Serious Clinical Outcomes of COVID-19 Related to Acetaminophen or NSAIDs from a Nationwide Population-Based Cohort Study

{ 'indexed': {'date-parts': [[2023, 2, 23]], 'date-time': '2023-02-23T05:36:37Z', 'timestamp': 1677130597731}, 'reference-count': 25, 'publisher': 'MDPI AG', 'issue': '5', 'license': [ { 'start': { 'date-parts': [[2023, 2, 21]], 'date-time': '2023-02-21T00:00:00Z', 'timestamp': 1676937600000}, 'content-version': 'vor', 'delay-in-days': 0, 'URL': 'https://creativecommons.org/licenses/by/4.0/'}], 'funder': [ { 'name': 'National Research Foundation of Korea', 'award': ['2022R1A2C2005916', '2022R1A2C2005887']}], 'content-domain': {'domain': [], 'crossmark-restriction': False}, 'abstract': '<jats:p>Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) have been widely ' 'prescribed to infected patients; however, the safety of them has not been investigated in ' 'patients with serious acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our ' 'objective was to evaluate the association between the previous use of acetaminophen or NSAIDs ' 'and the clinical outcomes of SARS-CoV-2 infection. A nationwide population-based cohort study ' 'was conducted using the Korean Health Insurance Review and Assessment Database through ' 'propensity score matching (PSM). A total of 25,739 patients aged 20 years and older who ' 'tested for SARS-CoV-2 were included from 1 January 2015 to 15 May 2020. The primary endpoint ' 'was a positive result for a SARS-CoV-2 test, and the secondary endpoint was serious clinical ' 'outcomes of SARS-CoV-2 infection, such as conventional oxygen therapy, admission to the ' 'intensive care unit, need for invasive ventilation care, or death. Of 1058 patients, after ' 'propensity score matching, 176 acetaminophen users and 162 NSAIDs users were diagnosed with ' 'coronavirus disease 2019. After PSM, 162 paired data sets were generated, and the clinical ' 'outcomes of the acetaminophen group were not significantly different from those of the NSAIDs ' 'group. This suggests that acetaminophen and NSAIDs can be used safely to control symptoms in ' 'patients suspected of having SARS-CoV-2.</jats:p>', 'DOI': '10.3390/ijerph20053832', 'type': 'journal-article', 'created': {'date-parts': [[2023, 2, 22]], 'date-time': '2023-02-22T07:57:38Z', 'timestamp': 1677052658000}, 'page': '3832', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Serious Clinical Outcomes of COVID-19 Related to Acetaminophen or NSAIDs from a Nationwide ' 'Population-Based Cohort Study', 'prefix': '10.3390', 'volume': '20', 'author': [ { 'ORCID': 'http://orcid.org/0000-0003-0186-5834', 'authenticated-orcid': False, 'given': 'Jin-Woo', 'family': 'Kim', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Orthopaedic Surgery, Nowon Eulji Medical Center, ' 'Eulji University, Seoul 01830, Republic of Korea'}]}, { 'ORCID': 'http://orcid.org/0000-0002-4240-4615', 'authenticated-orcid': False, 'given': 'Siyeong', 'family': 'Yoon', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Orthopaedic Surgery, CHA Bundang Medical Center, ' 'School of Medicine, CHA University, Seongnam-si 13488, Republic ' 'of Korea'}]}, { 'ORCID': 'http://orcid.org/0000-0002-0136-1372', 'authenticated-orcid': False, 'given': 'Jongheon', 'family': 'Lee', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Orthopaedic Surgery, Nowon Eulji Medical Center, ' 'Eulji University, Seoul 01830, Republic of Korea'}]}, { 'ORCID': 'http://orcid.org/0000-0002-8425-6673', 'authenticated-orcid': False, 'given': 'Soonchul', 'family': 'Lee', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Orthopaedic Surgery, CHA Bundang Medical Center, ' 'School of Medicine, CHA University, Seongnam-si 13488, Republic ' 'of Korea'}]}], 'member': '1968', 'published-online': {'date-parts': [[2023, 2, 21]]}, 'reference': [ { 'key': 'ref_1', 'doi-asserted-by': 'crossref', 'first-page': '269', 'DOI': '10.1038/s41577-020-0308-3', 'article-title': 'COVID-19: Immunopathology and its implications for therapy', 'volume': '20', 'author': 'Cao', 'year': '2020', 'journal-title': 'Nat. 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