Analgesics
Antiandrogens
Antihistamines
Azvudine
Bromhexine
Budesonide
Colchicine
Conv. Plasma
Curcumin
Famotidine
Favipiravir
Fluvoxamine
Hydroxychlor..
Ivermectin
Lifestyle
Melatonin
Metformin
Minerals
Molnupiravir
Monoclonals
Naso/orophar..
Nigella Sativa
Nitazoxanide
PPIs
Paxlovid
Quercetin
Remdesivir
Thermotherapy
Vitamins
More

Other
Feedback
Home
Top
Abstract
All sotrovimab studies
Meta analysis
 
Feedback
Home
next
study
previous
study
c19early.org COVID-19 treatment researchSotrovimabSotrovimab (more..)
Melatonin Meta
Metformin Meta
Antihistamines Meta
Azvudine Meta Molnupiravir Meta
Bromhexine Meta
Budesonide Meta
Colchicine Meta Nigella Sativa Meta
Conv. Plasma Meta Nitazoxanide Meta
Curcumin Meta PPIs Meta
Famotidine Meta Paxlovid Meta
Favipiravir Meta Quercetin Meta
Fluvoxamine Meta Remdesivir Meta
Hydroxychlor.. Meta Thermotherapy Meta
Ivermectin Meta

All Studies   Meta Analysis       

Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID‐19: A systematic review and meta‐analysis

Amani et al., Immunity, Inflammation and Disease, doi:10.1002/iid3.1262, PROSPERO CRD42023429910
Apr 2024  
  Post
  Facebook
Share
  Source   PDF   All Studies   Meta AnalysisMeta
Sotrovimab for COVID-19
41st treatment shown to reduce risk in May 2023, now with p = 0.002 from 25 studies, recognized in 38 countries. Efficacy is variant dependent.
Lower risk for mortality, ICU admission, and hospitalization.
No treatment is 100% effective. Protocols combine treatments.
5,000+ studies for 104 treatments. c19early.org
Meta analysis of 13 studies involving 16,166 patients showing higher mortality and higher incidence of adverse events with molnupiravir compared with sotrovimab.
Efficacy is variant dependent. In Vitro studies predict lower efficacy for BA.11-3, BA.4, BA.54, XBB.1.9.3, XBB.1.5.24, XBB.2.9, CH.1.15, and no efficacy for BA.26, XBB, XBB.1.5, ХВВ.1.9.17, XBB.1.16, BQ.1.1.45, and CL.15. US EUA has been revoked.
Currently there are 25 sotrovimab studies and meta analysis shows:
OutcomeImprovement
Mortality51% lower [7‑74%]
Ventilation71% lower [-23‑93%]
ICU admission69% lower [28‑86%]
Hospitalization26% lower [2‑44%]
Study covers sotrovimab and molnupiravir.
Amani et al., 23 Apr 2024, peer-reviewed, 2 authors, trial PROSPERO CRD42023429910. Contact: b_amani@alumnus.tums.ac.ir.
This PaperSotrovimabAll
Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID‐19: A systematic review and meta‐analysis
Bahman Amani, Behnam Amani
Immunity, Inflammation and Disease, doi:10.1002/iid3.1262
Background and Aim: This systematic review and meta-analysis aimed to compare the effectiveness and safety of molnupiravir and sotrovimab in the treatment of patients with coronavirus disease 2019 (COVID-19). Methods: Cochrane Library, Web of Science, PubMed, medRxiv, and Google Scholar were systematically searched to identify relevant evidence up to December 2023. The risk of bias was assessed using the risk of bias in nonrandomized studies of interventions tool. Data were analyzed using Comprehensive Meta-Analysis (CMA). Results: Our search identified and included 13 studies involving 16166 patients. The meta-analysis revealed a significant difference between the molnupiravir and sotrovimab groups in terms of the mortality rate (odds ratio [OR] = 2.07, 95% confidence interval [CI]: 1.16, 3.70). However, no significant difference was observed between the two groups in terms of hospitalization rate (OR = 0.71, 95% CI: 0.47, 1.06), death or hospitalization rate (OR = 1.51, 95% CI: 0.81, 2.83), and intensive care unit admission (OR = 0.59, 95% CI: 0.07, 4.84). In terms of safety, molnupiravir was associated with a higher incidence of adverse events (OR = 1.67, 95% CI: 1.21, 2.30). Conclusion: The current findings indicate that sotrovimab may be more effective than molnupiravir in reducing the mortality rate in COVID-19 patients. However, no statistical difference was observed between the two treatments for other effectiveness outcomes. The certainty of evidence for these findings was rated as low or moderate. Further research is required to provide a better comparison of these interventions in treating COVID-19 patients.
