Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Results
Abstract
All fluvoxamine studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchFluvoxamineFluvoxamine (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a reduced risk of subsequent hospitalization and death compared to their non-prescribed peers: population-based matched cohort study

Trkulja et al., European Journal of Clinical Pharmacology, doi:10.1007/s00228-023-03479-3 (date from preprint)
Nov 2022  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Mortality 27% Improvement Relative Risk Hospitalization -37% Fluvoxamine for COVID-19  Trkulja et al.  Prophylaxis Is prophylaxis with fluvoxamine beneficial for COVID-19? PSM retrospective 32,085 patients in Croatia Lower mortality (p=0.41) and higher hospitalization (p=0.5), not sig. c19early.org Trkulja et al., European J. Clinical P.., Nov 2022 Favorsfluvoxamine Favorscontrol 0 0.5 1 1.5 2+
27th treatment shown to reduce risk in November 2021, now with p = 0.00014 from 21 studies, recognized in 3 countries.
No treatment is 100% effective. Protocols combine treatments.
5,100+ studies for 109 treatments. c19early.org
Retrospective COVID+ patients in Croatia, showing no significant difference in outcomes with fluvoxamine prophylaxis.
risk of death, 27.0% lower, RR 0.73, p = 0.41, treatment 749, control 31,336, cohort A vs. B, propensity score matching.
risk of hospitalization, 37.0% higher, RR 1.37, p = 0.50, treatment 749, control 31,336, cohort A vs. B, COVID-related, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Trkulja et al., 7 Nov 2022, retrospective, Croatia, peer-reviewed, 2 authors. Contact: vladimir.trkulja@mef.hr.
This PaperFluvoxamineAll
Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a reduced risk of subsequent hospitalization and death compared to their non-prescribed peers: population-based matched cohort study
Vladimir Trkulja, Ivan Kodvanj
European Journal of Clinical Pharmacology, doi:10.1007/s00228-023-03479-3
Purpose To assess the effect of exposure to fluvoxamine around the COVID-19 diagnosis on subsequent hospitalizations and mortality in COVID-19 outpatients in a real-life setting. Methods Using nationwide administrative data, we identified adult COVID-19 outpatients diagnosed up to August 15, 2021 and conducted two cohort studies. Study 1 included subjects prescribed fluvoxamine around the index COVID-19 diagnosis (Cohort A), their peers suffering similar psychiatric difficulties but not prescribed fluvoxamine (Cohort B) and those free of psychiatric difficulties/treatments (Cohort C). Study 2 included subjects prescribed fluvoxamine (Cohort Fluvoxamine) and their peers prescribed paroxetine (Cohort Paroxetine). Cohorts were mutually exactly matched and incidence of COVID-19-related hospitalization, 30-day all-cause hospitalization and of COVID-19-related mortality was estimated.
Supplementary Information The online version contains supplementary material available at https:// doi. org/ 10. 1007/ s00228-023-03479-3. Author contribution Vladimir Trkulja and Ivan Kodvanj designed the study, prepared and analyzed the data, drafted the manuscript and completed the final version. Both authors meet the ICMJE criteria for authorship. Declarations Ethics approval This study used anonymized administrative data standardly collected on routine procedures, hence ethical approval was waived by the Ethics Committee of the Zagreb University School of Medicine and Croatian Institute for Public Healthy. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
References
Ballenger, Clinical guidelines for establishing remission in patients with depression and anxiety, J Clin Psyciatry
Beliveau, Boyne, Slater, Brenner, Arora, BUGSnet: an R package to facilitate the conduct and reporting of Bayesian network meta-analyses, Med Res Methodol, doi:10.1186/s12874-019-0829-2
