The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer
Al-Kuraishy et al., Current Medical and Drug Research (Review) (Preprint)
Al-Kuraishy et al., The potential role of Bromhexine in the management of COVID-19: Decipher and a real game-changer, Current Medical and Drug Research (Review) (Preprint)
Review article noting that bromhexine is a TMPRSS2 inhibitor with greater effect in lung tissue and attenuates the entry and proliferation of SARS-CoV-2.
Al-Kuraishy et al., 31 Dec 2020, preprint, 5 authors.
Abstract: See discussions, stats, and author profiles for this publication at: https://www.researchgate.net/publication/347446399
The potential role of Bromhexine in the management of COVID-19: Decipher
and a real game-changer
Article · December 2020
DOI: 10.4103/2305-
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Curr Med Drug Res, 2021, 5 (1), Article ID 212
Concept note
The potential role of Bromhexine in the management of COVID-19: Decipher and a
real game-changer
Hayder M. Al-Kuraishy1,*, Marwa S. Al-Niemi2, Nawar R. Hussain2, Ali I. Al-Gareeb1 and Claire
Lugnier3,*
1
Department of Clinical Pharmacology, Medicine and Therapeutics, College of Medicine, Al-Mustansiriya
University, P.O. Box 14132, Baghdad, Iraq
2
Department of Pharmacology, College of Pharmacy, Al-Farahidi University, P.O. Box 14132, Baghdad, Iraq
3
Unistra, Faculté de Médecine, Institut de Physiologie, EA 3072 “Mitochondrie, stress oxydant et protection
musculaire”, 4 Rue Kirschleger, 67085, Strasbourg Cedex, France
*Corresponding authors. E-mail: hayderm36@yahoo.com (HMA); claire.lugnier@unistra.fr (CL); Phone: +96407906230487
Article history
Received : December 06, 2020
Accepted : December 18, 2020
Keywords
Bromhexine
COVID-19
Novel coronavirus
SARS‐CoV‐2
TMPRSS2
ABSTRACT
Primary infection of SARS‐CoV‐2 (novel coronavirus or 2019‐nCoV), which leads to
Covid-19, targets specific cells, such as nasal, bronchial epithelial and pneumocytes,
through the viral structural spike (S) protein that binds to the angiotensin-converting
enzyme 2 (ACE2) receptor. Also, type 2 transmembrane serine protease (TMPRSS2)
present in the host cell promotes viral uptake by cleaving ACE2 and triggering the
SARS-CoV-2 S protein, which facilitates SARS-CoV-2 entry into host cells. One of the
TMPRSS2 inhibitors with a greater distribution capacity into the lung tissue is
bromhexine hydrochloride which attenuates the entry and proliferation of
SARS‐CoV‐2. Bromhexine is an effective drug in the management and treatment of
Covid-19 pneumonia via targeting ACE2/ TMPRSS2 pathway. However, prospective
and controlled clinical trials are recommended to confirm this observation.
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