Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study

Boukef et al., NCT05670444, NCT05670444, Feb 2023

Melatonin for COVID-19

11th treatment shown to reduce risk in December 2020, now with p = 0.000000011 from 20 studies.

Lower risk for mortality, ventilation, and recovery.

No treatment is 100% effective. Protocols combine treatments.

6,200+ studies for 200+ treatments. c19early.org

Download Meta Analysis

150 patient melatonin early treatment RCT with results not reported over 2 years after completion.

3 melatonin RCTs have results missing long after expected1-3
The trials report a total of 268 patients, with 2 trials having actual enrollment of 168, and the other estimated.

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Study covers melatonin, vitamin C, vitamin D, and zinc.

1. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444clinicaltrials.gov.

2. Piovezan et al., Adjuvant Therapeutic Effects of Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19, NCT04470297, clinicaltrials.gov/study/NCT04470297clinicaltrials.gov.

3. Rodríguez-Rubio et al., A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial, Trials, doi:10.1186/s13063-020-04632-4.biomedcentral.com, doi.org.

Boukef et al., 28 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, trial NCT05670444 (history).