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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Progression 79% Improvement Relative Risk Hospitalization time 13% Regdanvimab for COVID-19  Park et al.  EARLY TREATMENT Is early treatment with regdanvimab beneficial for COVID-19? PSM retrospective 754 patients in South Korea (Dec 2020 - Apr 2021) Lower progression (p<0.0001) and shorter hospitalization (p<0.0001) c19early.org Park et al., J. Korean Medical Science, Mar 2022 Favors regdanvimab Favors control

Effectiveness and Safety of Regdanvimab in Patients With Mild-To-Moderate COVID-19: A Retrospective Cohort Study

Park et al., Journal of Korean Medical Science, doi:10.3346/jkms.2022.37.e102
Mar 2022  
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35th treatment shown to reduce risk in March 2022
 
*, now known with p = 0.0000009 from 7 studies, recognized in 27 countries. Efficacy is variant dependent.
Lower risk for hospitalization, progression, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments. c19early.org
Retrospective propensity score matched analysis of 970 high-risk mild-moderate COVID-19 patients in South Korea, showing regdanvimab significantly reduced risk of disease progression or death by 77% compared to standard care alone. No deaths occurred in either group. Regdanvimab also significantly shortened hospital stay and reduced hematological adverse events.
Confounding by treatment propensity. This study analyzes a population where only a fraction of eligible patients received the treatment. Patients receiving treatment may be more likely to follow other recommendations, more likely to receive additional care, and more likely to use additional treatments that are not tracked in the data (e.g., nasal/oral hygiene c19early.org, c19early.org (B), vitamin D c19early.org (C), etc.) — either because the physician recommending regdanvimab also recommended them, or because the patient seeking out regdanvimab is more likely to be familiar with the efficacy of additional treatments and more likely to take the time to use them. Therefore, these kind of studies may overestimate the efficacy of treatments.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2, BA.4, BA.5 Haars, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.1 Pochtovyi.
risk of progression, 79.4% lower, RR 0.21, p < 0.001, treatment 19 of 377 (5.0%), control 81 of 377 (21.5%), NNT 6.1, adjusted per study, odds ratio converted to relative risk, disease aggravation or death, propensity score matching, multivariable.
hospitalization time, 13.1% lower, relative time 0.87, p < 0.001, treatment mean 11.9 (±3.3) n=377, control mean 13.7 (±5.4) n=377, propensity score matching.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Park et al., 29 Mar 2022, retrospective, South Korea, peer-reviewed, 5 authors, study period 1 December, 2020 - 16 April, 2021. Contact: mdhuh@hanmail.net.
This PaperRegdanvimabAll
Effectiveness and Safety of Regdanvimab in Patients With Mild-To-Moderate COVID-19: A Retrospective Cohort Study
Susin Park, Nam Kyung Je, Dong Wan Kim, Miran Park, MD Jeonghun Heo
Journal of Korean Medical Science, doi:10.3346/jkms.2022.37.e102
Background: Regdanvimab has decreased the time to clinical recovery from coronavirus disease 2019 (COVID-19) and lowered the rate of oxygen therapy according to the results from phase 2/3 randomized controlled trial. More information is needed about the effects and safety of regdanvimab. Methods: We analyzed data for patients with high-risk mild or moderate COVID-19 being admitted to Busan Medical Center between December 1, 2020 and April 16, 2021. A propensity score (PS) matched analysis was conducted to compare patients treated with and without regdanvimab. The primary outcome was in-hospital death or disease aggravation which means the need for oxygen therapy (low-or high-flow oxygen therapy and mechanical ventilation) and secondary outcomes comprised the length of hospital stay and adverse reactions. Results: Among 1,617 selected patients, 970 (60.0%) were indicated for regdanvimab. Of these, 377 (38.9%) were administered with regdanvimab. Among a 1:1 PS-matched cohort of 377 patients each treated with and without regdanvimab, 19 (5%) and 81 (21.5%) reached the composite outcome of death, or disease aggravation, respectively (absolute risk difference, -16.4%; 95% confidence interval [CI], -21.1, -11.7; relative risk difference, 76.5%; P < 0.001). Regdanvimab significantly reduced the composite outcome of death, or disease aggravation in univariate (odds ratio [OR], 0.194; 95% CI, 0.112-0.320; P < 0.001) and multivariableadjusted analyses (OR, 0.169; 95% CI, 0.095-0.289; P < 0.001). The hospital stay was shorter for the group with than without regdanvimab. Some hematological adverse reactions were more frequent in the group without regdanvimab, but other adverse reactions did not significantly differ between the groups. Conclusion: Regdanvimab was associated with a significantly lower risk of disease aggravation without increasing adverse reactions.
SUPPLEMENTARY MATERIALS Supplementary Table 1 Missing baseline laboratory data in propensity score-matched cohort Click here to view Supplementary Table 2 Associations between regdanvimab and primary endpoint in PS-matched and overall cohorts Click here to view Supplementary Table 3 Clinical outcomes in overall cohort Click here to view Supplementary Fig. 1 Distribution of covariates before and after propensity matching study patients who were and were not treated with regdanvimab. Click here to view Supplementary Fig. 2 Standardized mean differences in unadjusted and adjusted cohorts. Click here to view
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