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All Studies   Meta Analysis    Recent:   

Management of immunosuppression in lung transplant recipients and COVID-19 outcomes: an observational retrospective cohort-study

Bes-Berlandier et al., BMC Infectious Diseases, doi:10.1186/s12879-024-09269-1
May 2024  
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Oxygen increase, ICU, o.. -67% Improvement Relative Risk Casirivimab/i..  Bes-Berlandier et al.  Prophylaxis Is prophylaxis with casirivimab/imdevimab beneficial for COVID-19? Retrospective 91 patients in France (March 2020 - April 2022) Higher progression with casirivimab/imdevimab (not stat. sig., p=0.31) c19early.org Bes-Berlandier et al., BMC Infectious .., May 2024 Favorscasirivimab/im.. Favorscontrol 0 0.5 1 1.5 2+
16th treatment shown to reduce risk in March 2021
 
*, now with p = 0.000055 from 29 studies, recognized in 45 countries. Efficacy is variant dependent.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 77 treatments. c19early.org
Retrospective 91 lung transplant recipients with COVID-19 showing no significant difference in poor outcomes with casirivimab/imdevimab or tixagevimab/cilgavimab prophylaxis in univariate analysis.
Efficacy is variant dependent. In Vitro research suggests a lack of efficacy for many omicron variants1-6.
Study covers casirivimab/imdevimab and tixagevimab/cilgavimab.
oxygen increase, ICU, or mortality, 67.4% higher, RR 1.67, p = 0.31, treatment 5 of 17 (29.4%), control 13 of 74 (17.6%).
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bes-Berlandier et al., 28 May 2024, retrospective, France, peer-reviewed, median age 51.0, 10 authors, study period March 2020 - April 2022. Contact: cassirnadim@gmail.com.
This PaperCasirivimab/i..All
Management of immunosuppression in lung transplant recipients and COVID-19 outcomes: an observational retrospective cohort-study
Hugo Bes-Berlandier, Benjamin Coiffard, Julien Bermudez, Nadine Demazes-Dufeu, Bérengère Coltey, Céline Boschi, Philippe Colson, Sami Hraiech, Martine Reynaud-Gaubert, Nadim Cassir
BMC Infectious Diseases, doi:10.1186/s12879-024-09269-1
Background The aim of this study was to assess the impact of immunosuppression management on coronavirus disease 2019 (COVID-19) outcomes. Methods We performed a single-center retrospective study in a cohort of 358 lung transplant recipients (LTx) over the period from March 2020 to April 2022. All included symptomatic patients had at least one positive SARS-CoV-2 rt-PCR. We used a composite primary outcome for COVID-19 including increased need for oxygen since the hospital admission, ICU transfer, and in-hospital mortality. We assessed by univariate and multivariate analyses the risk factors for poor outcomes. Results Overall, we included 91 LTx who contracted COVID-19. The COVID-19 in-hospital mortality rate reached 4.4%. By hierarchical clustering, we found a strong and independent association between the composite poor outcome and the discontinuation of at least one immunosuppressive molecule among tacrolimus, cyclosporine, mycophenolate mofetil, and everolimus. Obesity (OR = 16, 95%CI (1.96; 167), p = 0.01) and chronic renal failure (OR = 4.6, 95%CI (1.4; 18), p = 0.01) were also independently associated with the composite poor outcome. Conversely, full vaccination was protective (OR = 0.23, 95%CI (0.046; 0.89), p = 0.047). Conclusion The administration of immunosuppressive drugs such as tacrolimus, cyclocporine or everolimus can have a protective effect in LTx with COVID-19, probably related to their intrinsic antiviral capacity.
