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Home   COVID-19 treatment studies for Bamlanivimab/etesevimab  COVID-19 treatment studies for Bamlaniv../e..  C19 studies: Bamlaniv../e..  Bamlaniv../e..   Select treatmentSelect treatmentTreatmentsTreatments
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All Studies   Meta Analysis   Recent: 
0 0.5 1 1.5 2+ Hospitalization 25% Improvement Relative Risk Hospitalization, 7000mg.. 52% Hospitalization, 700mg.. -1% Time to symptom impro.. -14% primary Time to symptom i.. (b) -17% primary Progression, 7000mg -1% Progression, 700mg 2% Viral load, 7000mg, day 3 26% Viral load, 700mg, day 3 35% c19early.org/l Chew et al. NCT04427501 ACTIV-2/A5401 Bamlaniv../e.. RCT LATE Favors bamlanivimab/e.. Favors control
Antiviral and clinical activity of bamlanivimab in a randomized trial of non-hospitalized adults with COVID-19
Chew et al., Nature Communications, doi:10.1038/s41467-022-32551-2, ACTIV-2/A5401, NCT04427501 (history)
22 Aug 2022    Source   PDF   Share   Tweet
RCT 317 outpatients in the USA showing faster viral load and inflammatory biomarker decline, but no significant differences in clinical outcomes.
Efficacy is highly variant dependent. In Vitro research suggests a lack of efficacy for omicron [Liu, Sheward, VanBlargan].
risk of hospitalization, 25.5% lower, RR 0.75, p = 0.60, treatment 6 of 159 (3.8%), control 8 of 158 (5.1%), NNT 78, combined.
risk of hospitalization, 52.1% lower, RR 0.48, p = 0.43, treatment 2 of 48 (4.2%), control 4 of 46 (8.7%), NNT 22, 7000mg, day 28.
risk of hospitalization, 0.9% higher, RR 1.01, p = 1.00, treatment 4 of 111 (3.6%), control 4 of 112 (3.6%), 700mg, day 28.
relative time to symptom improvement, 13.5% higher, relative time 1.14, p = 0.97, treatment 48, control 46, 7000mg, primary outcome.
relative time to symptom improvement, 17.1% higher, relative time 1.17, p = 0.08, treatment 111, control 112, 700mg, primary outcome.
risk of progression, 0.6% higher, RR 1.01, p = 1.00, treatment 42 of 48 (87.5%), control 40 of 46 (87.0%), at least one symptom more severe than baseline, 7000mg.
risk of progression, 2.0% lower, RR 0.98, p = 0.62, treatment 102 of 111 (91.9%), control 105 of 112 (93.8%), NNT 54, at least one symptom more severe than baseline, 700mg.
viral load, 25.6% lower, relative load 0.74, p = 0.002, treatment 48, control 46, 7000mg, day 3.
viral load, 35.3% lower, relative load 0.65, p = 0.07, treatment 111, control 112, 700mg, day 3.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Chew et al., 22 Aug 2022, Randomized Controlled Trial, placebo-controlled, USA, peer-reviewed, 26 authors, study period 19 August, 2020 - 15 November, 2020, average treatment delay 6.0 days, trial NCT04427501 (history) (ACTIV-2/A5401).
Contact: kchew@mednet.ucla.edu.
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This PaperBamlaniv../e..All
Late treatment
is less effective
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