Host factors associated with respiratory particle emission and virus presence within respiratory particles: a systematic review
Nils Horstink, Kirsten Lassing, Marjolein Knoester, Lucie C Vermeulen, John W A Rossen, Andreas Voss, Mariëtte Lokate
Frontiers in Microbiology, doi:10.3389/fmicb.2025.1652124
Introduction: Understanding host factor-related mechanisms that drive variability in respiratory particle emission and virus presence in exhaled particles is essential to assess transmission risk and potentially identify individuals with elevated infectiousness. Methods: We conducted a systematic review of human observational studies examining associations between host factors and either respiratory particle emission or virus presence in exhaled particles. Searches in PubMed, EMBASE, and Web of Science covered studies up to September 2024. Risk of bias was assessed using STROBE-based criteria. Findings were synthesized narratively, grouped by host factor and outcome type. Results: Forty-four studies met inclusion criteria: 34 assessed host factors in relation to particle emission, and 11 examined viral presence in exhaled particles. Fine particle emission (<5 μm) was most consistently associated with older age (n = 16), physical exercise (n = 6), and active infection (n = 6). No consistent associations were found for sex (n = 21), body mass index (BMI; n = 10), or smoking (n = 6). Viral presence-mainly influenza and SARS-CoV-2-was more strongly associated with time since symptom onset (n = 8) and lower respiratory symptoms (n = 3), based largely on genomic detection. Associations with other factors, including upper respiratory symptoms (n = 6), swab viral load (n = 11), age (n = 6), sex (n = 6), and BMI (n = 2), were inconsistent or absent. Physical exercise was not evaluated in relation to viral presence. Discussion: Fine respiratory particles (<5 μm) were the predominant size fraction detected and often contained higher concentrations of viral RNA. Age, physical exercise, and active infection were consistently associated with increased emission of these particles. The presence of respiratory viruses in exhaled air was more strongly linked to infection-related factors such as early symptom onset and lower respiratory involvement. These patterns suggest distinct mechanisms contributing to airborne transmission. Interpretation was limited by methodological heterogeneity and predominant reliance on PCR. Still, consistent associations with host factors suggest their potential as indicators for transmission risk. As evidence focused mainly on influenza and SARS-CoV-2, generalizability is limited. Standardized methods and further research are needed to strengthen outbreak preparedness.
Frontiers in Microbiology 16 frontiersin.org
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References
Ahmed, Rawat, Ferro, Mofakham, Helenbrook et al., Characterizing respiratory aerosol emissions during sustained phonation, J. Expo. Sci. Environ. Epidemiol,
doi:10.1038/s41370-022-00430-zAlsved, Nygren, Thuresson, Fraenkel, Medstrand et al., Size distribution of exhaled aerosol particles containing SARS-CoV-2 RNA, Infect. Dis,
doi:10.1080/23744235.2022.2140822Archer, Mccarthy, Symons, Watson, Orton et al., Comparing aerosol number and mass exhalation rates from children and adults during breathing, speaking and singing, Interface Focus,
doi:10.1098/rsfs.2021.0078Asadi, Wexler, Cappa, Barreda, Bouvier et al., Aerosol emission and superemission during human speech increase with voice loudness, Sci. Rep,
doi:10.1038/s41598-019-38808-zBagheri, Schlenczek, Turco, Thiede, Stieger et al., Size, concentration, and origin of human exhaled particles and their dependence on human factors with implications on infection transmission, J. Aerosol Sci,
doi:10.1016/j.jaerosci.2022.106102Bake, Ljungström, Claesson, Carlsen, Holm, Exhaled particles after a standardized breathing maneuver, J. Aerosol Med. Pulm. Drug Deliv,
doi:10.1089/jamp.2016.1330Bender, Sirota, Swetschinski, Dominguez, Novotney et al., Global, regional, and national incidence and mortality burden of non-COVID-19 lower respiratory infections and aetiologies, 1990-2021: a systematic analysis from the global burden of disease study 2021, Lancet Infect. Dis,
doi:10.1016/S1473-3099(24)00176-2Chatterjee, Bhattacharya, Nag, Dhama, .-O et al., A detailed overview of SARS-CoV-2 omicron: its subvariants, mutations and pathophysiology, clinical characteristics, immunological landscape, immune escape, and therapies, Viruses,
doi:10.3390/v15010167Chen, Bobrovitz, Premji, Koopmans, Fisman et al., Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols, eLife,
doi:10.7554/eLife.65774Chow, Tay, Chen, Tang, Milton et al., Influenza A and B viruses in fine aerosols of exhaled breath samples from patients in tropical Singapore, Viruses,
doi:10.3390/v15102033Clark, Glasziou, Del Mar, Bannach-Brown, Stehlik et al., A full systematic review was completed in 2 weeks using automation tools: a case study, J. Clin. Epidemiol,
doi:10.1016/j.jclinepi.2020.01.008Coleman, Tay, Tan, Ong, Than et al., Viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory aerosols emitted by patients with coronavirus disease 2019 (COVID-19) while breathing, talking, and singing, Clin. Infect. Dis,
