Vitamin D supplementation prior to or during COVID-19 associated with better 3-month survival in geriatric patients: Extension phase of the GERIA-COVID study
Cédric Annweiler, Mélinda Beaudenon, Romain Simon, Mialy Guenet, Marie Otekpo, Thomas Célarier, Jennifer Gautier
The Journal of Steroid Biochemistry and Molecular Biology, doi:10.1016/j.jsbmb.2021.105958
Background: The objective of this extension phase of the quasi-experimental GERIA− COVID study was to determine whether vitamin D3 supplementation taken prior to or during COVID-19 was associated with better 3month survival in geriatric patients hospitalized for COVID-19. Methods: Intervention group was defined as all participants supplemented with vitamin D3 prior to or during COVID-19 (n = 67). Supplements were either bolus vitamin D3 (ie, 50,000 IU per month, or 80,000 IU or 100,000 IU or 200,000 IU every 2-3 months), or daily supplementation with 800 IU. Comparator group involved those without vitamin D supplements (n = 28). Outcome was 3-month mortality. Covariables were age, sex, functional abilities, history of malignancies, cardiomyopathy, undernutrition, number of acute health issues, antibiotics use, systemic corticosteroids use, and 25(OH)D concentration. Results: 76.1 % (n = 51) of participants survived at 3 months in Intervention group, compared to only 53.6 % (n = 15) in Comparator group (P = 0.03). The fully-adjusted hazard ratio for 3-month mortality was HR = 0.23 [95 %CI: 0.09;0.58](P = 0.002) in Intervention group compared to Comparator group. Intervention group had also longer survival time (log-rank P = 0.008). Conclusions: Vitamin D3 supplementation was associated with better 3-month survival in older COVID-19 patients.
Declaration of Competing Interest CA occasionally serves as a consultant for Mylan Laboratories Inc (2020). All authors declare they do not have any other financial and personal conflicts of interest with this manuscript.
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