AUTHOR CONTRIBUTIONS Conceptualization and project administration: Bahman Amani and Behnam Amani. Literature searching: Behnam Amani and Bahman Amani. Data extraction and quality assessment: Bahman Amani and Behnam Amani. Data analysis: Bahman Amani and Behnam Amani. Writing-original draft: Behnam Amani. Writing-review and editing: Bahman Amani and Behnam Amani. CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. SUPPORTING INFORMATION Additional supporting information can be found online in the Supporting Information section at the end of this article.
References
Amani, Amani, Efficacy and safety of sotrovimab in patients with COVID-19: a rapid review and meta-analysis, Rev Med Virol
Amani, Zareei, Amani, Rapid review and meta-analysis of adverse events associated with molnupiravir in patients with COVID-19, Br J Clin Pharmacol
Behzad, Ali, Niinuma, Butler, Alqahtani, Real world effectiveness of sotrovimab in preventing COVID-19-related hospitalisation or death in patients infected with Omicron BA.2, J Infect Public Health
Benaicha, Khenhrani, Veer, Efficacy of molnupiravir for the treatment of mild or moderate COVID-19 in adults: a meta-analysis, Cureus
Caillard, Thaunat, COVID-19 vaccination in kidney transplant recipients, Nat Rev Nephrol
Calimeri, Lo Giudice, Buda, Role of the 1st booster dose of COVID-19 vaccine in the protection against the infection: a fundamental public health tool, J Prev Med Hyg
Cegolon, Pol, Simonetti, Filon, Luzzati, Molnupiravir, Nirmatrelvir/Ritonavir, or Sotrovimab for highrisk COVID-19 patients infected by the omicron variant: hospitalization, mortality, and time until negative swab test in real life, Pharmaceuticals
Cheng, Reyes, Satram, Real-world effectiveness of sotrovimab for the early treatment of COVID-19 during SARS-CoV-2 Delta and Omicron waves in the USA, Infect Dis Ther
Driouich, Bernadin, Touret, De Lamballerie, Nougairède, Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in a hamster model, Antiviral Res
Drysdale, Tibble, Patel, Characteristics and outcomes of patients with COVID-19 at high risk of disease progression receiving sotrovimab, oral antivirals or no treatment in Scotland. medRxiv, doi:10.1101/2023.06.09.23291195
Evans, Qi, Adebayo, Real-world effectiveness of molnupiravir, nirmatrelvir-ritonavir, and sotrovimab on preventing hospital admission among higher-risk patients with COVID-19 in Wales: a retrospective cohort study, J Infect
Fernandes, Inchakalody, Merhi, Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines, Ann Med
Flisiak, Zarębska-Michaluk, Rogalska, Real-world experience with molnupiravir during the period of SARS-CoV-2 Omicron variant dominance, Pharmacol Rep
Gao, Liu, Li, Xu, Zhang et al., Molnupiravir for treatment of adults with mild or moderate COVID-19: a systematic review and meta-analysis of randomised controlled trials, Clin Microbiol Infect
Gleeson, Martin, Thomson, Kidney transplant recipients and omicron: outcomes, effect of vaccines and the efficacy and safety of novel treatments, medRxiv, doi:10.1101/2022.05.03.22274524
Goodwin, Thompson, Hall, Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: the experience of a regional centre in the UK, PLoS One
Huang, Liu, Wu, Tsai, Lai, Clinical efficacy and safety of molnupiravir for nonhospitalized and hospitalized patients with COVID-19: a systematic review and metaanalysis of randomized control trials, J Med Virol
Hérate, Touret, Sotrovimab retains activity against SARS-CoV-2 Omicron variant BQ.1.1 in a non-human primate model, Heliyon