doi:10.1093/cid/ciab691De Mesquita, Nguyen-Van-Tam, Killingley, Enstone, Lambkin-Williams et al., Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases, Influenza Other Respir. Viruses,
doi:10.1111/irv.12790Edwards, Ausiello, Salzman, Devlin, Langer et al., Exhaled aerosol increases with COVID-19 infection, age, and obesity, Proc. Natl. Acad. Sci,
doi:10.1073/pnas.2021830118Edwards, Man, Brand, Katstra, Sommerer et al., Inhaling to mitigate exhaled bioaerosols, Proc. Natl. Acad. Sci. USA,
doi:10.1073/pnas.0408159101Fleischer, Schumann, Hartmann, Walker, Ifrim et al., Pre-adolescent children exhibit lower aerosol particle volume emissions than adults for breathing, speaking, singing and shouting, J. R. Soc. Interface,
doi:10.1098/rsif.2021.0833Flerlage, Boyd, Meliopoulos, Thomas, Schultz-Cherry, Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract, Nat. Rev. Microbiol,
doi:10.1038/s41579-021-00542-7Forbes, Greenwood, Carter, Clark, Automation of duplicate record detection for systematic reviews: Deduplicator, Syst. Rev,
doi:10.1186/s13643-024-02619-9Good, Fedak, Goble, Keisling, L'orange et al., Respiratory aerosol emissions from vocalization: age and sex differences are explained by volume and exhaled CO2, Environ. Sci. Technol. Lett,
doi:10.1021/acs.estlett.1c00760Gregson, Watson, Orton, Haddrell, Mccarthy et al., Comparing aerosol concentrations and particle size distributions generated by singing, speaking and breathing, Aerosol Sci. Technol,
doi:10.1080/02786826.2021.1883544Guo, Zhao, Lee, Hung, Wong et al., A statistical framework for tracking the time-varying superspreading potential of COVID-19 epidemic, Epidemics,
doi:10.1016/j.epidem.2023.100670Gutmann, Donath, Herrlich, Lehmkuehler, Landeis et al., Exhaled aerosols in SARS-CoV-2 polymerase chain reaction-positive children and age-matched-negative controls, Front. Pediatr,
doi:10.3389/fped.2022.941785Gutmann, Scheuch, Lehmkühler, Herrlich, Hutter et al., Aerosol measurement identifies SARS-CoV 2 PCR positive adults compared with healthy controls, Environ. Res,
doi:10.1101/2022.01.21.22269423Harrison, Saccente-Kennedy, Orton, Mccarthy, Archer et al., Emission rates, size distributions, and generation mechanism of oral respiratory droplets, Aerosol Sci. Technol,
doi:10.1080/02786826.2022.2158778Hersen, Moularat, Robine, Géhin, Corbet et al., Impact of health on particle size of exhaled respiratory aerosols: case-control study, Clean (Weinh),
doi:10.1002/clen.200700189Hu, Yuan, Gram, Yao, Sadrizadeh, Review of experimental measurements on particle size distribution and airflow behaviors during human respiration, Build. Environ,
doi:10.1016/j.buildenv.2023.110994Hussain-Alkhateeb, Bake, Holm, Emilsson, Mirgorodskaya, Novel non-invasive particles in exhaled air method to explore the lining fluid of small airways-a European population-based cohort study, BMJ Open Respir. Res,
doi:10.1136/bmjresp-2020-000804Iannone, Cheng, Schloerke, Hughes, Lauer et al., Gt: easily create presentation-ready display tables
Igo, Geneva, The burden of influenza
Jaumdally, Tomasicchio, Pooran, Esmail, Kotze et al., Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the beta, delta or omicron variants, Nat. Commun,
doi:10.1038/s41467-024-45400-1Kappelt, Russell, Kwiatkowski, Afshari, Johnson, Correlation of respiratory aerosols and metabolic carbon dioxide, Sustainability,
doi:10.3390/su132112203Lai, Coleman, Tai, German, Hong et al., Exhaled breath aerosol shedding of highly transmissible versus prior severe acute respiratory syndrome coronavirus 2 variants, Clin. Infect. Dis,
doi:10.1093/cid/ciac846Lee, Shih, Leu, Chang, Lin et al., Implications of age-related changes in anatomy for geriatric-focused difficult airways, Int. J. Gerontol,
doi:10.1016/j.ijge.2016.11.003Lee, Yoo, Ryu, Ham, Lee et al., Quantity, size distribution, and characteristics of cough-generated aerosol produced by patients with an upper respiratory tract infection, Aerosol Air Qual. Res,
doi:10.4209/aaqr.2018.01.0031Lim, Cheong, Oh, Lee, So et al., Modeling the early temporal dynamics of viral load in respiratory tract specimens of COVID-19 patients in Incheon, the Republic of Korea, Int. J. Infect. Dis,
doi:10.1016/j.ijid.2021.05.062Lindsley, Blachere, Beezhold, Thewlis, Noorbakhsh et al., Viable influenza A virus in airborne particles expelled during coughs versus exhalations, Influenza Other Respir. Viruses,
doi:10.1111/irv.12390Lindsley, Blachere, Thewlis, Vishnu, Davis et al., Measurements of airborne influenza virus in aerosol particles from human coughs, PLoS One,
doi:10.1371/journal.pone.0015100Lindsley, Pearce, Hudnall, Davis, Davis et al., Quantity and size distribution of cough-generated aerosol particles produced by influenza patients during and after illness, J. Occup. Environ. Hyg,
doi:10.1080/15459624.2012.684582Marshall, Gibson, Romer, Illidi, Hull et al., Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults, J. Appl. Physiol,
doi:10.1152/japplphysiol.00311.2020Martins Rodrigues, Torres Pereira, De Castro Lopes, Massaroni, Baroni et al., Is age rating enough to investigate changes in breathing motion pattern associated with aging of physically active women?, J. Biomech,
doi:10.1016/j.jbiomech.2021.110582Milton, Fabian, Cowling, Grantham, Mcdevitt, Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks, PLoS Pathog,
