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Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity

Alkafaas et al., BMC Public Health, doi:10.1186/s12889-024-17747-z

Feb 2024

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Fluvoxamine

27th treatment shown to reduce risk in November 2021, now with p = 0.00014 from 21 studies, recognized in 3 countries.

Lower risk for mortality, hospitalization, progression, recovery, and cases.

No treatment is 100% effective. Protocols combine treatments.

5,100+ studies for 112 treatments. c19early.org

In Silico molecular docking analysis evaluating 71 functional inhibitors of acid sphingomyelinase (FIASMAs), showing that FIASMAs may prevent SARS-CoV-2 cell entry and infection via inhibiting ceramide platform formation that facilitates viral uptake. Dilazep, emetine, pimozide, carvedilol, mebeverine, cepharanthine, hydroxyzine, astemizole, sertindole, and bepridil showed higher predicted binding affinity and inhibition potential compared to the candidate drug amiodarone.

4 preclinical studies support the efficacy of fluvoxamine for COVID-19:

2 In Silico studies1,2

2 In Vitro studies2,3

Fluvoxamine may inhibit SARS-CoV-2 cell entry by preventing the formation of ceramide platforms that facilitates viral uptake1 and may help restore autophagic processes disrupted by NSP6, thereby reducing SARS-CoV-2 replication and improving host cellular defenses3.

Important missing comments or errors? Let us know.

1. Alkafaas et al., Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity, BMC Public Health, doi:10.1186/s12889-024-17747-z.biomedcentral.com, doi.org.

2. Abatematteo et al., A conformational rearrangement of the SARS-CoV-2 host protein sigma-1 is required for antiviral activity: insights from a combined in-silico/in-vitro approach, Scientific Reports, doi:10.1038/s41598-023-39662-w.nature.com, doi.org.

3. Zhang et al., SARS-CoV-2 NSP6 reduces autophagosome size and affects viral replication via sigma-1 receptor, Journal of Virology, doi:10.1128/jvi.00754-24.asm.org, doi.org.

Alkafaas et al., 6 Feb 2024, peer-reviewed, 18 authors. Contact: samar.alkafas@science.tanta.edu.eg, samarsamy2017@yahoo.com.

In Silico studies are an important part of preclinical research, however results may be very different in vivo.

This Paper Fluvoxamine All

Molecular docking as a tool for the discovery of novel insight about the role of acid sphingomyelinase inhibitors in SARS- CoV-2 infectivity

Samar Sami Alkafaas, Abanoub Mosaad Abdallah, Mai H Hassan, Aya Misbah Hussien, Sara Samy Elkafas, Samah A Loutfy, Abanoub Mikhail, Omnia G Murad, Mohamed I Elsalahaty, Mohamed Hessien, Rami M Elshazli, Fatimah A Alsaeed, Ahmed Ezzat Ahmed, Hani K Kamal, Wael Hafez, Mohamed T El-Saadony, Khaled A El-Tarabily, Soumya Ghosh

BMC Public Health, doi:10.1186/s12889-024-17747-z

Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, caused > 6 million deaths. Symptoms included respiratory strain and complications, leading to severe pneumonia. SARS-CoV-2 attaches to the ACE-2 receptor of the host cell membrane to enter. Targeting the SARS-CoV-2 entry may effectively inhibit infection. Acid sphingomyelinase (ASMase) is a lysosomal protein that catalyzes the conversion of sphingolipid (sphingomyelin) to ceramide. Ceramide molecules aggregate/assemble on the plasma membrane to form "platforms" that facilitate the viral intake into the cell. Impairing the ASMase activity will eventually disrupt viral entry into the cell. In this review, we identified the metabolism of sphingolipids, sphingolipids' role in cell signal transduction cascades, and viral infection mechanisms. Also, we outlined ASMase structure and underlying mechanisms inhibiting viral entry 40 with the aid of inhibitors of acid sphingomyelinase (FIASMAs). In silico molecular docking analyses of FIASMAs with inhibitors revealed that dilazep (S = -12.58 kcal/mol), emetine (S = -11.65 kcal/ mol), pimozide (S = -11.29 kcal/mol), carvedilol (S = -11.28 kcal/mol), mebeverine (S = -11.14 kcal/mol), cepharanthine (S = -11.06 kcal/mol), hydroxyzin (S = -10.96 kcal/mol), astemizole (S = -10.81 kcal/mol), sertindole (S = -10.55 kcal/mol), and bepridil (S = -10.47 kcal/mol) have higher inhibition activity than the candidate drug amiodarone (S = -10.43 kcal/mol), making them better options for inhibition.

Declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Financial interest All authors declare that they have no financial or non-financial interests that are directly or indirectly related to the work submitted for publication. Competing interests The authors declare no competing interests. Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

References

Aizaki, Lee, Sung, Ishiko, Lai, Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts, Virology

Akinyemi, Ns, Ft, Fakorede, Ho et al., Extended-spectrum Beta-lactamases Encoding Genes among Salmonella Enterica serovar Typhi Isolates in Patients with Typhoid Fever from four Academic Medical Centers in Lagos, Nigeria Revista de investigacion clinica

Al-Qaisi, Garawi, Karawi, Hammood, Abdallah et al., Antiureolytic activity of new water-soluble thiadiazole derivatives: Spectroscopic, DFT, and molecular docking studies, Spectrochim Acta Part A Mol Biomol Spectrosc

Alduhaidhawi, Alhuchaimi, Al-Mayah, Mt, Alkafaas et al., Prevalence of CRISPR-Cas Systems and Their Possible Association with Antibiotic Resistance in Enterococcus faecalis and Enterococcus faecium Collected from Hospital Wastewater, Infection and Drug Resistance

Alhouri, Salloum, Harfouch, Soumya, Possible side effects of using detergents during the Covid19 pandemic in Syria, Ann Clin Cases

Alkafaas, Abdallah, Ghosh, Loutfy, Elkaffas et al., Insight into the role of clathrin-mediated endocytosis inhibitors in SARS-CoV-2 infection, Reviews in Medical Virology

Alkafaas, Abdallah, Hussien, Bedair, Abdo et al., A study on the effect of natural products against the transmission of B.1.1. 529 Omicron, Virol J