Kamal, Ramadan, Farraj, Bahig, Ezzat, The pill of recovery; Molnupiravir for treatment of COVID-19 patients; a systematic review, Saudi Pharm J, doi:10.1016/j.jsps.2022.03.002
Kauer, Totschnig, Karolyi, Zoufaly, Naegeli, Efficacy and tolerability of Sotrovimab Molnupiravir and Nirmatrelvir/Ritonavir for non-hospitalized patients at high risk for COVID-19: a retrospective, single-center analysis, doi:10.21203/rs.3.rs-2786240.v1
Kwok, Tsoi, Leung, Real-world study on effectiveness of molnupiravir and Nirmatrelvir-Ritonavir in unvaccinated patients with chronic respiratory diseases with confirmed SARS-CoV-2 infection managed in out-patient setting, Viruses
Lasagna, Cassaniti, Lilleri, Effectiveness of the available early therapies in reducing severe COVID-19 in nonhospitalized patients with solid tumors on active treatment, Front Med
Lin, Hung, Lai, Wang, Chen, The impact of neutralizing monoclonal antibodies on the outcomes of COVID-19 outpatients: a systematic review and metaanalysis of randomized controlled trials, J Med Virol
Maas, Strizki, Miller, Molnupiravir: mechanism of action, clinical, and translational science, Clin Transl Sci
Malin, Weibel, Gruell, Kreuzberger, Stegemann et al., Efficacy and safety of molnupiravir for the treatment of SARS-CoV-2 infection: a systematic review and meta-analysis, J Antimicrob Chemother
Manciulli, Spinicci, Rossetti, Safety and efficacy of outpatient treatments for COVID-19: real-life data from a regionwide cohort of high-risk patients in Tuscany, Italy (the FEDERATE Cohort), Viruses
Martin-Blondel, Marcelin, Soulié, Sotrovimab to prevent severe COVID-19 in high-risk patients infected with Omicron BA.2, J Infect
Mazzotta, Lepri, Colavita, Viral load decrease in SARS-CoV-2 BA.1 and BA.2 Omicron sublineages infection after treatment with monoclonal antibodies and direct antiviral agents, J Med Virol
Minotti, Mengato, Pieri, Early treatments of fragile children with COVID-19-results of CLEVER (Children COVID Early Treatment), a retrospective, observational study, Viruses
Miyashita, Nakamori, Ogata, Clinical efficacy of the neutralizing antibody therapy sotrovimab in patients with SARS-CoV-2 omicron BA.1 and BA.2 subvariant infections, Viruses
Nene, Santodomingo, Balog, Use of sotrovimab in vaccinated versus unvaccinated COVID-19 patients in a resource-limited emergency department during the omicron surge, J Am Coll Emerg Physicians Open
Page, Mckenzie, Bossuyt, The PRISMA 2020 statement: an updated guideline for reporting systematic reviews, Int J Surg
Painter, Holman, Bush, Human safety, tolerability, and pharmacokinetics of molnupiravir, a novel broad-spectrum oral antiviral agent with activity against SARS-CoV-2, Antimicrob Agents Chemother, doi:10.1128/aac
Patel, Yarwood, Levick, Characteristics and outcomes of patients with COVID-19 at high-risk of disease progression receiving sotrovimab, oral antivirals or no treatment in England. medRxiv, doi:10.1101/2022.11.28.22282808
Radcliffe, Palacios, Azar, Cohen, Malinis, Realworld experience with available, outpatient COVID-19 therapies in solid organ transplant recipients during the omicron surge, Am J Transplant, doi:10.1111/ajt.17098
Ramos-Rincon, López-Carmona, Cobos-Palacios, Remdesivir in very old patients (≥ 80 years) hospitalized with COVID-19: real world data from the SEMI-COVID-19 registry, J Clin Med
Sterne, Hernán, Reeves, ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions, BMJ
Tian, Feng, Chen, Efficacy and safety of molnupiravir treatment for COVID-19: a systematic review and metaanalysis of randomized controlled trials, Int J Antimicro Agents
