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All Studies   Meta Analysis    Recent:   

Association Between Vitamin D Levels and COVID-19 Infection in Children: A Case-Control Study

Bayrak et al., Turkish Archives of Pediatrics, doi:10.5152/turkarchpediatr.2023.22217
Apr 2023  
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Moderate/severe case 27% Improvement Relative Risk Case 33% Vitamin D for COVID-19  Bayrak et al.  Sufficiency Are vitamin D levels associated with COVID-19 outcomes? Retrospective 149 patients in Turkey (November 2020 - January 2021) Fewer cases with higher vitamin D levels (not stat. sig., p=0.23) c19early.org Bayrak et al., Turkish Archives of Ped.., Apr 2023 Favorsvitamin D Favorscontrol 0 0.5 1 1.5 2+
Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
 
*, now with p < 0.00000000001 from 122 studies, recognized in 9 countries.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,400+ studies for 79 treatments. c19early.org
Retrospective 73 COVID-19 and 76 healthy pediatric patients in Turkey, showing significantly lower vitamin D levels in COVID-19 patients.
This is the 172nd of 199 COVID-19 sufficiency studies for vitamin D, which collectively show higher levels reduce risk with p<0.0000000001 (1 in 835,162 vigintillion).
risk of moderate/severe case, 26.5% lower, RR 0.73, p = 1.00, high D levels (≥20ng/mL) 3 of 49 (6.1%), low D levels (<20ng/mL) 2 of 24 (8.3%), NNT 45.
risk of case, 33.4% lower, OR 0.67, p = 0.23, high D levels (≥20ng/mL) 41 of 73 (56.2%) cases, 50 of 76 (65.8%) controls, NNT 9.9, case control OR.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Bayrak et al., 5 Apr 2023, retrospective, Turkey, peer-reviewed, mean age 19.0, 8 authors, study period November 2020 - January 2021. Contact: hrnbyrk@gmail.com.
This PaperVitamin DAll
Association Between Vitamin D Levels and COVID-19 Infection in Children: A Case-Control Study
Harun Bayrak, Didem Ozturk, Ahmet Bolat, Bulent Unay
Turkish Archives of Pediatrics, doi:10.5152/turkarchpediatr.2023.22217
Objective: Coronavirus disease 2019 (COVID-19) infection is seen in all age groups, and its symptoms are very variable. The course of the disease can be asymptomatic or mortal. In pediatric patients, vitamin D is thought to be protective against (COVID-19) with its immunomodulator, antiviral, anti-inflammatory, and epithelial integrity properties. Our aim is to investigate the relationship between (COVID-19) infection and vitamin D level. Materials and Methods: We included (COVID-19) patients between 1 month and 18 years of age and healthy control groups. We compared epidemiological, clinical, laboratory, and imaging findings in patients. Results: One hundred forty-nine patients were evaluated in our study. Seventy-three (49%) of them were (COVID-19)-positive patients and 76 (51%) of them were healthy control group. The mean 25(OH)-D vitamin level was 15.80 ng/mL (5-41.56) in (COVID-19) patients and 21.51 ng/mL (5-69.80) in the control group. Vitamin D level was shown to be statistically significantly lower in coronavirus disease 2019 patients (P < .001). It was observed that myalgia was more common in patients with low 25(OH)-D levels (P < .048). Conclusion: Our study is one of the rare studies examining the relationship between (COVID-19) and 25(OH)-D vitamins in the pediatric age group. Children with (COVID-19) have a lower 25(OH)-D vitamin level than the control group.
Ethics Committee Approval: Ethical committee approval was received from the Ethics Committee of University of Health Sciences University (Approval No: 2020-493). Informed Consent: Informed consent was obtained from the patient's family, who agreed to take part in the study. Peer-review: Externally peer-reviewed.
References
Carpagnano, Lecce, Quaranta, Vitamin D deficiency as a predictor of poor prognosis in patients with acute respiratory failure due to COVID-19, J Endocrinol Invest, doi:10.1007/s40618-020-01370-x
Dalvi, Ramraje, Patil, Hegde, Yeram, Study of IL-6 and vitamin D3 in patients of pulmonary tuberculosis, Indian J Tuberc, doi:10.1016/j.ijtb.2018.05.018
Dong, Mo, Hu, Epidemiology of COVID-19 among children in China, Pediatrics, doi:10.1542/peds.2020-0702
Esposito, Lelii, Vitamin D and respiratory tract infections in childhood, BMC Infect Dis, doi:10.1186/s12879-015-1196-1
Gombart, Borregaard, Koeffler, Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3, FASEB J, doi:10.1096/fj.04-3284com
Grant, Lahore, Mcdonnell, Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients, doi:10.3390/nu12040988
Greiller, Martineau, Modulation of the immune response to respiratory viruses by vitamin D, Nutrients, doi:10.3390/nu7064240
Gül, Gür, Erener Ercan, Can, The effect of vitamin D prophylaxis on 25-OH vitamin D levels in children, Turk Arch Pediatr, doi:10.5152/TurkArchPediatr.2021.21166
Holick, The vitamin D deficiency pandemic: approaches for diagnosis, treatment and prevention, Rev Endocr Metab Disord, doi:10.1007/s11154-017-9424-1
Ilie, Stefanescu, Smith, The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality, Aging Clin Exp Res, doi:10.1007/s40520-020-01570-8
