Cross-regulation of antibody responses against the SARS-CoV-2 Spike protein and commensal microbiota via molecular mimicry
Marina Bondareva, Pawel Durek, ..., Lisa Budzinski, Pawel Durek, Mario Witkowski, Stefan Angermair, Justus Ninnemann, Jakob Kreye, Philine Letz, Marta Ferreira-Gomes, Iaroslav Semin, Gabriela Maria Guerra, S Momsen Reincke, Elisa Sánchez-Sendin, Selin Yilmaz, Toni Sempert, Gitta Anne Heinz, Caroline Tizian, Martin Raftery, Günther Schönrich, Daria Matyushkina, Ivan V Smirnov, Vadim M Govorun, Eva Schrezenmeier, Anna-Luisa Stefanski, Thomas Dörner, Silvia Zocche, Edoardo Viviano, Nele Klement, Katharina Johanna Sehmsdorf, Alexander Lunin, Hyun-Dong Chang, Marina Drutskaya, Liubov Kozlovskaya, Sascha Treskatsch, Andreas Radbruch, Andreas Diefenbach, Harald Prüss, Philipp Enghard, Mir-Farzin Mashreghi, Andrey A Kruglov
Cell Host & Microbe, doi:10.1016/j.chom.2023.10.007
In brief Bondareva et al. show that commensal bacteria, including Streptococcus salivarius, trigger cross-reactive anti-Spike antibodies capable of SARS-CoV-2 virus inhibition. Streptococcus salivarius abundance correlates with salivary anti-Spike antibodies early after SARS-CoV-2 vaccination. Streptococcus salivarius supplementation enhances salivary anti-Spike antibodies in vaccinees.
AUTHOR CONTRIBUTIONS Conceptualization, A.A.K. and M.-F.M.; methodology, A.A.K., M.-F.M., P.D., L.K., M.D., G.S., M.B., S.A., I.V.S., and V.M.G.; software, P.D.; investigation, M.B., S.A., L.B., P.L., J.N., A.A.K., M.W., J.K., S.M.R., I.S., G.M.G., M.F.-G., E.S.-S., S.Y., T.S., G.A.H., C.T., M.R., D.M., I.V.S., M.D., L.K., and A.L.; resources, J.K., S.M.R., E.S.-S., H.P., E.S., A.-L.S., T.D., S.Z., E.V., N.K., K.J.S., S.T., A.D., and P.E.; writing -original draft, A.A.K., M.W., M.B., L.B., J.N., P.D., M.-F.M., and A.R.; writing -review & editing, M.W., M.B., L.B., J.N., J.K., M.F.-G., S.M.R., M.R., G.S., E.S., A.-L.S., T.D., H.-D.C., M.D., L.K., S.T., A.R., H.P., and P.E.; visualization, A.A.K., P.D., M.B., L.B., and J.N.; project administration, A.A.K., M.-F.M., L.K., P.E., S.T., A.R., A.D., and H.P.; funding acquisition, H.-D.C., A.R., M.-F.M., A.A.K., H.P., V.M.G., J.K., S.M.R., and E.S.
DECLARATION OF INTERESTS Related to this work, Deutsches Rheuma-Forschungszentrum (DRFZ) has filed a patent application.
RESOURCE AVAILABILITY
Lead contact Further information and requests for resources and reagents should be directed to and will be fulfilled by the lead contact, Andrey Kruglov (kruglov@drfz.de).
Materials availability Plasmids, cell lines and antibodies, bacterial strains generated during the study are available upon request to the lead contact.
Data and code availability
Supplementation of healthy individuals with probiotic bacteria Healthy volunteers..
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