Effectiveness of regdanvimab on mortality in COVID-19 infected patients on hemodialysis
Youn Kyung Kee, Hayne Cho Park, Su Jin Yoon, Sungbong Yu, Eunsil Ko, Ajin Cho, Do Hyoung Kim, Jinseog Kim, Young-Ki Lee
Kidney Research and Clinical Practice, doi:10.23876/j.krcp.23.137
Background: Although several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 , there are lack of effective and proven treatments for end-stage renal disease (ESRD). The present study aims to evaluate the effectiveness of regdanvimab on mortality in COVID-19-infected patients on hemodialysis (HD). Methods: We conducted an observational retrospective study in 230 COVID-19-infected patients on HD, of whom 77 (33.5%) were administered regdanvimab alone or in combination with dexamethasone or remdesivir during hospitalization (regdanvimab group) and 153 patients (66.5%) were not (no regdanvimab group). The primary outcome was in-hospital mortality. We compared mortality rates according to the use of regdanvimab and investigated the factors associated with mortality. Results: Fifty-nine deaths occurred during hospitalization, 49 in the no regdanvimab group (32.0%) and 10 in the regdanvimab group (13.0%), and the mortality rate was significantly higher in the no regdanvimab group than that in the regdanvimab group (p = 0.001). Multivariate Cox regression analysis showed that malignancy (p = 0.001), SPO 2 of <95% at admission (p = 0.003), and administration of antibiotics and regdanvimab (p = 0.007 and p = 0.002, respectively) were significantly associated factors with mortality. Conclusion: Regdanvimab administration is beneficial in improving prognosis in hospitalized COVID-19 patients on HD. Considering the vulnerability to infection and high mortality of ESRD patients, regdanvimab may be considered as a therapeutic option in COVID-19 patients on HD.
Conflicts of interest All authors have no conflicts of interest to declare.
Authors' contributions
ORCID Youn Kyung Kee, https://orcid.org/0000-0002-0555-9909 Hayne Cho Park, https://orcid.org/0000-0002-1128-3750 Su Jin Yoon, https://orcid.org/0009-0008-3676-1799 Sungbong Yu, https://orcid.org/0000-0002-1989-6121 Eunsil Ko, https://orcid.org/0000-0001-5959-5545 AJin Cho, https://orcid.org//0000-0001-7097-7026 Do Hyoung Kim, https://orcid.org/0000-0002-8664-8830 Jinseog Kim, https://orcid.org/0000-0003-3172-3212 Young-Ki Lee, https://orcid.org/0000-0003-3464-6144
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