Tiseo, Barbieri, Galfo, Efficacy and safety of nirmatrelvir/ritonavir, molnupiravir, and remdesivir in a realworld cohort of outpatients with COVID-19 at high risk of progression: the PISA outpatient clinic experience, Infect Dis Ther
Touret, Baronti, Bouzidi, De Lamballerie, In vitro evaluation of therapeutic antibodies against a SARS-CoV-2 Omicron B.1.1.529 isolate, Sci Rep
Twohig, Nyberg, Zaidi, Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B.1.617.2) compared with alpha (B.1.1.7) variants of concern: a cohort study, Lancet Infect Dis
Uraki, Kiso, Imai, Therapeutic efficacy of monoclonal antibodies and antivirals against SARS-CoV-2 Omicron BA.1 in Syrian hamsters, Nat Microbiol
Vito, Colpani, Poliseno, What is the efficacy of sotrovimab in reducing disease progression and death in people with COVID-19 during the omicron era? Answers from a real-life study, Viruses
Wen, Chen, Tang, Efficacy and safety of three new oral antiviral treatment (molnupiravir, fluvoxamine and Paxlovid) for COVID-19: a meta-analysis, Ann Med
Wong, Au, Lau, Lau, Cowling et al., Realworld effectiveness of early molnupiravir or nirmatrelvirritonavir in hospitalised patients with COVID-19 without supplemental oxygen requirement on admission during Hong Kong's omicron BA.2 wave: a retrospective cohort study, Lancet Infect Dis
Zheng, Campbell, Carr, Comparative effectiveness of sotrovimab and molnupiravir for preventing severe COVID-19 outcomes in non-hospitalised patients on kidney replacement therapy: observational cohort study using the OpenSAFELY-UKRR linked platform and SRR database, medRxiv, doi:10.1101/2022.12.02.22283049
Zheng, Green, Tazare, Comparative effectiveness of sotrovimab and molnupiravir for prevention of severe covid-19 outcomes in patients in the community: observational cohort study with the OpenSAFELY platform, BMJ, doi:10.1136/bmj-2022-071932
{ 'indexed': {'date-parts': [[2024, 4, 24]], 'date-time': '2024-04-24T00:36:39Z', 'timestamp': 1713918999165}, 'reference-count': 48, 'publisher': 'Wiley', 'issue': '4', 'license': [ { 'start': { 'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T00:00:00Z', 'timestamp': 1713830400000}, 'content-version': 'vor', 'delay-in-days': 22, 'URL': 'http://creativecommons.org/licenses/by/4.0/'}], 'content-domain': {'domain': ['onlinelibrary.wiley.com'], 'crossmark-restriction': True}, 'published-print': {'date-parts': [[2024, 4]]}, 'abstract': '<jats:title>Abstract</jats:title><jats:sec><jats:title>Background and ' 'Aim</jats:title><jats:p>This systematic review and meta‐analysis aimed to compare the ' 'effectiveness and safety of molnupiravir and sotrovimab in the treatment of patients with ' 'coronavirus disease 2019 ' '(COVID‐19).</jats:p></jats:sec><jats:sec><jats:title>Methods</jats:title><jats:p>Cochrane ' 'Library, Web of Science, PubMed, medRxiv, and Google Scholar were systematically searched to ' 'identify relevant evidence up to December 2023. The risk of bias was assessed using the risk ' 'of bias in nonrandomized studies of interventions tool. Data were analyzed using ' 'Comprehensive Meta‐Analysis ' '(CMA).