Metformin use before COVID-19 vaccination and the risks of COVID-19 incidence, medical utilization, and all-cause mortality in patients with type 2 diabetes mellitus
Yen et al.,
Metformin use before COVID-19 vaccination and the risks of COVID-19 incidence, medical utilization, and..,
Diabetes Research and Clinical Practice, doi:10.1016/j.diabres.2023.110692
TriNetX retrospective 123,709 vaccinated patients with type 2 diabetes, showing significantly lower risk of COVID-19 mortality, mechanical ventilation, and hospitalization with metformin use. There was no significant difference for cases. The increasing benefit for more serious outcomes matches the results of studies to date.
risk of death, 25.0% lower, HR 0.75, p = 0.001, treatment 232 of 20,894 (1.1%), control 295 of 20,894 (1.4%), NNT 332, propensity score matching, Kaplan–Meier.
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risk of mechanical ventilation, 25.0% lower, HR 0.75, p = 0.01, treatment 133 of 20,894 (0.6%), control 168 of 20,894 (0.8%), NNT 597, propensity score matching, Kaplan–Meier.
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risk of ICU admission, 19.0% lower, HR 0.81, p = 0.005, treatment 332 of 20,894 (1.6%), control 390 of 20,894 (1.9%), NNT 360, propensity score matching, Kaplan–Meier.
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risk of hospitalization, 15.0% lower, HR 0.85, p < 0.001, treatment 2,820 of 20,894 (13.5%), control 3,139 of 20,894 (15.0%), NNT 65, propensity score matching, Kaplan–Meier.
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risk of case, 2.0% higher, HR 1.02, p = 0.63, treatment 1,467 of 20,894 (7.0%), control 1,364 of 20,894 (6.5%), propensity score matching, Kaplan–Meier.
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Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
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Yen et al., 6 May 2023, retrospective, multiple countries, peer-reviewed, 4 authors, study period 1 January, 2020 - 22 November, 2022.
Contact:
yenfushun@gmail.com, shiowing0107@gmail.com, sylin@vghtc.gov.tw, jccwei@gmail.com.
Abstract: Journal Pre-proofs
Metformin use before COVID-19 vaccination and the risks of COVID-19 incidence, medical utilization, and all-cause mortality in patients with type 2
diabetes mellitus
Fu-Shun Yen, Shiow-Ing Wang, Shih-Yi Lin, James Cheng-Chung Wei
PII:
DOI:
Reference:
S0168-8227(23)00454-0
https://doi.org/10.1016/j.diabres.2023.110692
DIAB 110692
To appear in:
Diabetes Research and Clinical Practice
Received Date:
Revised Date:
Accepted Date:
8 March 2023
14 April 2023
1 May 2023
Please cite this article as: F-S. Yen, S-I. Wang, S-Y. Lin, J. Cheng-Chung Wei, Metformin use before COVID-19
vaccination and the risks of COVID-19 incidence, medical utilization, and all-cause mortality in patients with
type 2 diabetes mellitus, Diabetes Research and Clinical Practice (2023), doi: https://doi.org/10.1016/j.diabres.
2023.110692
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© 2023 Published by Elsevier B.V.
Metformin use before COVID-19 vaccination and the risks of COVID-19 incidence,
medical utilization, and all-cause mortality in patients with type 2 diabetes mellitus
Fu-Shun Yen a†, Shiow-Ing Wang b,c†, Shih-Yi Lin d,e, James Cheng-Chung Wei c,f,g,*
a Dr. Yen’s Clinic, No. 15, Shanying Road, Gueishan District, Taoyuan 33354, Taiwan
b Center for Health Data Science, Department of Medical Research, Chung Shan Medical
University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201, Taiwan
c Institute of Medicine, Chung Shan Medical University, No. 110, Sec. 1, Jianguo N. Rd.,
South District, Taichung 40201, Taiwan
d Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, No. 1650
Taiwan Boulevard, Sect. 4, Taichung 40705, Taiwan
e Department of Medicine, School of Medicine, National Yang Ming Chiao Tung University,
No. 155, Sec.2, Linong Street, Taipei 11221, Taiwan
f Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University
Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung City 40201, Taiwan
g Graduate Institute of Integrated Medicine, China Medical University, No. 91, Hsueh-Shih
Road, Taichung 40402, Taiwan
† Fu-Shun Yen and Shiow-Ing Wang contributed equally in this work.
* Corresponding author. James Cheng-Chung Wei, Institute of Medicine, Chung Shan
Medical University, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung 40201,
Taiwan, Tel: +886 4 24739595 #34718, Fax: +886 4 24734323
E-mail addresses: yenfushun@gmail.com (F.S. Yen), shiowing0107@gmail.com (S.I.
Wang), sylin@vghtc.gov.tw (S.Y. Lin), jccwei@gmail.com (J.C.C. Wei).
1
ABSTRACT
Aims: We designed this study to determine whether metformin use before COVID-19
vaccination influences the risk of COVID-19 infection, medical utilization, and mortality.
Methods: We used the US collaborative network of TriNetX to identify 123,709 patients with
type 2 diabetes mellitus fully vaccinated against COVID-19 between January 1, 2020, and
November 22, 2022. The study..
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
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