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All Studies   Meta Analysis    Recent:   

5α-Reductase Inhibitors Are Associated with Reduced Risk of SARS-CoV-2 Infection: A Matched-Pair, Registry-Based Analysis

Lyon et al., Journal of Urology, doi:10.1097/JU.0000000000002180
Jan 2022  
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Mortality 17% Improvement Relative Risk Case 7% Antiandrogens for COVID-19  Lyon et al.  Prophylaxis Is prophylaxis with antiandrogens beneficial for COVID-19? Retrospective 1,938 patients in the USA (March 2020 - February 2021) Fewer cases with antiandrogens (p=0.042) c19early.org Lyon et al., J. Urology, January 2022 Favorsvarious Favorscontrol 0 0.5 1 1.5 2+
7th treatment shown to reduce risk in September 2020
 
*, now with p = 0.000000056 from 49 studies.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 944 5ARI users in the USA and 944 matched controls, showing lower risk of COVID-19 cases with treatment.
risk of death, 16.9% lower, RR 0.83, p = 0.61, treatment 15 of 944 (1.6%), control 19 of 994 (1.9%), NNT 310.
risk of case, 7.2% lower, RR 0.93, p = 0.04, treatment 399 of 944 (42.3%), control 446 of 994 (44.9%), NNT 38, adjusted per study, odds ratio converted to relative risk, multivariable.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lyon et al., 31 Jan 2022, retrospective, USA, peer-reviewed, 8 authors, study period 8 March, 2020 - 15 February, 2021.
This PaperAntiandrogensAll
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