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Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry

Bondareva et al., Cell Host & Microbe, doi:10.1016/j.chom.2023.10.007
Nov 2023  
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Analysis of the role of oral microbiota, particularly Streptococcus salivarius, in enhancing immune response against SARS-CoV-2. Authors show that several commensal bacteria express proteins that mimic the receptor binding domain of the spike protein and are recognized by spike-specific neutralizing antibodies. Oral supplementation of mice with S. salivarius induced cross-reactive antibodies against the spike protein and supplementation in humans increased the levels of salivary anti-spike IgG antibodies. Overall, the study provides evidence that molecular mimicry between the spike protein and proteins from commensal oral bacteria can enhance mucosal antibody responses against SARS-CoV-2.
The immune effects of probiotics are strain-specific.
Bondareva et al., 8 Nov 2023, Germany, peer-reviewed, 40 authors.
Contact: (corresponding author), (corresponding author).
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Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry
Marina Bondareva, Pawel Durek, ..., Lisa Budzinski, Pawel Durek, Mario Witkowski, Stefan Angermair, Justus Ninnemann, Jakob Kreye, Philine Letz, Marta Ferreira-Gomes, Iaroslav Semin, Gabriela Maria Guerra, S Momsen Reincke, Elisa Sánchez-Sendin, Selin Yilmaz, Toni Sempert, Gitta Anne Heinz, Caroline Tizian, Martin Raftery, Günther Schönrich, Daria Matyushkina, Ivan V Smirnov, Vadim M Govorun, Eva Schrezenmeier, Anna-Luisa Stefanski, Thomas Dörner, Silvia Zocche, Edoardo Viviano, Nele Klement, Katharina Johanna Sehmsdorf, Alexander Lunin, Hyun-Dong Chang, Marina Drutskaya, Liubov Kozlovskaya, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Prüss, Philipp Enghard, Mir-Farzin Mashreghi, Andrey A Kruglov
Cell Host & Microbe, doi:10.1016/j.chom.2023.10.007
In brief Bondareva et al. show that commensal bacteria, including Streptococcus salivarius, trigger cross-reactive anti-Spike antibodies capable of SARS-CoV-2 virus inhibition. Streptococcus salivarius abundance correlates with salivary anti-Spike antibodies early after SARS-CoV-2 vaccination. Streptococcus salivarius supplementation enhances salivary anti-Spike antibodies in vaccinees.
AUTHOR CONTRIBUTIONS Conceptualization, A.A.K. and M.-F.M.; methodology, A.A.K., M.-F.M., P.D., L.K., M.D., G.S., M.B., S.A., I.V.S., and V.M.G.; software, P.D.; investigation, M.B., S.A., L.B., P.L., J.N., A.A.K., M.W., J.K., S.M.R., I.S., G.M.G., M.F.-G., E.S.-S., S.Y., T.S., G.A.H., C.T., M.R., D.M., I.V.S., M.D., L.K., and A.L.; resources, J.K., S.M.R., E.S.-S., H.P., E.S., A.-L.S., T.D., S.Z., E.V., N.K., K.J.S., S.T., A.D., and P.E.; writing -original draft, A.A.K., M.W., M.B., L.B., J.N., P.D., M.-F.M., and A.R.; writing -review & editing, M.W., M.B., L.B., J.N., J.K., M.F.-G., S.M.R., M.R., G.S., E.S., A.-L.S., T.D., H.-D.C., M.D., L.K., S.T., A.R., H.P., and P.E.; visualization, A.A.K., P.D., M.B., L.B., and J.N.; project administration, A.A.K., M.-F.M., L.K., P.E., S.T., A.R., A.D., and H.P.; funding acquisition, H.-D.C., A.R., M.-F.M., A.A.K., H.P., V.M.G., J.K., S.M.R., and E.S. DECLARATION OF INTERESTS Related to this work, Deutsches Rheuma-Forschungszentrum (DRFZ) has filed a patent application. RESOURCE AVAILABILITY Lead contact Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Andrey Kruglov ( Materials availability Plasmids, cell lines and antibodies, bacterial strains generated during the study are available upon request to the lead contact. Data and code availability Supplementation of healthy individuals with probiotic bacteria Healthy volunteers..