Alkafaas, Elsalahaty, Ismail, Radwan, Elkafas et al., The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target, Cancer cell Interna, doi:10.1186/s12935-024-03221-8

Alkafaas, Loutfy, Diab, Hessien, Vasopressin induces apoptosis but does not enhance the antiproliferative effect of dynamin 2 or PI3K/ Akt inhibition in luminal A breast cancer cells, Med Oncol

Alves, Magarkar, Horta, Lima, Bunker et al., Influence of doxorubicin on model cell membrane properties: insights from in vitro and in silico studies, Sci Rep

Alves, Ribeiro, Horta, Lima, Nunes et al., A biophysical approach to daunorubicin interaction with model membranes: relevance for the drug's biological activity, J R Soc Interface

Antonescu, Mcgraw, Klip, Reciprocal regulation of endocytosis and metabolism, Cold Spring Harb Perspect Biol

Ausili, Torrecillas, Aranda, Mollinedo, Gajate et al., Edelfosine is incorporated into rafts and alters their organization, J Phys Chem B

Avota, Gulbins, Schneider-Schaulies, DC-SIGN mediated sphingomyelinase-activation and ceramide generation is essential for enhancement of viral uptake in dendritic cells, PLoS Pathog

Bailly, Vergoten, Glycyrrhizin: An alternative drug for the treatment of COVID-19 infection and the associated respiratory syndrome?, Pharmacol Ther

Bakillah, Hejji, Almasaud, Jami, Hawwari et al., Lipid raft integrity and cellular cholesterol homeostasis are critical for SARS-CoV-2 entry into cells, Nutrients

Barnard, Day, Bailey, Heiner, Montgomery et al., Is the anti-psychotic, 10-(3-(dimethylamino)propyl)phenothiazine (promazine), a potential drug with which to treat SARS infections? Lack of efficacy of promazine on SARS-CoV replication in a mouse model, Antiviral Res

Berquand, Fa, Dufrene, Mingeot-Leclercq, Interaction of the macrolide antibiotic azithromycin with lipid bilayers: effect on membrane organization, fluidity, and permeability, Pharm Res

Carpinteiro, Edwards, Hoffmann, Kochs, Gripp et al., Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells, Cell Rep Med

Carpinteiro, Edwards, Hoffmann, Kochs, Gripp et al., Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells, Cell Reports Medicine

Carpinteiro, Gripp, Hoffmann, Pöhlmann, Hoertel et al., Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells, Trends Biochem Sci

Castaldo, Aimo, Castiglione, Padalino, Emdin et al., Safety and Efficacy of Amiodarone in a Patient With COVID-19, JACC Case Rep

Castro, Fedorov, Hornillos, Delgado, Acuña et al., Edelfosine and miltefosine effects on lipid raft properties: membrane biophysics in cell death by antitumor lipids, J Phys Chem B

Chavarría, Vázquez, Cherit, Bello, Suastegui et al., Antioxidants and pentoxifylline as coadjuvant measures to standard therapy to improve prognosis of patients with pneumonia by COVID-19, Comput Struct Biotechnol J

Chemical, None

Chen, Pang, Chen, Ye, Liu et al., The Acid Sphingomyelinase Inhibitor Amitriptyline Ameliorates TNF-α-Induced Endothelial Dysfunction, Cardiovasc Drugs Ther

Chen, Shinn, Itkin, Eastman, Bostwick et al., Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2, Front Pharmacol

Chen, Shinn, Itkin, Eastman, Bostwick et al., Drug repurposing screen for compounds inhibiting the cytopathic effect of SARS-CoV-2, Front Pharmacol

Chen, Xu, Pradhan, Gorshkov, Petersen et al., Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles, ACS Pharmacol Transl Sci

Cheng, Rao, Mehra, COVID-19 treatment: Combining anti-inflammatory and antiviral therapeutics using a network-based approach, Cleve Clin J Med

Choi, Aizaki, Lai, Murine coronavirus requires lipid rafts for virus entry and cell-cell fusion but not for virus release, J Virol

Choy, Wong, Kaewpreedee, Sia, Chen et al., Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro, Antiviral Res

Corre, Loas, Repurposing functional inhibitors of acid sphingomyelinase (fiasmas): an opportunity against SARS-CoV-2 infection?, J Clin Pharm Ther

Coutard, Valle, Lamballerie, Canard, Seidah et al., The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade, Antiviral Res

Daisy, Daniel, Rasmus, Yuling, Liuliu et al., Modulating the transcriptional landscape of SARS-CoV-2 as an effective method for developing antiviral compounds, bioRxiv

Danthi, Chow, Cholesterol removal by methyl-β-cyclodextrin inhibits poliovirus entry, J Virol

Darquennes, Corre, Moine, Loas, Association between Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) and Reduced Risk of Death in COVID-19 Patients: A Retrospective Cohort Study, Pharmaceuticals

Das, Sarmah, Lyndem, Roy, An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study, J Biomol Struct Dyn

Donaldson, Jackson, ARF family G proteins and their regulators: roles in membrane transport, development and disease, Nat Rev Mol Cell Biol

Duarte, Copertino, Jr, Iñiguez, Marston et al., Identifying FDA-approved drugs with multimodal properties against COVID-19 using a datadriven approach and a lung organoid model of SARS-CoV-2 entry, Mol Med

Esen, Schreiner, Jendrossek, Lang, Fassbender et al., Mechanisms of Staphylococcus aureus induced apoptosis of human endothelial cells, Apoptosis

Fantini, Scala, Chahinian, Yahi, Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection, Int J Antimicrob Agents

Fecchi, Anticoli, Peruzzu, Iessi, Gagliardi et al., Coronavirus interplay with lipid rafts and autophagy unveils promising therapeutic targets, Front Microbiol

Ferlinz, Hurwitz, Moczall, Lansmann, Schuchman et al., Functional characterization of the N-glycosylation sites of human acid sphingomyelinase by site-directed mutagenesis, Eur J Biochem

Fred, Kuivanen, Ugurlu, Casarotto, Levanov et al., Antidepressant and Antipsychotic Drugs Reduce Viral Infection by SARS-CoV-2 and Fluoxetine Shows Antiviral Activity Against the Novel Variants in vitro, Front Pharmacol

