Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU

Sharmin et al., NCT04558424, NCT04558424, Sep 2021

6th treatment shown to reduce risk in September 2020, now with p = 0.00000002 from 75 studies, recognized in 22 countries.

Lower risk for mortality, ICU, hospitalization, and recovery.

No treatment is 100% effective. Protocols combine treatments.

6,300+ studies for 210+ treatments. c19early.org

Download Meta Analysis

Estimated 50 patient vitamin C late treatment RCT with results not reported over 4 years after estimated completion.

6 vitamin C RCTs have results missing long after expected1-6
The trials report a total of 1,420 patients, with 3 trials having actual enrollment of 602, and the remainder estimated.

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Study covers vitamin C and zinc.

1. Liu et al., Clinical Efficacy of Megadose Vitamin C in Severe and Critical Ill COVID-19 Patients (CEMVISCC): A Multicenter, Randomized, Single-blind, Placebo-controlled Clinical Trial, NCT05694975, clinicaltrials.gov/study/NCT05694975clinicaltrials.gov.

2. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444clinicaltrials.gov.

3. Lamontagne et al., Lessening Organ Dysfunction With VITamin C - COVID, NCT04401150, clinicaltrials.gov/study/NCT04401150clinicaltrials.gov.

4. Galindo et al., High-dose Intravenous Vitamin C (HDIVC) as Adjuvant Therapy in Critical Patients With Positive COVID-19. A Pilot Randomized Controlled Dose-comparison Trial., NCT05029037, clinicaltrials.gov/study/NCT05029037clinicaltrials.gov.

5. Sharmin et al., Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU, NCT04558424, clinicaltrials.gov/study/NCT04558424clinicaltrials.gov.

6. He et al., Efficacy and Safety of High-dose Vitamin C Combined With Traditional Chinese Medicine in the Treatment of Moderate and Severe Coronavirus Pneumonia (COVID-19), NCT04664010, clinicaltrials.gov/study/NCT04664010clinicaltrials.gov.

Sharmin et al., 1 Sep 2021, Double Blind Randomized Controlled Trial, placebo-controlled, Bangladesh, trial NCT04558424 (history). Contact: elora.sharmin@bsmmu.edu.bd.

Late treatment
is less effective