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0 0.5 1 1.5 2+ Mortality 64% Improvement Relative Risk Vitamin D  Annweiler et al.  EARLY TREATMENT Is early treatment with vitamin D beneficial for COVID-19? Prospective study of 95 patients in France Lower mortality with vitamin D (p=0.002) Annweiler et al., The J. Steroid Bioch.., Jul 2021 Favors vitamin D Favors control

Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study

Annweiler et al., The Journal of Steroid Biochemistry and Molecular Biology, doi:0.1016/j.jsbmb.2021.105958
Jul 2021  
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Report on extended results from the GERIA-COVID study, showing significantly lower mortality at 3 months with vitamin D treatment. Results combine prophylaxis and early treatment.
risk of death, 64.2% lower, RR 0.36, p = 0.002, treatment 16 of 67 (23.9%), control 13 of 28 (46.4%), NNT 4.4, adjusted per study, odds ratio converted to relative risk, multiple Cox proportional hazards.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Annweiler et al., 29 Jul 2021, prospective, France, peer-reviewed, 7 authors.
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This PaperVitamin DAll
Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study
Cédric Annweiler, Mélinda Beaudenon, Romain Simon, Mialy Guenet, Marie Otekpo, Thomas Célarier, Jennifer Gautier
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105958
Background: The objective of this extension phase of the quasi-experimental GERIA− COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3month survival in geriatric patients hospitalized for COVID-19. Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000 IU per month, or 80,000 IU or 100,000 IU or 200,000 IU every 2-3 months), or daily supplementation with 800 IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration. Results: 76.1 % (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6 % (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23 [95 %CI: 0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008). Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.
Declaration of Competing Interest CA occasionally serves as a consultant for Mylan Laboratories Inc (2020). All authors declare they do not have any other financial and personal conflicts of interest with this manuscript.
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