Frick, Bright, Riento, Bray, Merrified et al., Coassembly of flotillins induces formation of membrane microdomains, membrane curvature, and vesicle budding, Curr Biol

Fugmann, Hausser, Schöffler, Schmid, Pfizenmaier et al., Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein, J Cell Biol

Gault, Obeid, Hannun, An overview of sphingolipid metabolism: from synthesis to breakdown. Sphingolipids as signaling and regulatory molecules

Ge, Lu, Hou, Lv, Wang et al., Azelastine inhibits viropexis of SARS-CoV-2 spike pseudovirus by binding to SARS-CoV-2 entry receptor ACE2, Virology

Ge, Wang, Hou, Lv, Wang et al., Repositioning of histamine H(1) receptor antagonist: Doxepin inhibits viropexis of SARS-CoV-2 Spike pseudovirus by blocking ACE2, Eur J Pharmacol

Gelemanović, Vidović, Stepanić, Trajković, Identification of 37 Heterogeneous Drug Candidates for Treatment of COVID-19 via a Rational Transcriptomics-Based Drug Repurposing Approach, Pharmaceuticals

Gelemanović, Vidović, Stepanić, Trajković, Identification of 37 heterogeneous drug candidates for treatment of COVID-19 via a rational transcriptomics-based drug repurposing approach, Pharmaceuticals

Ghosh, Al-Sharify, Maleka, Onyeaka, Maleke et al., Propolis efficacy on SARS-COV viruses: a review on antimicrobial activities and molecular simulations, Environ Sci Pollut Res

Ghosh, Bornman, Zafer, Antimicrobial Resistance Threats in the emerging COVID-19 pandemic: Where do we stand?, J Infect Public Health

Glebov, Bright, Nichols, Flotillin-1 defines a clathrin-independent endocytic pathway in mammalian cells, Nat Cell Biol

Goh, Sorkin, Sandvig, Deurs, Selective modulation of the endocytic uptake of ricin and fluid phase markers without alteration in transferrin endocytosis, Cold Spring Harb Perspect Biol

Gomide, Thomé, Santos, Ferreira, Faça et al., Disrupting membrane raft domains by alkylphospholipids, Biochimica et Biophysica Acta (BBA)-Biomembranes

Gopal, Rehman, Chadha, Qiu, Colella, Matrigel influences morphology and cathepsin B distribution of prostate cancer PC3 cells, Oncol Rep

Gordon, Jang, Bouhaddou, Xu, Obernier et al., A SARS-CoV-2 protein interaction map reveals targets for drug repurposing, Nature

Gorelik, Illes, Heinz, Superti-Furga, Nagar, Crystal structure of mammalian acid sphingomyelinase, Nat Commun

Grassmé, Gulbins, Brenner, Ferlinz, Sandhoff et al., Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells, Cell

Grassmé, Jekle, Riehle, Schwarz, Berger et al., CD95 signaling via ceramide-rich membrane rafts, J Biol Chem

Grim, Abcejo, Barnes, Sathish, Smelter et al., Caveolae and propofol effects on airway smooth muscle, Br J Anaesth

Guo, Huang, Yuan, Wei, Gao et al., The important role of lipid raft-mediated attachment in the infection of cultured cells by coronavirus infectious bronchitis virus beaudette strain, PLoS ONE

Gurung, Ali, Lee, Farah, Km, The potential of Paritaprevir and Emetine as inhibitors of SARS-CoV-2 RdRp, Saudi J Biol Sci

Hajjo, Tropsha, A systems biology workflow for drug and vaccine repurposing: identifying small-molecule BCG mimics to reduce or prevent COVID-19 mortality, Pharm Res

Hannun, Obeid, Principles of bioactive lipid signalling: lessons from sphingolipids, Nat Rev Mol Cell Biol

Hansen, Sandvig, Van Deurs, The preendosomal compartment comprises distinct coated and noncoated endocytic vesicle populations, J Cell Biol

Hauck, Grassmé, Bock, Jendrossek, Ferlinz et al., Acid sphingomyelinase is involved in CEACAM receptor-mediated phagocytosis of Neisseria gonorrhoeae, FEBS Lett

Heinrich, Wickel, Schneider-Brachert, Sandberg, Gahr et al., Cathepsin D targeted by acid sphingomyelinase-derived ceramide, EMBO J

Henseler, Klein, Glombitza, Suziki, Sandhoff, Expression of the three alternative forms of the sphingolipid activator protein precursor in baby hamster kidney cells and functional assays in a cell culture system, J Biol Chem

Heron, Shinitzky, Zamir, Samuel, Adaptive modulations of brain membrane lipid fluidity in drug addiction and denervation supersensitivity, Biochem Pharmacol

Hessien, Donia, Tabll, Adly, Abdelhafez et al., Mechanistic-Based Classification of Endocytosis-Related Inhibitors: Does It Aid in Assigning Drugs against SARS-CoV-2?, Viruses

Hoertel, Blachier, Blanco, Olfson, Massetti et al., A stochastic agent-based model of the SARS-CoV-2 epidemic in France, Nat Med

Hoertel, Sánchez-Rico, Gulbins, Kornhuber, Carpinteiro et al., Association Between FIASMAs and Reduced Risk of Intubation or Death in Individuals Hospitalized for Severe COVID-19: An Observational Multicenter Study, Clin Pharmacol Ther

Hoertel, Sánchez-Rico, Gulbins, Kornhuber, Carpinteiro et al., Association between FIASMA psychotropic medications and reduced risk of intubation or death in individuals with psychiatric disorders hospitalized for severe COVID-19: an observational multicenter study, Transl Psychiatry

Hoertel, Sánchez-Rico, Vernet, Beeker, Jannot et al., Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study, Mol Psychiatry

Hoffmann, Kleine-Weber, Schroeder, Krüger, Herrler et al., SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor, Cell

Hou, Ge, Li, Wang, He et al., Testing of the inhibitory effects of loratadine and desloratadine on SARS-CoV-2 spike pseudotyped virus viropexis, Chem Biol Interact

Hu, Zhao, Li, Cheng, Sun, Effect of tetracaine on dynamic reorganization of lipid membranes, Biochimica et Biophysica Acta (BBA)-Biomembranes

