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A Randomized, Double-Blinded, Placebo-Controlled, Phase 2 Study to Evaluate the Safety and Efficacy of Sesderma LACTYFERRIN™ Forte and Sesderma ZINC Defense™ (Liposomal Bovine Lactoferrin (LbLf) and Liposomal Zn (LZn)) and Standard of Care (SOC) vs SOC in the Treatment of Non-hospitalized Patients With COVID-19

Avella et al., NCT05783180, NCT05783180

Nov 2024

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Zinc for COVID-19

2nd treatment shown to reduce risk in July 2020, now with p = 0.00000032 from 46 studies, recognized in 17 countries.

Lower risk for mortality, ventilation, hospitalization, progression, recovery, and viral clearance.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

Estimated 40 patient zinc early treatment RCT with results expected soon (estimated completion over 1 month ago).

5 zinc RCTs have results missing long after expected1-5
The trials report a total of 1,040 patients, with 3 trials having actual enrollment of 330, and the remainder estimated.

Important missing comments or errors? Let us know.

Study covers lactoferrin and zinc.

1. Boukef et al., Melatonin, Vitamins and Minerals Supplements for the Treatment of Covid-19 and Covid-like Illness: Results of a Prospective, Randomised, Double-blinded Multicentre Study, NCT05670444, clinicaltrials.gov/study/NCT05670444.clinicaltrials.gov.

2. Güerri-Fernández et al., Zinc-based Nutritional Immunity to Lower Inflammation, Viral Load and COVID-19 Mortality During SARS-CoV-2 Infection., NCT05778383, clinicaltrials.gov/study/NCT05778383.clinicaltrials.gov.

3. Correa et al., Evaluation of SARS-COV-2 Viral Load of Covid-19 Patients After Rinsing With Oral Antimicrobial Mouthwashes, NCT04902976, clinicaltrials.gov/study/NCT04902976.clinicaltrials.gov.

4. Sharmin et al., Randomized, Double -Blind, Placebo Controlled, Trial to Evaluate the Effect of Zinc and Ascorbic Acid Supplementation in COVID-19 Positive Hospitalized Patients in BSMMU, NCT04558424, clinicaltrials.gov/study/NCT04558424.clinicaltrials.gov.

5. Ajili et al., A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers (COVID-Milit), NCT04377646, clinicaltrials.gov/study/NCT04377646.clinicaltrials.gov.

Avella et al., 1 Nov 2024, Double Blind Randomized Controlled Trial, placebo-controlled, USA, trial NCT05783180 (history). Contact: maria.bertoli@keraltyhospital.com, gmasferrer@keraltyhospital.com.

This Paper Zinc All

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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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