Comparison of clinical and laboratory parameters of COVID-19 in diabetic patients using different glucose-lowering drugs: a retrospective study
Khafri et al.,
Comparison of clinical and laboratory parameters of COVID-19 in diabetic patients using different..,
Current Research in Medical Sciences, doi:10.22088/crms.6.2.32
Retrospective 157 diabetic patients in Iran reporting shorter hospitalization with metformin, however numbers in this paper are inconsistent. The counts and percentages for death in Table 1 are not possible - 11 (13.92%) for metformin could indicate that the outcome was only known for 79/100 patients, however 8 (10.25%) for the no metformin group indicates 78 patients while the total group size is 57.
Khafri et al., 31 Dec 2022, retrospective, Iran, peer-reviewed, 6 authors, study period 20 April, 2020 - 21 July, 2020.
Contact:
srostami.m@gmail.com.
Abstract: Comparison of clinical and laboratory parameters of COVID-19 in
diabetic patients using different glucose-lowering drugs:
a retrospective study
Soraya Khafri1, Seyedeh Farzaneh Jalali2, Faezeh Mohsenipoor3, Hadi Parsian4,
Masoumeh Bayani 5, Sahar Rostami-Mansoor2,4*
1.Social Determinants of Health Research Center, Health resrearch institute, Babol University of Medical Sciences, Babol, Iran.
2.Department of Laboratory Sciences, Faculty of Paramedical Sciences, Babol University of Medical Sciences, Babol, Iran
3.Student Research Committee, Babol University of Medical Sciences, Babol, Iran
4.Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5.Infectious Diseases and Tropical Medicine Research, Center, Health Research Institute, Babol University of Medical Sciences,
[
Babol, Iran
Article Info
ABSTRACT
Article type:
Research Article
Background and Objective: Diabetes is a common metabolic disease that
Received: 2 December 2022
Revised: 16 December 2022
Accepted: 17 December 2022
increases the risk of mortality of COVID-19. This study was done to compare
the clinical characteristics and laboratory parameters of COVID-19 in diabetic
patients using different glucose-lowering drugs to find out the proper
predictors of disease severity.
Methods: 157 diabetic patients with confirmed COVID-19 were enrolled in
three groups according to the antidiabetic medications used before admission
(metformin, insulin and sulfonylurea).
Findings: In 157 diabetic patients, the hospitalization length in the
metformin group was lower than the no metformin group while duration of
hospitalization and critical form of the disease in the insulin group were higher
than the no insulin group. Furthermore, the levels of blood sugar, BUN, ALT
and WBC were lower in the metformin group while ALP, ALT, BUN and
creatinine levels were significantly higher in insulin group. In sulfonylurea
group the levels of BUN and ALT were lower compared to the no
sulfonylurea group. We also found that BUN and total bilirubin were the
proper parameters to predict COVID-19 severity and mortality in metformin
and insulin group respectively.
Conclusion: It seems that the outcomes of renal function test, bilirubin and
O2 saturation are important parameters to predict COVID-19 severity in
diabetic patients using different antidiabetic medications.
Keywords: COVID-19, diabetes, glucose- lowering drugs, laboratory
parameters.
Cite this article: khafri S, et al. Comparison of clinical and laboratory parameters of COVID-19 in diabetic patients using
different glucose-lowering drugs: a retrospective study. Current Research in Medical Sciences. 2022; 6(2): 32-49
© The Author(s).
[ DOI: 10.22088/crms.6.2.32 ]
Publisher: Babol University of Medical Sciences
Corresponding Author: Dr. Sahar Rostami-Mansoor;
Address: Assistant Professor of Clinical Biochemistry, Cellular and Molecular Biology Research Center, Health Research
Institute, Babol University of Medical Sciences, Babol, I.R.Iran
Tel: +98 1132 238 284
E-mail: srostami.m@gmail.com, ORCID:0000-0003-4999-5806
COVID-19 and different glucose-lowering drugs / Khafri S, et al
33
[ DOI: 10.22088/crms.6.2.32 ]
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