doi:10.1371/journal.ppat.1003205Molgat-Seon, Peters, Sheel, Sex-differences in the human respiratory system and their impact on resting pulmonary function and the integrative response to exercise, Curr. Opin. Physio,
doi:10.1016/j.cophys.2018.03.007Morawska, Johnson, Ristovski, Hargreaves, Mengersen et al., Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities, J. Aerosol Sci,
doi:10.1016/j.jaerosci.2008.11.002Moseley, Archer, Orton, Symons, Watson et al., Relationship between exhaled aerosol and carbon dioxide emission across respiratory activities, Environ. Sci. Technol,
doi:10.1021/acs.est.4c01717Mutsch, Heiber, Grätz, Hain, Schönfelder et al., Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise, Proc. Natl. Acad. Sci,
doi:10.1073/pnas.2202521119Mürbe, Kriegel, Lange, Schumann, Hartmann et al., Aerosol emission of adolescents voices during speaking, singing and shouting, PLoS One,
doi:10.1371/journal.pone.0246819Nikolić, Sun, Rawlins, Human lung development: recent progress and new challenges, Development,
doi:10.1242/dev.163485Oh, Bu, Kikumoto, Ooka, Correlation between beverage consumption and droplet production during respiratory activity using interferometric Mie imaging experiment, J. Aerosol Sci,
doi:10.1016/j.jaerosci.2024.106458Oldham, Moss, Pores of Kohn: forgotten alveolar structures and potential source of aerosols in exhaled breath, J. Breath Res,
doi:10.1088/1752-7163/ab0524Organization, Global technical consultation report on proposed terminology for pathogens that transmit through the air
Orton, Symons, Moseley, Archer, Watson et al., A comparison of respiratory particle emission rates at rest and while speaking or exercising, Commun Med,
doi:10.1038/s43856-022-00103-wPage, Mckenzie, Bossuyt, Boutron, Hoffmann et al., The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, BMJ,
doi:10.1136/bmj.n71Pan, Xu, Francis Yu, Liu, Characterization and size distribution of initial droplet concentration discharged from human breathing and speaking, Indoor and Built Environment,
doi:10.1177/1420326X221110975Pöhlker, Pöhlker, Krüger, Förster, Berkemeier et al., Respiratory aerosols and droplets in the transmission of infectious diseases, Rev. Mod. Phys,
doi:10.1103/RevModPhys.95.045001Rathnayake, Ditz, Van Nijnatten, Sadaf, Hansbro et al., Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier, Respirology,
doi:10.1111/resp.14401Rawat, Agirsoy, Senarathna, Erath, Ahmed et al., Comparing respiratory aerosol emissions between children and adults during sustained phonation, Aerosol Sci. Technol,
doi:10.1080/02786826.2023.2261715Roth, Stiti, Frantz, Corber, Berrocal, Exhaled aerosols and saliva dropletsmeasured in time and 3D space: quantification of pathogens flow rate applied to SARS-CoV-2, Nat. Sci,
doi:10.1002/ntls.20230007Sajgalik, Garzona-Navas, Csécs, Askew, Lopez-Jimenez et al., Characterization of aerosol generation during various intensities of exercise, Chest,
doi:10.1016/j.chest.2021.04.041Schuchmann, Scheuch, Naumann, Keute, Lücke et al., Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children, Front. Pediatr,
doi:10.3389/fped.2023.1156366Schumm, Bremer, Knoedlseder, Schoenfelder, Hain et al., Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups, Sci. Rep,
doi:10.1038/s41598-024-55117-2Schumm, Bremer, Knödlseder, Schönfelder, Hain et al., Lung aerosol particle emission increases with age at rest and during exercise, Proc. Natl. Acad. Sci,
doi:10.1073/pnas.2301145120Schwarz, Biller, Windt, Koch, Hohlfeld, Characterization of exhaled particles from the healthy human lung--a systematic analysis in relation to pulmonary function variables, J. Aerosol Med. Pulm. Drug Deliv,
doi:10.1089/jamp.2009.0809Schwarz, Biller, Windt, Koch, Hohlfeld, Characterization of exhaled particles from the human lungs in airway obstruction, J. Aerosol Med. Pulm. Drug Deliv,
doi:10.1089/jamp.2013.1104Sirota, Doxey, Dominguez, Bender, Vongpradith et al., Global, regional, and national burden of upper respiratory infections and otitis media, 1990-2021: a systematic analysis from the global burden of disease study 2021, Lancet Infect. Dis,
doi:10.1016/S1473-3099(24)00430-4Sun, Zhang, Liu, Liu, Wu et al., Association between body mass index and respiratory symptoms in US adults: a national cross-sectional study, Sci. Rep,
doi:10.1038/s41598-024-51637-zTeam, R: A language and environment for statistical computing
Thomas, Guppy, Straus, Bell, Glasziou, Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies, BMJ Open,
doi:10.1136/bmjopen-2018-028150Tinglev, Ullah, Ljungkvist, Viklund, Olin et al., Characterization of exhaled breath particles collected by an electret filter technique, J. Breath Res,
doi:10.1088/1752-7155/10/2/026001Varga, Kwiatkowski, Pedro, Groepenhoff, Rose et al., Observation of aerosol generation by human subjects during cardiopulmonary exercise testing using a high-powered laser technique: A pilot project, J. Med. Biol. Eng,
doi:10.1007/s40846-021-00675-3Viklund, Kokelj, Larsson, Nordén, Andersson et al., Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or coughing, Influenza Other Respir. Viruses,
doi:10.1111/irv.12964Von Elm, Altman, Egger, Pocock, Gøtzsche et al., The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies, Lancet,
doi:10.1016/S0140-6736(07)61602-XWegehaupt, Endo, Vassall, Superspreading, overdispersion and their implications in the SARS-CoV-2 (COVID-19) pandemic: a systematic review and metaanalysis of the literature, BMC Public Health,
