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0 0.5 1 1.5 2+ Mortality 41% Improvement Relative Risk Ventilation -16% ICU admission 3% Hospitalization -4% c19early.org/mf Morrison et al. Metformin for COVID-19 Prophylaxis Favors metformin Favors control
COVID-19 outcomes in patients taking cardioprotective medications
Morrison et al., PLOS ONE, doi:10.1371/journal.pone.0275787
10 Oct 2022    Source   PDF   Share   Tweet
Retrospective 13,585 COVID+ patients in the USA, showing lower mortality with metformin use, but no significant difference for ventilation, ICU admission, and hospitalization.
risk of death, 41.1% lower, OR 0.59, p = 0.003, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of mechanical ventilation, 15.7% higher, OR 1.16, p = 0.49, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of ICU admission, 2.8% lower, OR 0.97, p = 0.85, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of hospitalization, 3.9% higher, OR 1.04, p = 0.72, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Morrison et al., 10 Oct 2022, retrospective, USA, peer-reviewed, mean age 62.5, 3 authors, study period March 2020 - March 2021.
Contact: aturchin@bwh.harvard.edu, irb@partners.org.
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