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Clinical outcomes, virological efficacy and safety of nitazoxanide in the treatment of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials

Weng et al., Expert Review of Anti-infective Therapy, doi:10.1080/14787210.2022.2142117
Nov 2022  
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Meta analysis of 5 RCTs showing improved viral clearance with nitazoxanide. Mortality was lower, but without statistical significance.
2 meta analyses show significant improvements with nitazoxanide for oxygen therapy1 and viral clearance1,2.
Currently there are 14 nitazoxanide for COVID-19 studies, showing 42% lower mortality [-24‑73%], 82% lower ventilation [24‑96%], 28% lower ICU admission [-21‑57%], 61% lower hospitalization [22‑80%], and 13% fewer cases [-31‑42%].
Weng et al., 3 Nov 2022, Randomized Controlled Trial, peer-reviewed, 5 authors.
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DOI record: { "DOI": "10.1080/14787210.2022.2142117", "ISSN": [ "1478-7210", "1744-8336" ], "URL": "http://dx.doi.org/10.1080/14787210.2022.2142117", "alternative-id": [ "10.1080/14787210.2022.2142117" ], "assertion": [ { "label": "Peer Review Statement", "name": "peerreview_statement", "order": 1, "value": "The publishing and review policy for this title is described in its Aims & Scope." }, { "URL": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierz20", "label": "Aim & Scope", "name": "aims_and_scope_url", "order": 2, "value": "http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=ierz20" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Received", "name": "received", "order": 0, "value": "2022-09-21" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Accepted", "name": "accepted", "order": 2, "value": "2022-10-25" }, { "group": { "label": "Publication History", "name": "publication_history" }, "label": "Published", "name": "published", "order": 3, "value": "2022-11-03" } ], "author": [ { "affiliation": [ { "name": "Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan" } ], "family": "Weng", "given": "Tzu-Chieh", "sequence": "first" }, { "affiliation": [ { "name": "Department of Pharmacy, Chi Mei Medical Center, Liouying, Taiwan" } ], "family": "Weng", "given": "Teng-Song", "sequence": "additional" }, { "ORCID": "http://orcid.org/0000-0002-6334-2388", "affiliation": [ { "name": "Division of Hospital Medicine, Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan" } ], "authenticated-orcid": false, "family": "Lai", "given": "Chih-Cheng", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Taiwan" } ], "family": "Chao", "given": "Chien-Ming", "sequence": "additional" }, { "affiliation": [ { "name": "Department of Internal Medicine, Division of Infection Disease, Kaohsiung Veterans General Hospital, Tainan Branch, Tainan, Taiwan" }, { "name": "Department of Health Care Administration, Chang Jung Christian University, Tainan, Taiwan" }, { "name": "Department of Food Nutrition, Chung-Hwa University of Medical Technology, Tainan, Taiwan" } ], "family": "Wang", "given": "Jui-Hsiang", "sequence": "additional" } ], "container-title": "Expert Review of Anti-infective Therapy", "container-title-short": "Expert Review of Anti-infective Therapy", "content-domain": { "crossmark-restriction": true, "domain": [ "www.tandfonline.com" ] }, "created": { "date-parts": [ [ 2022, 11, 1 ] ], "date-time": "2022-11-01T11:28:49Z", "timestamp": 1667302129000 }, "deposited": { "date-parts": [ [ 2023, 1, 3 ] ], "date-time": "2023-01-03T11:47:40Z", "timestamp": 1672746460000 }, "indexed": { "date-parts": [ [ 2023, 12, 2 ] ], "date-time": "2023-12-02T14:33:33Z", "timestamp": 1701527613112 }, "is-referenced-by-count": 1, "issue": "12", "issued": { "date-parts": [ [ 2022, 11, 3 ] ] }, "journal-issue": { "issue": "12", "published-print": { "date-parts": [ [ 2022, 12, 2 ] ] } }, "language": "en", "link": [ { "URL": "https://www.tandfonline.com/doi/pdf/10.1080/14787210.2022.2142117", "content-type": "unspecified", "content-version": "vor", "intended-application": "similarity-checking" } ], "member": "301", "original-title": [], "page": "1615-1622", "prefix": "10.1080", "published": { "date-parts": [ [ 2022, 11, 3 ] ] }, "published-online": { "date-parts": [ [ 2022, 11, 3 ] ] }, "published-print": { "date-parts": [ [ 2022, 12, 2 ] ] }, "publisher": "Informa UK Limited", "reference": [ { "DOI": "10.1016/j.ijantimicag.2020.105924", "doi-asserted-by": "publisher", "key": "cit0001" }, { "key": "cit0002", "unstructured": "World Health Organization. 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