Abstract: RWD26
Variation in Demographic Characteristics, Socioeconomic Status, Clinical Presentation and Selected Treatments in
Mortality Among Patients with a Diagnosis of COVID-19 in the United States
Rolin L Wade, RPh, MS; Riddhi Doshi, PhD; Dajun Tian, MS
IQVIA, Falls Church, Virginia, USA
Background
Results
• As of November 2022, 1,070,947 Coronavirus disease 2019 (COVID19)-related deaths were reported in the United States (US)1
• Older age, male sex, smoking, chronic obstructive pulmonary disease
(COPD), cardiovascular disease, diabetes, obesity, hypertension and
kidney disease are associated with a higher risk of mortality among
patients with COVID-19 infection2
• The US case-mortality rate for COVID-19 was reported to be 1.1%
as of March 20233
• Research on the impact of neighborhood socioeconomic
disadvantage on mortality in COVID-19 patients is lacking
Objective
• This study described the variation in patient demographic and clinical
characteristics and utilization of COVID-specific treatments by
neighborhood socioeconomic disadvantage among patients
confirmed dead after a medical claim with COVID-19 diagnosis
Table 2: Age Distribution of
Confirmed Deaths
Table 3: ADI Distribution of
Confirmed Deaths
Age Group: (n, %)
N
%
Total Mortality Population
563,744
100.00%
2,023
0.36%
0 - 17 y
18-34 y
8,606
1.53%
35-44 y
11,517
2.04%
ADI Level
N
%
0-20 Most Affluent
58,144
10.3%
21-40
91,629
41-60
45-54 y
25,572
4.54%
55-64 y
63,136
11.20%
65 -75 y
133,157
23.62%
> 75 y
319,730
56.72%
3 were unknown age
CCI 0
19.88%
Cardiovascular
CCI 3+
48.45%
CCI 1
15.72%
33.5%
57,887
CCI 2
15.96%
10.3%
CNS,
Cerebrovascular
3 were unknown ADI
Renal
Figure 1: Mortality Rate Total COVID-19 Study Population Q2-2020 to Q1-2022
Metabolic
8.00%
Study Design
7.30%
Mortality Rate
7.00%
• This retrospective cohort study utilized linked data from IQVIA’s
Professional fee claims (Dx), Longitudinal prescription claims (LRx)
and mortality data from Veritas Data Research to identify and
characterize patients with a COVID-19 diagnosis between April 1,
2020 and April 30, 2022
6.00%
3.00%
• A modified version of the Area Deprivation Index (ADI) was used to
assess neighborhood socioeconomic disadvantage from HIPAA
compliant databases
0.00%
• Presence of chain-of-event conditions (COE) (+/- 7 days of the last
COVID diagnosis date) and significant contributing conditions
(SCC) (over the study period) were assessed5
Mean Study Mortality
rate 3.19%
3.49%
4.00%
2.00%
2.39%
2.56%
J Hopkins reported
Mortality Rate 1.1%
Q2 2020
Q3 2020
Q4 2020
Q1 2021
Q2 2021
Q3 2021
Q4 2021
Q1 2022
Time Period
Figure 3: Mortality Rate by Age Group
18%
277,286,899
17,682,111
6.4%
Patients with a mortality flag in the Veritas Data Research database
563,744
0.2%
34.02%
10.95%
Atrial fibrillation and flutter
31.77%
15.50%
Congestive heart failure
37.82%
15.79%
Hypertensive heart disease without CHF
5.00%
7.43%
Hyperlipidemia, unspecified
39.88%
5.66%
Alzheimer disease, unspecified
11.20%
23.40%
Unspecified dementia
23.70%
21.62%
Stroke, not specified as hemorrhage or
infarction (I64)
11.56%
13.37%
Other specified disorders of kidney and ureter
13.62%
8.74%
Chronic kidney disease, unspecified
23.64%
15.30%
Unspecified diabetes mellitus without complications
0.69%
7.14%
Type 2 diabetes mellitus without complications
44.61%
7.46%
Obesity, unspecified
16.97%
2.75%
Pulmonary
Chronic..