Jain, Parsanathan, Can vitamin D and L-cysteine co-supplementation reduce 25(OH)-Vitamin D Deficiency and the Mortality Associated with COVID-19 in African Americans?, J Am Coll Nutr, doi:10.1080/07315724.2020.1789518
Jolliffe, Camargo, Jr, Sluyter, Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials, Lancet Diabetes Endocrinol, doi:10.1016/S2213-8587(21)00051-6
Kakodkar, Kaka, Baig, A comprehensive literature review on the clinical presentation, and management of the pandemic coronavirus disease 2019 (COVID-19), Cureus, doi:10.7759/cureus.7560
Kara, Ekiz, Ricci, Kara, Chang et al., Scientific Strabismus' or two related pandemics: coronavirus disease and vitamin D deficiency, Br J Nutr, doi:10.1017/S0007114520001749
Kaufman, Niles, Kroll, Bi, Holick, SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels, PLoS One, doi:10.1371/journal.pone.0239252
Khayznikov, Hemachrandra, Pandit, Kumar, Wang et al., Statin intolerance because of myalgia, myositis, myopathy, or myonecrosis can in most cases be safely resolved by vitamin D supplementation, N Am J Med Sci, doi:10.4103/1947-2714.153919
Kurnik, Hochman, Vesterman-Landes, Muscle pain and serum creatine kinase are not associated with low serum 25(OH) vitamin D levels in patients receiving statins, Clin Endocrinol (Oxf), doi:10.1111/j.1365-2265.2011.04321.x
Köse, Korelasyon Ve, Regresyon Analizi
Lechien, Chiesa-Estomba, Place, Clinical and epidemiological characteristics of 1420 European patients with mildto-moderate coronavirus disease 2019, J Intern Med, doi:10.1111/joim.13089
Li, Huang, Wang, COVID-19 patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis, J Med Virol, doi:10.1002/jmv.25757
Li, Tian, Wang, The prevalence of vitamin D deficiency among schoolchildren: a cohort study from Xinxiang, China, J Pediatr Endocrinol Metab, doi:10.1515/jpem-2014-0250
Lu, Zhang, Ma, Link between community-acquired pneumonia and vitamin D levels in older patients
López, Gerber, Leonard, Xie, Schinnar et al., Children with lower respiratory tract infections and serum 25-hydroxyvitamin D3 levels: a case-control study, Pediatr Pulmonol, doi:10.1002/ppul.23439
Manion, Hullsiek, Wilson, Vitamin D deficiency is associated with IL-6 levels and monocyte activation in HIV-infected persons, PLoS One, doi:10.1371/journal.pone.0175517
Martineau, Jolliffe, Greenberg, Vitamin D supplementation to prevent acute respiratory infections: individual participant data meta-analysis, Health Technol Assess, doi:10.3310/hta23020
Meltzer, Best, Zhang, Vokes, Arora et al., Association of vitamin D status and other clinical characteristics with COVID-19 test results, JAMA Netw Open, doi:10.1001/jamanetworkopen.2020.19722
Merzon, Tworowski, Gorohovski, Low plasma 25(OH) vitamin D level is associated with increased risk of COVID-19 infection: an Israeli population-based study, FEBS Journal, doi:10.1111/febs.15495
Misra, Pacaud, Petryk, Collett-Solberg, Kappy, Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Vitamin D deficiency in children and its management: review of current knowledge and recommendations, Pediatrics, doi:10.1542/peds.2007-1894
Parri, Lenge, Cantoni, COVID-19 in 17 Italian pediatric emergency departments, Pediatrics, doi:10.1542/peds.2020-1235
Pennisi, Bartolo, Malaguarnera, Bella, Lanza et al., Vitamin D serum levels in patients with statininduced musculoskeletal pain, Dis Markers, doi:10.1155/2019/3549402
Poudel-Tandukar, Poudel, Jimba, Kobayashi, Johnson et al., Serum 25-hydroxyvitamin d levels and C-reactive protein in persons with human immunodeficiency virus infection, AIDS Res Hum Retrovir, doi:10.1089/AID.2012.0120
Scott, Gronowski, Reid, Holick, Thadhani et al., Vitamin D: the more we know, the less we know, Clin Chem, doi:10.1373/clinchem.2014.222521
Shen, Yang, Wang, Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts' consensus statement, World J Pediatr, doi:10.1007/s12519-020-00343-7
Sinha, Calfee, Cherian, Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study, Lancet Respir Med, doi:10.1016/S2213-2600(20)30366-0
Tiosano, Abrams, Weisman, Lessons learned from hereditary 1,25-dihydroxyvitamin D-resistant rickets patients on vitamin D functions, J Nutr, doi:10.1093/jn/nxaa380
Vankadari, Wilce, Emerging WuHan (COVID-19) coronavirus: glycan shield and structure prediction of spike glycoprotein and its interaction with human CD26, Emerg Microbes Infect, doi:10.1080/22221751.2020.1739565
Wang, Liu, Zhao, Clinical characteristics of 80 hospitalized frontline medical workers infected with COVID-19 in Wuhan, China, J Hosp Infect, doi:10.1016/j.jhin.2020.04.019
Worldometer, None
Yılmaz, Şen, Is vitamin D deficiency a risk factor for COVID-19 in children?, Pediatr Pulmonol, doi:10.1002/ppul.25106
Zhou, Luo, Qin, The association between vitamin D deficiency and community-acquired pneumonia: a meta-analysis of observational studies, Med (Baltim), doi:10.1097/MD.0000000000017252
Zimmermann, Curtis, Why is COVID-19 less severe in children? A review of the proposed mechanisms underlying the age-related difference in severity of SARS-CoV-2 infections, Arch Dis Child, doi:10.1136/archdischild-2020-320338
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