Akaishi, Takahashi, Sato, Jin, Masamune et al., Prolonged diarrhea following COVID-19 vaccination: A case report and literature review, Tohoku J. Exp. Med, doi:10.1620/tjem.2022.J043
Anderson, Goodwin, Verma, Arevalo, Bolton et al., Seasonal human coronavirus antibodies are boosted upon SARS-CoV-2 infection but not associated with protection, Cell, doi:10.1016/j.cell.2021.02.010
Bacci, Mengoni, Emiliani, Chiellini, Cipriani et al., Defining the resilience of the human salivary microbiota by a 520-day longitudinal study in a confined environment: the Mars500 mission, Microbiome, doi:10.1186/s40168-021-01070-5
Barretto, Alvarez-Martin, Foata, Renault, Berger, Genome sequence of the lantibiotic bacteriocin producer Streptococcus salivarius strain K12, J. Bacteriol, doi:10.1128/JB.01268-12
Beller, Kruglov, Durek, Von Goetze, Werner et al., Specific microbiota enhances intestinal IgA levels by inducing TGF-beta in T follicular helper cells of Peyer's patches in mice, Eur. J. Immunol, doi:10.1002/eji.201948474
Bondareva, Letz, Karberg, Schrezenmeier, Semin et al., Induction of cross-reactive, mucosal anti-SARS-CoV-2 antibody responses in rheumatoid arthritis patients after 3rd dose of COVID-19 vaccination, J. Autoimmun, doi:10.1016/j.jaut.2022.102918
Bradley, Finsterbusch, Schnepf, Crotta, Llorian et al., Microbiotadriven tonic interferon signals in lung stromal cells protect from influenza virus infection, Cell Rep, doi:10.1016/j.celrep.2019.05.105
Bunker, Erickson, Flynn, Henry, Koval et al., Natural polyreactive IgA antibodies coat the intestinal microbiota, Science, doi:10.1126/science.aan6619
Cao, Su, Guo, Sun, Deng et al., Potent neutralizing antibodies against SARS-CoV-2 identified by high-throughput single-cell sequencing of convalescent patients' B cells, Cell, doi:10.1016/j.cell.2020.05.025
Chan, Liu, Cheung, Tsun, Chan et al., The mucosal and serological immune responses to the novel coronavirus (SARS-CoV-2) vaccines, Front. Immunol, doi:10.3389/fimmu.2021.744887
Chen, Wu, Chen, Gao, Lv et al., Alterations of the gut microbiota in patients with COVID-19 or H1N1 influenza, Clin. Infect. Dis, doi:10.1093/cid/ciaa709
Cole, Wang, Fish, Chai, Mcgarrell et al., Ribosomal Database Project: data and tools for high throughput rRNA analysis, Nucleic Acids Res, doi:10.1093/nar/gkt1244
Costello, Lauber, Hamady, Fierer, Gordon et al., Bacterial community variation in human body habitats across space and time, Science, doi:10.1126/science.1177486
Cui, Rao, Zeng, Wang, Ren et al., Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up, Mil. Med Res, doi:10.1186/s40779-022-00387-y
Devi, Kumari, Yadav, Tarai, Budhiraja et al., Transcriptionally active nasopharyngeal commensals and opportunistic microbial dynamics define mild symptoms in the COVID 19 vaccination breakthroughs, PLoS Pathog, doi:10.1371/journal.ppat.1011160
Di Pierro, Colombo, The administration of S. salivarius K12 to children may reduce the rate of SARS-CoV-2 infection, Minerva Med, doi:10.23736/S0026-4806.21.07487-5
Di Pierro, Iqtadar, Mumtaz, Bertuccioli, Recchia et al., Clinical effects of Streptococcus salivarius K12 in Hospitalized COVID-19 patients: results of a preliminary study, Microorganisms, doi:10.3390/microorganisms10101926
Donaldson, Ladinsky, Yu, Sanders, Yoo et al., Gut microbiota utilize immunoglobulin A for mucosal colonization, Science, doi:10.1126/science.aaq0926
