Early pandemic associations of latitude, sunshine duration, and vitamin D status with COVID-19 incidence and fatalities: A global analysis of 187 Countries
Reagan M Mogire
PLOS Global Public Health, doi:10.1371/journal.pgph.0004074
In the face of the COVID-19 pandemic, understanding the interplay between environmental factors and virus spread is crucial for global preparedness strategies. This study explores how geographic latitude, sunshine duration, and vitamin D status were associated with the incidence and fatality rates of COVID-19 across 187 countries during the crucial early months of the outbreak. Data on the total number of COVID-19 cases by country were obtained from the COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) as of June 30, 2020. Univariate and multivariate regression analyses were conducted to determine the associations between COVID-19 cases and latitude, average hours of sunshine from January to June, and mean 25-hydroxyvitamin D (25(OH)D) levels. The average COVID-19 cumulative incidence and mortality per million population were 2,087 and 69, respectively, with a case fatality rate of 3.19%. COVID-19 case fatality rate was positively associated with latitude (β = 0.030; 95% CI: 0.008, 0.052) and negatively associated with hours of sunshine (β = -1.51; 95% CI: -4.44, 1.41) and 25(OH) D levels (β = -0.054; 95% CI: -0.089, -0.019) in adjusted linear regression analyses. Findings were similar for COVID-19 cumulative incidence and mortality rate. These findings indicate that higher latitude and lower 25(OH)D levels were associated with increased COVID-19 severity and mortality. While the data highlight potential links between vitamin D status and COVID-19 outcomes, causality cannot be inferred.
References
Asyary, Veruswati, Sunlight exposure increased Covid-19 recovery rates: A study in the central pandemic area of Indonesia, Sci Total Environ,
doi:10.1016/j.scitotenv.2020.139016Benedetti, Pachetti, Marini, Ippodrino, Gallo et al., Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas, J Transl Med,
doi:10.1186/s12967-020-02418-5Castillo, Costa, Barrios, Díaz, Miranda et al., Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, The Journal of Steroid Biochemistry and Molecular Biology
D'avolio, Avataneo, Manca, Cusato, Nicolò et al., 25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2, Nutrients,
doi:10.3390/nu12051359Daneshkhah, Eshein, Subramanian, Roy, Backman, The role of vitamin D in suppressing cytokine storm in COVID-19 patients and associated mortality, MedRxiv
England, Disparities in the risk and outcomes of COVID-19
Fauci, Lane, Redfield, Covid-19-navigating the uncharted, N Engl J Med
Grant, Lahore, Mcdonnell, Baggerly, French et al., Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths, Nutrients,
doi:10.3390/nu12040988Hariyanto, Intan, Hananto, Harapan, Kurniawan, Vitamin D supplementation and Covid-19 outcomes: a systematic review, metaanalysis and meta-regression
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res,
doi:10.1007/s40520-020-01570-8Jolliffe, Holt, Greenig, Talaei, Perdek et al., Effect of a test-and-treat approach to vitamin D supplementation on risk of all cause acute respiratory tract infection and covid-19: phase 3 randomised controlled trial (CORONAVIT), BMJ
Jordan, Adab, Cheng, Covid-19: risk factors for severe disease and death, BMJ
Jääskeläinen, Itkonen, Lundqvist, Erkkola, Koskela et al., The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data, Am J Clin Nutr,
doi:10.3945/ajcn.116.151415Kontis, Bennett, Rashid, Parks, Pearson-Stuttard et al., Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in 21 industrialized countries, Nat Med,
