Serious Clinical Outcomes of COVID-19 Related to Acetaminophen or NSAIDs from a Nationwide Population-Based Cohort Study
Kim et al.,
Serious Clinical Outcomes of COVID-19 Related to Acetaminophen or NSAIDs from a Nationwide Population-Based..,
International Journal of Environmental Research and Public Health, doi:10.3390/ijerph20053832
PSM retrospective in South Korea, showing no significant differences in outcomes with acetaminophen use vs. NSAID use. Adherence and dosage are unknown.
risk of death, 71.4% higher, RR 1.71, p = 0.34, treatment 12 of 162 (7.4%), control 7 of 162 (4.3%), propensity score matching.
|
risk of mechanical ventilation, 14.3% higher, RR 1.14, p = 1.00, treatment 8 of 162 (4.9%), control 7 of 162 (4.3%), propensity score matching.
|
risk of ICU admission, 40.0% lower, RR 0.60, p = 0.72, treatment 3 of 162 (1.9%), control 5 of 162 (3.1%), NNT 81, propensity score matching.
|
risk of oxygen therapy, 9.1% higher, RR 1.09, p = 0.87, treatment 24 of 162 (14.8%), control 22 of 162 (13.6%), propensity score matching.
|
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
|
Kim et al., 21 Feb 2023, retrospective, South Korea, peer-reviewed, mean age 55.8, 4 authors, this trial compares with another treatment - results may be better when compared to placebo.
Contact:
lsceline78@gmail.com (corresponding author).
Abstract: International Journal of
Environmental Research
and Public Health
Article
Serious Clinical Outcomes of COVID-19 Related to
Acetaminophen or NSAIDs from a Nationwide
Population-Based Cohort Study
Jin-Woo Kim 1,† , Siyeong Yoon 2,† , Jongheon Lee 1
1
2
*
†
Citation: Kim, J.-W.; Yoon, S.; Lee, J.;
and Soonchul Lee 2, *
Department of Orthopaedic Surgery, Nowon Eulji Medical Center, Eulji University,
Seoul 01830, Republic of Korea
Department of Orthopaedic Surgery, CHA Bundang Medical Center, School of Medicine, CHA University,
Seongnam-si 13488, Republic of Korea
Correspondence: lsceline78@gmail.com; Tel.: +82-31-780-5289; Fax: +82-31-881-7114
These authors contributed equally to this work.
Abstract: Acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) have been widely
prescribed to infected patients; however, the safety of them has not been investigated in patients
with serious acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Our objective was
to evaluate the association between the previous use of acetaminophen or NSAIDs and the clinical
outcomes of SARS-CoV-2 infection. A nationwide population-based cohort study was conducted
using the Korean Health Insurance Review and Assessment Database through propensity score
matching (PSM). A total of 25,739 patients aged 20 years and older who tested for SARS-CoV-2
were included from 1 January 2015 to 15 May 2020. The primary endpoint was a positive result
for a SARS-CoV-2 test, and the secondary endpoint was serious clinical outcomes of SARS-CoV-2
infection, such as conventional oxygen therapy, admission to the intensive care unit, need for invasive
ventilation care, or death. Of 1058 patients, after propensity score matching, 176 acetaminophen users
and 162 NSAIDs users were diagnosed with coronavirus disease 2019. After PSM, 162 paired data
sets were generated, and the clinical outcomes of the acetaminophen group were not significantly
different from those of the NSAIDs group. This suggests that acetaminophen and NSAIDs can be
used safely to control symptoms in patients suspected of having SARS-CoV-2.
Lee, S. Serious Clinical Outcomes of
COVID-19 Related to Acetaminophen
or NSAIDs from a Nationwide
Keywords: SARS-CoV-2; COVID-19; acetaminophen; NSAIDs
Population-Based Cohort Study. Int.
J. Environ. Res. Public Health 2023, 20,
3832. https://doi.org/10.3390/
ijerph20053832
Academic Editor: Paul B. Tchounwou
Received: 31 December 2022
Revised: 19 February 2023
Accepted: 20 February 2023
Published: 21 February 2023
Copyright: © 2023 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://
creativecommons.org/licenses/by/
4.0/).
Please send us corrections, updates, or comments. Vaccines and
treatments are complementary. All practical, effective, and safe means should
be used based on risk/benefit analysis. No treatment, vaccine, or intervention
is 100% available and effective for all current and future variants. We do not
provide medical advice. Before taking any medication, consult a qualified
physician who can provide personalized advice and details of risks and
benefits based on your medical history and situation.
FLCCC and
WCH
provide treatment protocols.
Submit