Hu, Zhu, Yang, Lin, Yang, The epidermal growth factor receptor regulates cofilin activity and promotes transmissible gastroenteritis virus entry into intestinal epithelial cells, Oncotarget

Huang, Li, Sadaoka, Tang, Yamamoto et al., Human herpesvirus 6 envelope cholesterol is required for virus entry, J Gen Virol

Huang, Wang, Li, Ren, Zhao et al., Clinical features of patients infected with 2019 novel coronavirus in Wuhan China, The lancet

Huotari, Helenius, Endosome maturation, EMBO J

Hurwitz, Ferlinz, Sandhoff, The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts, Bio Chem Hoppe-Seyler

Hurwitz, Ferlinz, Vielhaber, Moczall, Sandhoff, Processing of human acid sphingomyelinase in normal and I-cell fibroblasts, J Biol Chem

Imamura, Sakurai, Enami, Shibukawa, Nishi et al., iPSC screening for drug repurposing identifies anti-RNA virus agents modulating host cell susceptibility, FEBS Open Bio

Irannejad, GPCR signaling along the endocytic pathway, Curr Opin Cell Biol

Jade, Ayyamperumal, Tallapaneni, Nanjan, Barge et al., Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PL(PRO) and 3CL(PRO) proteases, Eur J Pharmacol

Jade, Ayyamperumal, Tallapaneni, Nanjan, Barge et al., Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PLPRO and 3CLPRO proteases, Eur J Pharmacol

Janabi, Molecular Docking Analysis of Anti-Severe Acute Respiratory Syndrome-Coronavirus 2 Ligands against Spike Glycoprotein and the 3-Chymotrypsin-Like Protease, J Med Signals Sens

Jehi, Ji, Milinovich, Erzurum, Rubin et al., Individualizing Risk Prediction for Positive Coronavirus Disease 2019 Testing: Results From 11,672 Patients, Chest

Jeon, Ko, Lee, Choi, Byun et al., Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs, Antimicrob Agents Chemother

Jeon, Ko, Lee, Choi, Byun et al., Identification of antiviral drug candidates against SARS-CoV-2 from FDA-approved drugs, Antimicrob Agents Chemother

Kamata, Manno, Ozaki, Takakuwa, Functional evidence for presence of lipid rafts in erythrocyte membranes: Gsα in rafts is essential for signal transduction, Am J Hematol

Kaneko, Takimoto, Sugiyama, Seki, Kawaguchi et al., Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors, Immunopharmacol Immunotoxicol

Kirkham, Fujita, Chadda, Nixon, Kurzchalia et al., Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles, J Cell Biol

Klutzny, Lesche, Keck, Kaulfuss, Schlicker et al., Functional inhibition of acid sphingomyelinase by Fluphenazine triggers hypoxia-specific tumor cell death, Cell Death Dis

Kornhuber, Hoertel, Gulbins, The acid sphingomyelinase/ceramide system in COVID-19, Mol Psychiatry

Kornhuber, Muehlbacher, Trapp, Pechmann, Friedl et al., Identification of Novel Functional Inhibitors of Acid Sphingomyelinase, PLOS ONE

Kornhuber, Muehlbacher, Trapp, Pechmann, Friedl et al., Identification of novel functional inhibitors of acid sphingomyelinase, PLoS ONE

Kornhuber, Tripal, Reichel, Terfloth, Bleich et al., Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model, J Med Chem

Kumari, Mg, Mayor, Endocytosis unplugged: multiple ways to enter the cell, Cell Res

Kölzer, Werth, Sandhoff, Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine, FEBS Lett

Lacour, Hammann, Grazide, Lagadic-Gossmann, Athias et al., Cisplatin-induced CD95 redistribution into membrane lipid rafts of HT29 human colon cancer cells, Can Res

Lansmann, Schuette, Bartelsen, Hoernschemeyer, Linke et al., Human acid sphingomyelinase: Assignment of the disulfide bond pattern, Eur J Biochem

Le, Andreoletti, Oskotsky, Vallejo-Gracia, Rosales et al., Transcriptomics-based drug repositioning pipeline identifies therapeutic candidates for COVID-19, Sci Rep

Lefrancois, Zeng, Hassan, Canuel, Morales, The lysosomal trafficking of sphingolipid activator proteins (SAPs) is mediated by sortilin, EMBO J

Lenze, Mattar, Zorumski, Stevens, Schweiger et al., Fluvoxamine vs placebo and clinical deterioration in outpatients with symptomatic COVID-19: a randomized clinical trial, JAMA

Liu, Liu, Liang, Meng, Greenbaum et al., Drug Repurposing for COVID-19 Treatment by Integrating Network Pharmacology and Transcriptomics, Pharmaceutics

Liu, Zhou, Li, Garner, Watkins et al., Research and development on therapeutic agents and vaccines for COVID-19 and related human coronavirus diseases

Loas, Corre, Update on Functional Inhibitors of Acid Sphingomyelinase (FIASMAs) in SARS-CoV-2 Infection, Pharmaceuticals

Loas, Corre, Update on functional inhibitors of acid sphingomyelinase (FIASMAs) in SARS-CoV-2 infection, Pharmaceuticals

Mahase, Covid-19: death rate is 0.66% and increases with age, study estimates, BMJ

Maldonado-Báez, Williamson, Donaldson, Clathrin-independent endocytosis: a cargo-centric view, Exp Cell Res

Mathewson, Bishop, Yao, Kemp, Ren et al., Interaction of severe acute respiratory syndrome-coronavirus and NL63 coronavirus spike proteins with angiotensin converting enzyme-2, J Gen Virol

Mayor, Parton, Donaldson, Clathrin-independent pathways of endocytosis, Cold Spring Harb Perspect Biol

Mañes, Del Real, Martínez-A C, Pathogens: raft hijackers, Nat Rev Immunol

Meng, Liu, Lou, Yang, Emodin suppresses lipopolysaccharideinduced pro-inflammatory responses and NF-κB activation by disrupting lipid rafts in CD14-negative endothelial cells, Br J Pharmacol

Meskini, Rami, Maroofi, Ghosh, Siadat et al., An overview on the epidemiology and immunology of COVID-19, J Infect Public Health

Miller, Adhikary, Kolokoltsov, Davey, Ebolavirus requires acid sphingomyelinase activity and plasma membrane sphingomyelin for infection, J Virol

Mitra, Oskeritzian, Payne, Beaven, Milstien et al., Role of ABCC1 in export of sphingosine-1-phosphate from mast cells, Proc Natl Acad Sci

Mizogami, Tsuchiya, Membrane interactivity of anesthetic adjuvant dexmedetomidine discriminable from clonidine and enantiomeric levomedetomidine, Journal of Advances in Medicine and Medical Research

Morin-Dewaele, Bartier, Berry, Brillet, López-Molina et al., Desloratadine, an FDAapproved cationic amphiphilic drug, inhibits SARS-CoV-2 infection in cell culture and primary human nasal epithelial cells by blocking viral entry, Sci Rep

Moya, Dautry-Varsat, Goud, Louvard, Boquet, Inhibition of coated pit formation in Hep2 cells blocks the cytotoxicity of diphtheria toxin but not that of ricin toxin, J Cell Biol

Naz, Asif, Alwutayd, Sarfaraz, Abbasi et al., Repurposing FIASMAs against Acid Sphingomyelinase for COVID-19: A Computational Molecular Docking and Dynamic Simulation Approach, Molecules

Nazeam, Mohammed, Raafat, Houssein, Elkafoury et al., Based on principles and insights of covid-19 epidemiology, genome sequencing, and pathogenesis: Retrospective analysis of sinigrin and prolixinrx (fluphenazine) provides off-label drug candidates, Slas Discovery

Ni, Morales, The lysosomal trafficking of acid sphingomyelinase is mediated by sortilin and mannose 6-phosphate receptor, Traffic

Nicolau, Burrage, Parton, Hancock, Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane, Mol Cell Biol

Nomura, Kiyota, Suzaki, Kataoka, Ohe et al., Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae, J Virol

Norinder, Tuck, Norgren, Kos, Existing highly accumulating lysosomotropic drugs with potential for repurposing to target COVID-19, Biomed Pharmacother

O'donovan, Imami, Eby, Henkel, Creeden et al., Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach, Sci Rep

Patel, Chowdhury, Noorani, Bickel, Huang, Isoflurane increases cell membrane fluidity significantly at clinical concentrations, Biochimica et Biophysica Acta (BBA)-Biomembranes

Plaze, Attali, Prot, Petit, Blatzer et al., Inhibition of the replication of SARS-CoV-2 in human cells by the FDA-approved drug chlorpromazine, Int J Antimicrob Agents

Preston, Abbott, Begley, Transcytosis of macromolecules at the blood-brain barrier, Adv Pharmacol

Radenkovic, Chawla, Pirro, Sahebkar, Banach, Cholesterol in relation to COVID-19: should we care about it?, J Clin Med

Radhakrishna, Donaldson, ADP-ribosylation factor 6 regulates a novel plasma membrane recycling pathway, J Cell Biol

Raheem, Hussein, Ghosh, Alkafaas, Bloemfontein, Resistance of Klebsiella pneumoniae from Different Clinical Samples to Penicillin, Cephalosporin. Carbapenem and Fluoroquinolone, Teikyo Medical Journal

Rao, Vaidyanathan, Rengasamy, Oommen, Somaiya et al., Sphingolipid Metabolic Pathway: An Overview of Major Roles Played in Human Diseases, J Lipids

Rebillard, Tekpli, Meurette, Sergent, Lemoigne-Muller et al., Cisplatininduced apoptosis involves membrane fluidification via inhibition of NHE1 in human colon cancer cells, Can Res

Reznikov, Norris, Vashisht, Bluhm, Li et al., Identification of antiviral antihistamines for COVID-19 repurposing, Biochem Biophys Res Commun

Rodrigues-Diez, Tejera-Muñoz, Marquez-Exposito, Rayego-Mateos, Sanchez et al., Statins: could an old friend help in the fight against COVID-19?, Br J Pharmacol

Ruan, Liu, Guo, He, Huang et al., SARS-CoV-2 and SARS-CoV: Virtual screening of potential inhibitors targeting RNA-dependent RNA polymerase activity (NSP12), J Med Virol

Sahoo, Bhattamisra, Das, Tiwari, Tiwari et al., Computational Approach to Combat COVID-19 Infection: Emerging Tools for Accelerating Drug Research, Curr Drug Discov Technol

Sakuragawa, Sakuragawa, Kuwabara, Pentchev, Barranger et al., Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944, Science

Sauvat, Ciccosanti, Colavita, Rienzo, Castilletti et al., On-target versus off-target effects of drugs the replication of SARS-CoV-2, Cell Death Dis

Sauvat, Ciccosanti, Colavita, Rienzo, Castilletti et al., On-target versus offtarget effects of drugs inhibiting the replication of SARS-CoV-2, Cell Death Dis

Schissel, Jiang X-C, Tweedie-Hardman, Jeong, Camejo, Najib et al., Secretory sphingomyelinase, a product Alkafaas et al. BMC Health (2024) 24:395 of the sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH: implications for atherosclerotic lesion development, J Biol Chem

Schloer, Brunotte, Goretzko, Mecate-Zambrano, Korthals et al., Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine, Emerging microbes & infections

Schneider-Schaulies, Schneider-Schaulies, Sphingolipids in viral infection, Biol Chem

Scott, Vacca, Gruenberg, Endosome maturation, transport and functions, Semin Cell Dev Biol

Sencanski, Perovic, Pajovic, Adzic, Paessler et al., Drug Repurposing for Candidate SARS-CoV-2 Main Protease Inhibitors by a Novel In Silico Method, Molecules

Sierra-Valdez, Ruiz-Suárez, Delint-Ramirez, Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABAA receptors, Biochimica et Biophysica Acta (BBA)-Biomembranes

Sorice, Misasi, Riitano, Manganelli, Martellucci et al., Targeting lipid rafts as a strategy against coronavirus, Front Cell Dev Biol

Tang, Liu, Zhang, Xu, Wen, Cytokine storm in COVID-19: the current evidence and treatment strategies, Front Immunol