doi:10.1038/s41591-020-1112-0Laird, Rhodes, Kenny, Vitamin D and Inflammation: Potential Implications for Severity of Covid-19, Ir Med J
Lips, Cashman, Lamberg-Allardt, Bischoff-Ferrari, Obermayer-Pietsch et al., Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society, Eur J Endocrinol,
doi:10.1530/EJE-18-0736Martineau, Jolliffe, Hooper, Greenberg, Aloia et al., Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D deficiency and treatment with COVID-19 incidence, MedRxiv
Munshi, Hussein, Toraih, Elshazli, Jardak et al., Vitamin D insufficiency as a potential culprit in critical COVID-19 patients, J Med Virol,
doi:10.1002/jmv.26360Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial, JAMA,
doi:10.1001/jama.2020.26848Organization, WHO Coronavirus (COVID-19) Dashboard
Rhodes, Subramanian, Laird, Kenny, Editorial: low population mortality from COVID-19 in countries south of latitude 35 degrees North supports vitamin D as a factor determining severity, Aliment Pharmacol Ther,
doi:10.1111/apt.15777Sajadi, Habibzadeh, Vintzileos, Shokouhi, Miralles-Wilhelm et al., Temperature, Humidity, and Latitude Analysis to Estimate Potential Spread and Seasonality of Coronavirus Disease 2019 (COVID-19), JAMA Netw Open,
doi:10.1001/jamanetworkopen.2020.11834Sattar, Ho, Gill, Ghouri, Gray et al., BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank, Diabetes Metab Syndr,
doi:10.1016/j.dsx.2020.06.060Siuka, Pfeifer, Pinter, Vitamin D supplementation during the COVID-19 pandemic
Ssentongo, Ssentongo, Heilbrunn, Ba, Chinchilli, Association of cardiovascular disease and 10 other pre-existing comorbidities with COVID-19 mortality: A systematic review and meta-analysis, PLoS One,
doi:10.1371/journal.pone.0238215Whittemore, COVID-19 fatalities, latitude, sunlight, and vitamin D, American Journal of Infection Control
Woolhouse, Scott, Hudson, Howey, Chase-Topping, Human viruses: discovery and emergence, Philos Trans R Soc Lond B Biol Sci,
doi:10.1098/rstb.2011.0354Wösten-Van Asperen, Lutter, Specht, Moll, Van Woensel et al., Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist, J Pathol,
doi:10.1002/path.2987Žmitek, Hribar, Lavriša, Hristov, Kušar et al., Socio-Demographic and Knowledge-Related Determinants of Vitamin D Supplementation in the Context of the COVID-19 Pandemic: Assessment of an Educational Intervention, Front Nutr,
doi:10.3389/fnut.2021.648450DOI record:
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"abstract": "<jats:p>In the face of the COVID-19 pandemic, understanding the interplay between environmental factors and virus spread is crucial for global preparedness strategies. This study explores how geographic latitude, sunshine duration, and vitamin D status were associated with the incidence and fatality rates of COVID-19 across 187 countries during the crucial early months of the outbreak. Data on the total number of COVID-19 cases by country were obtained from the COVID-19 Data Repository by the Center for Systems Science and Engineering (CSSE) as of June 30, 2020. Univariate and multivariate regression analyses were conducted to determine the associations between COVID-19 cases and latitude, average hours of sunshine from January to June, and mean 25-hydroxyvitamin D (25(OH)D) levels. The average COVID-19 cumulative incidence and mortality per million population were 2,087 and 69, respectively, with a case fatality rate of 3.19%. COVID-19 case fatality rate was positively associated with latitude (β = 0.030; 95% CI: 0.008, 0.052) and negatively associated with hours of sunshine (β = -1.51; 95% CI: -4.44, 1.41) and 25(OH)D levels (β = -0.054; 95% CI: -0.089, -0.019) in adjusted linear regression analyses. Findings were similar for COVID-19 cumulative incidence and mortality rate. These findings indicate that higher latitude and lower 25(OH)D levels were associated with increased COVID-19 severity and mortality. While the data highlight potential links between vitamin D status and COVID-19 outcomes, causality cannot be inferred.</jats:p>",