doi:10.1186/s12889-023-15915-1Weston, Frieman, Respiratory viruses
Wickham, Averick, Bryan, Chang, Mcgowan et al., Welcome to the tidyverse, J. Open Source Softw,
doi:10.21105/joss.01686Xie, Li, Sun, Liu, Yan et al., Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community, Proc. Natl. Acad. Sci. USA,
doi:10.1073/pnas.1716561115Zayas, Chiang, Wong, Macdonald, Lange et al., Cough aerosol in healthy participants: fundamental knowledge to optimize droplet-spread infectious respiratory disease management, BMC Pulm. Med,
doi:10.1186/1471-2466-12-11DOI record:
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"abstract": "<jats:sec><jats:title>Introduction</jats:title><jats:p>Understanding host factor-related mechanisms that drive variability in respiratory particle emission and virus presence in exhaled particles is essential to assess transmission risk and potentially identify individuals with elevated infectiousness.</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>We conducted a systematic review of human observational studies examining associations between host factors and either respiratory particle emission or virus presence in exhaled particles. Searches in PubMed, EMBASE, and Web of Science covered studies up to September 2024. Risk of bias was assessed using STROBE-based criteria. Findings were synthesized narratively, grouped by host factor and outcome type.</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Forty-four studies met inclusion criteria: 34 assessed host factors in relation to particle emission, and 11 examined viral presence in exhaled particles. Fine particle emission (&lt;5 μm) was most consistently associated with older age (<jats:italic>n =</jats:italic> 16), physical exercise (<jats:italic>n =</jats:italic> 6), and active infection (<jats:italic>n =</jats:italic> 6). No consistent associations were found for sex (<jats:italic>n =</jats:italic> 21), body mass index (BMI; <jats:italic>n =</jats:italic> 10), or smoking (<jats:italic>n =</jats:italic> 6). Viral presence—mainly influenza and SARS-CoV-2—was more strongly associated with time since symptom onset (<jats:italic>n =</jats:italic> 8) and lower respiratory symptoms (<jats:italic>n =</jats:italic> 3), based largely on genomic detection. Associations with other factors, including upper respiratory symptoms (<jats:italic>n =</jats:italic> 6), swab viral load (<jats:italic>n =</jats:italic> 11), age (<jats:italic>n =</jats:italic> 6), sex (<jats:italic>n =</jats:italic> 6), and BMI (<jats:italic>n =</jats:italic> 2), were inconsistent or absent. Physical exercise was not evaluated in relation to viral presence.</jats:p></jats:sec><jats:sec><jats:title>Discussion</jats:title><jats:p>Fine respiratory particles (&lt;5 μm) were the predominant size fraction detected and often contained higher concentrations of viral RNA. Age, physical exercise, and active infection were consistently associated with increased emission of these particles. The presence of respiratory viruses in exhaled air was more strongly linked to infection-related factors such as early symptom onset and lower respiratory involvement. These patterns suggest distinct mechanisms contributing to airborne transmission. Interpretation was limited by methodological heterogeneity and predominant reliance on PCR. Still, consistent associations with host factors suggest their potential as indicators for transmission risk. As evidence focused mainly on influenza and SARS-CoV-2, generalizability is limited. Standardized methods and further research are needed to strengthen outbreak preparedness.</jats:p></jats:sec>",
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{
"DOI": "10.3390/v15010167",
"article-title": "A detailed overview of SARS-CoV-2 omicron: its sub-variants, mutations and pathophysiology, clinical characteristics, immunological landscape, immune escape, and therapies",
"author": "Chatterjee",
"doi-asserted-by": "publisher",
"first-page": "167",
"journal-title": "Viruses",
"key": "ref9",
"volume": "15",
"year": "2023"
},
{
"DOI": "10.7554/eLife.65774",
"article-title": "Heterogeneity in transmissibility and shedding SARS-CoV-2 via droplets and aerosols",
"author": "Chen",
"doi-asserted-by": "publisher",
"first-page": "65774",
"journal-title": "eLife",
"key": "ref10",
"volume": "10",
"year": "2021"
},
{
"DOI": "10.3390/v15102033",
"article-title": "Influenza A and B viruses in fine aerosols of exhaled breath samples from patients in tropical Singapore",
"author": "Chow",
"doi-asserted-by": "publisher",
"first-page": "2033",
"journal-title": "Viruses",
"key": "ref11",
"volume": "15",
"year": "2023"
},
{
"DOI": "10.1016/j.jclinepi.2020.01.008",
"article-title": "A full systematic review was completed in 2 weeks using automation tools: a case study",
"author": "Clark",
"doi-asserted-by": "publisher",
"first-page": "81",
"journal-title": "J. Clin. Epidemiol.",
"key": "ref12",
"volume": "121",
"year": "2020"
},
{
"DOI": "10.1093/cid/ciab691",
"article-title": "Viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in respiratory aerosols emitted by patients with coronavirus disease 2019 (COVID-19) while breathing, talking, and singing",
"author": "Coleman",
"doi-asserted-by": "publisher",
"first-page": "1722",
