Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study

Boukef et al., NCT05670444, NCT05670444, Feb 2023

Vitamin C for COVID-19

6th treatment shown to reduce risk in September 2020, now with p = 0.000000069 from 72 studies, recognized in 22 countries.
Lower risk for mortality, ICU, hospitalization, and recovery.

No treatment is 100% effective.
Protocols combine treatments.

150 patient vitamin C early treatment RCT with results not reported over 3 years after completion.
6 vitamin C RCTs have results missing long after expected1-6
The trials report a total of 1,420 patients, with 3 trials having actual enrollment of 602, and the remainder estimated.
Study covers melatonin, vitamin C, vitamin D, and zinc.
Boukef et al., 28 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, trial NCT05670444 (history).