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"article-title": "Africa’s low COVID-19 mortality rate: A paradox?",
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"author": "AR Martineau",
"journal-title": "BMJ",
"key": "pgph.0004074.ref016",
"volume": "356",
"year": "2017"
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{
"article-title": "The role of vitamin D in suppressing cytokine storm in COVID-19 patients and associated mortality",
"author": "A Daneshkhah",
"journal-title": "MedRxiv",
"key": "pgph.0004074.ref017",
"year": "2020"
},
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"DOI": "10.1016/j.mayocp.2020.05.036",
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"key": "pgph.0004074.ref020",
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"year": "2020"
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"article-title": "Vitamin D and Inflammation: Potential Implications for Severity of Covid-19",
"author": "E Laird",
"first-page": "81",
"issue": "5",
"journal-title": "Ir Med J",
"key": "pgph.0004074.ref021",
"volume": "113",
"year": "2020"
},
{
"DOI": "10.1016/j.ajic.2020.06.193",
"article-title": "COVID-19 fatalities, latitude, sunlight, and vitamin D",
"author": "PB Whittemore",
"doi-asserted-by": "crossref",
"first-page": "1042",
"issue": "9",
"journal-title": "American Journal of Infection Control",
"key": "pgph.0004074.ref022",
"volume": "48",
"year": "2020"
},
{
"DOI": "10.1056/NEJMp2002106",
"article-title": "Escaping Pandora’s Box - Another Novel Coronavirus",
"author": "DM Morens",
"doi-asserted-by": "crossref",
"first-page": "1293",
"issue": "14",
"journal-title": "N Engl J Med",
"key": "pgph.0004074.ref023",
"volume": "382",
"year": "2020"
},
{
"DOI": "10.1016/j.cell.2018.02.025",
"article-title": "From “A”IV to “Z”IKV: Attacks from Emerging and Re-emerging Pathogens",
"author": "GF Gao",
"doi-asserted-by": "crossref",
"first-page": "1157",
"issue": "6",
"journal-title": "Cell",
"key": "pgph.0004074.ref024",
"volume": "172",
"year": "2018"
},
{
"author": "United Nations DoEaSA, Population Division",
"key": "pgph.0004074.ref025",
"volume-title": "World Population Prospects 2019. Department of Economic and Social Affairs PD",
"year": "2019"
},
{
"author": "World Meteorological Organization",
"key": "pgph.0004074.ref026",
"volume-title": "World Weather Information ServiceReport No"
},
{
"DOI": "10.1111/apt.15752",
"article-title": "Letter: Covid-19, and vitamin D",
"author": "A Panarese",
"doi-asserted-by": "crossref",
"first-page": "993",
"issue": "10",
"journal-title": "Aliment Pharmacol Ther",
"key": "pgph.0004074.ref027",
"volume": "51",
"year": "2020"
},
{
"DOI": "10.1001/jamanetworkopen.2020.11834",
"article-title": "Temperature, Humidity, and Latitude Analysis to Estimate Potential Spread and Seasonality of Coronavirus Disease 2019 (COVID-19)",
"author": "MM Sajadi",
"doi-asserted-by": "crossref",
"issue": "6",
"journal-title": "JAMA Netw Open",
"key": "pgph.0004074.ref028",
"volume": "3",
"year": "2020"
},
{
"DOI": "10.1186/s12967-020-02418-5",
"article-title": "Inverse correlation between average monthly high temperatures and COVID-19-related death rates in different geographical areas",
"author": "F Benedetti",
"doi-asserted-by": "crossref",
"first-page": "251",
"issue": "1",
"journal-title": "J Transl Med",
"key": "pgph.0004074.ref029",
"volume": "18",
"year": "2020"
},
{
"DOI": "10.3390/v11030210",
"article-title": "Bat Coronaviruses in China",
"author": "Y Fan",
"doi-asserted-by": "crossref",
"first-page": "210",
"issue": "3",
"journal-title": "Viruses",
"key": "pgph.0004074.ref030",
"volume": "11",
"year": "2019"
},
{
"DOI": "10.1371/journal.ppat.0030151",
"article-title": "Influenza virus transmission is dependent on relative humidity and temperature",
"author": "AC Lowen",
"doi-asserted-by": "crossref",
"first-page": "1470",
"issue": "10",
"journal-title": "PLoS Pathog",
"key": "pgph.0004074.ref031",
"volume": "3",
"year": "2007"
},
{
"DOI": "10.1080/16549716.2020.1760490",
"article-title": "Eco-epidemiological assessment of the COVID-19 epidemic in China, January-February 2020",
"author": "P Byass",
"doi-asserted-by": "crossref",
"first-page": "1760490",
"issue": "1",
"journal-title": "Glob Health Action",
"key": "pgph.0004074.ref032",
"volume": "13",
"year": "2020"
},
{
"DOI": "10.1016/j.scitotenv.2020.139016",
"article-title": "Sunlight exposure increased Covid-19 recovery rates: A study in the central pandemic area of Indonesia",
"author": "A Asyary",
"doi-asserted-by": "crossref",
"first-page": "139016",
"journal-title": "Sci Total Environ",
"key": "pgph.0004074.ref033",
"volume": "729",
"year": "2020"
},
{
"DOI": "10.1002/path.2987",
"article-title": "Acute respiratory distress syndrome leads to reduced ratio of ACE/ACE2 activities and is prevented by angiotensin-(1-7) or an angiotensin II receptor antagonist",
"author": "RM Wösten-van Asperen",
"doi-asserted-by": "crossref",
"first-page": "618",
"issue": "4",
"journal-title": "J Pathol",
"key": "pgph.0004074.ref034",
"volume": "225",
"year": "2011"
},
{
"DOI": "10.1016/j.dsx.2020.06.060",
"article-title": "BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: Preliminary findings from UK biobank",
"author": "N Sattar",
"doi-asserted-by": "crossref",
"first-page": "1149",
"issue": "5",
"journal-title": "Diabetes Metab Syndr",
"key": "pgph.0004074.ref035",
"volume": "14",
"year": "2020"
},
{
"DOI": "10.1530/EJE-18-0736",
"article-title": "Current vitamin D status in European and Middle East countries and strategies to prevent vitamin D deficiency: a position statement of the European Calcified Tissue Society",
"author": "P Lips",
"doi-asserted-by": "crossref",
"issue": "4",
"journal-title": "Eur J Endocrinol",
"key": "pgph.0004074.ref036",
"volume": "180",
"year": "2019"
},
{
"DOI": "10.3945/ajcn.116.151415",
"article-title": "The positive impact of general vitamin D food fortification policy on vitamin D status in a representative adult Finnish population: evidence from an 11-y follow-up based on standardized 25-hydroxyvitamin D data",
"author": "T Jääskeläinen",
"doi-asserted-by": "crossref",
"first-page": "1512",
"issue": "6",
"journal-title": "Am J Clin Nutr",
"key": "pgph.0004074.ref037",
"volume": "105",
"year": "2017"
},
{
"DOI": "10.1038/s41591-020-1112-0",
"article-title": "Magnitude, demographics and dynamics of the effect of the first wave of the COVID-19 pandemic on all-cause mortality in 21 industrialized countries",
"author": "V Kontis",
"doi-asserted-by": "crossref",
"first-page": "1919",
"issue": "12",
"journal-title": "Nat Med",
"key": "pgph.0004074.ref038",
"volume": "26",
"year": "2020"
},
{
"DOI": "10.3389/fnut.2021.648450",
"article-title": "Socio-Demographic and Knowledge-Related Determinants of Vitamin D Supplementation in the Context of the COVID-19 Pandemic: Assessment of an Educational Intervention",
"author": "K Žmitek",
"doi-asserted-by": "crossref",
"first-page": "648450",
"journal-title": "Front Nutr",
"key": "pgph.0004074.ref039",
"volume": "8",
"year": "2021"
},
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