Eren, Borisy, Huse, Welch, Oligotyping analysis of the human oral microbiome, Proc. Natl. Acad. Sci, doi:10.1073/pnas.1409644111
Eren, Morrison, Lescault, Reveillaud, Vineis et al., Minimum entropy decomposition: unsupervised oligotyping for sensitive partitioning of high-throughput marker gene sequences, ISME J, doi:10.1038/ismej.2014.195
Fajnzylber, Regan, Coxen, Corry, Wong et al., SARS-CoV-2 viral load is associated with increased disease severity and mortality, Nat. Commun, doi:10.1038/s41467-020-19057-5
Ferreira-Gomes, Kruglov, Durek, Heinrich, Tizian et al., SARS-CoV-2 in severe COVID-19 induces a TGF-beta-dominated chronic immune response that does not target itself, Nat. Commun, doi:10.1038/s41467-021-22210-3
Geva-Zatorsky, Sefik, Kua, Pasman, Tan et al., Mining the human gut microbiota for immunomodulatory organisms, Cell, doi:10.1016/j.cell.2017.01.022
Gil-Cruz, Perez-Shibayama, De Martin, Ronchi, Van Der Borght et al., Microbiota-derived peptide mimics drive lethal inflammatory cardiomyopathy, Science, doi:10.1126/science.aav3487
Greiling, Dehner, Chen, Hughes, In ˜iguez et al., Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus, Sci. Transl. Med, doi:10.1126/scitranslmed.aan2306
Hoffmann, Kleine-Weber, Schroeder, Kr€ Uger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell, doi:10.1016/j.cell.2020.02.052
Ichinohe, Pang, Kumamoto, Peaper, Ho et al., Microbiota regulates immune defense against respiratory tract influenza A virus infection, Proc. Natl. Acad. Sci. USA, doi:10.1073/pnas.1019378108
Jari Oksanen, Friendly, Kindt, Legendre, Mcglinn et al., vegan: community Ecology Package
Jeffries, Jr, Sacha, Pollara, Himes et al., The function and affinity maturation of HIV-1 gp120-specific monoclonal antibodies derived from colostral B cells, Mucosal Immunol, doi:10.1038/mi.2015.70
Ju, Zhang, Ge, Wang, Sun et al., Human neutralizing antibodies elicited by SARS-CoV-2 infection, Nature, doi:10.1038/s41586-020-2380-z
Klindworth, Pruesse, Schweer, Peplies, Quast et al., Antibodies Anti-human IgA1 Alexa Fluor 647 (clone: B3506B4) Southern Biotech Cat. No. 9130-31; RRID: AB_2796658 Anti-human IgA2 Alexa Fluor 488 (clone: A9604D2) Southern Biotech Cat. No. 9140-30; RRID: AB_2796665 Rabbit SARS-CoV-2 Spike Neutralizing Antibody (clone: HA14JL2302), doi:10.1093/nar/gks808
Kozlovskaya, Piniaeva, Ignatyev, Gordeychuk, Volok et al., Long-term humoral immunogenicity, safety and protective efficacy of inactivated vaccine against COVID-19 (CoviVac) in preclinical studies, Emerg. Microbes Infect, doi:10.1080/22221751.2021.1971569
Kreye, Reincke, Kornau, Sa ´nchez-Sendin, Corman et al., A therapeutic non-self-reactive SARS-CoV-2 antibody protects from lung pathology in a COVID-19 hamster model, Cell, doi:10.1016/j.cell.2020.09.049
Liu, Mak, Su, Yeoh, Lui et al., Gut microbiota dynamics in a prospective cohort of patients with post-acute COVID-19 syndrome, Gut, doi:10.1136/gutjnl-2021-325989
Liu, Yan, Wan, Xiang, Le et al., Viral dynamics in mild and severe cases of COVID-19, Lancet Infect. Dis, doi:10.1016/S1473-3099(20)30232-2
Lloyd-Price, Mahurkar, Rahnavard, Crabtree, Orvis et al., Strains, functions and dynamics in the expanded Human Microbiome Project, Nature, doi:10.1038/nature23889
Lynn, Benson, Lynn, Pulendran, Modulation of immune responses to vaccination by the microbiota: implications and potential mechanisms, Nat. Rev. Immunol, doi:10.1038/s41577-021-00554-7
