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All Studies   Meta Analysis    Recent:   
0 0.5 1 1.5 2+ Mortality 23% Improvement Relative Risk Metformin  Lewandowski et al.  Prophylaxis Is prophylaxis with metformin beneficial for COVID-19? Retrospective 430 patients in Poland Lower mortality with metformin (not stat. sig., p=0.15) c19early.org Lewandowski et al., Biomedicines, March 2024 Favors metformin Favors control

Insulin and Metformin Administration: Unravelling the Multifaceted Association with Mortality across Various Clinical Settings Considering Type 2 Diabetes Mellitus and COVID-19

Lewandowski et al., Biomedicines, doi:10.3390/biomedicines12030605
Mar 2024  
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Metformin for COVID-19
3rd treatment shown to reduce risk in July 2020
 
*, now known with p < 0.00000000001 from 89 studies.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,100+ studies for 60+ treatments. c19early.org
Retrospective 430 hospitalized COVID-19 patients with type 2 diabetes in Poland showing lower mortality with metformin and higher mortality with remdesivir, convalescent plasma, and aspirin in univariable analysis. These results were not statistically significant except for aspirin, and no baseline information per treatment is provided to assess confounding.
Study covers metformin, remdesivir, convalescent plasma, and aspirin.
risk of death, 22.9% lower, RR 0.77, p = 0.15, treatment 14 of 101 (13.9%), control 83 of 329 (25.2%), NNT 8.8, odds ratio converted to relative risk.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Lewandowski et al., 7 Mar 2024, retrospective, Poland, peer-reviewed, 15 authors.
This PaperMetforminAll
Insulin and Metformin Administration: Unravelling the Multifaceted Association with Mortality across Various Clinical Settings Considering Type 2 Diabetes Mellitus and COVID-19
Łukasz Lewandowski, Agnieszka Bronowicka-Szydełko, Maciej Rabczyński, Dorota Bednarska-Chabowska, Joanna Adamiec-Mroczek, Adrian Doroszko, Małgorzata Trocha, Krzysztof Kujawa, Agnieszka Matera-Witkiewicz, Edwin Kuźnik, Paweł Lubieniecki, Marcin Madziarski, Janusz Sokołowski, Ewa A Jankowska, Katarzyna Madziarska
Biomedicines, doi:10.3390/biomedicines12030605
Due to the molecular mechanisms of action of antidiabetic drugs, they are considered to be effective in the treatment of both COVID-19 and the post-COVID-19 syndromes. The aim of this study was to determine the effect of administering insulin and metformin on the mortality of patients with type 2 diabetes (T2DM) with symptomatic COVID-19 with the use of logistic regression models. The association between death and insulin and metformin was weak and could not be included in the multivariate model. However, the interaction of both drugs with other factors, including remdesivir and low-molecular-weight heparin (metformin), age and hsCRP (insulin), modulated the odds of death. These interactions hint at multifaceted (anti-/pro-) associations of both insulin and metformin with the odds of death, depending on the patient's characteristics. In the multivariate model, RDW-SD, adjusted with low-molecular-weight heparin treatment, age, sex and K + , was associated with mortality among patients with COVID-19 and T2DM. With a 15% increase in RDW-SD, the risk of death increased by 87.7%. This preliminary study provides the foundations for developing further, more personalized models to assess the risk of death in T2DM patients, as well as for identifying patients at an increased risk of death due to COVID-19.
Conflicts of Interest: The authors declare no conflicts of interest. The Wald test was utilized in assessing the value of the factors to be included in the model. The score test (Lagrange multiplier test) was used to check if, at any step, the previously excluded factors should be re-included into the current model. The final model is described in Table 2 and visualized in Figure 3 .
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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