Bramante, Juling, Tignanelli, Buse, Liebovitz et al., Randomized trial of metformin, ivermectin and fluvoxamine for Covid-19, N Engl J Med
Ceban, Nogo, Carvalho, Lee, Nasri et al., Association between mood disorders and risk of COVID-19 infection, hospitalization and death. A systematic review and meta-analysis, JAMA Psychiat
Core, R: a language and environment for statistical computing
Fond, Nemani, Etchecopar-Etchart, Loundou, Goff et al., Association between mental health disorders and mortality among patients with COVID-19 in 7 countries: a systematic review and meta-analysis, JAMA Psychiat
Goodrich, Gabry, Ali, Brilleman, rstanarm: Bayesian applied regression modeling via Stan
Griffith, Morris, Tudball, Herbert, Mancano et al., Collider bias undermines our understanding of COVID-19 disease risk and severity, Nat Commun, doi:10.1038/s41467-020-19478-2
Hadley, Rhea, Jones, Li, Sotner et al., Enhancing the prediction of hospitalization from a COVID-19 agent-based model: a Bayesian method for model parameter estimation, PloS ONE, doi:10.1371/journal.pone.0264704
Heine, The episensr package: basic sensitivity analysis of epidemiological results, doi:10.5281/zenodo.4554553
Herrera-Esposito, De Los Campos, Age-specific rate of severe and critical SARS-CoV-2 infections estimated with multicountry seroprevalence studies, BMC Infect Dis, doi:10.1186/s12879-022-07262-0
Ho, Imai, King, Stuart, MatchIt : nonparametric preprocessing for parametric causal inference, J Stat Softw, doi:10.18637/jss.v042.i08
Ia, Coron aviru s Pande mic Count ry Profi le -Our World in Data
Kuran, Greer, Trivedi, Strategies to enhance the therapeutic efficacy of antidepressants: targeting residual symptoms, Expert Rev Neurother
Lenze, Fluvoxamine for early treatment of COVID-19: a fullyremote, randomized placebo controlled trial
Lenze, Mattar, Zorumski, Stevens, Schweiger et al., Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial, JAMA
Mahdi, Herman, Rethelyi, Balint, Potential role of antidepressants fluoxetine and fluvoxamine in the treatment of COVID-19, Int J Mol Sci, doi:10.3390/ijms23073812
Mas, Garcia-Vincente, Estrada-Gelnoch, Perez-Mana, Papaseit et al., Antidepressant drugs and COVID-19: a review of basic and clinical evidence, J Clin Med, doi:10.3390/jcm11144038
Mccarthy, Naggie, Boulware, Lindsell, Stewart et al., placebo-controlled, randomized platform clinical trial, doi:10.1101/2022.10.17.22281178
Oskotsky, Marić, Tang, Oskotsky, Wong et al., Mortality risk among patients with COVID-19 prescribed selective serotonin reuptake inhibitor antidepressants, JAMA Network Open, doi:10.1001/jamanetworkopen.2021.33090
Reis, Moreira-Silva, Silva, Thabane, Milagres, Effect of early treatment with fluvoxamine on risk of emergeny care and hospitalizations among patients with COVID-19: the TOGETHER randomized platform trial, Lancet Glob Health, doi:10.1016/S2214-109X(21)00448-4
Ros, Aguera, De La Gandara, Rojo, De Pedro, Potentiation strategies for treatment-resistant depression, Acta Psyhciatr Scand Suppl
Schneeweiss, Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics, Pharmacoepidemiol Drug Saf
Schwarzer, Carpenter, Rucker, Meta-analysis with R
Seo, Kim, Bae, Park, Chung et al., Fluvoxamine treatment of patients with symptomatic COVID-19 in a community treatment center: a preliminary result of randomized controlled trial, Infect Chemother
Strom, Study design available for pharmacoepidemiological studies
Sukhatme, Reiersen, Vayttaden, Sukhatme, Fluvoxiamine: a review of its mechanism of action and its role in COVID-19, Frontiers Pharmacol, doi:10.3389/fphar.2021.652688
Trkulja, Fluvoxamine for COVID-19 outpatients: for the time being, we might prefer to curb our optimism, Br J Clin Pharmacol