Ma, Zhang, Zhou, Li, Ge et al., Metagenomic analysis reveals oropharyngeal microbiota alterations in patients with COVID-19, Signal Transduct. Target. Ther, doi:10.1038/s41392-021-00614-3
Macpherson, Yilmaz, Limenitakis, Ganal-Vonarburg, IgA function in relation to the intestinal microbiota, Annu. Rev. Immunol, doi:10.1146/annurev-immunol-042617-053238
Majdoubi, Michalski, O'connell, Dada, Narpala et al., A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2, JCI Insight, doi:10.1172/jci.insight.146316
Masella, Bartram, Truszkowski, Brown, Neufeld, PANDAseq: paired-end assembler for Illumina sequences, BMC Bioinformatics, doi:10.1186/1471-2105-13-31
Mcmurdie, Holmes, phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data, PLoS One, doi:10.1371/journal.pone.0061217
Nagao-Kitamoto, Leslie, Kitamoto, Jin, Thomsson et al., Interleukin-22-mediated host glycosylation prevents Clostridioides difficile infection by modulating the metabolic activity of the gut microbiota, Nat. Med, doi:10.1038/s41591-020-0764-0
Ng, Faulkner, Cornish, Rosa, Harvey et al., Preexisting and de novo humoral immunity to SARS-CoV-2 in humans, Science, doi:10.1126/science.abe1107
Ng, Peng, Zhang, Mok, Zhao et al., Gut microbiota composition is associated with SARS-CoV-2 vaccine immunogenicity and adverse events, Gut, doi:10.1136/gutjnl-2021-326563
Planas, Santos, Tomas-Ojer, Cruciani, Lutterotti et al., GDP-l-fucose synthase is a CD4(+) T cell-specific autoantigen in DRB3*02:02 patients with multiple sclerosis, Sci. Transl. Med, doi:10.1126/scitranslmed.aat4301
Ren, Wang, Duan, Patel, Liggett et al., Cross-immunoreactivity between bacterial aquaporin-Z and human aquaporin-4: potential relevance to neuromyelitis optica, J. Immunol, doi:10.4049/jimmunol.1200486
Renegar, Small, Jr, Boykins, Wright, Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract, J. Immunol, doi:10.4049/jimmunol.173.3.1978
Robak, Heimesaat, Kruglov, Prepens, Ninnemann et al., Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia, J. Clin. Invest, doi:10.1172/JCI97065
Sayers, Beck, Bolton, Bourexis, Brister et al., Database resources of the National Center for Biotechnology Information, Nucleic Acids Res, doi:10.1093/nar/gkaa892
Schaupp, Muth, Rogell, Kofoed-Branzk, Melchior et al., Microbiota-induced Type I interferons instruct a poised basal state of dendritic cells, Cell, doi:10.1016/j.cell.2020.04.022
Scott, Andrusaite, Andersen, Lawson, Alcon-Giner et al., Antibiotics induce sustained dysregulation of intestinal T cell immunity by perturbing macrophage homeostasis, Sci. Transl. Med, doi:10.1126/scitranslmed.aao4755
Segata, Izard, Waldron, Gevers, Miropolsky et al., Metagenomic biomarker discovery and explanation, Genome Biol, doi:10.1186/gb-2011-12-6-r60
Shang, Wan, Luo, Ye, Geng et al., Cell entry mechanisms of SARS-CoV-2, Proc. Natl. Acad. Sci. USA, doi:10.1073/pnas.2003138117
Sheikh-Mohamed, Isho, Chao, Zuo, Cohen et al., Systemic and mucosal IgA responses are variably induced in response to SARS-CoV-2 mRNA vaccination and are associated with protection against subsequent infection, Mucosal Immunol, doi:10.1038/s41385-022-00511-0
Simula, Manca, Jasemi, Uzzau, Rubino et al., HCoV-NL63 and SARS-CoV-2 share recognized epitopes by the humoral response in sera of people collected Pre-and during CoV-2 pandemic, Microorganisms, doi:10.3390/microorganisms8121993
Sokal, Chappert, Barba-Spaeth, Roeser, Fourati et al., Maturation and persistence of the anti-SARS-CoV-2 memory B cell response, Cell, doi:10.1016/j.cell.2021.01.050
