu', 'year': '2022', 'journal-title': 'Expert Rev. Anti Infect. Ther.'}, { 'key': 'ref_47', 'doi-asserted-by': 'crossref', 'unstructured': 'Pinzariu, A.C., Sova, I.A., Maranduca, M.A., Filip, N., Drochioi, I.C., ' 'Vamesu, C.G., Clim, A., Hurjui, L.L., Moscalu, M., and Soroceanu, R.P. ' '(2022). Vitamin D Deficiency in Both Oral and Systemic Manifestations in ' 'SARS-CoV-2 Infection: Updated Review. Medicina, 59.', 'DOI': '10.3390/medicina59010068'}, { 'key': 'ref_48', 'doi-asserted-by': 'crossref', 'unstructured': 'Gois, P.H.F., Ferreira, D., Olenski, S., and Seguro, A.C. (2017). ' 'Vitamin D and Infectious Diseases: Simple Bystander or Contributing ' 'Factor?. Nutrients, 9.', 'DOI': '10.3390/nu9070651'}, { 'key': 'ref_49', 'doi-asserted-by': 'crossref', 'unstructured': 'AlSafar, H., Grant, W.B., Hijazi, R., Uddin, M., Alkaabi, N., Tay, G., ' 'Mahboub, B., and Al Anouti, F. (2021). COVID-19 Disease Severity and ' 'Death in Relation to Vitamin D Status among SARS-CoV-2-Positive UAE ' 'Residents. Nutrients, 13.', 'DOI': '10.3390/nu13051714'}, { 'key': 'ref_50', 'first-page': 'e2119', 'article-title': 'A brief review of interplay between vitamin D and ' 'angiotensin-converting enzyme 2: Implications for a potential treatment ' 'for COVID-19', 'volume': '30', 'author': 'Mahdavi', 'year': '2020', 'journal-title': 'Rev. Med. Virol.'}, { 'key': 'ref_51', 'doi-asserted-by': 'crossref', 'first-page': '105522', 'DOI': '10.1016/j.jsbmb.2019.105522', 'article-title': 'Principal results of the VITamin D and OmegA-3 TriaL (VITAL) and ' 'updated meta-analyses of relevant vitamin D trials', 'volume': '198', 'author': 'Manson', 'year': '2019', 'journal-title': 'J. Steroid Biochem. Mol. Biol.'}, { 'key': 'ref_52', 'doi-asserted-by': 'crossref', 'unstructured': 'Zittermann, A., Trummer, C., Theiler-Schwetz, V., Lerchbaum, E., März, ' 'W., and Pilz, S. (2021). Vitamin D and Cardiovascular Disease: An ' 'Updated Narrative Review. Int. J. Mol. Sci., 22.', 'DOI': '10.3390/ijms22062896'}, { 'key': 'ref_53', 'doi-asserted-by': 'crossref', 'first-page': '366', 'DOI': '10.1161/CIRCRESAHA.116.309115', 'article-title': 'Decline in Cardiovascular Mortality: Possible Causes and Implications', 'volume': '120', 'author': 'Mensah', 'year': '2017', 'journal-title': 'Circ. Res.'}, { 'key': 'ref_54', 'first-page': '1179', 'article-title': 'Vitamin D Status, Supplementation and Cardiovascular Disease', 'volume': '38', 'author': 'Zittermann', 'year': '2018', 'journal-title': 'Anticancer Res.'}, { 'key': 'ref_55', 'doi-asserted-by': 'crossref', 'unstructured': 'Cosentino, N., Campodonico, J., Milazzo, V., De Metrio, M., Brambilla, ' 'M., Camera, M., and Marenzi, G. (2021). Vitamin D and Cardiovascular ' 'Disease: Current Evidence and Future Perspectives. Nutrients, 13.', 'DOI': '10.3390/nu13103603'}, { 'key': 'ref_56', 'doi-asserted-by': 'crossref', 'first-page': '346', 'DOI': '10.14336/AD.2016.1021', 'article-title': 'Vitamin D and Chronic Diseases', 'volume': '8', 'author': 'Wang', 'year': '2017', 'journal-title': 'Aging Dis.'