Vai, Mazza, Colli, Foiselle, Allen et al., Mental disorders and risk of COVID-19-related mortality, hospitalization, and intensive care unit admission: a systematic review and meta-analysis, Lancet Psychiatry
Van Valkenhoef, Lu, De Brock, Hillege, Ades et al., Automating network meta-analysis, Res Synth. Methods
Zheng, Sun, Cai, Zhang, Ng et al., Antidepressants for COVID-19: a systematic review, J Affective Disord
{ 'indexed': {'date-parts': [[2023, 3, 25]], 'date-time': '2023-03-25T04:57:36Z', 'timestamp': 1679720256928}, 'reference-count': 31, 'publisher': 'Springer Science and Business Media LLC', 'license': [ { 'start': { 'date-parts': [[2023, 3, 24]], 'date-time': '2023-03-24T00:00:00Z', 'timestamp': 1679616000000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}, { 'start': { 'date-parts': [[2023, 3, 24]], 'date-time': '2023-03-24T00:00:00Z', 'timestamp': 1679616000000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://www.springernature.com/gp/researchers/text-and-data-mining'}], 'funder': [ { 'DOI': '10.13039/501100007682', 'name': 'Medicinski Fakultet, Sveučilište u Zagrebu', 'doi-asserted-by': 'publisher', 'award': ['no grant id', 'no grant id']}], 'content-domain': {'domain': ['link.springer.com'], 'crossmark-restriction': False}, 'DOI': '10.1007/s00228-023-03479-3', 'type': 'journal-article', 'created': {'date-parts': [[2023, 3, 24]], 'date-time': '2023-03-24T07:02:56Z', 'timestamp': 1679641376000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Outpatients prescribed with fluvoxamine around the time of COVID-19 diagnosis are not at a ' 'reduced risk of subsequent hospitalization and death compared to their non-prescribed peers: ' 'population-based matched cohort study', 'prefix': '10.1007', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-0968-1194', 'authenticated-orcid': False, 'given': 'Vladimir', 'family': 'Trkulja', 'sequence': 'first', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-1359-3701', 'authenticated-orcid': False, 'given': 'Ivan', 'family': 'Kodvanj', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2023, 3, 24]]}, 'reference': [ { 'key': '3479_CR1', 'doi-asserted-by': 'publisher', 'first-page': '2292', 'DOI': '10.1001/jama.2020.22760', 'volume': '324', 'author': 'EJ Lenze', 'year': '2020', 'unstructured': 'Lenze EJ, Mattar C, Zorumski CF, Stevens A, Schweiger J, Nicol GE et al ' '(2020) Fluvoxamine vs placebo and clinical deterioration in outpatients ' 'with symptomatic COVID-19: a randomized clinical trial. JAMA ' '324:2292–2300', 'journal-title': 'JAMA'}, { 'key': '3479_CR2', 'doi-asserted-by': 'publisher', 'first-page': 'e42', 'DOI': '10.1016/S2214-109X(21)00448-4', 'volume': '10', 'author': 'G Reis', 'year': '2022', 'unstructured': 'Reis G, dos Santos Moreira-Silva EA, Medeiros Silva DC, Thabane L, Cruz ' 'Milagres A et al (2022) Effect of early treatment with fluvoxamine on ' 'risk of emergeny care and hospitalizations among patients with COVID-19: ' 'the TOGETHER randomized platform trial. Lancet Glob Health 10:e42-51. ' 'https://doi.org/10.1016/S2214-109X(21)00448-4', 'journal-title': 'Lancet Glob Health'}, { 'key': '3479_CR3', 'unstructured': 'Lenze E. Fluvoxamine for early treatment of COVID-19: a fully-remote, ' 'randomized placebo controlled trial. ClinicalTrials.gov.\xa0' 'https://clinicaltrials.gov/ct2/show/NCT04668950. Accessed 26 Sept 2022'}, { 'key': '3479_CR4', 'doi-asserted-by': 'publisher', 'first-page': '102', 'DOI': '10.3947/ic.2021.0142', 'volume': '54', 'author': 'H Seo', 'year': '2022', 'unstructured': 'Seo H, Kim H, Bae S, Park S, Chung H, Sung HS et al (2022) Fluvoxamine ' 'treatment of patients with symptomatic COVID-19 in a community treatment ' 'center: a preliminary result of randomized controlled trial. Infect ' 'Chemother 54:102–113', 'journal-title': 'Infect Chemother'}, { 'key': '3479_CR5', 'doi-asserted-by': 'publisher', 'first-page': '599', 