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All Studies   Meta Analysis    Recent:   

The Effect of Vitamin B12, Magnesium and Vitamin D in COVID-19 among Geriatric Patients

Valecha et al., International Journal of Pharmaceutical and Clinical Research, 14:5
Apr 2022  
  Source   PDF   All Studies   Meta AnalysisMeta
ICU admission 87% Improvement Relative Risk Hospitalization time 38% Vitamin B12  Valecha et al.  EARLY TREATMENT Is early treatment with vitamin B12 + combined treatments beneficial for COVID-19? Prospective study of 55 patients in India Shorter hospitalization with vitamin B12 + combined treatments (p<0.000001) Valecha et al., Int. J. Pharmaceutical.., Apr 2022 Favorsvitamin B12 Favorscontrol 0 0.5 1 1.5 2+
34th treatment shown to reduce risk in February 2022
*, now with p = 0.023 from 4 studies.
Lower risk for recovery.
No treatment is 100% effective. Protocols combine treatments. * >10% efficacy, ≥3 studies.
4,300+ studies for 75 treatments.
Prospective study of 30 patients treated with vitamin D, magnesium, and vitamin B12, and 25 control patients, showing shorter hospitalization and lower oxygen and ICU requirements with treatment. Cholecalciferol 1000IU, magnesium oxide 150mg, vitamin B12 500μg.
This study is excluded in meta analysis: combined treatments may contribute more to the effect seen.
Study covers vitamin B12 and vitamin D.
risk of ICU admission, 86.8% lower, RR 0.13, p = 0.09, treatment 0 of 30 (0.0%), control 3 of 25 (12.0%), NNT 8.3, relative risk is not 0 because of continuity correction due to zero events (with reciprocal of the contrasting arm).
hospitalization time, 38.5% lower, relative time 0.62, p < 0.001, treatment mean 11.2 (±2.8) n=30, control mean 18.2 (±1.21) n=25.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Valecha et al., 26 Apr 2022, prospective, India, peer-reviewed, 1 author, average treatment delay 3.7 days, this trial uses multiple treatments in the treatment arm (combined with magnesium and vitamin B12) - results of individual treatments may vary.
This PaperVitamin B12All
The Effect of Vitamin B12, Magnesium and Vitamin D in COVID-19 among Geriatric Patients
Vijay Valecha
Introduction: The pandemic hit caused a high prevalence of COVID-19 and fatalities globally. This disease has affected various organ systems and caused systemic inflammation, other than respiratory symptoms. The pathophysiological mechanism also showed that lower levels of vitamin B12 caused disruption in gut microbiota and increased oxidative stress. Reduced levels of vitamins and magnesium, which resulted from the infection of this disease, have led to further deterioration of the health status. Aims and Objectives: This study is intended to evaluate the effect of combination therapy of vitamin D, magnesium, and vitamin B12 in COVID-19 patients by analyzing the outcomes of the disease when this combination therapy is applied. Materials and Methods: This current study is a cohort observational prospective, in which 30 patients were given a combination of cholecalciferol (vitamin D3) of 1000 IU, magnesium oxide at 150 mg dose and methylcobalamin (Vitamin B12) of 500 µg, referred to as Intervention group. Another 25 patients were taken for comparison and referred to as the Control group. The baseline data was collected and the outcomes were observed and compared between the two groups. Results: The study also found that the duration required to run the management of COVID-19 is significantly less in the Intervention group than the control group (p<0.05). The study further added that the group which received the combination therapy required less oxygen therapy with or without ICU support (p<0.05). Conclusion: The study concluded that this combination therapy can improve the health status of COVID-19 patients by decreasing the probability to require oxygen therapy and ICU support. The study also concluded that this combined therapy can reduce the duration of hospitalization of COVID-19 patients.
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