</jats:p></jats:sec><jats:sec><jats:title>Results</jats:title><jats:p>Our search ' 'identified and included 13 studies involving 16166 patients. The meta‐analysis revealed a ' 'significant difference between the molnupiravir and sotrovimab groups in terms of the ' 'mortality rate (odds ratio [OR]\u2009=\u20092.07, 95% confidence interval [CI]: 1.16, 3.70). ' 'However, no significant difference was observed between the two groups in terms of ' 'hospitalization rate (OR\u2009=\u20090.71, 95% CI: 0.47, 1.06), death or hospitalization rate ' '(OR\u2009=\u20091.51, 95% CI: 0.81, 2.83), and intensive care unit admission (OR\u2009=\u2009' '0.59, 95% CI: 0.07, 4.84). In terms of safety, molnupiravir was associated with a higher ' 'incidence of adverse events (OR\u2009=\u20091.67, 95% CI: 1.21, ' '2.30).</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>The current ' 'findings indicate that sotrovimab may be more effective than molnupiravir in reducing the ' 'mortality rate in COVID‐19 patients. However, no statistical difference was observed between ' 'the two treatments for other effectiveness outcomes. The certainty of evidence for these ' 'findings was rated as low or moderate. Further research is required to provide a better ' 'comparison of these interventions in treating COVID‐19 patients.</jats:p></jats:sec>', 'DOI': '10.1002/iid3.1262', 'type': 'journal-article', 'created': {'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T13:44:49Z', 'timestamp': 1713879889000}, 'update-policy': 'http://dx.doi.org/10.1002/crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Comparison of effectiveness and safety of molnupiravir versus sotrovimab for COVID‐19: A ' 'systematic review and meta‐analysis', 'prefix': '10.1002', 'volume': '12', 'author': [ { 'given': 'Bahman', 'family': 'Amani', 'sequence': 'first', 'affiliation': [ { 'name': 'Department of Health Management and Economics, School of Public ' 'Health Tehran University of Medical Sciences Tehran Iran'}]}, { 'ORCID': 'http://orcid.org/0000-0003-4298-1807', 'authenticated-orcid': False, 'given': 'Behnam', 'family': 'Amani', 'sequence': 'additional', 'affiliation': [ { 'name': 'Department of Health Management and Economics, School of Public ' 'Health Tehran University of Medical Sciences Tehran Iran'}]}], 'member': '311', 'published-online': {'date-parts': [[2024, 4, 23]]}, 'reference': [ { 'issue': '4', 'key': 'e_1_2_9_2_1', 'first-page': '520', 'article-title': 'Role of the 1st booster dose of COVID‐19 vaccine in the protection ' 'against the infection: a fundamental public health tool', 'volume': '63', 'author': 'Calimeri S', 'year': '2022', 'journal-title': 'J Prev Med Hyg'}, {'key': 'e_1_2_9_3_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41581-021-00491-7'}, {'key': 'e_1_2_9_4_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.27623'}, { 'key': 'e_1_2_9_5_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07853890.2022.2034936'}, { 'key': 'e_1_2_9_6_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1473-3099(22)00507-2'}, {'key': 'e_1_2_9_7_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/jcm11133769'}, { 'key': 'e_1_2_9_8_1', 'doi-asserted-by': 'crossref', 'unstructured': 'ZhengB CampbellJ CarrEJ et al.Comparative effectiveness of sotrovimab ' 'and molnupiravir for preventing severe COVID‐19 outcomes in ' 'non‐hospitalised patients on kidney replacement therapy: observational ' 'cohort study using the OpenSAFELY‐UKRR linked platform and SRR ' 'database.medRxiv. Preprint posted online December 4 ' '2022.doi:10.1101/2022.12.02.22283049', 'DOI': '10.1101/2022.12.02.22283049'}, {'key': 'e_1_2_9_9_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/v15081757'}, {'key': 'e_1_2_9_10_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.jsps.2022.03.002'}, { 'issue': '5', 'key': 'e_1_2_9_11_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1128/AAC.02428-20', 