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Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury

Wu et al., Bulletin of Experimental Biology and Medicine, doi:10.1007/s10517-022-05407-4
Feb 2022  
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Animal study showing benefit of ultra-short wave diathermy (USWD) in reducing lung injury in a rat model of LPS-induced acute lung injury, a condition similar to COVID-19 acute respiratory distress. Authors found USWD decreased lung edema, injury, and inflammation in LPS-treated rats.
Authors did not measure temperature and it is unknown how much the observed benefit is due to the thermal effects of UWSD versus other potential mechanisms of action.
2 preclinical studies support the efficacy of thermotherapy for COVID-19:
Wu et al., 17 Feb 2022, peer-reviewed, 11 authors. Contact: (corresponding author).
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Anti-Inflammatory and Anti-Oxidant Activity of Ultra-Short Wave Diathermy on LPS-Induced Rat Lung Injury
Q Wu, M Qu, P Zhong, Y Zeng, J Wang, Q Zhang, Ting Wang, D Liu, L Yang, J Zhou, Tong Wang
Bulletin of Experimental Biology and Medicine, doi:10.1007/s10517-022-05407-4
We studied the lung-protective effect and mechanisms of the anti-inflammatory and antioxidant effects of ultra-short-wave diathermy (USWD) in a rat model of LPS-induced acute lung injury. Histological examination of the lung tissues was performed and the levels of oxidative stress-related factors and inflammatory cytokines were measured. It was shown that the lung injury score, the lung wet-to-dry weight ratio (W/D), oxidative stress-related factors malondialdehyde and acyl-CoA synthetase long-chain family member 4 (ACSL4), and inflammatory cytokines were increased after LPS administration, while USWD treatment reduced these parameters. In addition, superoxide dismutase and glutathione peroxidase 4 were decreased in rats with LPS-induced acute lung injury, while USWD therapy up-regulated the expression of these enzymes. Thus, USWD could antagonize lung injury by inhibiting oxidative stress and inflammatory response in rats with acute lung injury. USWD can be a promising adjunctive treatment to counter oxidative stress and inflammation and a potential therapeutic candidate for the treatment of patients with this pathology.
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