}, { 'key': 'ref_57', 'doi-asserted-by': 'crossref', 'first-page': '4', 'DOI': '10.1016/j.pbiomolbio.2006.02.016', 'article-title': 'Vitamin D physiology', 'volume': '92', 'author': 'Lips', 'year': '2006', 'journal-title': 'Prog. Biophys. Mol. Biol.'}, { 'key': 'ref_58', 'doi-asserted-by': 'crossref', 'unstructured': 'Vranić, L., Mikolašević, I., and Milić, S. (2019). Vitamin D Deficiency: ' 'Consequence or Cause of Obesity?. Medicina, 55.', 'DOI': '10.3390/medicina55090541'}, { 'key': 'ref_59', 'doi-asserted-by': 'crossref', 'first-page': '213', 'DOI': '10.1089/met.2017.0003', 'article-title': 'High Prevalence of Vitamin D Deficiency and Correlation of Serum ' 'Vitamin D with Cardiovascular Risk in Patients with Metabolic Syndrome', 'volume': '15', 'author': 'Alkhatatbeh', 'year': '2017', 'journal-title': 'Metab. Syndr. Relat. Disord.'}, { 'key': 'ref_60', 'doi-asserted-by': 'crossref', 'first-page': '181', 'DOI': '10.3892/etm.2011.205', 'article-title': 'Prevalence of serum vitamin D deficiency and insufficiency in cancer: ' 'Review of the epidemiological literature', 'volume': '2', 'author': 'Gupta', 'year': '2011', 'journal-title': 'Exp. Ther. Med.'}, { 'key': 'ref_61', 'doi-asserted-by': 'crossref', 'first-page': '342', 'DOI': '10.1038/nrc3691', 'article-title': 'The role of vitamin D in reducing cancer risk and progression', 'volume': '14', 'author': 'Feldman', 'year': '2014', 'journal-title': 'Nat. Rev. Cancer'}, { 'key': 'ref_62', 'doi-asserted-by': 'crossref', 'first-page': '33', 'DOI': '10.1056/NEJMoa1809944', 'article-title': 'Vitamin D Supplements and Prevention of Cancer and Cardiovascular ' 'Disease', 'volume': '380', 'author': 'Manson', 'year': '2019', 'journal-title': 'N. Engl. J. Med.'}, { 'key': 'ref_63', 'doi-asserted-by': 'crossref', 'first-page': '27', 'DOI': '10.1007/s40519-016-0312-6', 'article-title': 'Vitamin D: Not just the bone. Evidence for beneficial pleiotropic ' 'extraskeletal effects', 'volume': '22', 'author': 'Caprio', 'year': '2017', 'journal-title': 'Eat. Weight. Disord.-Stud. Anorex. Bulim. Obes.'}, { 'key': 'ref_64', 'doi-asserted-by': 'crossref', 'first-page': 'v95', 'DOI': '10.1093/annonc/mdz240.106', 'article-title': 'Prevalence of vitamin D3 deficiency among women with early breast ' 'cancer receiving chemotherapy in an oncology dayward', 'volume': '30', 'author': 'Finstad', 'year': '2019', 'journal-title': 'Ann. Oncol.'}, { 'key': 'ref_65', 'doi-asserted-by': 'crossref', 'first-page': '3167', 'DOI': '10.2147/JIR.S363840', 'article-title': 'The Role of Vitamin D in Immune System and Inflammatory Bowel Disease', 'volume': '15', 'author': 'Wu', 'year': '2022', 'journal-title': 'J. Inflamm. Res.'}, { 'key': 'ref_66', 'doi-asserted-by': 'crossref', 'first-page': '323', 'DOI': '10.1186/s12967-019-2070-5', 'article-title': 'Vitamin D deficiency associated with Crohn’s disease and ulcerative ' 'colitis: A meta-analysis of 55 observational studies', 'volume': '17', 'author': 'Li', 'year': '2019', 'journal-title': 'J. Transl. Med.'