A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ (Liposomal Bovine Lactoferrin (LbLf) and Liposomal Zn (LZn)) and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19

Avella et al., NCT05783180, NCT05783180, Nov 2024

Zinc for COVID-19

2nd treatment shown to reduce risk in July 2020, now with p = 0.00000028 from 47 studies, recognized in 23 countries.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

6,300+ studies for 210+ treatments. c19early.org

Download Meta Analysis

Estimated 40 patient zinc early treatment RCT with results not reported over 1 year after estimated completion.

4 zinc RCTs have results missing long after expected1-4
The trials report a total of 900 patients, with 1 trial having actual enrollment of 150, and the remainder estimated.

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Study covers lactoferrin and zinc.

1. Avella et al., A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ (Liposomal Bovine Lactoferrin (LbLf) and Liposomal Zn (LZn)) and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19, NCT05783180, clinicaltrials.gov/study/NCT05783180clinicaltrials.gov.

2. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444clinicaltrials.gov.

3. Sharmin et al., Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU, NCT04558424, clinicaltrials.gov/study/NCT04558424clinicaltrials.gov.

4. Ajili et al., A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers (COVID-Milit), NCT04377646, clinicaltrials.gov/study/NCT04377646clinicaltrials.gov.

Avella et al., 1 Nov 2024, Double Blind Randomized Controlled Trial, placebo-controlled, USA, trial NCT05783180 (history). Contact: maria.bertoli@keraltyhospital.com, gmasferrer@keraltyhospital.com.