Abstract: See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/347446399 The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer Article · December 2020 DOI: 10.4103/2305- CITATIONS READS 0 2,112 5 authors, including: Hayder Al-kuraishy Ali Ismail Al-Gareeb Al-Mustansiriyah University Al-Mustansiriya University 262 PUBLICATIONS 1,379 CITATIONS 211 PUBLICATIONS 1,267 CITATIONS SEE PROFILE SEE PROFILE Claire Lugnier University of Strasbourg 197 PUBLICATIONS 6,627 CITATIONS SEE PROFILE Some of the authors of this publication are also working on these related projects: Salivary nitrite levels in patients with T2DM: effect of diabetic pharmacotherapy View project Purification and molecular characterization of cardiovascular phosphodiesterase isoenzymes View project All content following this page was uploaded by Hayder Al-kuraishy on 18 December 2020. The user has requested enhancement of the Curr Med Drug Res, 2021, 5 (1), Article ID 212 Concept note The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer Hayder M. Al-Kuraishy1,*, Marwa S. Al-Niemi2, Nawar R. Hussain2, Ali I. Al-Gareeb1 and Claire Lugnier3,* 1 Department of Clinical Pharmacology, Medicine and Therapeutics, College of Medicine, Al-Mustansiriya University, P.O. Box 14132, Baghdad, Iraq 2 Department of Pharmacology, College of Pharmacy, Al-Farahidi University, P.O. Box 14132, Baghdad, Iraq 3 Unistra, Faculté de Médecine, Institut de Physiologie, EA 3072 “Mitochondrie, stress oxydant et protection musculaire”, 4 Rue Kirschleger, 67085, Strasbourg Cedex, France *Corresponding authors. E-mail: hayderm36@yahoo.com (HMA); claire.lugnier@unistra.fr (CL); Phone: +96407906230487 Article history Received : December 06, 2020 Accepted : December 18, 2020 Keywords Bromhexine COVID-19 Novel coronavirus SARS‐CoV‐2 TMPRSS2 ABSTRACT Primary infection of SARS‐CoV‐2 (novel coronavirus or 2019‐nCoV), which leads to Covid-19, targets specific cells, such as nasal, bronchial epithelial and pneumocytes, through the viral structural spike (S) protein that binds to the angiotensin-converting enzyme 2 (ACE2) receptor. Also, type 2 transmembrane serine protease (TMPRSS2) present in the host cell promotes viral uptake by cleaving ACE2 and triggering the SARS-CoV-2 S protein, which facilitates SARS-CoV-2 entry into host cells. One of the TMPRSS2 inhibitors with a greater distribution capacity into the lung tissue is bromhexine hydrochloride which attenuates the entry and proliferation of SARS‐CoV‐2. Bromhexine is an effective drug in the management and treatment of Covid-19 pneumonia via targeting ACE2/ TMPRSS2 pathway. However, prospective and controlled clinical trials are recommended to confirm this observation. © 2021 Global SciTech Ocean Publishing Co. All rights reserved. ISSN. 2581-5008