'article-title': 'Human safety, tolerability, and pharmacokinetics of molnupiravir, a ' 'novel broad‐spectrum oral antiviral agent with activity against ' 'SARS‐CoV‐2', 'volume': '65', 'author': 'Painter WP', 'year': '2021', 'journal-title': 'Antimicrob Agents Chemother'}, {'key': 'e_1_2_9_12_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s43440-022-00408-6'}, {'key': 'e_1_2_9_13_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/v15030610'}, {'key': 'e_1_2_9_14_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s40121-022-00729-2'}, {'key': 'e_1_2_9_15_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1007/s40121-022-00755-0'}, {'key': 'e_1_2_9_16_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/emp2.12958'}, { 'key': 'e_1_2_9_17_1', 'unstructured': 'Food and Drug Administration. Drug safety and ' 'availability.2022.https://www.fda.gov/drugs/drug-safety-and-availability/fda-updates-sotrovimab-emergency-use-authorization'}, { 'issue': '2', 'key': 'e_1_2_9_18_1', 'doi-asserted-by': 'crossref', 'first-page': '315', 'DOI': '10.1016/j.jiph.2023.11.029', 'article-title': 'Real world effectiveness of sotrovimab in preventing COVID‐19‐related ' 'hospitalisation or death in patients infected with Omicron BA.2', 'volume': '17', 'author': 'Behzad A', 'year': '2023', 'journal-title': 'J Infect Public Health'}, { 'issue': '4', 'key': 'e_1_2_9_19_1', 'doi-asserted-by': 'crossref', 'first-page': 'e104', 'DOI': '10.1016/j.jinf.2022.06.033', 'article-title': 'Sotrovimab to prevent severe COVID‐19 in high‐risk patients infected ' 'with Omicron BA.2', 'volume': '85', 'author': 'Martin‐Blondel G', 'year': '2022', 'journal-title': 'J Infect'}, { 'issue': '6', 'key': 'e_1_2_9_20_1', 'doi-asserted-by': 'crossref', 'first-page': '1300', 'DOI': '10.3390/v15061300', 'article-title': 'Clinical efficacy of the neutralizing antibody therapy sotrovimab in ' 'patients with SARS‐CoV‐2 omicron BA.1 and BA.2 subvariant infections', 'volume': '15', 'author': 'Miyashita N', 'year': '2023', 'journal-title': 'Viruses'}, {'key': 'e_1_2_9_21_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/rmv.2402'}, {'key': 'e_1_2_9_22_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.28621'}, { 'key': 'e_1_2_9_23_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1136/bmj-2022-071932', 'article-title': 'Comparative effectiveness of sotrovimab and molnupiravir for prevention ' 'of severe covid‐19 outcomes in patients in the community: observational ' 'cohort study with the OpenSAFELY platform', 'volume': '379', 'author': 'Zheng B', 'year': '2022', 'journal-title': 'BMJ'}, { 'key': 'e_1_2_9_24_1', 'doi-asserted-by': 'crossref', 'unstructured': 'GleesonS MartinP ThomsonT et al.Kidney transplant recipients and ' 'omicron: outcomes effect of vaccines and the efficacy and safety of ' 'novel treatments.medRxiv. Preprint posted online May 3 ' '2022.doi:10.1101/2022.05.03.22274524', 'DOI': '10.1101/2022.05.03.22274524'}, {'key': 'e_1_2_9_25_1', 'doi-asserted-by': 'publisher', 'DOI': '10.3390/v15020438'}, {'key': 'e_1_2_9_26_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/cts.13732'}, { 'key': 'e_1_2_9_27_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/S1473-3099(21)00475-8'}, {'key': 'e_1_2_9_28_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijsu.2021.105906'}, {'key': 'e_1_2_9_29_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1136/bmj.i4919'}, { 'issue': '5', 'key': 'e_1_2_9_30_1', 'doi-asserted-by': 'crossref', 'first-page': '721', 'DOI': '10.3390/ph16050721', 