'DOI': '10.1056/NEJMoa2201662', 'volume': '387', 'author': 'CT Bramante', 'year': '2022', 'unstructured': 'Bramante CT, Juling JD, Tignanelli CJ, Buse JB, Liebovitz DM, Nicklas JM ' 'et al (2022) Randomized trial of metformin, ivermectin and fluvoxamine ' 'for Covid-19. N Engl J Med 387:599–610', 'journal-title': 'N Engl J Med'}, { 'key': '3479_CR6', 'doi-asserted-by': 'publisher', 'unstructured': 'McCarthy MW, Naggie S, Boulware DR, Lindsell CJ, Stewart TG, Felker GM ' 'et al (2022) Fluvoxamine for outpatient treatment of COVID-19: a ' 'decentralized, placebo-controlled, randomized platform clinical trial. ' 'medRxiv.\xa0https://doi.org/10.1101/2022.10.17.22281178', 'DOI': '10.1101/2022.10.17.22281178'}, { 'key': '3479_CR7', 'doi-asserted-by': 'publisher', 'unstructured': 'Sukhatme VP, Reiersen AM, Vayttaden SJ, Sukhatme VV (2021) Fluvoxiamine: ' 'a review of its mechanism of action and its role in COVID-19. Frontiers ' 'Pharmacol 12:652688. https://doi.org/10.3389/fphar.2021.652688', 'DOI': '10.3389/fphar.2021.652688'}, { 'key': '3479_CR8', 'doi-asserted-by': 'publisher', 'first-page': '108', 'DOI': '10.1016/j.jad.2022.03.059', 'volume': '307', 'author': 'W Zheng', 'year': '2022', 'unstructured': 'Zheng W, Sun HL, Cai H, Zhang Q, Ng CH, Xiang YT (2022) Antidepressants ' 'for COVID-19: a systematic review. J Affective Disord 307:108–114', 'journal-title': 'J Affective Disord'}, { 'key': '3479_CR9', 'doi-asserted-by': 'publisher', 'first-page': '4038', 'DOI': '10.3390/jcm11144038', 'volume': '11', 'author': 'M Mas', 'year': '2022', 'unstructured': 'Mas M, Garcia-Vincente JA, Estrada-Gelnoch A, Perez-Mana C, Papaseit E, ' 'Torrens M et al (2022) Antidepressant drugs and COVID-19: a review of ' 'basic and clinical evidence. J Clin Med 11:4038. ' 'https://doi.org/10.3390/jcm11144038', 'journal-title': 'J Clin Med'}, { 'key': '3479_CR10', 'doi-asserted-by': 'crossref', 'unstructured': 'Strom BL (2021) Study design available for pharmacoepidemiological ' 'studies. In: Strom BL, Kimmel E, Hennessy S, eds. Textbook of ' 'pharmacoepidemiology, 3rd ed. Hoboken, NJ: Wiley-Blackwell 20–46', 'DOI': '10.1002/9781119701101'}, { 'key': '3479_CR11', 'doi-asserted-by': 'publisher', 'first-page': '797', 'DOI': '10.1016/S2215-0366(21)00232-7', 'volume': '8', 'author': 'B Vai', 'year': '2021', 'unstructured': 'Vai B, Mazza MG, Delli Colli C, Foiselle M, Allen B, Benedetti F et al ' '(2021) Mental disorders and risk of COVID-19-related mortality, ' 'hospitalization, and intensive care unit admission: a systematic review ' 'and meta-analysis. Lancet Psychiatry 8:797–812', 'journal-title': 'Lancet Psychiatry'}, { 'key': '3479_CR12', 'doi-asserted-by': 'publisher', 'first-page': '1208', 'DOI': '10.1001/jamapsychiatry.2021.2274', 'volume': '78', 'author': 'G Fond', 'year': '2021', 'unstructured': 'Fond G, Nemani K, Etchecopar-Etchart D, Loundou A, Goff DC, Lee SW et al ' '(2021) Association between mental health disorders and mortality among ' 'patients with COVID-19 in 7 countries: a systematic review and ' 'meta-analysis. JAMA Psychiat 78:1208–1217', 'journal-title': 'JAMA Psychiat'}, { 'issue': '1', 'key': '3479_CR13', 'doi-asserted-by': 'publisher', 'first-page': '5749', 'DOI': '10.1038/s41467-020-19478-2', 'volume': '11', 'author': 'GJ Griffith', 'year': '2020', 'unstructured': 'Griffith GJ, Morris TT, Tudball MJ, Herbert A, Mancano G, Pike L et al ' '(2020) Collider bias undermines our understanding of COVID-19 disease ' 'risk and severity. Nat Commun 11(1):5749. ' 'https://doi.org/10.1038/s41467-020-19478-2', 'journal-title': 'Nat Commun'}, { 'key': '3479_CR14', 'doi-asserted-by': 'publisher', 'first-page': '1079', 'DOI': '10.1001/jamapsychiatry.2021.1818', 'volume': '78', 'author': 'F Ceban', 'year': '2021', 'unstructured': 'Ceban F, Nogo D, Carvalho IP, Lee Y, Nasri F, Xiong J et al (2021) ' 