Abstract: Indian Journal of Forensic Medicine & Toxicology, April-June 2021, Vol. 15, No. 2 4021 Probiotics Intake as Adjunct Therapy for Infected Health-Care with SARS COV-2 Anna Surgean Veterini1, Eighty Mardiyan Kurniawati2, Hamzah3, Subijanto Marto Soedarmo4, Cita Rosita Sigit Prakoeswa5, Damayanti Tinduh6 1Anesthesiologist Intensivist, 2Obstetrician, 3Anesthesiologist Intensivist, 4Prof., Pediatrician, 5 Prof. Dermatologist, 6Medical Rehabilition Specialist of Dr Soetomo General Academic Hospital – Universitas Airlangga, Address: Jalan Prof. Dr. Moestopo 6-8 Surabaya, Indonesia Abstract Objectives: We performed this case-control observational study to evaluate the comparison of the length of duration of SARS COV-2 infection and the cycle threshold (Ct) value of reverse-transcriptase polymerase chain reaction (RT-PCR) nasopharynx swab between the probiotics intake (case) group and the nonprobiotics intake (control) group. Materials and Methods: Our study was a case-control study involving 15 cases and 15 controls match for RT-PCR positive results. The participants were healthcare consisted of registrars, consultants, and nurses. Each participant was interviewed by google forms using a structured questionnaire to collect sociodemographic characteristics, diet, therapy from a pulmonologist, and adjunct therapy. Results: The total participants consisted of 15 males and 15 females. 4 participants in the case group had febrile, 1 participant with anosmia, 1 participant with febrile, nausea, and vomit before they consumed probiotics, and 9 participants without clinical complaints. One participant in the control group had fevered and cough, 14 participants without clinical complaints—1 participant with co-morbidities in the control group. The data of age, duration of infection, and cycle threshold (Ct) value were in the normal distribution. Analysis results using SPSS 21.00 show no significant differences in the course of disease between the case group and the control group. We found 2 participants in the control group had re-infection, while there was no re-infection in the case group. Conclusion: The present study’s finding may imply future care for the viral infection through the immunomodulation mechanism by probiotics consumption. Keywords: Probiotics; Immunomodulator; COVID-19