Spiekermann, Finn, Ward, Dumont, Dickinson et al., Receptor-mediated immunoglobulin G transport across mucosal barriers in adult life: functional expression of FcRn in the mammalian lung, J. Exp. Med, doi:10.1084/jem.20020400
Stefan, Kim, Iwasaki, Kasper, Commensal microbiota modulation of natural resistance to virus infection, Cell, doi:10.1016/j.cell.2020.10.047
Sulaiman, Chung, Angel, Tsay, Wu et al., Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome, Nat. Microbiol, doi:10.1038/s41564-021-00961-5
Tierney, Yang, Luber, Beaudin, Wibowo et al., The landscape of genetic content in the gut and oral human microbiome, Cell Host Microbe, doi:10.1016/j.chom.2019.07.008
Trama, Moody, Alam, Jaeger, Lockwood et al., HIV-1 envelope gp41 antibodies can originate from terminal ileum B cells that share cross-reactivity with commensal bacteria, Cell Host Microbe, doi:10.1016/j.chom.2014.07.003
Uehara, Abiko, Nagasawa, Morikawa, Hiraki et al., Alterations in the oral microbiome of individuals with a healthy oral environment following COVID-19 vaccination, BMC Oral Health, doi:10.1186/s12903-022-02093-6
Walls, Park, Tortorici, Wall, Mcguire et al., Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein, Cell, doi:10.1016/j.cell.2020.02.058
Wang, Garrity, Tiedje, Cole, Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy, Appl. Environ. Microbiol, doi:10.1128/AEM.00062-07
Wang, Jia, Zhang, Peng, Zhao, Tracing the accumulation of in vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract, Gut, doi:10.1136/gutjnl-2019-318977
Wardemann, Yurasov, Schaefer, Young, Meffre et al., Predominant autoantibody production by early human B cell precursors, Science, doi:10.1126/science.1086907
Wijburg, Uren, Simpfendorfer, Johansen, Brandtzaeg et al., Innate secretory antibodies protect against natural Salmonella typhimurium infection, J. Exp. Med, doi:10.1084/jem.20052093
Williams, Liao, Moody, Kepler, Alam et al., HIV-1 vaccines. Diversion of HIV-1 vaccine-induced immunity by gp41-microbiota crossreactive antibodies, Science, doi:10.1126/science.aab1253
Woo, Leung, Leung, Yuen, Identification by 16S ribosomal RNA gene sequencing of an Enterobacteriaceae species from a bone marrow transplant recipient, Mol. Pathol, doi:10.1136/mp.53.4.211
Yamazaki, Ogura, Minami, Ogai, Horiguchi et al., Oral microbiome changes associated with the menstrual cycle in healthy young adult females, Front. Cell. Infect. Microbiol, doi:10.3389/fcimb.2023.1119602
Yang, Xie, Li, Wei, More than 9,000,000 unique genes in human gut bacterial community: estimating gene numbers inside a human body, PLoS One, doi:10.1371/journal.pone.0006074
Yeoh, Zuo, Lui, Zhang, Liu et al., Gut microbiota composition reflects disease severity and dysfunctional immune responses in patients with COVID-19, Gut, doi:10.1136/gutjnl-2020-323020
Za ´rate-Blade ´s, Horai, Mattapallil, Ajami, Wong et al., Gut microbiota as a source of a surrogate antigen that triggers autoimmunity in an immune privileged site, Gut Microbes, doi:10.1080/19490976.2016.1273996
Zhou, Yang, Wang, Hu, Zhang et al., A pneumonia outbreak associated with a new coronavirus of probable bat origin, Nature, doi:10.1038/s41586-020-2012-7
Zuo, Zhang, Lui, Yeoh, Li et al., Alterations in gut microbiota of patients with COVID-19 during time of hospitalization, Gastroenterology, doi:10.1053/j.gastro.2020.05.048
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