Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study

Boukef et al., NCT05670444, NCT05670444, Feb 2023

Zinc for COVID-19

2nd treatment shown to reduce risk in July 2020, now with p = 0.00000028 from 47 studies, recognized in 23 countries.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,300+ studies for 210+ treatments. c19early.org

Meta Analysis

150 patient zinc early treatment RCT with results not reported over 2 years after completion.

4 zinc RCTs have results missing long after expected1-4
The trials report a total of 900 patients, with 1 trial having actual enrollment of 150, and the remainder estimated.

Important missing comments or errors? Let us know.

Study covers melatonin, vitamin C, vitamin D, and zinc.

1. Avella et al., A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ (Liposomal Bovine Lactoferrin (LbLf) and Liposomal Zn (LZn)) and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19, NCT05783180, clinicaltrials.gov/study/NCT05783180clinicaltrials.gov.

2. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444clinicaltrials.gov.

3. Sharmin et al., Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU, NCT04558424, clinicaltrials.gov/study/NCT04558424clinicaltrials.gov.

4. Ajili et al., A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers (COVID-Milit), NCT04377646, clinicaltrials.gov/study/NCT04377646clinicaltrials.gov.

Boukef et al., 28 Feb 2023, Double Blind Randomized Controlled Trial, placebo-controlled, Tunisia, trial NCT05670444 (history).