Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment
Maria Luisa Navacchia, Caterina Cinti, Elena Marchesi, Daniela Perrone
Molecules, doi:10.3390/molecules29225403
The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral anti-SARS-CoV-2 activity.
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'link': [ { 'URL': 'https://www.mdpi.com/1420-3049/29/22/5403/pdf',
'content-type': 'unspecified',
'content-version': 'vor',
'intended-application': 'similarity-checking'}],
'deposited': { 'date-parts': [[2024, 11, 19]],
'date-time': '2024-11-19T12:54:11Z',
'timestamp': 1732020851000},
'score': 1,
'resource': {'primary': {'URL': 'https://www.mdpi.com/1420-3049/29/22/5403'}},
'subtitle': [],
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'issued': {'date-parts': [[2024, 11, 15]]},
'references-count': 118,
'journal-issue': {'issue': '22', 'published-online': {'date-parts': [[2024, 11]]}},
'alternative-id': ['molecules29225403'],
'URL': 'http://dx.doi.org/10.3390/molecules29225403',
'relation': {},
'ISSN': ['1420-3049'],
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'container-title-short': 'Molecules',
'published': {'date-parts': [[2024, 11, 15]]}}