Characteristics and outcomes of COVID-19 patients with COPD from the United States, South Korea, and Europe

{ 'indexed': {'date-parts': [[2023, 1, 14]], 'date-time': '2023-01-14T06:11:25Z', 'timestamp': 1673676685679}, 'update-to': [ { 'updated': { 'date-parts': [[2023, 1, 10]], 'date-time': '2023-01-10T00:00:00Z', 'timestamp': 1673308800000}, 'DOI': '10.12688/wellcomeopenres.17403.1', 'type': 'new_version', 'label': 'New version'}, { 'updated': { 'date-parts': [[2023, 1, 10]], 'date-time': '2023-01-10T00:00:00Z', 'timestamp': 1673308800000}, 'DOI': '10.12688/wellcomeopenres.17403.2', 'type': 'new_version', 'label': 'New version'}], 'reference-count': 28, 'publisher': 'F1000 Research Ltd', 'license': [ { 'start': { 'date-parts': [[2023, 1, 10]], 'date-time': '2023-01-10T00:00:00Z', 'timestamp': 1673308800000}, 'content-version': 'tdm', 'delay-in-days': 0, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'DOI': '10.13039/100010269', 'name': 'Wellcome Trust', 'doi-asserted-by': 'crossref', 'award': ['214588']}], 'content-domain': {'domain': ['wellcomeopenresearch.org'], 'crossmark-restriction': False}, 'abstract': '<ns3:p><ns3:bold>Background</ns3:bold>: Characterization studies of COVID-19 patients with ' 'chronic obstructive pulmonary disease (COPD) are limited in size and scope. The aim of the ' 'study is to provide a large-scale characterization of COVID-19 patients with ' 'COPD.</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: We included thirteen databases ' 'contributing data from January-June 2020 from North America (US), Europe and Asia. We defined ' 'two cohorts of patients with COVID-19 namely a ‘diagnosed’ and ‘hospitalized’ cohort. We ' 'followed patients from COVID-19 index date to 30 days or death. We performed descriptive ' 'analysis and reported the frequency of characteristics and outcomes among COPD patients with ' 'COVID-19.</ns3:p><ns3:p> <ns3:bold>Results</ns3:bold>: The study included 934,778 patients in ' 'the diagnosed COVID-19 cohort and 177,201 in the hospitalized COVID-19 cohort. Observed COPD ' 'prevalence in the diagnosed cohort ranged from 3.8% (95%CI 3.5-4.1%) in French data to 22.7% ' '(95%CI 22.4-23.0) in US data, and from 1.9% (95%CI 1.6-2.2) in South Korean to 44.0% (95%CI ' '43.1-45.0) in US data, in the hospitalized cohorts. COPD patients in the hospitalized cohort ' 'had greater comorbidity than those in the diagnosed cohort, including hypertension, heart ' 'disease, diabetes and obesity. Mortality was higher in COPD patients in the hospitalized ' 'cohort and ranged from 7.6% (95%CI 6.9-8.4) to 32.2% (95%CI 28.0-36.7) across databases. ' 'ARDS, acute renal failure, cardiac arrhythmia and sepsis were the most common outcomes among ' 'hospitalized COPD patients. \xa0</ns3:p><ns3:p> <ns3:bold>Conclusion</ns3:bold>: COPD ' 'patients with COVID-19 have high levels of COVID-19-associated comorbidities and poor ' 'COVID-19 outcomes. Further research is required to identify patients with COPD at high risk ' 'of worse outcomes.</ns3:p>', 'DOI': '10.12688/wellcomeopenres.17403.3', 'type': 'journal-article', 'created': {'date-parts': [[2023, 1, 10]], 'date-time': '2023-01-10T21:20:09Z', 'timestamp': 1673385609000}, 'page': '22', 'update-policy': 'http://dx.doi.org/10.12688/wellcomeopenres.crossmark-policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Characteristics and outcomes of COVID-19 patients with COPD from the United States, South Korea, ' 'and Europe', 'prefix': '10.12688', 'volume': '7', 'author': [ { 'ORCID': 'http://orcid.org/0000-0002-8652-6235', 'authenticated-orcid': False, 'given': 'David', 'family': 'Moreno-Martos', 'sequence': 'first', 'affiliation': []}, {'given': 'Katia', 'family': 'Verhamme', 'sequence': 'additional', 'affiliation': []}, { 'ORCID': 'http://orcid.org/0000-0002-0847-6682', 'authenticated-orcid': False, 'given': 'Anna', 'family': 'Ostropolets', 'sequence': 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Kisiel, Department of Medical ' 'Sciences, Environmental and Occupational Medicine, Uppsala University, Uppsala, ' 'Sweden, 31 Mar 2022, version 2, 1 approved, 1 approved with reservations', 'URL': 'https://wellcomeopenresearch.org/articles/7-22/v2#referee-response-49458', 'order': 0, 'name': 'referee-response-49458', 'label': 'Referee Report', 'group': {'name': 'article-reports', 'label': 'Article Reports'}}, { 'value': '10.21956/wellcomeopenres.20813.r54044, Laurie Tomlinson, Department of ' 'Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical ' 'Medicine, London, UK, 13 Jan 2023, version 3, indexed', 'URL': 'https://wellcomeopenresearch.org/articles/7-22/v3#referee-response-54044', 'order': 1, 'name': 'referee-response-54044', 'label': 'Referee Report', 'group': {'name': 'article-reports', 'label': 'Article Reports'}}, { 'value': 'The European Health Data & Evidence Network has received funding from the ' 'Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement ' 'No 806968. The JU receives support from the European Union’s Horizon 2020 ' 'research and innovation programme and EFPIA; This research received partial ' 'support from the National Institute for Health Research (NIHR) Oxford ' 'Biomedical Research Centre (BRC), US National Institutes of Health, US ' 'Department of Veterans Affairs, Janssen Research & Development, and IQVIA; The ' 'University of Oxford received funding related to this work from the Bill & ' 'Melinda Gates Foundation (Investment ID INV-016201 and INV-019257); IDIAPJGol ' 'received funding from the Health Department from the Generalitat de Catalunya ' 'with a grant for research projects on SARS-CoV-2 and COVID-19 disease organized ' 'by the Direcció General de Recerca i Innovació en Salut; DPA receives funding ' 'from NIHR Academy in the form of an NIHR Senior Research Fellowship. The views ' 'and opinions expressed are those of the authors and do not necessarily reflect ' 'those of the Clinician Scientist Award programme, NIHR, United States ' 'Department of Veterans Affairs or the United States Government, NHS, or the ' 'Department of Health, England; DRM is supported by a Wellcome Trust Clinical ' 'Research Development Fellowship (Grant 214588/Z/18/Z, <a ' 'href=https://doi.org/10.35802/214588>https://doi.org/10.35802/214588</a>); and ' 'DMM is funded by Health Data Research-UK. The funders had no role in study ' 'design, data collection and analysis, decision to publish, or preparation of ' 'the manuscript.', 'order': 2, 'name': 'grant-information', 'label': 'Grant Information'}, { 'value': 'This is an open access article distributed under the terms of the Creative ' 'Commons Attribution Licence, which permits unrestricted use, distribution, and ' 'reproduction in any medium, provided the original work is properly cited.', 'order': 0, 'name': 'copyright-info', 'label': 'Copyright'}]}