Famotidine in COVID-19 treatment
Canatan Taşdemir, Ertuğrul Güçlü, Zeynep Devran Muharremoğlu, El Medina Hotschka, Yusuf Aydemir, Aziz Öğütlü, Oğuz Karabay
Konuralp Tıp Dergisi, doi:10.18521/ktd.935888
Objective: Famotidine is an H2 receptor antagonist (H2RA) and has been shown to have antiviral properties in in vitro studies. Pantoprazole is one of the proton pump inhibitors (PPI). In this study, it was aimed to compare the efficacy of famotidine with pantoprazole in the treatment of COVID-19. Methods: Patients who were hospitalized and given famotidine and pantoprazole treatment for at least 48 hours were included in the study. Demographic, clinical and laboratory findings of the patients were analyzed retroprospectively from the patient files. The patients were divided into two groups as the famotidine group and the pantoprazole group. The groups were compared in terms of the need for intensive care and mortality rates. In addition, among the groups, the number of patients with normal oxygen saturation at discharge, number of days needed for oxygen support, number of days with fever, and length of hospital stay were evaluated. Results: A total of 179 Covid-19 patients (85 famotidine, 94 pantoprazole) were included in the study. Demographic findings and other symptoms except dyspnea were similar in both groups. Dyspnea, chronic diseases, and the number of patients given steroids were higher in those who were given pantoprazole (p<0.05). Mortality and ICU need were similar in both groups (respectively; p=0.25, p=0.26). The number of days with fever, duration of hospitalization, and the number of days requiring oxygen support were less in those given famotidine (respectively; p=0.04, p=0.003, p=0.014). Conclusions: Famotidine did not reduce the need for intensive care and mortality in COVID-19 patients treated in the hospital. New therapeutic agents are needed to reduce disease severity and mortality.
References
Bourinbaiar, Fruhstorfer, The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents, Life Sci
Branco, Yoshikawa, Pietrobon, Sato, Role of Histamine in Modulating the Immune Response and Inflammation, Mediators Inflamm
Ennis, Tiligada, Histamine receptors and COVID-19, Inflammation Research
Freedberg, Conigliaro, Wang, Tracey, Callahan et al., Famotidine Use Is Associated With Improved Clinical Outcomes in Hospitalized COVID-19 Patients: A Propensity Score Matched Retrospective Cohort Study, Gastroenterology,
doi:10.1053/j.gastro.2020.05.053García, Immune response, inflammation, and the clinical spectrum of COVID-19, Frontiers in immunology
Kalpaklıoglu, Kalkan, Kavut, Histamin ve antihistaminler. Türkiye Klinikleri İmmünoloji Allerji-Özel Konular
Li, Xu, Yu, Wang, Tao et al., Risk factors for severity and mortality in adult COVID-19 inpatients in Wuhan, J Allergy Clin Immunol,
doi:10.1016/j.jaci.2020.04.006Trivedi, Verma, Kumar, Possible treatment and strategies for COVID-19: review and assessment, Eur Rev Med Pharmacol Sci
{ 'indexed': { 'date-parts': [[2021, 12, 17]],
'date-time': '2021-12-17T13:27:07Z',
'timestamp': 1639747627637},
'reference-count': 12,
'publisher': 'Konuralp Medical Journal',
'content-domain': {'domain': [], 'crossmark-restriction': False},
'short-container-title': [],
'DOI': '10.18521/ktd.935888',
'type': 'journal-article',
'created': {'date-parts': [[2021, 7, 13]], 'date-time': '2021-07-13T06:21:08Z', 'timestamp': 1626157268000},
'source': 'Crossref',
'is-referenced-by-count': 0,
'title': ['Famotidine in COVID-19 treatment'],
'prefix': '10.18521',
'author': [ {'given': 'Canatan', 'family': 'TAŞDEMİR', 'sequence': 'first', 'affiliation': []},
{'given': 'Ertuğrul', 'family': 'GÜÇLÜ', 'sequence': 'additional', 'affiliation': []},
{ 'given': 'Zeynep',
'family': 'DEVRAN MUHARREMOĞLU',
'sequence': 'additional',
'affiliation': []},
{'given': 'El Medina', 'family': 'HOTSCHKA', 'sequence': 'additional', 'affiliation': []},
{'given': 'Yusuf', 'family': 'AYDEMİR', 'sequence': 'additional', 'affiliation': []},
{'given': 'Aziz', 'family': 'ÖĞÜTLÜ', 'sequence': 'additional', 'affiliation': []},
{'given': 'Oğuz', 'family': 'KARABAY', 'sequence': 'additional', 'affiliation': []}],
'member': '7783',
'published-online': {'date-parts': [[2021, 7, 12]]},
'container-title': ['Konuralp Tıp Dergisi'],
'original-title': [],
'deposited': { 'date-parts': [[2021, 7, 13]],
'date-time': '2021-07-13T06:21:26Z',
'timestamp': 1626157286000},
'score': 1,
'subtitle': [],
'short-title': [],
'issued': {'date-parts': [[2021, 7, 12]]},
'references-count': 12,
'URL': 'http://dx.doi.org/10.18521/ktd.935888',
'relation': {},
'ISSN': ['1309-3878'],
'issn-type': [{'value': '1309-3878', 'type': 'print'}],
'subject': ['General Medicine'],
'published': {'date-parts': [[2021, 7, 12]]}}
