Melatonin for COVID-19
No treatment is 100% effective.
Protocols combine treatments.
150 patient melatonin early treatment RCT with results not reported over 3 years after completion.
1.
Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444.
2.
Piovezan et al., Adjuvant Therapeutic Effects of Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19, NCT04470297, clinicaltrials.gov/study/NCT04470297.
3.
Rodríguez-Rubio et al., A phase II, single-center, double-blind, randomized placebo-controlled trial to explore the efficacy and safety of intravenous melatonin in patients with COVID-19 admitted to the intensive care unit (MelCOVID study): a structured summary of a study protocol for a randomized controlled trial, Trials, doi:10.1186/s13063-020-04632-4.
Boukef et al., 28 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, trial NCT05670444 (history).