A Phase 2 Trial of the Effect of Antiandrogen Therapy on COVID-19 Outcome: No Evidence of Benefit, Supported by Epidemiology and In Vitro Data
Karin Welén, Ebba Rosendal, Magnus Gisslén, Annasara Lenman, Eva Freyhult, Osvaldo Fonseca-Rodríguez, Daniel Bremell, Johan Stranne, Åse Östholm Balkhed, Katarina Niward, Johanna Repo, David Robinsson, Anna J Henningsson, Johan Styrke, Martin Angelin, Elisabeth Lindquist, Annika Allard, Miriam Becker, Stina Rudolfsson, Robert Buckland, Camilla Thellenberg Carlsson, Anders Bjartell, Anna C Nilsson, Clas Ahlm, Anne-Marie Fors Connolly, Anna K Överby, Andreas Josefsson
European Urology, doi:10.1016/j.eururo.2021.12.013
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Author contributions: Andreas Josefsson had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
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Welén, Rosendal, Gisslén, Lenman, Freyhult et al., Josefsson This study shows no effect of enzalutamide on hospitalized COVID-19 patients or a decrease in the risk of COVID-19 severity from any androgen-inhibiting drug in the population. Collectively, there is evidence of no beneficial role of androgen inhibition in COVID-19
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