All Studies Meta Analysis

A Multi-centre, Adaptive, Randomized, Open-label, Controlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients (CATCO: Canadian Treatments for COVID-19), in Conjunction With the Public Health Emergency SOLIDARITY Trial (World Health Organization)

Fowler et al., NCT04330690, CATCO, NCT04330690

May 2024

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Artemisinin

41st treatment shown to reduce risk in November 2022, now with p = 0.0066 from 3 studies, recognized in 13 countries.

Lower risk for recovery.

No treatment is 100% effective. Protocols combine treatments.

5,400+ studies for 117 treatments. c19early.org

Estimated 966 patient artemisinin late treatment RCT with results not reported over 9 months after estimated completion.

2 artemisinin RCTs have results missing long after expected1,2
The trials report an estimated total of 1,366 patients.

Important missing comments or errors? Let us know.

1. Fowler et al., A Multi-centre, Adaptive, Randomized, Open-label, Controlled Clinical Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Patients (CATCO: Canadian Treatments for COVID-19), in Conjunction With the Public Health Emergency SOLIDARITY Trial (World Health Organization), NCT04330690, clinicaltrials.gov/study/NCT04330690.clinicaltrials.gov.

2. Gyanwali et al., WHO Solidarity Trial Plus: An International Randomised Trial of Additional Treatments for COVID-19 in Hospitalised Patients Who Are All Receiving the Local Standard of Care in Nepal, NCT05273242, clinicaltrials.gov/study/NCT05273242.clinicaltrials.gov.

Fowler et al., 18 May 2024, Randomized Controlled Trial, Canada, trial NCT04330690 (history) (CATCO). Contact: rob.fowler@sunnybrook.ca, CATCO@sunnybrook.ca, atrembla@ucalgary.ca, cjdumonc@ucalgary.ca, conar@ualberta.ca, Matt.Munan@covenanthealth.ca, wendy.sligl@ahs.ca, Kimberly.Robertson2@albertahealthservices.ca, Caitlyn.Marek@interiorhealth.ca, Mai.Hayashi@interiorhealth.ca, james.douglas@vch.ca, Valla.sahraei@vch.ca, jennifer.grant@vch.ca, Gabriel.Loh@vch.ca, allimah@mail.ubc.ca, laura.oliveira@ubc.ca, npress@cfenet.ubc.ca, llove@cheos.ubc.ca, daniel.ovakim@viha.ca, fiona.auld@viha.ca, yoav.keynan@umanitoba.ca, nchoi@hsc.mb.ca, Peter.Daley@easternhealth.ca, laura.genge@easternhealth.ca, lisa.barrett@nshealth.ca, barbara.goodall@nshealth.ca, Alexandra.Binnie@williamoslerhs.ca, sergio.borgia@williamoslerhs.ca, thomas.havey@williamoslerhs.ca, Erick.duan@medportal.ca, clarkef@mcmaster.ca, Michael.Silverman@sjhc.london.on.ca, SeemaNair.Parvathy@sjhc.london.on.ca, efera@msh.on.ca, nshah@msh.on.ca, Christopher.Graham@thp.ca, Mobina.Khurram@thp.ca, senglish@ohri.ca, iwatpool@ohri.ca, nicolaschagnon@montfort.on.ca, christinencompas@montfort.on.ca, rporteous@ohri.ca, jennifer.tsang@mail.utoronto.ca, Lisa.patterson@niagarahealth.on.ca, sjohn@shn.ca, crobb@shn.ca, gambleg@me.com, moonl@tbh.net, christopher.kandel@one-mail.on.ca, jeff.powis@tehn.ca, Asgar.Rishu@sunnybrook.ca, Darrell.tan@gmail.com, Attia.Qamar@unityhealth.to, michael.fralick@sinaihealth.ca, bryan.Coburn@uhn.ca, kevin.schwartz@unityhealth.to, kanthi.kavikondala@unityhealth.to, madeleine.durand.chum@ssss.gouv.qc.ca, stephanie.matte.chum@ssss.gouv.qc.ca, matthew.cheng@mcgill.ca, sondramandy.sinanan@muhc.mcgill.ca, alexis.turgeon@crchudequebec.ulaval.ca, David.Bellemare@crchudequebec.ulaval.ca, francois.lellouche@criucpq.ulaval.ca, patricia.lizotte@criucpq.ulaval.ca, francois.lamontagne@usherbrooke.ca, marie-pier.bouchard.ciussse-chus@ssss.gouv.qc.ca.

This Paper Artemisinin All

Late treatment
is less effective

Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.

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