Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All antiandrogen studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchAntiandrogensAntiandrogens (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

5α-Reductase Inhibitors Are Associated with Reduced Risk of SARS-CoV-2 Infection: A Matched-Pair, Registry-Based Analysis

Lyon et al., Journal of Urology, doi:10.1097/JU.0000000000002180
Jan 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 17% Improvement Relative Risk Case 7% Antiandrogens for COVID-19  Lyon et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 1,938 patients in the USA (March 2020 - February 2021) Fewer cases with antiandrogens (p=0.042) c19early.org Lyon et al., J. Urology, January 2022 Favorsvarious Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 109 treatments. c19early.org
Retrospective 944 5ARI users in the USA and 944 matched controls, showing lower risk of COVID-19 cases with treatment.
risk of death, 16.9% lower, RR 0.83, p = 0.61, treatment 15 of 944 (1.6%), control 19 of 994 (1.9%), NNT 310.
risk of case, 7.2% lower, RR 0.93, p = 0.04, treatment 399 of 944 (42.3%), control 446 of 994 (44.9%), NNT 38, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lyon et al., 31 Jan 2022, retrospective, USA, peer-reviewed, 8 authors, study period 8 March, 2020 - 15 February, 2021.
This PaperAntiandrogensAll
{ 'indexed': {'date-parts': [[2022, 3, 25]], 'date-time': '2022-03-25T01:14:45Z', 'timestamp': 1648170885055}, 'reference-count': 0, 'publisher': 'Ovid Technologies (Wolters Kluwer Health)', 'issue': '1', 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'short-container-title': ['Journal of Urology'], 'published-print': {'date-parts': [[2022, 1]]}, 'DOI': '10.1097/ju.0000000000002180', 'type': 'journal-article', 'created': {'date-parts': [[2021, 8, 26]], 'date-time': '2021-08-26T08:00:48Z', 'timestamp': 1629964848000}, 'page': '183-189', 'source': 'Crossref', 'is-referenced-by-count': 2, 'title': [ '5α-Reductase Inhibitors Are Associated with Reduced Risk of SARS-CoV-2 Infection: A ' 'Matched-Pair, Registry-Based Analysis'], 'prefix': '10.1097', 'volume': '207', 'author': [ { 'given': 'Madison', 'family': 'Lyon', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Urology, Glickman Urological and Kidney Institute, ' 'Cleveland Clinic, Cleveland, Ohio'}]}, { 'given': 'Jianbo', 'family': 'Li', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Quantitative Health Sciences, Lerner Research ' 'Institute, Cleveland Clinic, Cleveland, Ohio'}]}, { 'given': 'Jennifer', 'family': 'Cullen', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Population and Quantitative Health Sciences, Case ' 'Western Reserve University School of Medicine, Cleveland, ' 'Ohio'}]}, { 'given': 'Alex', 'family': 'Milinovich', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Quantitative Health Sciences, Lerner Research ' 'Institute, Cleveland Clinic, Cleveland, Ohio'}]}, { 'given': 'Michael', 'family': 'Kattan', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Quantitative Health Sciences, Lerner Research ' 'Institute, Cleveland Clinic, Cleveland, Ohio'}]}, { 'given': 'Lara', 'family': 'Jehi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Neurology, Neurological Institute, Cleveland ' 'Clinic, Cleveland, Ohio'}]}, { 'given': 'Nima', 'family': 'Sharifi', 'sequence': 'additional', 'affiliation': [ { 'name': 'Genitourinary Malignancies Research Center, Department of Cancer ' 'Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, ' 'Ohio'}]}, { 'given': 'Eric A.', 'family': 'Klein', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Urology, Glickman Urological and Kidney Institute, ' 'Cleveland Clinic, Cleveland, Ohio'}]}], 'member': '276', 'container-title': ['Journal of Urology'], 'original-title': [], 'language': 'en', 'deposited': { 'date-parts': [[2022, 3, 25]], 'date-time': '2022-03-25T00:29:55Z', 'timestamp': 1648168195000}, 'score': 1, 'resource': {'primary': {'URL': 'http://www.jurology.com/doi/10.1097/JU.0000000000002180'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2022, 1]]}, 'references-count': 0, 'journal-issue': {'issue': '1', 'published-print': {'date-parts': [[2022, 1]]}}, 'alternative-id': ['10.1097/JU.0000000000002180'], 'URL': 'http://dx.doi.org/10.1097/ju.0000000000002180', 'relation': {}, 'ISSN': ['0022-5347', '1527-3792'], 'issn-type': [{'value': '0022-5347', 'type': 'print'}, {'value': '1527-3792', 'type': 'electronic'}], 'subject': ['Urology'], 'published': {'date-parts': [[2022, 1]]}}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit