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All Studies   Meta Analysis    Recent:   

Vitamin D-independent benefits of safe sunlight exposure

Erem et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105957
Oct 2021  
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Sunlight for COVID-19
32nd treatment shown to reduce risk in December 2021
 
*, now with p = 0.000052 from 5 studies.
Lower risk for mortality, hospitalization, recovery, and cases.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Review of the benefits of sunlight exposure independent of vitamin D.
Reviews covering sunlight for COVID-19 include1-3.
Erem et al., 31 Oct 2021, peer-reviewed, 2 authors.
This PaperSunlightAll
Vitamin D-independent benefits of safe sunlight exposure
Anna S Erem, Mohammed S Razzaque
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105957
This review examines the beneficial effects of ultraviolet radiation on systemic autoimmune diseases, including multiple sclerosis and type I diabetes, where the epidemiological evidence for the vitamin D-independent effects of sunlight is most apparent. Ultraviolet radiation, in addition to its role in the synthesis of vitamin D, stimulates anti-inflammatory pathways, alters the composition of dendritic cells, T cells, and T regulatory cells, and induces nitric oxide synthase and heme oxygenase metabolic pathways, which may directly or indirectly mitigate disease progression and susceptibility. Recent work has also explored how the immune-modulating functions of ultraviolet radiation affect type II diabetes, cancer, and the current global pandemic caused by SARS-CoV-2. These diseases are particularly important amidst global changes in lifestyle that result in unhealthy eating, increased sedentary habits, and alcohol and tobacco consumption. Compelling epidemiological data shows increased ultraviolet radiation associated with reduced rates of certain cancers, such as colorectal cancer, breast cancer, non-Hodgkins lymphoma, and ultraviolet radiation exposure correlated with susceptibility and mortality rates of COVID-19. Thus, understanding the effects of ultraviolet radiation on both vitamin D-dependent andindependent pathway is necessary to understand how they influence the course of many human diseases.
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