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All Studies   Meta Analysis   Recent:  
0 0.5 1 1.5 2+ Mortality 45% Improvement Relative Risk ICU admission 37% Hospitalization time 18% Recovery time 20% c19early.org/fm Taşdemir et al. Famotidine for COVID-19 LATE Is late treatment with famotidine beneficial for COVID-19? Retrospective 179 patients in Turkey Study compares with pantoprazole, results vs. placebo may differ Shorter hospitalization (p=0.003) and faster recovery (p=0.04) Taşdemir et al., Konuralp Tıp Dergisi, doi:10.18521/ktd.935888 Favors famotidine Favors pantoprazole
Famotidine in COVID-19 treatment
Taşdemir et al., Konuralp Tıp Dergisi, doi:10.18521/ktd.935888
Taşdemir et al., Famotidine in COVID-19 treatment, Konuralp Tıp Dergisi, doi:10.18521/ktd.935888
Jul 2021   Source   PDF  
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Retrospective 179 hospitalized patients in Turkey, 85 treated with famotidine and 94 treated with pantoprazole, showing faster recovery with famotidine in unadjusted results. This study is excluded in the after exclusion results of meta analysis: excessive unadjusted differences between groups.
risk of death, 44.7% lower, RR 0.55, p = 0.29, treatment 5 of 85 (5.9%), control 10 of 94 (10.6%), NNT 21.
risk of ICU admission, 36.8% lower, RR 0.63, p = 0.36, treatment 8 of 85 (9.4%), control 14 of 94 (14.9%), NNT 18.
hospitalization time, 18.1% lower, relative time 0.82, p = 0.003, treatment 85, control 94.
recovery time, 20.0% lower, relative time 0.80, p = 0.04, treatment 85, control 94, duration of fever.
Effect extraction follows pre-specified rules prioritizing more serious outcomes. Submit updates
Taşdemir et al., 12 Jul 2021, retrospective, Turkey, peer-reviewed, 7 authors, this trial compares with another treatment - results may be better when compared to placebo.
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This PaperFamotidineAll
Abstract: Tasdemir C et al. RESEARCH ARTICLE Canatan Tasdemir1 Ertugrul Guclu2 Zeynep Devran3 El Medina Hotschka2 Yusuf Aydemir4 Aziz Ogutlu2 Oguz Karabay2 1 Sakarya University Training and Research Hospital, Department of Chest Diseases, Sakarya, Turkey 2 Sakarya University Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology, Sakarya, Turkey 3 Sakarya Provincial Health Directorate, Sakarya, Turkey 4 Sakarya University Faculty of Medicine Department of Pulmonology, Sakarya, Turkey Famotidine in COVID-19 Treatment ABSTRACT Objective: Famotidine is an H2 receptor antagonist (H2RA) and has been shown to have antiviral properties in in vitro studies. Pantoprazole is one of the proton pump inhibitors (PPI). In this study, it was aimed to compare the efficacy of famotidine with pantoprazole in the treatment of COVID-19. Methods: Patients who were hospitalized and given famotidine and pantoprazole treatment for at least 48 hours were included in the study. Demographic, clinical and laboratory findings of the patients were analyzed retroprospectively from the patient files. The patients were divided into two groups as the famotidine group and the pantoprazole group. The groups were compared in terms of the need for intensive care and mortality rates. In addition, among the groups, the number of patients with normal oxygen saturation at discharge, number of days needed for oxygen support, number of days with fever, and length of hospital stay were evaluated. Results: A total of 179 Covid-19 patients (85 famotidine, 94 pantoprazole) were included in the study. Demographic findings and other symptoms except dyspnea were similar in both groups. Dyspnea, chronic diseases, and the number of patients given steroids were higher in those who were given pantoprazole (p<0.05). Mortality and ICU need were similar in both groups (respectively; p=0.25, p=0.26). The number of days with fever, duration of hospitalization, and the number of days requiring oxygen support were less in those given famotidine (respectively; p=0.04, p=0.003, p=0.014). Conclusions: Famotidine did not reduce the need for intensive care and mortality in COVID-19 patients treated in the hospital. New therapeutic agents are needed to reduce disease severity and mortality. Keywords: COVID-19, Famotidine, Pantoprazole, Mortality. Corresponding Author: Yusuf Aydemir Sakarya University Faculty of Medicine Department of Pulmonology, Sakarya, Turkey mail: dryaydemir@yahoo.com Phone: +90 5056369494 Received: 11.05.2021 Acceptance: 12.07.2021 DOI: 10.18521/ktd.935888 Konuralp Medical Journal e-ISSN1309–3878 konuralptipdergi@duzce.edu.tr konuralptipdergisi@gmail.com www.konuralptipdergi.duzce.edu.tr COVID-19 Tedavisinde Famotidin Kullanımı ÖZET Amaç: Famotidin, bir H2 reseptör antagonistidir ve in vitro çalışmalarda antiviral özelliklere sahip olduğu gösterilmiştir. Pantoprazol, proton pompası inhibitörlerinden biridir. Bu çalışmada, COVID19 tedavisinde Famotidinin ile Pantaprazolun etkinliğinin karşılaştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya en az 48 saat famotidin ve pantaprazol tedavisi verilen ve hastanede yatan hastalar dâhil edildi. Hastaların demografik, klinik ve laboratuvar bulguları hasta dosyalarından geriye dönük olarak incelendi. Hastalar famotidin grubu ve pantoprazol grubu olarak iki gruba ayrıldı. Gruplar yoğun bakım ihtiyacı ve ölüm oranları açısından karşılaştırıldı. Ayrıca gruplar arasında taburculukta oksijen saturasyonu normal olan hasta..
Late treatment
is less effective
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