Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Bucurica et al.,
Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients,
Diagnostics, doi:10.3390/diagnostics13050998
Retrospective 11,182 hospitalized patients in Romania, showing vitamin D deficiency associated with COVID-19 cases.
risk of case, 27.6% lower, OR 0.72, p < 0.001, high D levels (≥20ng/mL) 7,958, low D levels (<20ng/mL) 3,224, inverted to make OR<1 favor high D levels (≥20ng/mL), RR approximated with OR.
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risk of case, 7.4% higher, OR 1.07, p = 0.19, high D levels (≥30ng/mL) 4,367, low D levels (<30ng/mL) 6,815, inverted to make OR<1 favor high D levels (≥30ng/mL), RR approximated with OR.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Bucurica et al., 6 Mar 2023, retrospective, Romania, peer-reviewed, mean age 55.2, 9 authors, study period 1 June, 2020 - 31 May, 2022.
Contact:
fionita04@yahoo.com (corresponding author).
Abstract: diagnostics
Article
Association of Vitamin D Deficiency and Insufficiency with
Pathology in Hospitalized Patients
Sandica Bucurica 1,2 , Ioana Prodan 1 , Mihaela Pavalean 1 , Corina Taubner 3 , Ana Bucurica 1 , Calin Socol 1 ,
Roxana Calin 4 , Florentina Ionita-Radu 1,2, * and Mariana Jinga 1,2
1
2
3
4
*
Citation: Bucurica, S.; Prodan, I.;
Department of Gastroenterology, “Carol Davila” University of Medicine and Pharmacy Bucharest,
020021 Bucharest, Romania
Department of Gastroenterology, “Carol Davila” University Central Emergency Military Hospital,
010825 Bucharest, Romania
Medical Analysis Laboratory, “Carol Davila” University Central Emergency Military Hospital,
010825 Bucharest, Romania
Department of Gastroenterology, Pucioasa City Hospital, 135400 Pucioasa, Romania
Correspondence: fionita04@yahoo.com
Abstract: Vitamin D deficiency is one of the most common medical conditions, with approximately
one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect
(immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency
in hospitalized patients focusing on demographic parameters as well as assessing the possibility of
its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study
over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin
D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies,
dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency
was prevalent and showed pathology association, while insufficiency of vitamin D (20–30 ng/mL)
had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and
recommendations are necessary for homogeneity of the monitoring and management of inadequately
vitamin D status in the risk categories.
Pavalean, M.; Taubner, C.;
Bucurica, A.; Socol, C.; Calin, R.;
Ionita-Radu, F.; Jinga, M. Association
Keywords: vitamin D deficiency; hospitalized; 25(OH)D; Romania
of Vitamin D Deficiency and
Insufficiency with Pathology in
Hospitalized Patients. Diagnostics
2023, 13, 998. https://doi.org/
10.3390/diagnostics13050998
Academic Editor: Giulia Bivona
Received: 31 January 2023
Revised: 23 February 2023
Accepted: 3 March 2023
Published: 6 March 2023
Copyright: © 2023 by the authors.
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