'article-title': 'Molnupiravir, Nirmatrelvir/Ritonavir, or Sotrovimab for high‐risk ' 'COVID‐19 patients infected by the omicron variant: hospitalization, ' 'mortality, and time until negative swab test in real life', 'volume': '16', 'author': 'Cegolon L', 'year': '2023', 'journal-title': 'Pharmaceuticals'}, { 'key': 'e_1_2_9_31_1', 'doi-asserted-by': 'crossref', 'unstructured': 'DrysdaleM TibbleH PatelV et al.Characteristics and outcomes of patients ' 'with COVID‐19 at high risk of disease progression receiving sotrovimab ' 'oral antivirals or no treatment in Scotland.medRxiv. Preprint posted ' 'online June 9 2023.doi:10.1101/2023.06.09.23291195', 'DOI': '10.1101/2023.06.09.23291195'}, { 'issue': '4', 'key': 'e_1_2_9_32_1', 'doi-asserted-by': 'crossref', 'first-page': '352', 'DOI': '10.1016/j.jinf.2023.02.012', 'article-title': 'Real‐world effectiveness of molnupiravir, nirmatrelvir‐ritonavir, and ' 'sotrovimab on preventing hospital admission among higher‐risk patients ' 'with COVID‐19 in Wales: a retrospective cohort study', 'volume': '86', 'author': 'Evans A', 'year': '2023', 'journal-title': 'J Infect'}, { 'issue': '3', 'key': 'e_1_2_9_33_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1371/journal.pone.0281915', 'article-title': 'Evaluation of outpatient treatment for non‐hospitalised patients with ' 'COVID‐19: the experience of a regional centre in the UK', 'volume': '18', 'author': 'Goodwin AT', 'year': '2023', 'journal-title': 'PLoS One'}, { 'key': 'e_1_2_9_34_1', 'doi-asserted-by': 'crossref', 'unstructured': 'KauerV TotschnigD AugustinM KarolyiM ZoufalyA NaegeliM.Efficacy and ' 'tolerability of Sotrovimab Molnupiravir and Nirmatrelvir/Ritonavir for ' 'non‐hospitalized patients at high risk for COVID‐19: a retrospective ' 'single‐center analysis. Preprint posted online April 10 ' '2023.doi:10.21203/rs.3.rs-2786240.v1', 'DOI': '10.21203/rs.3.rs-2786240/v1'}, { 'key': 'e_1_2_9_35_1', 'doi-asserted-by': 'crossref', 'DOI': '10.3389/fmed.2022.1036473', 'article-title': 'Effectiveness of the available early therapies in reducing severe ' 'COVID‐19 in non‐hospitalized patients with solid tumors on active ' 'treatment', 'volume': '9', 'author': 'Lasagna A', 'year': '2022', 'journal-title': 'Front Med'}, {'key': 'e_1_2_9_36_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1002/jmv.28186'}, { 'key': 'e_1_2_9_37_1', 'doi-asserted-by': 'crossref', 'unstructured': 'PatelV YarwoodMJ LevickB et al. Characteristics and outcomes of patients ' 'with COVID‐19 at high‐risk of disease progression receiving sotrovimab ' 'oral antivirals or no treatment in England.medRxiv. Preprint posted ' 'online November 29 2022.doi:10.1101/2022.11.28.22282808', 'DOI': '10.1101/2022.11.28.22282808'}, {'key': 'e_1_2_9_38_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/ajt.17098'}, { 'key': 'e_1_2_9_39_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1080/07853890.2022.2031274'}, { 'key': 'e_1_2_9_40_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.antiviral.2023.105638', 'article-title': 'Activity of Sotrovimab against BQ.1.1 and XBB.1 Omicron sublineages in ' 'a hamster model', 'volume': '215', 'author': 'Driouich J‐S', 'year': '2023', 'journal-title': 'Antiviral Res'}, { 'key': 'e_1_2_9_41_1', 'doi-asserted-by': 'crossref', 'DOI': '10.1016/j.heliyon.2023.e16664', 'article-title': 'Sotrovimab retains activity against SARS‐CoV‐2 Omicron variant BQ.1.1 ' 'in a non‐human primate model', 'volume': '9', 'author': 'Hérate C', 'year': '2023', 'journal-title': 'Heliyon'}, {'key': 'e_1_2_9_42_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41598-022-08559-5'}, {'key': 'e_1_2_9_43_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1038/s41564-022-01170-4'}, { 'issue': '7', 'key': 'e_1_2_9_44_1', 'doi-asserted-by': 'crossref', 'first-page': '1586', 'DOI': '10.1093/jac/dkad132', 'article-title': 'Efficacy and safety of molnupiravir for the treatment of SARS‐CoV‐2 ' 'infection: a systematic review and meta‐analysis', 'volume': '78', 'author': 'Malin JJ', 'year': '2023', 'journal-title': 'J Antimicrob Chemother'}, { 'key': 'e_1_2_9_45_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.ijantimicag.2023.106870'}, { 'issue': '5', 'key': 'e_1_2_9_46_1', 'article-title': 'Efficacy of molnupiravir for the treatment of mild or moderate COVID‐19 ' 'in adults: a meta‐analysis', 'volume': '15', 'author': 'Benaicha K', 'year': '2023', 'journal-title': 'Cureus'}, {'key': 'e_1_2_9_47_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1016/j.cmi.2023.04.014'}, { 'issue': '1', 'key': 'e_1_2_9_48_1', 'doi-asserted-by': 'crossref', 'first-page': '192', 'DOI': '10.3390/v15010192', 'article-title': 'Early treatments of fragile children with COVID‐19—results of CLEVER ' '(Children COVID Early Treatment), a retrospective, observational study', 'volume': '15', 'author': 'Minotti C', 'year': '2023', 'journal-title': 'Viruses'}, {'key': 'e_1_2_9_49_1', 'doi-asserted-by': 'publisher', 'DOI': '10.1111/bcp.15449'}], 'container-title': 'Immunity, Inflammation and Disease', 'original-title': [], 'language': 'en', 'link': [ { 'URL': 'https://onlinelibrary.wiley.com/doi/pdf/10.1002/iid3.1262', 'content-type': 'unspecified', 'content-version': 'vor', 'intended-application': 'similarity-checking'}], 'deposited': { 'date-parts': [[2024, 4, 23]], 'date-time': '2024-04-23T13:44:56Z', 'timestamp': 1713879896000}, 'score': 1, 'resource': {'primary': {'URL': 'https://onlinelibrary.wiley.com/doi/10.1002/iid3.1262'}}, 'subtitle': [], 'short-title': [], 'issued': {'date-parts': [[2024, 4]]}, 'references-count': 48, 'journal-issue': {'issue': '4', 'published-print': {'date-parts': [[2024, 4]]}}, 'alternative-id': ['10.1002/iid3.1262'], 'URL': 'http://dx.doi.org/10.1002/iid3.1262', 'relation': {}, 'ISSN': ['2050-4527', '2050-4527'], 'subject': [], 'container-title-short': 'Immunity Inflam &amp;amp; Disease', 'published': {'date-parts': [[2024, 4]]}, 'assertion': [ { 'value': '2023-09-04', 'order': 0, 'name': 'received', 'label': 'Received', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-04-12', 'order': 1, 'name': 'accepted', 'label': 'Accepted', 'group': {'name': 'publication_history', 'label': 'Publication History'}}, { 'value': '2024-04-23', 'order': 2, 'name': 'published', 'label': 'Published', 'group': {'name': 'publication_history', 'label': 'Publication History'}}]}
Loading..
Please send us corrections, updates, or comments. c19early involves the extraction of 100,000+ datapoints from thousands of papers. Community updates help ensure high accuracy. Treatments and other interventions are complementary. All practical, effective, and safe means should be used based on risk/benefit analysis. No treatment or intervention is 100% available and effective for all current and future variants. We do not provide medical advice. Before taking any medication, consult a qualified physician who can provide personalized advice and details of risks and benefits based on your medical history and situation. FLCCC and WCH provide treatment protocols.
  or use drag and drop   
Submit