Figure S1. Love plot displaying standardized differences for the baseline characteristics by the use of azvudine in patients with myocardial injuries, before and after propensity score matching. SBP: systolic blood pressure; DBP: diastolic blood pressure; RR: respiratory rate; HR: heart rate
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'reference-count': 30,
'publisher': 'Ovid Technologies (Wolters Kluwer Health)',
'issue': '2',
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'date-time': '2023-04-01T00:00:00Z',
'timestamp': 1680307200000},
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'abstract': '<jats:sec>\n'
' <jats:title>Background and purpose:</jats:title>\n'
' <jats:p>Omicron is currently the dominant strain of severe acute respiratory '
'syndrome coronavirus 2, but little is known about the characteristics and management of '
'omicron related myocardial injury, particularly the potential benefit of the antiviral agent '
'azvudine.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Methods:</jats:title>\n'
' <jats:p>Patients with confirmed and suspected coronavirus disease 2019 (COVID-19) '
'admitted to Wuhan Union Hospital from December 7, 2022, to December 30, 2022, were included '
'in this study. Cox regression was conducted to identify risk factors for all-cause mortality. '
'A propensity score-matched analysis was performed at a 1:1 ratio with a caliper of 0.1 pooled '
'standard deviations of relevant confounders.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Results:</jats:title>\n'
' <jats:p>The final analysis included a total of 332 patients (167 confirmed cases '
'and 165 suspected cases), 42.77% (142/332) of the patients were 80 years of age or older and '
'68.67% (228/332) of them were men, 158 patients were treated with azvudine. In the matched '
'cohort, the total mortality was 30.30% (60/198), 40 (20.20%, 40/198) patients received '
'noninvasive ventilation and 22 (11.11%, 22/198) received invasive ventilation, 34 (17.17%, '
'34/198) patients were admitted to intensive care unit (ICU). The rate of shock, multiple '
'organ damages and arrhythmia were 11.62% (23/198), 20.20% (40/198), and 12.12% (24/198), '
'respectively. There was no significant difference on these clinical outcomes in patients '
'treated with azvudine or not. Azvudine reduced early mortality (within 14 days from '
'admission) (hazard ratio: 0.37, 95% confidence interval: 0.18–0.77) even after adjusting for '
'other treatments including glucocorticoids, immunoglobin and anticoagulant therapy, but not '
'the final in-hospital mortality of patients.</jats:p>\n'
' </jats:sec>\n'
' <jats:sec>\n'
' <jats:title>Conclusions:</jats:title>\n'
' <jats:p>Patients with COVID-19-related myocardial injury had a high mortality of '
'about 30.30% (60/198). Azvudine improved the early survival of the patients but not final '
'mortality.</jats:p>\n'
' </jats:sec>',
'DOI': '10.1097/cp9.0000000000000049',
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'created': {'date-parts': [[2023, 6, 8]], 'date-time': '2023-06-08T10:00:35Z', 'timestamp': 1686218435000},
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'source': 'Crossref',
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'title': 'All-cause mortality in moderate and severe COVID-19 patients with myocardial injury receiving '
'versus not receiving azvudine: a propensity score-matched analysis',
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{ 'name': 'Clinic Center of Human Gene Research, Union Hospital, Tongji '
'Medical College, Huazhong University of Science and Technology, '
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'relation': {},
'ISSN': ['2470-7511'],
'subject': ['Cardiology and Cardiovascular Medicine'],
'published': {'date-parts': [[2023, 4]]}}