"journal-title": "Clin. Infect. Dis.",
"key": "ref13",
"volume": "74",
"year": "2022"
},
{
"DOI": "10.1111/irv.12790",
"article-title": "Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases",
"author": "de Mesquita",
"doi-asserted-by": "publisher",
"first-page": "154",
"journal-title": "Influenza Other Respir. Viruses",
"key": "ref14",
"volume": "15",
"year": "2021"
},
{
"DOI": "10.1080/17476348.2018.1506331",
"article-title": "The effect of obesity on lung function",
"author": "Dixon",
"doi-asserted-by": "publisher",
"first-page": "755",
"journal-title": "Expert Rev. Respir. Med.",
"key": "ref15",
"volume": "12",
"year": "2018"
},
{
"DOI": "10.1073/pnas.2021830118",
"article-title": "Exhaled aerosol increases with COVID-19 infection, age, and obesity",
"author": "Edwards",
"doi-asserted-by": "publisher",
"first-page": "118",
"journal-title": "Proc. Natl. Acad. Sci. USA",
"key": "ref16",
"volume": "22",
"year": "2021"
},
{
"DOI": "10.1073/pnas.0408159101",
"article-title": "Inhaling to mitigate exhaled bioaerosols",
"author": "Edwards",
"doi-asserted-by": "publisher",
"first-page": "17383",
"journal-title": "Proc. Natl. Acad. Sci. USA",
"key": "ref17",
"volume": "101",
"year": "2004"
},
{
"DOI": "10.1371/journal.pone.0002691",
"article-title": "Influenza virus in human exhaled breath: an observational study",
"author": "Fabian",
"doi-asserted-by": "publisher",
"first-page": "e2691",
"journal-title": "PLoS One",
"key": "ref18",
"volume": "3",
"year": "2008"
},
{
"DOI": "10.1098/rsif.2021.0833",
"article-title": "Pre-adolescent children exhibit lower aerosol particle volume emissions than adults for breathing, speaking, singing and shouting",
"author": "Fleischer",
"doi-asserted-by": "publisher",
"first-page": "20210833",
"journal-title": "J. R. Soc. Interface",
"key": "ref19",
"volume": "19",
"year": "2022"
},
{
"DOI": "10.1038/s41579-021-00542-7",
"article-title": "Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract",
"author": "Flerlage",
"doi-asserted-by": "publisher",
"first-page": "425",
"journal-title": "Nat. Rev. Microbiol.",
"key": "ref20",
"volume": "19",
"year": "2021"
},
{
"DOI": "10.1186/s13643-024-02619-9",
"article-title": "Automation of duplicate record detection for systematic reviews: Deduplicator",
"author": "Forbes",
"doi-asserted-by": "publisher",
"first-page": "206",
"journal-title": "Syst. Rev.",
"key": "ref21",
"volume": "13",
"year": "2024"
},
{
"DOI": "10.1021/acs.estlett.1c00760",
"article-title": "Respiratory aerosol emissions from vocalization: age and sex differences are explained by volume and exhaled CO2",
"author": "Good",
"doi-asserted-by": "publisher",
"first-page": "1071",
"journal-title": "Environ. Sci. Technol. Lett.",
"key": "ref22",
"volume": "8",
"year": "2021"
},
{
"DOI": "10.1080/02786826.2021.1883544",
"article-title": "Comparing aerosol concentrations and particle size distributions generated by singing, speaking and breathing",
"author": "Gregson",
"doi-asserted-by": "publisher",
"first-page": "681",
"journal-title": "Aerosol Sci. Technol.",
"key": "ref23",
"volume": "55",
"year": "2021"
},
{
"DOI": "10.1016/j.epidem.2023.100670",
"article-title": "A statistical framework for tracking the time-varying superspreading potential of COVID-19 epidemic",
"author": "Guo",
"doi-asserted-by": "publisher",
"first-page": "100670",
"journal-title": "Epidemics",
"key": "ref24",
"volume": "42",
"year": "2023"
},
{
"DOI": "10.3389/fped.2022.941785",
"article-title": "Exhaled aerosols in SARS-CoV-2 polymerase chain reaction-positive children and age-matched-negative controls",
"author": "Gutmann",
"doi-asserted-by": "publisher",
"first-page": "941785",
"journal-title": "Front. Pediatr.",
"key": "ref25",
"volume": "10",
"year": "2022"
},
{
"DOI": "10.1101/2022.01.21.22269423",
"article-title": "Aerosol measurement identifies SARS-CoV 2 PCR positive adults compared with healthy controls",
"author": "Gutmann",
"doi-asserted-by": "publisher",
"first-page": "114417",
"journal-title": "Environ. Res.",
"key": "ref26",
"volume": "216",
"year": "2022"
},
{
"DOI": "10.1080/02786826.2022.2158778",
"article-title": "Emission rates, size distributions, and generation mechanism of oral respiratory droplets",
"author": "Harrison",
"doi-asserted-by": "publisher",
"first-page": "187",
"journal-title": "Aerosol Sci. Technol.",
"key": "ref27",
"volume": "57",
"year": "2023"
},
{
"DOI": "10.1002/clen.200700189",
"article-title": "Impact of health on particle size of exhaled respiratory aerosols: case-control study",
"author": "Hersen",
"doi-asserted-by": "publisher",
"first-page": "572",
"journal-title": "Clean (Weinh)",
"key": "ref28",
"volume": "36",
"year": "2008"
},
{
"DOI": "10.1016/j.buildenv.2023.110994",
"article-title": "Review of experimental measurements on particle size distribution and airflow behaviors during human respiration",
"author": "Hu",
"doi-asserted-by": "publisher",
"first-page": "110994",
"journal-title": "Build. Environ.",
"key": "ref29",
"volume": "247",
"year": "2024"
},
{
"DOI": "10.1136/bmjresp-2020-000804",
"article-title": "Novel non-invasive particles in exhaled air method to explore the lining fluid of small airways-a European population-based cohort study",
"author": "Hussain-Alkhateeb",
"doi-asserted-by": "publisher",
"first-page": "804",
"journal-title": "BMJ Open Respir. Res.",
"key": "ref30",