}, { 'key': 'ref_67', 'doi-asserted-by': 'crossref', 'first-page': '1', 'DOI': '10.1155/2021/5556354', 'article-title': 'NAFLD and Infection, a Nuanced Relationship', 'volume': '2021', 'author': 'Adenote', 'year': '2021', 'journal-title': 'Can. J. Gastroenterol. Hepatol.'}, { 'key': 'ref_68', 'doi-asserted-by': 'crossref', 'first-page': 'e000052', 'DOI': '10.1136/bmjgast-2015-000052', 'article-title': 'Vitamin D associates with improved quality of life in participants with ' 'irritable bowel syndrome: Outcomes from a pilot trial', 'volume': '2', 'author': 'Tazzyman', 'year': '2015', 'journal-title': 'BMJ Open Gastroenterol.'}, { 'key': 'ref_69', 'doi-asserted-by': 'crossref', 'first-page': '24', 'DOI': '10.1186/s12937-022-00777-x', 'article-title': 'The efficacy of vitamin D supplementation for irritable bowel syndrome: ' 'A systematic review with meta-analysis', 'volume': '21', 'author': 'Huang', 'year': '2022', 'journal-title': 'Nutr. J.'}, { 'key': 'ref_70', 'doi-asserted-by': 'crossref', 'first-page': '1645', 'DOI': '10.1158/1940-6207.CAPR-11-0105', 'article-title': 'Effects of Supplemental Vitamin D and Calcium on Biomarkers of ' 'Inflammation in Colorectal Adenoma Patients: A Randomized, Controlled ' 'Clinical Trial', 'volume': '4', 'author': 'Hopkins', 'year': '2011', 'journal-title': 'Cancer Prev. Res.'}, { 'key': 'ref_71', 'doi-asserted-by': 'crossref', 'first-page': '69', 'DOI': '10.2147/JIR.S63898', 'article-title': 'Vitamin D and inflammatory diseases', 'volume': '7', 'author': 'Agrawal', 'year': '2014', 'journal-title': 'J. Inflamm. Res.'}, { 'key': 'ref_72', 'doi-asserted-by': 'crossref', 'first-page': '167', 'DOI': '10.3389/fpsyt.2019.00167', 'article-title': 'Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 ' 'Inpatients With Mental Illness', 'volume': '10', 'author': 'Cuomo', 'year': '2019', 'journal-title': 'Front. Psychiatry'}, { 'key': 'ref_73', 'doi-asserted-by': 'crossref', 'unstructured': 'Wintermeyer, E., Ihle, C., Ehnert, S., Stöckle, U., Ochs, G., de Zwart, ' 'P., Flesch, I., Bahrs, C., and Nussler, A.K. (2016). Crucial Role of ' 'Vitamin D in the Musculoskeletal System. Nutrients, 8.', 'DOI': '10.3390/nu8060319'}, { 'key': 'ref_74', 'doi-asserted-by': 'crossref', 'first-page': '358', 'DOI': '10.2215/CJN.04040411', 'article-title': 'Vitamin D Therapy in Chronic Kidney Disease and End Stage Renal Disease', 'volume': '7', 'author': 'Melamed', 'year': '2012', 'journal-title': 'Clin. J. Am. Soc. Nephrol.'}, { 'key': 'ref_75', 'doi-asserted-by': 'crossref', 'first-page': '72', 'DOI': '10.1159/000498838', 'article-title': 'Effects of Vitamin D Supplementation on Renal Function, Inflammation ' 'and Glycemic Control in Patients with Diabetic Nephropathy: A ' 'Systematic Review and Meta-Analysis', 'volume': '44', 'author': 'Wang', 'year': '2019', 'journal-title': 'Kidney Blood Press. Res.'