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The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer

Al-Kuraishy et al., Current Medical and Drug Research
Dec 2020  
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Review article noting that bromhexine is a TMPRSS2 inhibitor with greater effect in lung tissue and attenuates the entry and proliferation of SARS-CoV-2.
See Maggio et al. for another review covering bromhexine for COVID-19.
Al-Kuraishy et al., 31 Dec 2020, preprint, 5 authors.
This PaperBromhexineAll
The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer
Hayder M Al-Kuraishy, Marwa S Al-Niemi, Nawar R Hussain, Ali I Al-Gareeb, Claire Lugnier
Primary infection of SARS-CoV-2 (novel coronavirus or 2019-nCoV), which leads to Covid-19, targets specific cells, such as nasal, bronchial epithelial and pneumocytes, through the viral structural spike (S) protein that binds to the angiotensin-converting enzyme 2 (ACE2) receptor. Also, type 2 transmembrane serine protease (TMPRSS2) present in the host cell promotes viral uptake by cleaving ACE2 and triggering the SARS-CoV-2 S protein, which facilitates SARS-CoV-2 entry into host cells. One of the TMPRSS2 inhibitors with a greater distribution capacity into the lung tissue is bromhexine hydrochloride which attenuates the entry and proliferation of SARS-CoV-2. Bromhexine is an effective drug in the management and treatment of Covid-19 pneumonia via targeting ACE2/ TMPRSS2 pathway. However, prospective and controlled clinical trials are recommended to confirm this observation.
CONFLICTS OF INTEREST The authors declare no conflicts of interest. DECLARATION The contents of this paper are published after receiving a signed copyright agreement from the corresponding author declaring that the contents of this paper are original. In case of any dispute related to the originality of the contents, editors, reviewers and publisher will remain neutral.
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Al-Kuraishy, Niemi, Hussain, Gareeb, Al-Harchan et al., The potential role of renin-angiotensin system (RAS) and dipeptidyl peptidase-4 (DPP-4) in COVID-19: Navigating the uncharted
Azimi, Barzegar, Ghadipasha, Rezaei, Forouzesh et al., TMPRSS2 Inhibitors, Bromhexine, Aprotinin, Camostat and Nafamostat as Potential Treatments for COVID-19, Internal and Emergency Medicine
El-Sayed, Hashem, Quality by design strategy for simultaneous HPLC determination of bromhexine HCl and its metabolite ambroxol HCl in dosage forms and plasma, Chromatographia
Fu, Zheng, Zhou, Tang, Chen et al., Rerecognizing bromhexine hydrochloride: pharmaceutical properties and its possible role in treating pediatric COVID-19, European Journal of Clinical Pharmacology, doi:10.1007/s00228-020-‫.4-17920‬
Hm, Witchcraft and Myths about Covid-19 in Iraq, Journal of Conventional Knowledge and Holistic Health
Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor, Cell
Hussien, Al-Naimi, Ak, Gareeb, Lungnier, Is ivermectinazithromycin combination the next step for COVID-19?, Biomedical and Biotechnology Research Journal
Hussien, Al-Naimi1, Ak, Gareeb, Lungnier et al., Renin-Angiotensin System and fibrinolytic pathway in COVID-19: One-way skepticism, Biomedical and Biotechnology Research Journal
Kron, Murison, Zhou, Huang, Yamaguchi et al., TMPRSS2-ERG fusion coopts master transcription factors and activates NOTCH signaling in primary prostate cancer, Nature Genetics
Li, Sun, Zhang, Zheng, Jiang et al., Bromhexine hydrochloride tablets for the treatment of moderate COVID-19: An open-label randomized controlled pilot study, Clinical and Translational Science
Rosa, Santos, Sagawa, Inoue, Takano, Clinical trials on drug repositioning for COVID-19 treatment, Revista Panamericana de Salud Pública
Sanders, Monogue, Jodlowski, Cutrell, Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review, JAMA
Semwal, Chauhan, Semwal, Sircar, Roy et al., Natural molecules having anti-SARS-CoV activity -cannot they be effective against SARS-CoV-2?, Current Science
Shrimp, Kales, Sanderson, Simeonov, Shen et al., An enzymatic TMPRSS2 assay for assessment of clinical candidates and discovery of inhibitors as potential treatment of COVID-19, ACS Pharmacology & Translational Science
Song, Seddighzadeh, Cooperberg, Huang, Expression of ACE2, the SARS-CoV-2 Receptor, and TMPRSS2 in Prostate Epithelial Cells, European Urology
Tj, Gareeb, Musa, Ali, COVID-19 pneumonia in an Iraqi pregnant woman with preterm delivery, Asian Pacific Journal of Reproduction, doi:10.4103/2305-0500.282984
Zanasi, Mazzolini, Kantar, A reappraisal of the mucoactive activity and clinical efficacy of bromhexine, Multidisciplinary Respiratory Medicine
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