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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 41% Improvement Relative Risk Ventilation -16% ICU admission 3% Hospitalization -4% Metformin for COVID-19  Morrison et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? PSM retrospective 13,585 patients in the USA (Mar 2020 - Mar 2021) Lower mortality with metformin (p=0.0032) c19early.org Morrison et al., PLOS ONE, October 2022 Favors metformin Favors control

COVID-19 outcomes in patients taking cardioprotective medications

Morrison et al., PLOS ONE, doi:10.1371/journal.pone.0275787
Oct 2022  
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Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
 
*, now known with p < 0.00000000001 from 88 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments. c19early.org
Retrospective 13,585 COVID+ patients in the USA, showing lower mortality with metformin use, but no significant difference for ventilation, ICU admission, and hospitalization.
Study covers aspirin and metformin.
risk of death, 41.1% lower, OR 0.59, p = 0.003, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of mechanical ventilation, 15.7% higher, OR 1.16, p = 0.49, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of ICU admission, 2.8% lower, OR 0.97, p = 0.85, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
risk of hospitalization, 3.9% higher, OR 1.04, p = 0.72, treatment 2,684, control 2,684, propensity score matching, RR approximated with OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Morrison et al., 10 Oct 2022, retrospective, USA, peer-reviewed, mean age 62.5, 3 authors, study period March 2020 - March 2021. Contact: aturchin@bwh.harvard.edu, irb@partners.org.
This PaperMetforminAll
COVID-19 outcomes in patients taking cardioprotective medications
Fritha J Morrison, Maxwell Su, Alexander Turchin
PLOS ONE, doi:10.1371/journal.pone.0275787
Introduction The coronavirus disease 2019 (COVID-19) caused a worldwide pandemic and has led to over five million deaths. Many cardiovascular risk factors (e.g. obesity or diabetes) are associated with an increased risk of adverse outcomes in COVID-19. On the other hand, it has been suggested that medications used to treat cardiometabolic conditions may have protective effects for patients with COVID-19. Objectives To determine whether patients taking four classes of cardioprotective medications-aspirin, metformin, renin angiotensin aldosterone system inhibitors (RAASi) and statins-have a lower risk of adverse outcomes of COVID-19. Methods We conducted a retrospective cohort study of primary care patients at a large integrated healthcare delivery system who had a positive COVID-19 test between March 2020 and March 2021. We compared outcomes of patients who were taking one of the study medications at the time of the COVID-19 test to patients who took a medication from the same class in the past (to minimize bias by indication). The following outcomes were compared: a) hospitalization; b) ICU admission; c) intubation; and d) death. Multivariable analysis was used to adjust for patient demographics and comorbidities. Results Among 13,585 study patients, 1,970 (14.5%) were hospitalized; 763 (5.6%) were admitted to an ICU; 373 (2.8%) were intubated and 720 (5.3%) died. In bivariate analyses, patients taking metformin, RAASi and statins had lower risk of hospitalization, ICU admission and death. However, in multivariable analysis, only the lower risk of death remained statistically significant. Patients taking aspirin had a significantly higher risk of hospitalization in both bivariate and multivariable analyses.
Author Contributions Conceptualization: Alexander Turchin.
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