Repurposing the mucolytic cough suppressant and TMPRSS2 protease inhibitor bromhexine for the prevention and management of SARS-CoV-2 infection
Roberto Maggio, Giovanni U Corsini
Pharmacological Research, doi:10.1016/j.phrs.2020.104837
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References
Böttcher, Matrosovich, Beyerle, Klenk, Garten et al., Proteolytic activation of influenza viruses by serine proteases TMPRSS2 and HAT from human airway epithelium, J. Virol
Hoffmann, Kleine-Weber, Schroeder, Hoffmann, Kleine-Weber, None, Pharmacological Research
Iwata-Yoshikawa, Okamura, Shimizu, Hasegawa, Takeda et al., TMPRSS2 contributes to virus spread and immunopathology in the airways of murine models after coronavirus infection, J. Virol
Kawase, Shirato, Van Der Hoek, Taguchi, Matsuyama, Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry, J. Virol
Lucas, Heinlein, Kim, Hernandez, Malik et al., The androgen-regulated protease TMPRSS2 activates a proteolytic cascade involving components of the tumor microenvironment and promotes prostate cancer metastasis, Cancer Discov
Schroeder, Krüger, Herrler, Erichsen, Schiergens et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell
Shen, Mao, Wu, Tanaka, Zhang, TMPRSS2: a potential target for treatment of influenza virus and coronavirus infections, Biochimie
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