}, { 'key': 'ref_76', 'doi-asserted-by': 'crossref', 'first-page': '868961', 'DOI': '10.1155/2015/868961', 'article-title': 'Prevalence and Prognostic Implications of Vitamin D Deficiency in ' 'Chronic Kidney Disease', 'volume': '2015', 'author': 'Obi', 'year': '2015', 'journal-title': 'Dis. Markers'}, { 'key': 'ref_77', 'doi-asserted-by': 'crossref', 'unstructured': 'Kantas, T., Capriles, C.A.A., Babor, S., Tamdin, T., Al-Rihani, H., ' 'Thalla, A., Abdelmawla, A.A., Muthanna, F.M.S., and Tousif, S. (2022). ' 'Relationship between Chronic Kidney Disease Staging and Vitamin D ' 'Deficiency: A Retrospective Study. Cureus.', 'DOI': '10.7759/cureus.r55'}, { 'key': 'ref_78', 'doi-asserted-by': 'crossref', 'first-page': 'e3533', 'DOI': '10.1097/MD.0000000000003533', 'article-title': 'Vitamin D Deficiency Strongly Predicts Adverse Medical Outcome Across ' 'Different Medical Inpatient Populations: Results from a Prospective ' 'Study', 'volume': '95', 'author': 'Graedel', 'year': '2016', 'journal-title': 'Medicine'}, { 'key': 'ref_79', 'doi-asserted-by': 'crossref', 'first-page': 'e250553', 'DOI': '10.1136/bcr-2022-250553', 'article-title': 'Vitamin D intoxication and severe hypercalcaemia complicating ' 'nutritional supplements misuse', 'volume': '15', 'author': 'Alkundi', 'year': '2022', 'journal-title': 'BMJ Case Rep.'}, { 'key': 'ref_80', 'doi-asserted-by': 'crossref', 'first-page': '577', 'DOI': '10.1016/j.mayocp.2015.02.012', 'article-title': 'Changing Incidence of Serum 25-Hydroxyvitamin D Values above 50 ng/mL: ' 'A 10-Year Population-Based Study', 'volume': '90', 'author': 'Dudenkov', 'year': '2015', 'journal-title': 'Mayo Clin. Proc.'}, { 'key': 'ref_81', 'doi-asserted-by': 'crossref', 'first-page': '561', 'DOI': '10.1016/j.mayocp.2015.03.015', 'article-title': 'Vitamin D Is Not as Toxic as Was Once Thought: A Historical and an ' 'Up-to-Date Perspective', 'volume': '90', 'author': 'Holick', 'year': '2015', 'journal-title': 'Mayo Clin. Proc.'}, { 'key': 'ref_82', 'doi-asserted-by': 'crossref', 'first-page': '521', 'DOI': '10.1210/er.2016-1070', 'article-title': 'Vitamin D-Mediated Hypercalcemia: Mechanisms, Diagnosis, and Treatment', 'volume': '37', 'author': 'Tebben', 'year': '2016', 'journal-title': 'Endocr. Rev.'}], 'container-title': 'Diagnostics', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://www.mdpi.com/2075-4418/13/5/998/pdf', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 3, 6]], 'date-time': '2023-03-06T13:01:42Z', 'timestamp': 1678107702000}, 'score': 1, 'resource': {'primary': {'URL': 'https://www.mdpi.com/2075-4418/13/5/998'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 3, 6]]}, 'references-count': 82, 'journal-issue': {'issue': '5', 'published-online': {'date-parts': [[2023, 3]]}}, 'alternative-id': ['diagnostics13050998'], 'URL': 'http://dx.doi.org/10.3390/diagnostics13050998', 'relation': {}, 'ISSN': ['2075-4418'], 'subject': ['Clinical Biochemistry'], 'container-title-short': 'Diagnostics', 'published': {'date-parts': [[2023, 3, 6]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit