Risk of severe case in COVID-19 patients and Azvudine: A Retrospective cohort study after exit from ‘zero-COVID’ policy

{ 'institution': [{'name': 'Research Square'}], 'indexed': {'date-parts': [[2024, 1, 6]], 'date-time': '2024-01-06T00:18:42Z', 'timestamp': 1704500322336}, 'posted': {'date-parts': [[2024, 1, 5]]}, 'group-title': 'In Review', 'reference-count': 21, 'publisher': 'Research Square Platform LLC', 'license': [ { 'start': { 'date-parts': [[2024, 1, 5]], 'date-time': '2024-01-05T00:00:00Z', 'timestamp': 1704412800000}, 'content-version': 'unspecified', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'accepted': {'date-parts': [[2023, 12, 5]]}, 'abstract': '<jats:title>Abstract</jats:title>\n' ' <jats:p><jats:bold>Background</jats:bold> COVID-19 leaded to significant morbidity ' 'and mortality. To investigate contributing factors to severity and examine whether Azvudine ' 'can reduce mortality, we conducted a single-center, retrospective cohort ' 'study.<jats:bold>Method</jats:bold> 4201 COVID-19 patients discharged from our hospital were ' 'enrolled. Logistic regression analysis and ROC curve were used to investigate the role of ' 'comorbidities, laboratory parameters and clinical manifestation on progression of COVID-19. ' 'Propensity-score models conditional on baseline characteristics and Univariate Cox regression ' 'model were used to examine whether Azvudine can reduce the mortality of ' 'COVID-19.<jats:bold>Result</jats:bold> Age, male sex, cerebrovascular disease, chronic kidney ' 'disease, liver disease, tumor and chronic lung disease were associated with elevated risk of ' 'mortality and chronic kidney disease contributed the most risk. Uric acid showed a U-shape ' 'risk of severity. Both hyperuricemia and hypouricemia increased the risk of severity. ' 'D-dimer, NT-BNP, LDH and FT3 were the most sensitive and specific markers for the prediction ' 'of mortality. Poor appetite, consciousness deterioration, polypnea and persistent high fever ' 'were associated with elevated risk of severity. Compared with no antiviral group, Azvudine ' 'can reduce the COVID-19 mortality (hazard ratio 0.708(95% confidence interval 0.516 to ' '0.971), P\u2009=\u20090.032. There was no significant difference in mortality reduction ' 'between Molnupiravir and Azvudine(P\u2009=\u20090.486).<jats:bold>Conclusions</jats:bold> ' 'Among COVID-19 patients, age, male sex and comorbidities can affect progression of COVID-19. ' 'D-dimer, NT-BNP, LDH, FT3, UA, poor appetite, consciousness deterioration, polypnea and ' 'persistent high fever can help doctors predict severe illness. Azvudine is neck and neck with ' 'Molnupiravir in the mortality reduction among COIVD-19.</jats:p>', 'DOI': '10.21203/rs.3.rs-3707560/v1', 'type': 'posted-content', 'created': {'date-parts': [[2024, 1, 5]], 'date-time': '2024-01-05T17:52:08Z', 'timestamp': 1704477128000}, 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Risk of severe case in COVID-19 patients and Azvudine: A Retrospective cohort study after exit ' 'from ‘zero-COVID’ policy', 'prefix': '10.21203', 'author': [ { 'given': 'Lishan', 'family': 'Li', 'sequence': 'first', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Li', 'family': 'Li', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Lihua', 'family': 'Ye', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Baijie', 'family': 'Lu', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Jieling', 'family': 'Wang', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Guanhua', 'family': 'Wei', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}, { 'given': 'Zhuang', 'family': 'Bian', 'sequence': 'additional', 'affiliation': [{'name': 'The Fifth Affiliated Hospital of Sun Yat-sen University'}]}], 'member': '8761', 'reference': [ { 'key': 'ref1', 'author': 'Singh AK', 'year': '2021', 'unstructured': 'Singh AK, Singh A, Singh R, Misra A. 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