Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment
Maria Luisa Navacchia, Caterina Cinti, Elena Marchesi, Daniela Perrone
Molecules, doi:10.3390/molecules29225403
The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral anti-SARS-CoV-2 activity.
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'journal-issue': {'issue': '22', 'published-online': {'date-parts': [[2024, 11]]}},
'alternative-id': ['molecules29225403'],
'URL': 'http://dx.doi.org/10.3390/molecules29225403',
'relation': {},
'ISSN': ['1420-3049'],
'subject': [],
'container-title-short': 'Molecules',
'published': {'date-parts': [[2024, 11, 15]]}}
