Abstract: Wellcome Open Research 2023, 7:22 Last updated: 10 MAR 2023 RESEARCH ARTICLE Characteristics and outcomes of COVID-19 patients with COPD from the United States, South Korea, and Europe [version 3; peer review: 2 approved] David Moreno-Martos 1, Katia Verhamme2, Anna Ostropolets 3, Kristin Kostka4,5, Talita Duarte-Sales6, Daniel Prieto-Alhambra7, Thamir M Alshammari8, Heba Alghoul 9, Waheed-Ul-Rahman Ahmed7,10, Clair Blacketer2,11, Scott DuVall12, Lana Lai13, Michael Matheny14,15, Fredrik Nyberg 16, Jose Posada 17, Peter Rijnbeek2, Matthew Spotnitz 3, Anthony Sena2,11, Nigam Shah17, Marc Suchard 18,19, Seng Chan You 20, George Hripcsak3, Patrick Ryan3,11, Daniel Morales 1,21 1Population Health and Genomics, University of Dundee, Dundee, UK 2Medical Informatics, Erasmus MC, Rotterdam, The Netherlands 3Biomedical Informatics, Columbia University Medical Center, New York, USA 4Real World Solutions, IQVIA, Cambridge, MA, USA 5OHDSI Center at The Roux Institute, Northeastern University, Portland, ME, USA 6Fundació Institut Universitari per a la recerca a l’Atenció Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), IDIAPJGol, Barcelona, Spain 7Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK 8College of Pharmacy, Riyadh Elm University, Riyadh, Saudi Arabia 9Faculty of Medicine, Islamic University of Gaza, Gaza, Palestinian Territory 10College of Medicine and Health, University of Exeter, Exeter, UK 11Janssen Research and Development, Janssen Research and Development, Titusville, NJ, USA 12VA Informatics and Computing Infrastructure, University of Utah, Salt Lake City, UT, USA 13Department of Medical Sciences, University of Manchester, Manchester, UK 14Geriatrics Research Education and Clinical Care Service & VINCI, Tennessee Valley Healthcare System VA, nashville, TN, USA 15Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA 16School of Public Health and Community Medicine, University of Gothenburg, Gothenburg, Sweden 17Department of Medicine, Stanford University, Redwood City, CA, USA 18Department of Biostatistics UCLA Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, USA 19Department of Computational Medicine David Geffen School of Medicine at UCLA,, University of California, Los Angeles, Los Angeles, CA, USA 20Department of Preventive Medicine, Yonsei University, Seoul, South Korea 21Department of Public Health, University of Southern Denmark, Odense, Denmark v3 First published: 24 Jan 2022, 7:22 https://doi.org/10.12688/wellcomeopenres.17403.1 Second version: 24 Mar 2022, 7:22 https://doi.org/10.12688/wellcomeopenres.17403.2 Open Peer Review Approval Status Latest published: 10 Jan 2023, 7:22 https://doi.org/10.12688/wellcomeopenres.17403.3 1 2 version 3 Abstract Background: Characterization studies of COVID-19 patients with view Page 1 of 25 Wellcome Open Research 2023, 7:22 Last updated: 10 MAR 2023 chronic obstructive pulmonary disease (COPD) are limited in size and scope. The aim of the study is to provide a large-scale characterization of COVID-19 patients with COPD. Methods: We included thirteen databases contributing data from January-June 2020 from North America (US), Europe and Asia. We defined two cohorts of patients with COVID-19 namely a ‘diagnosed’ and ‘hospitalized’ cohort. We followed patients from COVID-19 index date to 30 days or death. We performed..