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Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis

Kee et al., Kidney Research and Clinical Practice, doi:10.23876/j.krcp.23.137
Jan 2024  
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35th treatment shown to reduce risk in March 2022
*, now known with p = 0.0000009 from 7 studies, recognized in 27 countries. Efficacy is variant dependent.
Lower risk for hospitalization, progression, and recovery.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
3,800+ studies for 60+ treatments.
Retrospective 230 hospitalized COVID-19 patients on hemodialysis, reporting lower mortality with regdanvimab treatment. The results are conflicting, with for example the text reporting HR 0.28 for regdanvimab in multivariable analysis, however Table 3 shows HR 0.95. The adjusted analysis is required because the groups are not comparable at baseline, with the control group having a much higher prevalence of severe cases.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for omicron BA.2, BA.4, BA.5 Haars, ХВВ.1.9.1, XBB.1.9.3, XBB.1.5.24, XBB.1.16, XBB.2.9, BQ.1.1.45, CL.1, and CH.1.1 Pochtovyi.
Kee et al., 23 Jan 2024, retrospective, South Korea, peer-reviewed, mean age 67.9, 10 authors, study period 1 December, 2020 - 30 November, 2021. Contact:,
This PaperRegdanvimabAll
Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis
Youn Kyung Kee, Hayne Cho Park, Su Jin Yoon, Sungbong Yu, Eunsil Ko, Ajin Cho, Do Hyoung Kim, Jinseog Kim, Young-Ki Lee
Kidney Research and Clinical Practice, doi:10.23876/j.krcp.23.137
Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 , there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the effectiveness of regdanvimab on mortality in COVID-19-infected patients on hemodialysis (HD). Methods: We conducted an observational retrospective study in 230 COVID-19-infected patients on HD, of whom 77 (33.5%) were administered regdanvimab alone or in combination with dexamethasone or remdesivir during hospitalization (regdanvimab group) and 153 patients (66.5%) were not (no regdanvimab group). The primary outcome was in-hospital mortality. We compared mortality rates according to the use of regdanvimab and investigated the factors associated with mortality. Results: Fifty-nine deaths occurred during hospitalization, 49 in the no regdanvimab group (32.0%) and 10 in the regdanvimab group (13.0%), and the mortality rate was significantly higher in the no regdanvimab group than that in the regdanvimab group (p = 0.001). Multivariate Cox regression analysis showed that malignancy (p = 0.001), SPO 2 of <95% at admission (p = 0.003), and administration of antibiotics and regdanvimab (p = 0.007 and p = 0.002, respectively) were significantly associated factors with mortality. Conclusion: Regdanvimab administration is beneficial in improving prognosis in hospitalized COVID-19 patients on HD. Considering the vulnerability to infection and high mortality of ESRD patients, regdanvimab may be considered as a therapeutic option in COVID-19 patients on HD.
Conflicts of interest All authors have no conflicts of interest to declare. Authors' contributions ORCID Youn Kyung Kee, Hayne Cho Park, Su Jin Yoon, Sungbong Yu, Eunsil Ko, AJin Cho, Do Hyoung Kim, Jinseog Kim, Young-Ki Lee,
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