{ 'indexed': {'date-parts': [[2023, 6, 11]], 'date-time': '2023-06-11T04:15:44Z', 'timestamp': 1686456944667},
'reference-count': 0,
'publisher': 'Elsevier BV',
'issue': '6',
'license': [ { 'start': { 'date-parts': [[2023, 6, 1]],
'date-time': '2023-06-01T00:00:00Z',
'timestamp': 1685577600000},
'content-version': 'tdm',
'delay-in-days': 0,
'URL': 'https://www.elsevier.com/tdm/userlicense/1.0/'}],
'content-domain': { 'domain': [ 'clinicalkey.fr', 'clinicalkey.jp', 'clinicalkey.es', 'clinicalkey.com.au',
'valueinhealthjournal.com', 'clinicalkey.com', 'elsevier.com',
'sciencedirect.com'],
'crossmark-restriction': True},
'published-print': {'date-parts': [[2023, 6]]},
'DOI': '10.1016/j.jval.2023.03.2056',
'type': 'journal-article',
'created': {'date-parts': [[2023, 6, 10]], 'date-time': '2023-06-10T16:28:47Z', 'timestamp': 1686414527000},
'page': 'S365',
'update-policy': 'http://dx.doi.org/10.1016/elsevier_cm_policy',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'RWD26 Variation in Demographic Characteristics, Socioeconomic Status, Clinical Presentation and '
'Selected Treatments in Mortality Among Patients with a Diagnosis of COVID-19 in the United '
'States',
'prefix': '10.1016',
'volume': '26',
'author': [ {'given': 'R.', 'family': 'Wade', 'sequence': 'first', 'affiliation': []},
{'given': 'R.', 'family': 'Doshi', 'sequence': 'additional', 'affiliation': []},
{'given': 'D.', 'family': 'Tian', 'sequence': 'additional', 'affiliation': []}],
'member': '78',
'container-title': 'Value in Health',
'original-title': [],
'language': 'en',
'link': [ { 'URL': 'https://api.elsevier.com/content/article/PII:S1098301523021563?httpAccept=text/xml',
'content-type': 'text/xml',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://api.elsevier.com/content/article/PII:S1098301523021563?httpAccept=text/plain',
'content-type': 'text/plain',
'content-version': 'vor',
'intended-application': 'text-mining'}],
'deposited': { 'date-parts': [[2023, 6, 10]],
'date-time': '2023-06-10T16:28:49Z',
'timestamp': 1686414529000},
'score': 1,
'resource': {'primary': {'URL': 'https://linkinghub.elsevier.com/retrieve/pii/S1098301523021563'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2023, 6]]},
'references-count': 0,
'journal-issue': {'issue': '6', 'published-print': {'date-parts': [[2023, 6]]}},
'alternative-id': ['S1098301523021563'],
'URL': 'http://dx.doi.org/10.1016/j.jval.2023.03.2056',
'relation': {},
'ISSN': ['1098-3015'],
'subject': ['Public Health, Environmental and Occupational Health', 'Health Policy'],
'container-title-short': 'Value in Health',
'published': {'date-parts': [[2023, 6]]},
'assertion': [ {'value': 'Elsevier', 'name': 'publisher', 'label': 'This article is maintained by'},
{ 'value': 'RWD26 Variation in Demographic Characteristics, Socioeconomic Status, Clinical '
'Presentation and Selected Treatments in Mortality Among Patients with a '
'Diagnosis of COVID-19 in the United States',
'name': 'articletitle',
'label': 'Article Title'},
{'value': 'Value in Health', 'name': 'journaltitle', 'label': 'Journal Title'},
{ 'value': 'https://doi.org/10.1016/j.jval.2023.03.2056',
'name': 'articlelink',
'label': 'CrossRef DOI link to publisher maintained version'},
{'value': 'simple-article', 'name': 'content_type', 'label': 'Content Type'},
{'name': 'copyright', 'label': 'Copyright'}]}