Tani, Shiokawa, Kaname, Kambara, Mori et al., Involvement of ceramide in the propagation of Japanese encephalitis virus, J Virol

Tay, Poh, Rénia, Macary, Ng, The trinity of COVID-19: immunity, inflammation and intervention, Nat Rev Immunol

Tay, Poh, Rénia, Macary, Ng, The trinity of COVID-19: immunity, inflammation and intervention, Nature Reviews Immunology

Thorp, Gallagher, Requirements for CEACAMs and cholesterol during murine coronavirus cell entry, J Virol

Touret, Gilles, Barral, Nougairède, Van Helden et al., In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication, Sci Rep

Tsuchiya, Mizogami, Interaction of drugs with lipid raft membrane domains as a possible target, Drug Target Insights

Tsuchiya, Mizogami, Takakura, Reversed-phase liquid chromatographic retention and membrane activity relationships of local anesthetics, J Chromatogr A

Tsukamoto, Hirotsu, Kumazoe, Goto, Sugihara et al., Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells, Biochemical Journal

Turkyilmaz, Almeida, Sl, Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase, Langmuir

Törnquist, Asghar, Srinivasan, Korhonen, Lindholm, Sphingolipids as modulators of SARS-CoV-2 infection, Front Cell Dev Biol

Udrea, Avram, Nistorescu, Pascu, Mo, Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking, J Photochem Photobiol B

Udrea, Nistorescu, Pascu, Mo, Laser irradiated phenothiazines: New potential treatment for COVID-19 explored by molecular docking, J Photochem Photobiol, B

Vatansever, Yang, Drelich, Kratch, Cho et al., Bepridil is potent against SARS-CoV-2 in vitro, Proc Natl Acad Sci

Vatansever, Yang, Drelich, Kratch, Cho et al., Bepridil is potent against SARS-CoV-2 in vitro, Proc Natl Acad Sci U S A

Verstraeten, Jaggers, Fraga, Oteiza, Procyanidins can interact with Caco-2 cell membrane lipid rafts: involvement of cholesterol, Biochimica et Biophysica Acta (BBA)-Biomembranes

Verstraeten, Oteiza, Fraga, Membrane effects of cocoa procyanidins in liposomes and Jurkat T cells, Biol Res

Viard, Parolini, Sargiacomo, Fecchi, Ramoni et al., Role of cholesterol in human immunodeficiency virus type 1 envelope protein-mediated fusion with host cells, J Virol

Villoutreix, Krishnamoorthy, Tamouza, Leboyer, Beaune, Chemoinformatic analysis of psychotropic and antihistaminic drugs in the light of experimental anti-SARS-CoV-2 activities, Advances and applications in bioinformatics and chemistry

Wang, Lu, Ge, Hou, Hu et al., Astemizole as a drug to inhibit the effect of SARS-COV-2 in vitro, Microb Pathog

Wang, Yuan, Sun, Mao, Tan et al., Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system, Virology

Wei, Wang, Shi, Liu, Yang et al., Saikosaponin a inhibits LPSinduced inflammatory response by inducing liver X receptor alpha activation in primary mouse macrophages, Oncotarget

Weston, Coleman, Haupt, Logue, Matthews et al., Broad Anti-coronavirus Activity of Food and Drug Administration-Approved Drugs against SARS-CoV-2 In Vitro and SARS-CoV In Vivo, J Virol

Weston, Coleman, Haupt, Logue, Matthews et al., Broad anti-coronavirus activity of food and drug administration-approved drugs against SARS-CoV-2 in vitro and SARS-CoV in vivo, J Virol

Wnętrzak, Łątka, Makyła-Juzak, Zemla, Dynarowicz-Łątka, The influence of an antitumor lipid-erucylphosphocholine-on artificial lipid raft system modeled as Langmuir monolayer, Mol Membr Biol

Wähe, Kasmapour, Schmaderer, Liebl, Sandhoff et al., Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin, J Cell Sci

Węder, Mach, Hąc-Wydro, Wydro, Studies on the interactions of anticancer drug-Minerval-with membrane lipids in binary and ternary Langmuir monolayers, Biochimica et Biophysica Acta (BBA)-Biomembranes

Xia, Gamble, Rye, Wang, Hii et al., Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway, Proc Natl Acad Sci

Xiao, Wang, Chang, Wang, Dong et al., Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2, Front Immunol

Xiong, Cao, Shen, Ma, Shi et al., Several FDA-approved drugs effectively inhibit SARS-CoV-2 infection in vitro, Front Pharmacol

Xiong, Huang, Poda, Pomès, Privé, Structure of human acid sphingomyelinase reveals the role of the saposin domain in activating substrate hydrolysis, J Mol Biol

Yan, Zhang, Li, Xia, Guo et al., Base estructural para el reconocimiento de SARS-CoV-2 por la enzima convertidora de angiotensina 2 (ACE2) humana completa, Science

Yang, Lv, Wang, Gao, Yao et al., Replication of murine coronavirus requires multiple cysteines in the endodomain of spike protein, Virology

Yang, Pei R-J, Li, Ma, -N et al., Identification of SARS-CoV-2 entry inhibitors among already approved drugs, Acta Pharmacol Sin

Yi, Choo, Cho, Kim, Kim et al., Ginsenoside Rh2 induces ligand-independent Fas activation via lipid raft disruption, Biochem Biophys Res Commun

Yoshida, Takashima, Nishio, Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems, MedChemComm

Yuan, Yin, Meng, Chan, Ye et al., Clofazimine broadly inhibits coronaviruses including SARS-CoV-2, Nature

Zhou, Cho, Plowman, Hancock, Nonsteroidal anti-inflammatory drugs alter the spatiotemporal organization of Ras proteins on the plasma membrane, J Biol Chem

Zhou, Hou, Shen, Huang, Martin et al., Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2, Cell Discov

Zhou, Hou, Shen, Mehra, Kallianpur et al., A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19, PLoS Biol

Zhou, Metcalf, Garman, Edmunds, Qiu et al., Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease, Nat Commun

溝上真樹, Plant components exhibit pharmacological activities and drug interactions by acting on lipid membranes, Pharmacognosy Communications

