Clinical outcomes, virological efficacy and safety of nitazoxanide in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Weng et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2022.2142117, Nov 2022
Meta analysis of 5 RCTs showing improved viral clearance with nitazoxanide. Mortality was lower, but without statistical significance.
2 meta-analyses show significant improvements with nitazoxanide for oxygen therapy1 and viral clearance1,2.
Currently there are 14 nitazoxanide for COVID-19 studies, showing 42% lower mortality [-24‑73%], 82% lower ventilation [24‑96%], 28% lower ICU admission [-21‑57%], 61% lower hospitalization [22‑80%], and 13% fewer cases [-31‑42%].
Weng et al., 3 Nov 2022, Randomized Controlled Trial, peer-reviewed, 5 authors.
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