Impact of anti-androgen therapies on COVID-19 susceptibility: a case-control study in male population from two COVID-19 regional centers of Lombardy (Italy)
MD-PhD Massimo Lazzeri, PhD Stefano Duga, MD Elena Azzolini, MD Vittorio Fasulo, MD Nicolò Buffi, MD Alberto Saita, MD Rodolfo Hurle, MD Alessandro Nobili, MD-PhD Maurizio Cecconi, MD Paolo Casale, PhD Rosanna Asselta
doi:10.1101/2020.04.20.20068056
May treatment of benign prostatic hyperplasia with 5-alpha reductase inhibitors (5ARIs) impact on COVID-19-related hospitalization risk?
Findings: In this case-control study, which compared 943 adult males hospitalized for COVID-19 with age-matched men from Lombardy (all beneficiaries of the Regional Health Service), the proportion of patients aged >55 years, who were exposed to 5ARIs (dutasteride, finasteride), was significantly lower (5.57%) than that of the general male population (8.14%) (p=0.0083, 95%CI=0.75-3.97%). Meaning: The use of 5ARIs was associated with a potential reduced risk of hospitalization for COVID-19 in men older than >55 years. This suggests the opportunity to test whether antiandrogen therapies can prevent the transition from paucisymptomatic SARS-CoV-2 infection to overt pulmonary disease.
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