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0 0.5 1 1.5 2+ Mortality 64% Improvement Relative Risk Vitamin D  Annweiler et al.  EARLY TREATMENT Is early treatment with vitamin D beneficial for COVID-19? Prospective study of 95 patients in France Lower mortality with vitamin D (p=0.002) Annweiler et al., The J. Steroid Bioch.., Jul 2021 Favors vitamin D Favors control

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

Annweiler et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:0.1016/j.jsbmb.2021.105958
Jul 2021  
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Vitamin D for COVID-19
8th treatment shown to reduce risk in October 2020
*, now known with p < 0.00000000001 from 120 studies, recognized in 8 countries.
No treatment is 100% effective. Protocols combine complementary and synergistic treatments. * >10% efficacy in meta analysis with ≥3 clinical studies.
4,000+ studies for 60+ treatments.
Report on extended results from the GERIA-COVID study, showing significantly lower mortality at 3 months with vitamin D treatment. Results combine prophylaxis and early treatment.
risk of death, 64.2% lower, RR 0.36, p = 0.002, treatment 16 of 67 (23.9%), control 13 of 28 (46.4%), NNT 4.4, adjusted per study, odds ratio converted to relative risk, multiple Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Annweiler et al., 29 Jul 2021, prospective, France, peer-reviewed, 7 authors.
This PaperVitamin DAll
Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study
Cédric Annweiler, Mélinda Beaudenon, Romain Simon, Mialy Guenet, Marie Otekpo, Thomas Célarier, Jennifer Gautier
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105958
Background: The objective of this extension phase of the quasi-experimental GERIA− COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3month survival in geriatric patients hospitalized for COVID-19. Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000 IU per month, or 80,000 IU or 100,000 IU or 200,000 IU every 2-3 months), or daily supplementation with 800 IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration. Results: 76.1 % (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6 % (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23 [95 %CI: 0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008). Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.
Declaration of Competing Interest CA occasionally serves as a consultant for Mylan Laboratories Inc (2020). All authors declare they do not have any other financial and personal conflicts of interest with this manuscript.
Annweiler, Cao, Sabatier, Point of view: Should COVID-19 patients be supplemented with vitamin D?, Maturitas
Annweiler, Corvaisier, Gautier, Vitamin d supplementation associated to better survival in hospitalized frail elderly COVID-19 patients: the GERIA-COVID quasi-experimental study, Nutrients
Annweiler, Hanotte, Grandin De L'eprevier, Sabatier, Lafaie et al., Vitamin D and survival in COVID-19 patients: a quasi-experimental study, J. Steroid Biochem. Mol. Biol
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Baktash, Hosack, Patel, Vitamin D status and outcomes for hospitalised older patients with COVID-19, Postgrad. Med. J, doi:10.1136/postgradmedj-2020-138712
Bishop, Ismailova, Dimeloe, Hewison, White, Vitamin D and immune regulation: anti-bacterial, antiviral, and anti-inflammatory, JBMR Plus, doi:10.1002/jbm4.10405
Bruyère, Deroisy, Dardenne, A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods, Osteoporos. Int
Castillo, Costa, Vaquero Barrios, Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study, J. Steroid Biochem. Mol. Biol
Dijkman, Jebbink, Deijs, Replication-dependent downregulation of cellular angiotensin-converting enzyme 2 protein expression by human coronavirus NL63, J. Gen. Virol
Glinsky, Tripartite combination of candidate pandemic mitigation agents: vitamin d, quercetin, and estradiol manifest properties of medicinal agents for targeted mitigation of the COVID-19 pandemic defined by genomics-guided tracing of SARS-CoV-2 targets in human cells, Biomedicines
Grant, Lahore, Mcdonnell, Evidence that vitamin d supplementation could reduce risk of influenza and COVID-19 infections and deaths, Nutrients
Hernández, Nan, Fernandez-Ayala, Vitamin d status in hospitalized patients with SARS-CoV-2 infection, J. Clin. Endocrinol. Metab, doi:10.1210/clinem/dgaa733
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Kong, Zhu, Shi, VDR attenuates acute lung injury by blocking Ang-2-Tie-2 pathway and renin-angiotensin system, Mol. Endocrinol
Martineau, Jolliffe, Hooper, Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data, BMJ
Murai, Fernandes, Sales, Pinto, Goessler et al., Effect of a single high dose of vitamin D3 on hospital length of stay in patients with moderate to severe COVID-19: a randomized clinical trial, JAMA
Raman, Cassar, Tunnicliffe, Medium-term effects of SARS-CoV-2 infection on multiple vital organs, exercise capacity, cognition, quality of life and mental health, post-hospital discharge, EClinicalMedicine
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