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0 0.5 1 1.5 2+ Case, 20ng/mL 28% Improvement Relative Risk Case, 30ng/mL -7% Vitamin D for COVID-19  Bucurica et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 11,182 patients in Romania (June 2020 - May 2022) Fewer cases with higher vitamin D levels (p<0.000001) Bucurica et al., Diagnostics, March 2023 Favors vitamin D Favors control

Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients

Bucurica et al., Diagnostics, doi:10.3390/diagnostics13050998
Mar 2023  
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Retrospective 11,182 hospitalized patients in Romania, showing vitamin D deficiency associated with COVID-19 cases.
This is the 161st of 184 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 712 vigintillion).
risk of case, 27.6% lower, OR 0.72, p < 0.001, high D levels (≥20ng/mL) 7,958, low D levels (<20ng/mL) 3,224, inverted to make OR<1 favor high D levels (≥20ng/mL), RR approximated with OR.
risk of case, 7.4% higher, OR 1.07, p = 0.19, high D levels (≥30ng/mL) 4,367, low D levels (<30ng/mL) 6,815, inverted to make OR<1 favor high D levels (≥30ng/mL), RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bucurica et al., 6 Mar 2023, retrospective, Romania, peer-reviewed, mean age 55.2, 9 authors, study period 1 June, 2020 - 31 May, 2022.
Contact: (corresponding author).
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Association of Vitamin D Deficiency and Insufficiency with Pathology in Hospitalized Patients
Sandica Bucurica, Ioana Prodan, Mihaela Pavalean, Corina Taubner, Ana Bucurica, Calin Socol, Roxana Calin, Florentina Ionita-Radu, Mariana Jinga
Diagnostics, doi:10.3390/diagnostics13050998
Vitamin D deficiency is one of the most common medical conditions, with approximately one billion people having low vitamin D levels. Vitamin D is associated with a pleiotropic effect (immunomodulatory, anti-inflammatory and antiviral), which can be essential for a better immune response. The aim of this research was to evaluate the prevalence of vitamin D deficiency/insufficiency in hospitalized patients focusing on demographic parameters as well as assessing the possibility of its associations with different comorbidities. Of 11,182 Romanian patients evaluated in the study over 2 years, 28.83% had vitamin D deficiency, 32.11% insufficiency and 39.05% had optimal vitamin D levels. The vitamin D deficiency was associated with cardiovascular disorders, malignancies, dysmetabolic disorders and SARS-CoV2 infection, older age and the male sex. Vitamin D deficiency was prevalent and showed pathology association, while insufficiency of vitamin D (20-30 ng/mL) had lower statistical relevance and represents a grey zone in vitamin D status. Guidelines and recommendations are necessary for homogeneity of the monitoring and management of inadequately vitamin D status in the risk categories.
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