"volume": "8",
"year": "2021"
},
{
"author": "Iannone",
"key": "ref31",
"volume-title": "Gt: easily create presentation-ready display tables",
"year": "2023"
},
{
"DOI": "10.1038/s41467-024-45400-1",
"article-title": "Frequency, kinetics and determinants of viable SARS-CoV-2 in bioaerosols from ambulatory COVID-19 patients infected with the beta, delta or omicron variants",
"author": "Jaumdally",
"doi-asserted-by": "publisher",
"first-page": "2003",
"journal-title": "Nat. Commun.",
"key": "ref32",
"volume": "15",
"year": "2024"
},
{
"DOI": "10.1089/jamp.2008.0720",
"article-title": "The mechanism of breath aerosol formation",
"author": "Johnson",
"doi-asserted-by": "publisher",
"first-page": "229",
"journal-title": "J. Aerosol Med. Pulm. Drug Deliv.",
"key": "ref33",
"volume": "22",
"year": "2009"
},
{
"DOI": "10.3390/su132112203",
"article-title": "Correlation of respiratory aerosols and metabolic carbon dioxide",
"author": "Kappelt",
"doi-asserted-by": "publisher",
"first-page": "2203",
"journal-title": "Sustainability",
"key": "ref34",
"volume": "13",
"year": "2021"
},
{
"DOI": "10.1016/j.coviro.2018.01.001",
"article-title": "Transmission routes of respiratory viruses among humans",
"author": "Kutter",
"doi-asserted-by": "publisher",
"first-page": "142",
"journal-title": "Curr. Opin. Virol.",
"key": "ref35",
"volume": "28",
"year": "2018"
},
{
"DOI": "10.1093/cid/ciac846",
"article-title": "Exhaled breath aerosol shedding of highly transmissible versus prior severe acute respiratory syndrome coronavirus 2 variants",
"author": "Lai",
"doi-asserted-by": "publisher",
"first-page": "786",
"journal-title": "Clin. Infect. Dis.",
"key": "ref36",
"volume": "76",
"year": "2023"
},
{
"DOI": "10.1016/j.ijge.2016.11.003",
"article-title": "Implications of age-related changes in anatomy for geriatric-focused difficult airways",
"author": "Lee",
"doi-asserted-by": "publisher",
"first-page": "130",
"journal-title": "Int. J. Gerontol.",
"key": "ref37",
"volume": "11",
"year": "2017"
},
{
"DOI": "10.4209/aaqr.2018.01.0031",
"article-title": "Quantity, size distribution, and characteristics of cough-generated aerosol produced by patients with an upper respiratory tract infection",
"author": "Lee",
"doi-asserted-by": "publisher",
"first-page": "840",
"journal-title": "Aerosol Air Qual. Res.",
"key": "ref38",
"volume": "19",
"year": "2019"
},
{
"DOI": "10.3389/fimmu.2021.701443",
"article-title": "Abnormal airway mucus secretion induced by virus infection",
"author": "Li",
"doi-asserted-by": "publisher",
"first-page": "701443",
"journal-title": "Front. Immunol.",
"key": "ref39",
"volume": "12",
"year": "2021"
},
{
"DOI": "10.1016/j.ijid.2021.05.062",
"article-title": "Modeling the early temporal dynamics of viral load in respiratory tract specimens of COVID-19 patients in Incheon, the Republic of Korea",
"author": "Lim",
"doi-asserted-by": "publisher",
"first-page": "428",
"journal-title": "Int. J. Infect. Dis.",
"key": "ref40",
"volume": "108",
"year": "2021"
},
{
"DOI": "10.1111/irv.12390",
"article-title": "Viable influenza A virus in airborne particles expelled during coughs versus exhalations",
"author": "Lindsley",
"doi-asserted-by": "publisher",
"first-page": "404",
"journal-title": "Influenza Other Respir. Viruses",
"key": "ref41",
"volume": "10",
"year": "2016"
},
{
"DOI": "10.1371/journal.pone.0015100",
"article-title": "Measurements of airborne influenza virus in aerosol particles from human coughs",
"author": "Lindsley",
"doi-asserted-by": "publisher",
"first-page": "e15100",
"journal-title": "PLoS One",
"key": "ref42",
"volume": "5",
"year": "2010"
},
{
"DOI": "10.1080/15459624.2012.684582",
"article-title": "Quantity and size distribution of cough-generated aerosol particles produced by influenza patients during and after illness",
"author": "Lindsley",
"doi-asserted-by": "publisher",
"first-page": "443",
"journal-title": "J. Occup. Environ. Hyg.",
"key": "ref43",
"volume": "9",
"year": "2012"
},
{
"DOI": "10.1183/20734735.000318",
"article-title": "Sex differences in respiratory function",
"author": "LoMauro",
"doi-asserted-by": "publisher",
"first-page": "131",
"journal-title": "Breathe",
"key": "ref44",
"volume": "14",
"year": "2018"
},
{
"DOI": "10.1152/japplphysiol.00311.2020",
"article-title": "Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults",
"author": "Marshall",
"doi-asserted-by": "publisher",
"first-page": "517",
"journal-title": "J. Appl. Physiol.",
"key": "ref45",
"volume": "130",
"year": "2020"
},
{
"DOI": "10.1016/j.jbiomech.2021.110582",
"article-title": "Is age rating enough to investigate changes in breathing motion pattern associated with aging of physically active women?",
"author": "Martins Rodrigues",
"doi-asserted-by": "publisher",
"first-page": "110582",
"journal-title": "J. Biomech.",
"key": "ref46",
"volume": "125",
"year": "2021"
},
{
"DOI": "10.1371/journal.ppat.1003205",
"article-title": "Influenza virus aerosols in human exhaled breath: particle size, culturability, and effect of surgical masks",
"author": "Milton",
"doi-asserted-by": "publisher",
"first-page": "e1003205",
"journal-title": "PLoS Pathog.",
"key": "ref47",
"volume": "9",
"year": "2013"
},
{
"DOI": "10.1016/j.cophys.2018.03.007",
"article-title": "Sex-differences in the human respiratory system and their impact on resting pulmonary function and the integrative response to exercise",