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Symptoms included respiratory strain and complications, leading to severe ' 'pneumonia. SARS-CoV-2 attaches to the ACE-2 receptor of the host cell membrane to enter. ' 'Targeting the SARS-CoV-2 entry may effectively inhibit infection. Acid sphingomyelinase ' '(ASMase) is a lysosomal protein that catalyzes the conversion of sphingolipid (sphingomyelin) ' 'to ceramide. Ceramide molecules aggregate/assemble on the plasma membrane to form “platforms” ' 'that facilitate the viral intake into the cell. Impairing the ASMase activity will eventually ' 'disrupt viral entry into the cell. In this review, we identified the metabolism of ' "sphingolipids, sphingolipids' role in cell signal transduction cascades, and viral infection " 'mechanisms. Also, we outlined ASMase structure and underlying mechanisms inhibiting viral ' 'entry 40 with the aid of inhibitors of acid sphingomyelinase (FIASMAs). In silico molecular ' 'docking analyses of FIASMAs with inhibitors revealed that dilazep (S\u2009=\u2009−\u200912.58 ' 'kcal/mol), emetine (S\u2009=\u2009−\u200911.65 kcal/mol), pimozide (S\u2009=\u2009−\u2009' '11.29 kcal/mol), carvedilol (S\u2009=\u2009−\u200911.28 kcal/mol), mebeverine (S\u2009=\u2009' '−\u200911.14 kcal/mol), cepharanthine (S\u2009=\u2009−\u200911.06 kcal/mol), hydroxyzin ' '(S\u2009=\u2009−\u200910.96 kcal/mol), astemizole (S\u2009=\u2009−\u200910.81 kcal/mol), ' 'sertindole (S\u2009=\u2009−\u200910.55 kcal/mol), and bepridil (S\u2009=\u2009−\u200910.47 ' 'kcal/mol) have higher inhibition activity than the candidate drug amiodarone (S\u2009=\u2009' '−\u200910.43 kcal/mol), making them better options for inhibition.', 'DOI': '10.1186/s12889-024-17747-z', 'type': 'journal-article', 'created': {'date-parts': [[2024, 2, 6]], 'date-time': '2024-02-06T15:03:35Z', 'timestamp': 1707231815000}, 'update-policy': 'http://dx.doi.org/10.1007/springer_crossmark_policy', 'source': 'Crossref', 'is-referenced-by-count': 0, 'title': 'Molecular docking as a tool for the discovery of novel insight about the role of acid ' 'sphingomyelinase inhibitors in SARS- CoV-2 infectivity', 'prefix': '10.1186', 'volume': '24', 'author': [ {'given': 'Samar Sami', 'family': 'Alkafaas', 'sequence': 'first', 'affiliation': []}, {'given': 'Abanoub Mosaad', 'family': 'Abdallah', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mai H.', 'family': 'Hassan', 'sequence': 'additional', 'affiliation': []}, {'given': 'Aya Misbah', 'family': 'Hussien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Sara Samy', 'family': 'Elkafas', 'sequence': 'additional', 'affiliation': []}, {'given': 'Samah A.', 'family': 'Loutfy', 'sequence': 'additional', 'affiliation': []}, {'given': 'Abanoub', 'family': 'Mikhail', 'sequence': 'additional', 'affiliation': []}, {'given': 'Omnia G.', 'family': 'Murad', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed I.', 'family': 'Elsalahaty', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed', 'family': 'Hessien', 'sequence': 'additional', 'affiliation': []}, {'given': 'Rami M.', 'family': 'Elshazli', 'sequence': 'additional', 'affiliation': []}, {'given': 'Fatimah A.', 'family': 'Alsaeed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Ahmed Ezzat', 'family': 'Ahmed', 'sequence': 'additional', 'affiliation': []}, {'given': 'Hani K.', 'family': 'Kamal', 'sequence': 'additional', 'affiliation': []}, {'given': 'Wael', 'family': 'Hafez', 'sequence': 'additional', 'affiliation': []}, {'given': 'Mohamed T.', 'family': 'El-Saadony', 'sequence': 'additional', 'affiliation': []}, {'given': 'Khaled A.', 'family': 'El-Tarabily', 'sequence': 'additional', 'affiliation': []}, {'given': 'Soumya', 'family': 'Ghosh', 'sequence': 'additional', 'affiliation': []}], 'member': '297', 'published-online': {'date-parts': [[2024, 2, 6]]}, 'reference': [ { 'issue': '9', 'key': '17747_CR1', 'doi-asserted-by': 'publisher', 'first-page': '1417', 'DOI': '10.1038/s41591-020-1001-6', 'volume': '26', 'author': 'N Hoertel', 'year': '2020', 'unstructured': 'Hoertel N, Blachier M, Blanco C, Olfson M, Massetti M, Rico MS, Limosin ' 'F, Leleu H. 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J Virol. 2010;84(6):2798–807.', 'journal-title': 'J Virol'}, { 'issue': '6', 'key': '17747_CR18', 'doi-asserted-by': 'publisher', 'first-page': '431', 'DOI': '10.1023/A:1012445925628', 'volume': '6', 'author': 'M Esen', 'year': '2001', 'unstructured': 'Esen M, Schreiner B, Jendrossek V, Lang F, Fassbender K, Grassme H, ' 'Gulbins E. Mechanisms of Staphylococcus aureus induced apoptosis of ' 'human endothelial cells. Apoptosis. 2001;6(6):431–9.', 'journal-title': 'Apoptosis'}, { 'issue': '5', 'key': '17747_CR19', 'doi-asserted-by': 'publisher', 'first-page': '605', 'DOI': '10.1016/S0092-8674(00)80448-1', 'volume': '91', 'author': 'H Grassmé', 'year': '1997', 'unstructured': 'Grassmé H, Gulbins E, Brenner B, Ferlinz K, Sandhoff K, Harzer K, Lang ' 'F, Meyer TF. Acidic sphingomyelinase mediates entry of N. gonorrhoeae ' 'into nonphagocytic cells. Cell. 1997;91(5):605–15.', 'journal-title': 'Cell.'}, { 'issue': '3', 'key': '17747_CR20', 'doi-asserted-by': 'publisher', 'first-page': '260', 'DOI': '10.1016/S0014-5793(00)01851-2', 'volume': '478', 'author': 'CR Hauck', 'year': '2000', 'unstructured': 'Hauck CR, Grassmé H, Bock J, Jendrossek V, Ferlinz K, Meyer TF, Gulbins ' 'E. Acid sphingomyelinase is involved in CEACAM receptor-mediated ' 'phagocytosis of Neisseria gonorrhoeae. FEBS Lett. 2000;478(3):260–6.', 'journal-title': 'FEBS Lett'}, { 'issue': '3', 'key': '17747_CR21', 'first-page': '165', 'volume': '74', 'author': 'KO Akinyemi', 'year': '2022', 'unstructured': 'Akinyemi KO, Al-Khafaji NS, Al-Alaq FT, Fakorede CO, Al-Dahmoshi HO, ' 'Iwalokun BA, Akpabio I, Alkafaas SS, Saki M. Extended-spectrum ' 'Beta-lactamases Encoding Genes among Salmonella Enterica serovar Typhi ' 'Isolates in Patients with Typhoid Fever from four Academic Medical ' 'Centers in Lagos. Nigeria Revista de investigacion clinica. ' '2022;74(3):165–71.', 'journal-title': 'Nigeria Revista de investigacion clinica'}, { 'key': '17747_CR22', 'doi-asserted-by': 'publisher', 'first-page': '1143', 'DOI': '10.2147/IDR.S358248', 'volume': '15', 'author': 'AHM Alduhaidhawi', 'year': '2022', 'unstructured': 'Alduhaidhawi AHM, AlHuchaimi SN, Al-Mayah TA, Al-Ouqaili MT, Alkafaas ' 'SS, Muthupandian S, Saki M. Prevalence of CRISPR-Cas Systems and Their ' 'Possible Association with Antibiotic Resistance in Enterococcus faecalis ' 'and Enterococcus faecium Collected from Hospital Wastewater. Infection ' 'and Drug Resistance. 2022;15:1143.', 'journal-title': 'Infection and Drug Resistance'}, { 'issue': '06', 'key': '17747_CR23', 'first-page': '1', 'volume': '44', 'author': 'HQ Raheem', 'year': '2021', 'unstructured': 'Raheem HQ, Hussein EF, Ghosh S, AlKafaas SS, Bloemfontein SA. Resistance ' 'of Klebsiella pneumoniae from Different Clinical Samples to Penicillin, ' 'Cephalosporin. Carbapenem and Fluoroquinolone Teikyo Medical Journal. ' '2021;44(06):1–8.', 'journal-title': 'Carbapenem and Fluoroquinolone Teikyo Medical Journal'}, { 'issue': '1', 'key': '17747_CR24', 'doi-asserted-by': 'publisher', 'first-page': '307', 'DOI': '10.1038/s41380-021-01309-5', 'volume': '27', 'author': 'J Kornhuber', 'year': '2022', 'unstructured': 'Kornhuber J, Hoertel N, Gulbins E. The acid sphingomyelinase/ceramide ' 'system in COVID-19. Mol Psychiatry. 2022;27(1):307–14.', 'journal-title': 'Mol Psychiatry'}, { 'issue': '4287', 'key': '17747_CR25', 'doi-asserted-by': 'publisher', 'first-page': '317', 'DOI': '10.1126/science.66749', 'volume': '196', 'author': 'N Sakuragawa', 'year': '1977', 'unstructured': 'Sakuragawa N, Sakuragawa M, Kuwabara T, Pentchev PG, Barranger JA, Brady ' 'RO. Niemann-Pick disease experimental model: sphingomyelinase reduction ' 'induced by AY-9944. 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The emerging roles of ' 'sphingosine 1-phosphate and SphK1 in cancer resistance: a promising ' 'therapeutic target. Cancer cell Interna. 2024. ' 'https://doi.org/10.1186/s12935-024-03221-8.', 'DOI': '10.1186/s12935-024-03221-8'}, { 'key': '17747_CR39', 'doi-asserted-by': 'crossref', 'unstructured': 'Pralhada Rao R, Vaidyanathan N, Rengasamy M, Mammen Oommen A, Somaiya N, ' 'Jagannath MR: Sphingolipid Metabolic Pathway: An Overview of Major Roles ' 'Played in Human Diseases. J Lipids. 2013;2013:1–12.', 'DOI': '10.1155/2013/178910'}, { 'issue': '24', 'key': '17747_CR40', 'doi-asserted-by': 'publisher', 'first-page': '14196', 'DOI': '10.1073/pnas.95.24.14196', 'volume': '95', 'author': 'P Xia', 'year': '1998', 'unstructured': 'Xia P, Gamble JR, Rye K-A, Wang L, Hii CS, Cockerill P, Khew-Goodall Y, ' 'Bert AG, Barter PJ, Vadas MA. Tumor necrosis factor-α induces adhesion ' 'molecule expression through the sphingosine kinase pathway. 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Lipid raft integrity and cellular cholesterol homeostasis ' 'are critical for SARS-CoV-2 entry into cells. Nutrients. ' '2022;14(16):3417.', 'journal-title': 'Nutrients'}, { 'issue': '21', 'key': '17747_CR88', 'doi-asserted-by': 'publisher', 'first-page': '4873', 'DOI': '10.1111/bph.15166', 'volume': '177', 'author': 'RR Rodrigues-Diez', 'year': '2020', 'unstructured': 'Rodrigues-Diez RR, Tejera-Muñoz A, Marquez-Exposito L, Rayego-Mateos S, ' 'Santos Sanchez L, Marchant V, Tejedor Santamaria L, Ramos AM, Ortiz A, ' 'Egido J. Statins: could an old friend help in the fight against ' 'COVID-19? Br J Pharmacol. 2020;177(21):4873–86.', 'journal-title': 'Br J Pharmacol'}, { 'key': '17747_CR89', 'doi-asserted-by': 'publisher', 'first-page': '1574', 'DOI': '10.3389/fcell.2021.689854', 'volume': '9', 'author': 'K Törnquist', 'year': '2021', 'unstructured': 'Törnquist K, Asghar MY, Srinivasan V, Korhonen L, Lindholm D. ' 'Sphingolipids as modulators of SARS-CoV-2 infection. 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