The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer
Hayder M Al-Kuraishy, Marwa S Al-Niemi, Nawar R Hussain, Ali I Al-Gareeb, Claire Lugnier
doi:10.4103/2305-
Primary infection of SARS-CoV-2 (novel coronavirus or 2019-nCoV), which leads to Covid-19, targets specific cells, such as nasal, bronchial epithelial and pneumocytes, through the viral structural spike (S) protein that binds to the angiotensin-converting enzyme 2 (ACE2) receptor. Also, type 2 transmembrane serine protease (TMPRSS2) present in the host cell promotes viral uptake by cleaving ACE2 and triggering the SARS-CoV-2 S protein, which facilitates SARS-CoV-2 entry into host cells. One of the TMPRSS2 inhibitors with a greater distribution capacity into the lung tissue is bromhexine hydrochloride which attenuates the entry and proliferation of SARS-CoV-2. Bromhexine is an effective drug in the management and treatment of Covid-19 pneumonia via targeting ACE2/ TMPRSS2 pathway. However, prospective and controlled clinical trials are recommended to confirm this observation.
CONFLICTS OF INTEREST The authors declare no conflicts of interest.
DECLARATION The contents of this paper are published after receiving a signed copyright agreement from the corresponding author declaring that the contents of this paper are original. In case of any dispute related to the originality of the contents, editors, reviewers and publisher will remain neutral.
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