"author": "Molgat-Seon",
"doi-asserted-by": "publisher",
"first-page": "21",
"journal-title": "Curr. Opin. Physio.",
"key": "ref48",
"volume": "6",
"year": "2018"
},
{
"DOI": "10.1016/j.jaerosci.2008.11.002",
"article-title": "Size distribution and sites of origin of droplets expelled from the human respiratory tract during expiratory activities",
"author": "Morawska",
"doi-asserted-by": "publisher",
"first-page": "256",
"journal-title": "J. Aerosol Sci.",
"key": "ref49",
"volume": "40",
"year": "2009"
},
{
"DOI": "10.1021/acs.est.4c01717",
"article-title": "Relationship between exhaled aerosol and carbon dioxide emission across respiratory activities",
"author": "Moseley",
"doi-asserted-by": "publisher",
"first-page": "15120",
"journal-title": "Environ. Sci. Technol.",
"key": "ref50",
"volume": "58",
"year": "2024"
},
{
"DOI": "10.1038/s41598-021-93281-x",
"article-title": "Aerosol emission in professional singing of classical music",
"author": "Mürbe",
"doi-asserted-by": "publisher",
"first-page": "14861",
"journal-title": "Sci. Rep.",
"key": "ref51",
"volume": "11",
"year": "2021"
},
{
"DOI": "10.1371/journal.pone.0246819",
"article-title": "Aerosol emission of adolescents voices during speaking, singing and shouting",
"author": "Mürbe",
"doi-asserted-by": "publisher",
"first-page": "e0246819",
"journal-title": "PLoS One",
"key": "ref52",
"volume": "16",
"year": "2021"
},
{
"DOI": "10.1073/pnas.2202521119",
"article-title": "Aerosol particle emission increases exponentially above moderate exercise intensity resulting in superemission during maximal exercise",
"author": "Mutsch",
"doi-asserted-by": "publisher",
"first-page": "e2202521119",
"journal-title": "Proc. Natl. Acad. Sci. USA",
"key": "ref53",
"volume": "119",
"year": "2022"
},
{
"DOI": "10.1242/dev.163485",
"article-title": "Human lung development: recent progress and new challenges",
"author": "Nikolić",
"doi-asserted-by": "publisher",
"first-page": "163485",
"journal-title": "Development",
"key": "ref54",
"volume": "145",
"year": "2018"
},
{
"DOI": "10.1016/j.jaerosci.2024.106458",
"article-title": "Correlation between beverage consumption and droplet production during respiratory activity using interferometric Mie imaging experiment",
"author": "Oh",
"doi-asserted-by": "publisher",
"first-page": "106458",
"journal-title": "J. Aerosol Sci.",
"key": "ref55",
"volume": "182",
"year": "2024"
},
{
"DOI": "10.1088/1752-7163/ab0524",
"article-title": "Pores of Kohn: forgotten alveolar structures and potential source of aerosols in exhaled breath",
"author": "Oldham",
"doi-asserted-by": "publisher",
"first-page": "021003",
"journal-title": "J. Breath Res.",
"key": "ref56",
"volume": "13",
"year": "2019"
},
{
"key": "ref57",
"volume-title": "Global technical consultation report on proposed terminology for pathogens that transmit through the air;. Licence: CC BY-NC-SA 3.0 IGO",
"year": "2024"
},
{
"key": "ref58",
"volume-title": "The burden of influenza",
"year": "2024"
},
{
"DOI": "10.1038/s43856-022-00103-w",
"article-title": "A comparison of respiratory particle emission rates at rest and while speaking or exercising",
"author": "Orton",
"doi-asserted-by": "publisher",
"first-page": "44",
"journal-title": "Commun Med",
"key": "ref59",
"volume": "2",
"year": "2022"
},
{
"DOI": "10.1136/bmj.n71",
"article-title": "The PRISMA 2020 statement: an updated guideline for reporting systematic reviews",
"author": "Page",
"doi-asserted-by": "publisher",
"first-page": "n71",
"journal-title": "BMJ",
"key": "ref60",
"volume": "372",
"year": "2021"
},
{
"DOI": "10.1177/1420326X221110975",
"article-title": "Characterization and size distribution of initial droplet concentration discharged from human breathing and speaking",
"author": "Pan",
"doi-asserted-by": "publisher",
"first-page": "2020",
"journal-title": "Indoor and Built Environment.",
"key": "ref61",
"volume": "32",
"year": "2023"
},
{
"DOI": "10.1103/RevModPhys.95.045001",
"article-title": "Respiratory aerosols and droplets in the transmission of infectious diseases",
"author": "Pöhlker",
"doi-asserted-by": "publisher",
"first-page": "045001",
"journal-title": "Rev. Mod. Phys.",
"key": "ref62",
"volume": "95",
"year": "2023"
},
{
"DOI": "10.1038/s41579-022-00822-w",
"article-title": "SARS-CoV-2 viral load and shedding kinetics",
"author": "Puhach",
"doi-asserted-by": "publisher",
"first-page": "147",
"journal-title": "Nat. Rev. Microbiol.",
"key": "ref63",
"volume": "21",
"year": "2023"
},
{
"DOI": "10.1111/resp.14401",
"article-title": "Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier",
"author": "Rathnayake",
"doi-asserted-by": "publisher",
"first-page": "132",
"journal-title": "Respirology",
"key": "ref64",
"volume": "28",
"year": "2023"
},
{
"DOI": "10.1080/02786826.2023.2261715",
"article-title": "Comparing respiratory aerosol emissions between children and adults during sustained phonation",
"author": "Rawat",
"doi-asserted-by": "publisher",
"first-page": "1186",
"journal-title": "Aerosol Sci. Technol.",
"key": "ref65",
"volume": "57",
"year": "2023"
},
{
"DOI": "10.1183/13993003.00347-2016",
"article-title": "Exercise, ageing and the lung",
"author": "Roman",
"doi-asserted-by": "publisher",
"first-page": "1471",
"journal-title": "Eur. Respir. J.",
"key": "ref66",
"volume": "48",
"year": "2016"
},
{