Supplementary Information The online version contains supplementary material available at https://doi. org/10.1186/s12879-024-09269-1. Supplementary Material 1 Author contributions Data availability The data that support the findings of this study are available from the corresponding author upon reasonable request. Declarations Ethics approval and consent to participate Due to the retrospective nature of the study, the need for informed consent was waived by the Ethics Committee of the Société de Pneumologie de Langue Française (CEPRO) (number CEPRO2023-036) Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
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Clin Exp ' 'Immunol. 2015;182:230–40.', 'journal-title': 'Clin Exp Immunol'}, { 'key': '9269_CR28', 'doi-asserted-by': 'publisher', 'first-page': '1145', 'DOI': '10.1681/ASN.2020030348', 'volume': '31', 'author': 'M Willicombe', 'year': '2020', 'unstructured': 'Willicombe M, Thomas D, McAdoo S. COVID-19 and calcineurin inhibitors: ' 'should they get left out in the storm? J Am Soc Nephrol. 2020;31:1145–6.', 'journal-title': 'J Am Soc Nephrol'}, { 'key': '9269_CR29', 'doi-asserted-by': 'publisher', 'first-page': '44', 'DOI': '10.1016/j.virusres.2014.02.010', 'volume': '184', 'author': 'J Carbajo-Lozoya', 'year': '2014', 'unstructured': 'Carbajo-Lozoya J, Ma-Lauer Y, Malešević M, et al. Human coronavirus NL63 ' 'replication is cyclophilin A-dependent and inhibited by ' 'non-immunosuppressive cyclosporine A-derivatives including Alisporivir. ' 'Virus Res. 2014;184:44–53.', 'journal-title': 'Virus Res'}, { 'key': '9269_CR30', 'doi-asserted-by': 'publisher', 'first-page': '10369', 'DOI': '10.3389/ti.2022.10369', 'volume': '35', 'author': 'NS Ogando', 'year': '2022', 'unstructured': 'Ogando NS, Metscher E, Moes DJAR, et al. The cyclophilin-dependent ' 'calcineurin inhibitor voclosporin inhibits SARS-CoV-2 replication in ' 'Cell Culture. Transpl Int. 2022;35:10369.', 'journal-title': 'Transpl Int'}, { 'key': '9269_CR31', 'doi-asserted-by': 'publisher', 'first-page': '472', 'DOI': '10.1016/j.bcp.2019.03.022', 'volume': '163', 'author': 'AM Liddicoat', 'year': '2019', 'unstructured': 'Liddicoat AM, Lavelle EC. Modulation of innate immunity by cyclosporine ' 'A. Biochem Pharmacol. 2019;163:472–80.', 'journal-title': 'Biochem Pharmacol'}, { 'key': '9269_CR32', 'doi-asserted-by': 'publisher', 'first-page': 'e13595', 'DOI': '10.1111/tid.13595', 'volume': '23', 'author': 'A Karruli', 'year': '2021', 'unstructured': 'Karruli A, Spiezia S, Boccia F, et al. Effect of immunosuppression ' 'maintenance in solid organ transplant recipients with COVID-19: ' 'systematic review and meta-analysis. Transpl Infect Dis. 2021;23:e13595.', 'journal-title': 'Transpl Infect Dis'}, { 'key': '9269_CR33', 'doi-asserted-by': 'publisher', 'first-page': '414', 'DOI': '10.1016/j.jinf.2020.10.024', 'volume': '82', 'author': 'M Merli', 'year': '2021', 'unstructured': 'Merli M, Pasulo L, Perricone G, et al. Impact of immunosuppressive ' 'therapy on the severity of COVID-19 in solid organ transplant ' 'recipients. J Infect. 2021;82:414–51.', 'journal-title': 'J Infect'}, { 'key': '9269_CR34', 'doi-asserted-by': 'publisher', 'first-page': '610', 'DOI': '10.1111/ajt.16807', 'volume': '22', 'author': 'LG Modelli de Andrade', 'year': '2022', 'unstructured': 'Modelli de Andrade LG, de Sandes-Freitas TV, Requião-Moura LR, et al. ' 'Development and validation of a simple web-based tool for early ' 'prediction of COVID-19-associated death in kidney transplant recipients. ' 'Am J Transpl. 2022;22:610–25.', 'journal-title': 'Am J Transpl'}, { 'key': '9269_CR35', 'doi-asserted-by': 'publisher', 'first-page': 'e1128', 'DOI': '10.1002/iid3.1128', 'volume': '12', 'author': 'UW Choi', 'year': '2024', 'unstructured': 'Choi UW, Ai X, Li H, Hao Y, Yao X, Guan Y. Immunosuppressive therapy and ' 'COVID-19 infection in patients with NMOSD. Immun Inflamm Dis. ' '2024;12:e1128.', 'journal-title': 'Immun Inflamm Dis'}, { 'key': '9269_CR36', 'doi-asserted-by': 'crossref', 'unstructured': 'Weder MM, Kadl A. Longitudinal impact of COVID-19 on lung function in ' 'lung transplant recipients: time to stop worrying? Transpl Infect Dis ' '2023;:e14131.', 'DOI': '10.1111/tid.14131'}, { 'key': '9269_CR37', 'doi-asserted-by': 'publisher', 'first-page': '309', 'DOI': '10.1007/s15010-021-01734-2', 'volume': '50', 'author': 'V Thakur', 'year': '2022', 'unstructured': 'Thakur V, Bhola S, Thakur P, et al. Waves and variants of SARS-CoV-2: ' 'understanding the causes and effect of the COVID-19 catastrophe. ' 'Infection. 