Impact of anti-androgen therapies on COVID-19 susceptibility: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)
MD-PhD Massimo Lazzeri, PhD Stefano Duga, MD Elena Azzolini, MD Vittorio Fasulo, MD Nicolò Buffi, MD Alberto Saita, MD Rodolfo Hurle, MD Alessandro Nobili, MD-PhD Maurizio Cecconi, MD Paolo Casale, PhD Rosanna Asselta
doi:10.1101/2020.04.20.20068056
May treatment of benign prostatic hyperplasia with 5-alpha reductase inhibitors (5ARIs) impact on COVID-19-related hospitalization risk?
Findings: In this case-control study, which compared 943 adult males hospitalized for COVID-19 with age-matched men from Lombardy (all beneficiaries of the Regional Health Service), the proportion of patients aged >55 years, who were exposed to 5ARIs (dutasteride, finasteride), was significantly lower (5.57%) than that of the general male population (8.14%) (p=0.0083, 95%CI=0.75-3.97%). Meaning: The use of 5ARIs was associated with a potential reduced risk of hospitalization for COVID-19 in men older than >55 years. This suggests the opportunity to test whether antiandrogen therapies can prevent the transition from paucisymptomatic SARS-CoV-2 infection to overt pulmonary disease.
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Yamana, Labrie, Luu-The, Human type 3 5α-reductase is expressed in peripheral tissues at higher levels than types 1 and 2 and its activity is potently inhibited by finasteride and dutasteride, Horm Mol Biol Clin Investig,
doi:10.1515/HMBCI.2010.035{ 'institution': [{'name': 'medRxiv'}],
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'abstract': '<jats:title>ABSTRACT</jats:title><jats:sec><jats:title>Importance</jats:title><jats:p>There '
'are gender differences in vulnerability to the Coronavirus disease 2019 (COVID-19), with men '
'experiencing more severe disease at any age. The use of anti-androgen drugs, like 5-alpha '
'reductase inhibitors (5ARIs), could protect from severe pulmonary '
'disease.</jats:p></jats:sec><jats:sec><jats:title>Objective</jats:title><jats:p>To determine '
'whether men who received 5ARIs for benign prostatic hyperplasia (BPH) have a lower risk of '
'hospitalization for '
'COVID-19.</jats:p></jats:sec><jats:sec><jats:title>Design</jats:title><jats:p>This is a '
'case-control study on patients hospitalized for COVID-19 (cases), matched to beneficiaries of '
'the Lombardy Regional Health Service '
'(controls).</jats:p></jats:sec><jats:sec><jats:title>Setting</jats:title><jats:p>Data were '
'collected by two high-volume COVID-19 regional centres of Lombardy (Italy) from '
'1<jats:sup>st</jats:sup> March to 24<jats:sup>th</jats:sup> April '
'2020.</jats:p></jats:sec><jats:sec><jats:title>Participants</jats:title><jats:p>Consecutive '
'patients positive for SARS-CoV-2 virus according to the WHO guidance, who required '
'hospitalization.</jats:p></jats:sec><jats:sec><jats:title>Exposure</jats:title><jats:p>BPH '
'treatment with 5ARIs (finasteride/dutasteride) in the last six '
'months.</jats:p></jats:sec><jats:sec><jats:title>Main Outcome(s) and '
'Measure(s)</jats:title><jats:p>The primary outcome was to compare the prevalence of male '
'patients chronically exposed to 5ARIs, who required hospitalization for COVID-19, with the '
'one of age-matched males in '
'Lombardy.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Overall, 1,432 '
'COVID-19 patients were included. Among the 943 males, 45 (4.77%) patients were exposed to '
'chronic 5ARI therapy. COVID-19 patients aged >55 years under 5ARI treatment were '
'significantly less than expected on the basis of the prevalence of 5ARI treatment among '
'age-matched controls (5.57 vs. 8.14%; p=0.0083, 95%CI=0.75-3.97%). This disproportion was '
'even higher for men aged >65 (7.14 vs. 12.31%; p=0.0001, '
'95%CI=2.83-6.97%).</jats:p><jats:p>Eighteen 5ARIs-patients died; the mean age of men who died '
'was higher than those who did not: 75.98±9.29 vs. 64.78±13.57 (p<0.001). Cox regression '
'and multivariable models did not show any correlation between the exposure to 5ARIs and '
'protection against ICU admission or death: HR=0.79 (95%CI=0.54-1.15; p=0.22) and OR=1.23 '
'(95%CI=0.81-1.87; p=0.33), respectively.</jats:p></jats:sec><jats:sec><jats:title>Conclusions '
'and Relevance</jats:title><jats:p>In this case-control study the use of 5ARIs was less '
'frequent among patients hospitalized for COVID-19 than among controls, suggesting that men '
'exposed to 5ARIs might be less vulnerable to severe COVID-19. This observation further '
'supports the idea to test in randomized clinical trials whether anti-androgen therapies can '
'prevent the transition from paucisymptomatic SARS-CoV-2 infection to overt pulmonary '
'disease.</jats:p></jats:sec><jats:sec><jats:title>KEY '
'POINTS</jats:title><jats:sec><jats:title>Question</jats:title><jats:p>May treatment of benign '
'prostatic hyperplasia with 5-alpha reductase inhibitors (5ARIs) impact on COVID-19-related '
'hospitalization '
'risk?</jats:p></jats:sec><jats:sec><jats:title>Findings</jats:title><jats:p>In this '
'case-control study, which compared 943 adult males hospitalized for COVID-19 with age-matched '
'men from Lombardy (all beneficiaries of the Regional Health Service), the proportion of '
'patients aged >55 years, who were exposed to 5ARIs (dutasteride, finasteride), was '
'significantly lower (5.57%) than that of the general male population (8.14%) (p=0.0083, '
'95%CI=0.75-3.97%).</jats:p></jats:sec><jats:sec><jats:title>Meaning</jats:title><jats:p>The '
'use of 5ARIs was associated with a potential reduced risk of hospitalization for COVID-19 in '
'men older than >55 years. This suggests the opportunity to test whether anti-androgen '
'therapies can prevent the transition from paucisymptomatic SARS-CoV-2 infection to overt '
'pulmonary disease.</jats:p></jats:sec></jats:sec>',
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