'Association between mood disorders and risk of COVID-19 infection, ' 'hospitalization and death. A systematic review and meta-analysis. JAMA ' 'Psychiat 78:1079–1091', 'journal-title': 'JAMA Psychiat'}, { 'key': '3479_CR15', 'doi-asserted-by': 'publisher', 'first-page': '3812', 'DOI': '10.3390/ijms23073812', 'volume': '23', 'author': 'M Mahdi', 'year': '2022', 'unstructured': 'Mahdi M, Herman L, Rethelyi JM, Balint L (2022) Potential role of ' 'antidepressants fluoxetine and fluvoxamine in the treatment of COVID-19. ' 'Int J Mol Sci 23:3812. https://doi.org/10.3390/ijms23073812', 'journal-title': 'Int J Mol Sci'}, { 'key': '3479_CR16', 'doi-asserted-by': 'publisher', 'unstructured': 'Oskotsky T, Marić I, Tang A, Oskotsky B, Wong RJ, Aghaeepour N et al ' '(2021) Mortality risk among patients with COVID-19 prescribed selective ' 'serotonin reuptake inhibitor antidepressants. JAMA Network Open ' '4(11):e2133090. https://doi.org/10.1001/jamanetworkopen.2021.33090', 'DOI': '10.1001/jamanetworkopen.2021.33090'}, { 'key': '3479_CR17', 'doi-asserted-by': 'publisher', 'unstructured': 'Ho DE, Imai K, King G, Stuart EA (2011) MatchIt\u202f: nonparametric ' 'preprocessing for parametric causal inference. J Stat Softw 42(8):1–28. ' 'https://doi.org/10.18637/jss.v042.i08', 'DOI': '10.18637/jss.v042.i08'}, { 'key': '3479_CR18', 'unstructured': 'R Core Team (2020) R: a language and environment for statistical ' 'computing. R Foundation for Statistical Computing, Vienna, Austria'}, { 'key': '3479_CR19', 'doi-asserted-by': 'publisher', 'first-page': '4654', 'DOI': '10.1111/bcp.15451', 'volume': '88', 'author': 'V Trkulja', 'year': '2022', 'unstructured': 'Trkulja V (2022) Fluvoxamine for COVID-19 outpatients: for the time ' 'being, we might prefer to curb our optimism. Br J Clin Pharmacol ' '88:4654–4656', 'journal-title': 'Br J Clin Pharmacol'}, { 'key': '3479_CR20', 'unstructured': 'Goodrich B, Gabry J, Ali I, Brilleman S (2022) rstanarm: Bayesian ' 'applied regression modeling via Stan. R package version 2.21.3 ' 'https://mc-stan.org/rstanarm/'}, { 'key': '3479_CR21', 'first-page': '187', 'volume': '2015', 'author': 'G Schwarzer', 'year': '2015', 'unstructured': 'Schwarzer G, Carpenter JR, Rucker G (2015) Meta-analysis with R. ' 'Springer International Publishing Switzerland 2015:187–216', 'journal-title': 'Springer International Publishing Switzerland'}, { 'key': '3479_CR22', 'doi-asserted-by': 'publisher', 'first-page': '196', 'DOI': '10.1186/s12874-019-0829-2', 'volume': '19', 'author': 'A Beliveau', 'year': '2019', 'unstructured': 'Beliveau A, Boyne DJ, Slater J, Brenner D, Arora P (2019) BUGSnet: an R ' 'package to facilitate the conduct and reporting of Bayesian network ' 'meta-analyses. Med Res Methodol 19:196. ' 'https://doi.org/10.1186/s12874-019-0829-2', 'journal-title': 'Med Res Methodology'}, { 'key': '3479_CR23', 'first-page': '285', 'volume': '3', 'author': 'G van Valkenhoef', 'year': '2012', 'unstructured': 'van Valkenhoef G, Lu G, de Brock B, Hillege H, Ades AE, Welton J (2012) ' 'Automating network meta-analysis. Res Synth. Methods 3:285–299', 'journal-title': 'Methods'}, { 'key': '3479_CR24', 'doi-asserted-by': 'publisher', 'first-page': '291', 'DOI': '10.1002/pds.1200', 'volume': '15', 'author': 'S Schneeweiss', 'year': '2006', 'unstructured': 'Schneeweiss S (2006) Sensitivity analysis and external adjustment for ' 'unmeasured confounders in epidemiologic database studies of ' 'therapeutics. Pharmacoepidemiol Drug Saf 15:291–303', 'journal-title': 'Pharmacoepidemiol Drug Saf'}, { 'key': '3479_CR25', 'doi-asserted-by': 'publisher', 'unstructured': 'Heine D (2021) The episensr package: basic sensitivity analysis of ' 'epidemiological results. https://doi.org/10.5281/zenodo.4554553, R ' 'package version 1.1.0. https://dhaine.github.io/episensr/', 'DOI': '10.5281/zenodo.4554553'}, { 