2022;50:309–25.', 'journal-title': 'Infection'}, { 'key': '9269_CR38', 'doi-asserted-by': 'publisher', 'first-page': '1037', 'DOI': '10.1007/s11596-021-2395-1', 'volume': '41', 'author': 'L Forchette', 'year': '2021', 'unstructured': 'Forchette L, Sebastian W, Liu T. A Comprehensive Review of COVID-19 ' 'Virology, vaccines, variants, and therapeutics. Curr Med Sci. ' '2021;41:1037–51.', 'journal-title': 'Curr Med Sci'}, { 'key': '9269_CR39', 'doi-asserted-by': 'publisher', 'first-page': '1504', 'DOI': '10.1016/j.transproceed.2021.12.014', 'volume': '54', 'author': 'J Zimmermann', 'year': '2022', 'unstructured': 'Zimmermann J, Glueck OM, Fertmann JM, et al. COVID-19 in recent lung ' 'transplant recipients: clinical outcomes and management strategies. ' 'Transpl Proc. 2022;54:1504–16.', 'journal-title': 'Transpl Proc'}, { 'key': '9269_CR40', 'doi-asserted-by': 'publisher', 'first-page': '177', 'DOI': '10.1097/TP.0000000000003508', 'volume': '105', 'author': 'J Messika', 'year': '2021', 'unstructured': 'Messika J, Eloy P, Roux A, et al. COVID-19 in lung transplant ' 'recipients. Transplantation. 2021;105:177–86.', 'journal-title': 'Transplantation'}, { 'key': '9269_CR41', 'doi-asserted-by': 'publisher', 'first-page': 'e0257807', 'DOI': '10.1371/journal.pone.0257807', 'volume': '16', 'author': 'JC Kamp', 'year': '2021', 'unstructured': 'Kamp JC, Hinrichs JB, Fuge J, Ewen R, Gottlieb J. COVID-19 in lung ' 'transplant recipients-risk prediction and outcomes. PLoS ONE. ' '2021;16:e0257807.', 'journal-title': 'PLoS ONE'}], 'container-title': 'BMC Infectious Diseases', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12879-024-09269-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/article/10.1186/s12879-024-09269-1/fulltext.html', 'content-type': 'text/html', 'content-version': 'vor', 'intended-application': 'text-mining'}, { 'URL': 'https://link.springer.com/content/pdf/10.1186/s12879-024-09269-1.pdf', 'content-type': 'application/pdf', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 5, 28]], 'date-time': '2024-05-28T15:09:06Z', 'timestamp': 1716908946000}, 'score': 1, 'resource': { 'primary': { 'URL': 'https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-024-09269-1'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 5, 28]]}, 'references-count': 41, 'journal-issue': {'issue': '1', 'published-online': {'date-parts': [[2024, 12]]}}, 'alternative-id': ['9269'], 'URL': 'http://dx.doi.org/10.1186/s12879-024-09269-1', 'relation': {}, 'ISSN': ['1471-2334'], 'subject': [], 'container-title-short': 'BMC Infect Dis', 'published': {'date-parts': [[2024, 5, 28]]}, 'assertion': [ { 'value': '28 January 2024', 'order': 1, 'name': 'received', 'label': 'Received', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 March 2024', 'order': 2, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, { 'value': '28 May 2024', 'order': 3, 'name': 'first_online', 'label': 'First Online', 'group': {'name': 'ArticleHistory', 'label': 'Article History'}}, {'order': 1, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Declarations'}}, { 'value': 'Due to the retrospective nature of the study, the need for informed consent was ' 'waived by the Ethics Committee of the Société de Pneumologie de Langue ' 'Française (CEPRO) (number CEPRO2023-036)', 'order': 2, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Ethics approval and consent to participate'}}, { 'value': 'The authors declare no competing interests.', 'order': 3, 'name': 'Ethics', 'group': {'name': 'EthicsHeading', 'label': 'Competing interests'}}], 'article-number': '536'}
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Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
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