"DOI": "10.1002/ntls.20230007",
"article-title": "Exhaled aerosols and saliva dropletsmeasured in time and 3D space: quantification of pathogens flow rate applied to SARS-CoV-2",
"author": "Roth",
"doi-asserted-by": "publisher",
"first-page": "7",
"journal-title": "Nat. Sci.",
"key": "ref67",
"volume": "3",
"year": "2023"
},
{
"DOI": "10.1016/j.chest.2021.04.041",
"article-title": "Characterization of aerosol generation during various intensities of exercise",
"author": "Sajgalik",
"doi-asserted-by": "publisher",
"first-page": "1377",
"journal-title": "Chest",
"key": "ref68",
"volume": "160",
"year": "2021"
},
{
"DOI": "10.1016/j.cell.2021.03.005",
"article-title": "The aging lung: physiology, disease, and immunity",
"author": "Schneider",
"doi-asserted-by": "publisher",
"first-page": "1990",
"journal-title": "Cell",
"key": "ref69",
"volume": "184",
"year": "2021"
},
{
"DOI": "10.3389/fped.2023.1156366",
"article-title": "Exhaled aerosols among PCR-confirmed SARS-CoV-2-infected children",
"author": "Schuchmann",
"doi-asserted-by": "publisher",
"first-page": "1156366",
"journal-title": "Front. Pediatr.",
"key": "ref70",
"volume": "11",
"year": "2023"
},
{
"DOI": "10.1073/pnas.2301145120",
"article-title": "Lung aerosol particle emission increases with age at rest and during exercise",
"author": "Schumm",
"doi-asserted-by": "publisher",
"first-page": "e2301145120",
"journal-title": "Proc. Natl. Acad. Sci. USA",
"key": "ref71",
"volume": "120",
"year": "2023"
},
{
"DOI": "10.1038/s41598-024-55117-2",
"article-title": "Indices of airway resistance and reactance from impulse oscillometry correlate with aerosol particle emission in different age groups",
"author": "Schumm",
"doi-asserted-by": "publisher",
"first-page": "4644",
"journal-title": "Sci. Rep.",
"key": "ref72",
"volume": "14",
"year": "2024"
},
{
"DOI": "10.1089/jamp.2009.0809",
"article-title": "Characterization of exhaled particles from the healthy human lung--a systematic analysis in relation to pulmonary function variables",
"author": "Schwarz",
"doi-asserted-by": "publisher",
"first-page": "371",
"journal-title": "J. Aerosol Med. Pulm. Drug Deliv.",
"key": "ref73",
"volume": "23",
"year": "2010"
},
{
"DOI": "10.1089/jamp.2013.1104",
"article-title": "Characterization of exhaled particles from the human lungs in airway obstruction",
"author": "Schwarz",
"doi-asserted-by": "publisher",
"first-page": "52",
"journal-title": "J. Aerosol Med. Pulm. Drug Deliv.",
"key": "ref74",
"volume": "28",
"year": "2015"
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"key": "ref77",
"volume-title": "R: A language and environment for statistical computing",
"year": "2023"
},
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"DOI": "10.1136/bmjopen-2018-028150",
"article-title": "Rate of normal lung function decline in ageing adults: a systematic review of prospective cohort studies",
"author": "Thomas",
"doi-asserted-by": "publisher",
"first-page": "e028150",
"journal-title": "BMJ Open",
"key": "ref78",
"volume": "9",
"year": "2019"
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"DOI": "10.1088/1752-7155/10/2/026001",
"article-title": "Characterization of exhaled breath particles collected by an electret filter technique",
"author": "Tinglev",
"doi-asserted-by": "publisher",
"first-page": "026001",
"journal-title": "J. Breath Res.",
"key": "ref79",
"volume": "10",
"year": "2016"
},
{
"DOI": "10.1007/s40846-021-00675-3",
"article-title": "Observation of aerosol generation by human subjects during cardiopulmonary exercise testing using a high-powered laser technique: A pilot project",
"author": "Varga",
"doi-asserted-by": "publisher",
"first-page": "1",
"journal-title": "J. Med. Biol. Eng.",
"key": "ref80",
"volume": "42",
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"DOI": "10.1128/mmbr.00002-08",
"article-title": "Methods for sampling of airborne viruses",
"author": "Verreault",
"doi-asserted-by": "publisher",
"first-page": "413",
"journal-title": "Microbiol. Mol. Biol. Rev.",
"key": "ref81",
"volume": "72",
"year": "2008"
},
{
"DOI": "10.1111/irv.12964",
"article-title": "Severe acute respiratory syndrome coronavirus 2 can be detected in exhaled aerosol sampled during a few minutes of breathing or coughing",
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"journal-title": "Influenza Other Respir. Viruses",
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{
"DOI": "10.1016/S0140-6736(07)61602-X",
"article-title": "The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies",
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"article-title": "Airborne transmission of respiratory viruses",
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"article-title": "Superspreading, overdispersion and their implications in the SARS-CoV-2 (COVID-19) pandemic: a systematic review and meta-analysis of the literature",
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"article-title": "Respiratory viruses",
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"key": "ref86",
"volume-title": "Encyclopedia of microbiology",
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"article-title": "Welcome to the tidyverse",
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"article-title": "Exhaled droplets due to talking and coughing",
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