'key': '3479_CR26', 'doi-asserted-by': 'publisher', 'first-page': '975', 'DOI': '10.1586/ern.09.53', 'volume': '9', 'author': 'BT Kuran', 'year': '2010', 'unstructured': 'Kuran BT, Greer TL, Trivedi MH (2010) Strategies to enhance the ' 'therapeutic efficacy of antidepressants: targeting residual symptoms. ' 'Expert Rev Neurother 9:975–984', 'journal-title': 'Expert Rev Neurother'}, { 'key': '3479_CR27', 'doi-asserted-by': 'publisher', 'first-page': '14', 'DOI': '10.1111/j.1600-0447.2005.00676.x', 'volume': '35', 'author': 'S Ros', 'year': '2005', 'unstructured': 'Ros S, Aguera L, de la Gandara J, Rojo JE, de Pedro JM (2005) ' 'Potentiation strategies for treatment-resistant depression. Acta ' 'Psyhciatr Scand Suppl 35:14–24', 'journal-title': 'Acta Psyhciatr Scand Suppl'}, { 'issue': 'Suppl. 22', 'key': '3479_CR28', 'first-page': '29', 'volume': '60', 'author': 'JC Ballenger', 'year': '1999', 'unstructured': 'Ballenger JC (1999) Clinical guidelines for establishing remission in ' 'patients with depression and anxiety. J Clin Psyciatry 60(Suppl. ' '22):29–34', 'journal-title': 'J Clin Psyciatry'}, { 'key': '3479_CR29', 'doi-asserted-by': 'publisher', 'unstructured': 'Hadley E, Rhea S, Jones K, Li L, Sotner M, Bobashev G (2022). Enhancing ' 'the prediction of hospitalization from a COVID-19 agent-based model: a ' 'Bayesian method for model parameter estimation. PloS ONE 17(3):e0264704. ' 'https://doi.org/10.1371/journal.pone.0264704', 'DOI': '10.1371/journal.pone.0264704'}, { 'key': '3479_CR30', 'doi-asserted-by': 'publisher', 'first-page': '311', 'DOI': '10.1186/s12879-022-07262-0', 'volume': '22', 'author': 'D Herrera-Esposito', 'year': '2022', 'unstructured': 'Herrera-Esposito D, de los Campos G, (2022) Age-specific rate of severe ' 'and critical SARS-CoV-2 infections estimated with multi-country ' 'seroprevalence studies. BMC Infect Dis 22:311. ' 'https://doi.org/10.1186/s12879-022-07262-0', 'journal-title': 'BMC Infect Dis'}, { 'key': '3479_CR31', 'unstructured': 'Croatia: Coronavirus Pandemic Country Profile - Our World in Data. ' 'Accessed 20 Sept\xa02022'}], 'container-title': 'European Journal of Clinical Pharmacology', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1007/s00228-023-03479-3.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1007/s00228-023-03479-3/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1007/s00228-023-03479-3.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2023, 3, 24]], 'date-time': '2023-03-24T09:03:23Z', 'timestamp': 1679648603000}, 'score': 1, 'resource': {'primary': {'URL': 'https://link.springer.com/10.1007/s00228-023-03479-3'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2023, 3, 24]]}, 'references-count': 31, 'alternative-id': ['3479'], 'URL': 'http://dx.doi.org/10.1007/s00228-023-03479-3', 'relation': {}, 'ISSN': ['0031-6970', '1432-1041'], 'subject': ['Pharmacology (medical)', 'Pharmacology', 'General Medicine'], 'container-title-short': 'Eur J Clin Pharmacol', 'published': {'date-parts': [[2023, 3, 24]]}, 'assertion': [ { 'value': '5 November 2022', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '14 March 2023', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '24 March 2023', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'This study used anonymized administrative data standardly collected on routine ' 'procedures, hence ethical approval was waived by the Ethics Committee of the ' 'Zagreb University School of Medicine and Croatian Institute for Public Healthy.', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval'}}, { 'value': 'The authors declare no competing interests.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}, { 'value': 'This content has been made available to all.', 'name': 'free', 'label': 'Free to read'}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit