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Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury

Wu et al., Bulletin of Experimental Biology and Medicine, doi:10.1007/s10517-022-05407-4
Feb 2022  
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Animal study showing benefit of ultra-short wave diathermy (USWD) in reducing lung injury in a rat model of LPS-induced acute lung injury, a condition similar to COVID-19 acute respiratory distress. Authors found USWD decreased lung edema, injury, and inflammation in LPS-treated rats.
Authors did not measure temperature and it is unknown how much the observed benefit is due to the thermal effects of UWSD versus other potential mechanisms of action.
2 preclinical studies support the efficacy of thermotherapy for COVID-19:
Wu et al., 17 Feb 2022, peer-reviewed, 11 authors. Contact: wangtong60621@163.com (corresponding author).
This PaperThermotherapyAll
Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury
Q Wu, M Qu, P Zhong, Y Zeng, J Wang, Q Zhang, Ting Wang, D Liu, L Yang, J Zhou, Tong Wang
Bulletin of Experimental Biology and Medicine, doi:10.1007/s10517-022-05407-4
We studied the lung-protective effect and mechanisms of the anti-inflammatory and antioxidant effects of ultra-short-wave diathermy (USWD) in a rat model of LPS-induced acute lung injury. Histological examination of the lung tissues was performed and the levels of oxidative stress-related factors and inflammatory cytokines were measured. It was shown that the lung injury score, the lung wet-to-dry weight ratio (W/D), oxidative stress-related factors malondialdehyde and acyl-CoA synthetase long-chain family member 4 (ACSL4), and inflammatory cytokines were increased after LPS administration, while USWD treatment reduced these parameters. In addition, superoxide dismutase and glutathione peroxidase 4 were decreased in rats with LPS-induced acute lung injury, while USWD therapy up-regulated the expression of these enzymes. Thus, USWD could antagonize lung injury by inhibiting oxidative stress and inflammatory response in rats with acute lung injury. USWD can be a promising adjunctive treatment to counter oxidative stress and inflammation and a potential therapeutic candidate for the treatment of patients with this pathology.
References
Dong, Yuan, Accelerated inflammation and oxidative stress induced by LPS in acute lung injury: Ιnhibition by ST1926, Int. J. Mol. Med, doi:10.3892/ijmm.2018.3574
Go, Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy, Biochim. Biophys. Acta Gen. Subj, doi:10.1016/j.bbagen.2017.05.019
Imai, Matsuoka, Kumagai, Sakamoto, Koumura, Lipid Peroxidation-Dependent Cell Death Regulated by GPx4 and Ferroptosis, Curr. Top Microbiol. Immunol, doi:10.1007/82_2016_508
Kellner, Noonepalle, Lu, Srivastava, Zemskov et al., ROS Signaling in the Pathogenesis of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS), Adv. Exp. Med. Biol, doi:10.1007/978-3-319-63245-2_8
Lei, Wei, Song, Li, Zhang et al., Cordycepin inhibits LPS-induced acute lung injury by inhibiting inflammation and oxidative stress, Eur. J. Pharmacol, doi:10.1016/j.ejphar.2017.10.029
Li, Cao, Xiao, Shang, Tan et al., Inhibitor of apoptosis-stimulating protein of p53 inhibits ferroptosis and alleviates intestinal ischemia/reperfusion-induced acute lung injury, Cell. Death Differ, doi:10.1038/s41418-020-0528-x
Li, Li, Leng, Xiong, Xia, Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress, DNA Cell. Biol, doi:10.1089/dna.2019.5097
Li, Wu, Wang, Ma, Zhai et al., Dapk1 improves inflammation, oxidative stress and autophagy in LPSinduced acute lung injury via p38MAPK/NF-κB signaling pathway, Mol. Immunol, doi:10.1016/j.mo-limm.2020.01.014
Mowery, Terzian, Nelson, Acute lung injury, Curr. Probl. Surg, doi:10.1016/j.cp-surg.2020.100777
Shields, Gormley, Hare, Short-wave diathermy: current clinical and safety practices, Physiother. Res. Int, doi:10.1002/pri.259
Wang, Deng, Dong, Huang, Li et al., Eriodictyol ameliorates lipopolysaccharide-induced acute lung injury by suppressing the inflammatory COX-2/NLRP3/NF-κB pathway in mice, J. Biochem. Mol. Toxicol, doi:10.1002/jbt.22434
Wang, Feng, Zhao, Zhang, Zhang, Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF-α pathway, Int. J. Mol. Med, doi:10.3892/ijmm.2018.3786
Wang, Jia, Cao, Feng, Na et al., HUCMSCs transplantation combined with ultrashort wave therapy attenuates neuroinflammation in spinal cord injury through NUR77/NF-κB pathway, Life Sci, doi:10.1016/j.lfs.2020.118958
Xu, Li, Cheng, Yang, Wang, Inhibition of ACSL4 attenuates ferroptotic damage after pulmonary ischemia-reperfusion, FASEB J, doi:10.1096/fj.202001758R
Yu, Jones, Dean, Laakso, Ultra-shortwave diathermy -a new purported treatment for management of patients with COVID-19, Physiother. Theory Pract, doi:10.1080/09593985.2020.1757264
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