Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes mellitus
Zoriana Tylishchak, Oleksandra Pryshliak, Oleksandr Boichuk, Sergiy Fedorov, Andrii Protsyk, Taras Kobryn, Ruslan Miziuk
Wiadomości Lekarskie, doi:10.36740/wlek/191875
Aim: To conduct a comparative analysis of the effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients with COVID-19 with concomitant type 2 diabetes. Materials and Methods: There were examined 60 patients with COVID-19 with concomitant T2DM. Upon admission into the hospital and again after 10 days, serum levels of interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and capillaroscopy of the nail plate was performed. Patients of the group I (30) against the background of protocol therapy received 0.5 g of quercetin intravenously once a day for 10 days. Patients of the group II (30) received to basic therapy. Results: After the treatment in patients of the group I general weakness decreased, body temperature normalized, improved saturation indicators, the level of acute-phase parameters (interleukin-6, CRP and ferritin) significantly decreased, a positive effect of quercetin on the level of D-dimer in blood serum was noted, indices of pericapillary edema and hemosiderin deposition significantly decreased, indices diameter of the arterial part of the capillary and capillary network density significantly increased. Conclusions: The use of quercetin against the background of basic therapy in patients with COVID-19 and concomitant T2DM reliably reduces the level of acute-phase indices, has an important clinical significance for reducing endothelial dysfunction and for preventing thrombotic complications.
CONFLICT OF INTEREST The Authors declare no conflict of interest
CORRESPONDING AUTHOR Oleksandr Boichuk Ivano-Frankivsk National Medical University 2 Halytska st, 76018 Ivano-Frankivsk, Ukraine e-mail: opboy@ukr.net ORCID AND CONTRIBUTIONSHIP Zoriana Tylishchak: 0000-0002-7891-2849 Oleksandra Pryshliak: 0000-0002-3256-5108 Oleksandr Boichuk: 0000-0003-0646-6533 Sergiy Fedorov: 0000-0002-2202-4279 Andrii Protsyk: 0000-0003-2041-5337 Taras Kobryn: 0000-0003-4381-6045 Ruslan Miziuk: 0000-0002-7829-9044
References
Chen, Zhou, Dong, Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study, Lancet,
doi:10.1016/S0140-6736(20)30211-7Gómez-Pastora, Weigand, Kim, Hyperferritinemia in critically ill COVID-19 patients -Is ferritin the product of inflammation or a pathogenic mediator?, Clin Chim Acta,
doi:10.1016/j.cca.2020.06.033Hayden, Endothelial activation and dysfunction in metabolic syndrome, type 2 diabetes and coronavirus disease 2019, J Int Med Res,
doi:10.1177/0300060520939746Hryzhak, Pryshliak, Kobryn, Clinical and echocardiographic findings in patients with COVID-19 across different severity levels, JOURNAL of MEDICINE and LIFE,
doi:10.25122/jml-2023-0206Hua, Yang, Zou, COVID-19 and metabolic comorbidities: An update on emerging evidences for optimal therapies, Biomed Pharmacother,
doi:10.1016/j.biopha.2021.111685Kolotylo, Moskaliuk, Syrota, Evaluation of D-dimer level as a biomarker of disease severity and mortality in patients with COVID-19, Wiad Lek,
doi:10.36740/WLek202307118Natalello, Luca, Gigante, Nailfold capillaroscopy findings in patients with coronavirus disease 2019: Broadening the spectrum of COVID-19 microvascular involvement, Microvasc Res,
doi:10.1016/j.mvr.2020.104071Nykonenko, Podluzhniy, Koliada, Thrombotic conditions in patients with COVID-19: Dynamics of D-dimer and tactics of anticoagulant therapy, Ukrainskyi Zhurnal Sertsevo-Sudynnoi Khirurhii,
doi:10.30702/ujcvs/22.30(01)/NP010-6470Pryshliak, Marynchak, Kondryn, Clinical and laboratory characteristics of COVID-19 in pregnant women, JOURNAL of MEDICINE and LIFE,
doi:10.25122/jml-2023-0044Smith, Herrick, Ingegnoli, Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud' s phenomenon and systemic sclerosis, Autoimmun Rev,
doi:10.1016/j.autrev.2020.102458Tylishchak, Peculiarities of endothelial dysfunction and capillary blood flow in patients with coronavirus disease (COVID-19) and accompanying type 2 diabetes mellitus, Bukovinian Medical Herald,
doi:10.24061/2413-0737.27.1.105.2023.7Tylishchak, Pryshliak, Skrypnyk, Coronavirus disease (COVID-19) in patients with type 2 diabetes mellitus: clinical and laboratory peculiarities, Rom J Diabetes Nutr Metab Dis,
doi:10.46389/rjd-2023-1224Wang, Hou, Luo, The laboratory tests and host immunity of COVID-19 patients with different severity of illness, JCI Insight,
doi:10.1172/jci.insight-137799Zhong, Wang, Zhang, Efficacy and safety of current therapeutic options for COVID-19 -lessons to be learnt from SARS and MERS epidemic: A systematic review and meta-analysis, Pharmacol Res,
doi:10.1016/j.phrs.2020.104872Zupanets, Golubovska, Tarasenko, Effectiveness of quercetin in patients with pneumonia associated with coronavirus disease (COVID-19), Zaporozhye medical journal,
doi:10.14739/2310-1210.2021.5.231714Zupanets, Shebeko, Bezugla, Pathophysiological substantiation of the effectiveness of quercetine use in coronavirus disease (COVID-19) therapy, Pathologia,
doi:10.14739/2310-1237.2020.1.203844Çakmak, Demirbuga, Demirkol, Nailfold capillaroscopy: A sensitive method for evaluating microvascular involvement in children with SARS-CoV-2 infection, Microvasc Res,
doi:10.1016/j.mvr.2021.104196{ 'indexed': { 'date-parts': [[2024, 12, 10]],
'date-time': '2024-12-10T05:10:11Z',
'timestamp': 1733807411483,
'version': '3.30.1'},
'reference-count': 0,
'publisher': 'ALUNA',
'issue': '10',
'content-domain': {'domain': [], 'crossmark-restriction': False},
'abstract': '<jats:sec><jats:title>Aim</jats:title><jats:p>To conduct a comparative analysis of the '
'effectiveness of basic therapy and basic therapy with the inclusion of quercetin in patients '
'with COVID-19 with concomitant type 2 '
'diabetes.</jats:p></jats:sec><jats:sec><jats:title>Material and '
'methods</jats:title><jats:p>There were examined 60 patients with COVID-19 with concomitant '
'T2DM. Upon admission into the hospital and again after 10 days, serum levels of '
'interleukin-6, C-reactive protein, procalcitonin, ferritin, endothelin-1 were determined, and '
'capillaroscopy of the nail plate was performed. Patients of the group I (30) against the '
'background of protocol therapy received 0.5 g of quercetin intravenously once a day for 10 '
'days. Patients of the group II (30) received to basic '
'therapy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>After the '
'treatment in patients of the group I general weakness decreased, body temperature normalized, '
'improved saturation indicators, the level of acute-phase parameters (interleukin-6, CRP and '
'ferritin) significantly decreased, a positive effect of quercetin on the level of D-dimer in '
'blood serum was noted, indices of pericapillary edema and hemosiderin deposition '
'significantly decreased, indices diameter of the arterial part of the capillary and capillary '
'network density significantly '
'increased.</jats:p></jats:sec><jats:sec><jats:title>Conclusions</jats:title><jats:p>The use '
'of quercetin against the background of basic therapy in patients with COVID-19 and '
'concomitant T2DM reliably reduces the level of acute-phase indices, has an important clinical '
'significance for reducing endothelial dysfunction and for preventing thrombotic '
'complications.</jats:p></jats:sec>',
'DOI': '10.36740/wlek/191875',
'type': 'journal-article',
'created': {'date-parts': [[2024, 12, 9]], 'date-time': '2024-12-09T09:56:57Z', 'timestamp': 1733738217000},
'page': '1962-1968',
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': 'Effectiveness of the quercetin use in patients with COVID-19 with concomitant type 2 diabetes '
'mellitus',
'prefix': '10.36740',
'volume': '77',
'author': [ { 'ORCID': 'https://orcid.org/0000-0002-7891-2849',
'authenticated-orcid': False,
'given': 'Zoriana',
'family': 'Tylishchak',
'sequence': 'first',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0002-3256-5108',
'authenticated-orcid': False,
'given': 'Oleksandra',
'family': 'Pryshliak',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0003-0646-6533',
'authenticated-orcid': False,
'given': 'Oleksandr',
'family': 'Boichuk',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0002-2202-4279',
'authenticated-orcid': False,
'given': 'Sergiy',
'family': 'Fedorov',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0003-2041-5337',
'authenticated-orcid': False,
'given': 'Andrii',
'family': 'Protsyk',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0003-4381-6045',
'authenticated-orcid': False,
'given': 'Taras',
'family': 'Kobryn',
'sequence': 'additional',
'affiliation': []},
{ 'ORCID': 'https://orcid.org/0000-0002-7829-9044',
'authenticated-orcid': False,
'given': 'Ruslan',
'family': 'Miziuk',
'sequence': 'additional',
'affiliation': []}],
'member': '22436',
'published-online': {'date-parts': [[2024, 12, 6]]},
'container-title': 'Wiadomości Lekarskie',
'original-title': [],
'link': [ { 'URL': 'https://www.wiadomoscilekarskie.pl/pdf-191875-117367',
'content-type': 'application/pdf',
'content-version': 'vor',
'intended-application': 'text-mining'},
{ 'URL': 'https://www.wiadomoscilekarskie.pl/pdf-191875-117367',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2024, 12, 9]],
'date-time': '2024-12-09T09:57:10Z',
'timestamp': 1733738230000},
'score': 1,
'resource': { 'primary': { 'URL': 'https://www.wiadomoscilekarskie.pl/Effectiveness-of-the-quercetin-use-in-patients-with-COVID-19-with-concomitant-type,191875,0,2.html'}},
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2024, 12, 6]]},
'references-count': 0,
'journal-issue': {'issue': '10', 'published-print': {'date-parts': [[2024]]}},
'alternative-id': ['191875'],
'URL': 'http://dx.doi.org/10.36740/WLek/191875',
'relation': {},
'ISSN': ['0043-5147', '2719-342X'],
'subject': [],
'container-title-short': 'Wiadomości Lekarskie',
'published': {'date-parts': [[2024, 12, 6]]}}
